AU7228394A - Indoline derivatives as 5HT2C antagonists - Google Patents

Indoline derivatives as 5HT2C antagonists

Info

Publication number
AU7228394A
AU7228394A AU72283/94A AU7228394A AU7228394A AU 7228394 A AU7228394 A AU 7228394A AU 72283/94 A AU72283/94 A AU 72283/94A AU 7228394 A AU7228394 A AU 7228394A AU 7228394 A AU7228394 A AU 7228394A
Authority
AU
Australia
Prior art keywords
indoline
pyridylcarbamoyl
chloro
methyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU72283/94A
Other languages
English (en)
Inventor
Ian Thomson Forbes
Peter Ham
Graham Elgin Jones
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of AU7228394A publication Critical patent/AU7228394A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Eyeglasses (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU72283/94A 1993-07-06 1994-06-30 Indoline derivatives as 5HT2C antagonists Abandoned AU7228394A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB939313913A GB9313913D0 (en) 1993-07-06 1993-07-06 Novel compounds
GB9313913 1993-07-06
PCT/EP1994/002148 WO1995001976A1 (en) 1993-07-06 1994-06-30 Indoline derivatives as 5ht2c antagonists

Publications (1)

Publication Number Publication Date
AU7228394A true AU7228394A (en) 1995-02-06

Family

ID=10738344

Family Applications (1)

Application Number Title Priority Date Filing Date
AU72283/94A Abandoned AU7228394A (en) 1993-07-06 1994-06-30 Indoline derivatives as 5HT2C antagonists

Country Status (15)

Country Link
US (1) US5834494A (cg-RX-API-DMAC7.html)
EP (1) EP0707581B1 (cg-RX-API-DMAC7.html)
JP (1) JPH08512299A (cg-RX-API-DMAC7.html)
CN (1) CN1129937A (cg-RX-API-DMAC7.html)
AP (1) AP463A (cg-RX-API-DMAC7.html)
AT (1) ATE149163T1 (cg-RX-API-DMAC7.html)
AU (1) AU7228394A (cg-RX-API-DMAC7.html)
CA (1) CA2166624A1 (cg-RX-API-DMAC7.html)
DE (1) DE69401823T2 (cg-RX-API-DMAC7.html)
GB (1) GB9313913D0 (cg-RX-API-DMAC7.html)
IL (1) IL110204A0 (cg-RX-API-DMAC7.html)
MA (1) MA23254A1 (cg-RX-API-DMAC7.html)
TW (1) TW297023B (cg-RX-API-DMAC7.html)
WO (1) WO1995001976A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA944807B (cg-RX-API-DMAC7.html)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5618824A (en) * 1994-03-09 1997-04-08 Merrell Pharmaceuticals Inc. Treatment of obsessive-compulsive disorders with 5-HT2 antagonists
GB9414139D0 (en) * 1994-07-13 1994-08-31 Smithkline Beecham Plc Novel compounds
GB9420521D0 (en) * 1994-10-12 1994-11-30 Smithkline Beecham Plc Novel compounds
BR9607016A (pt) * 1995-02-02 1997-10-28 Smithkline Beecham Plc Derivados de indol como antagonísta de receptor 5-ht
WO1996023769A2 (en) * 1995-02-02 1996-08-08 Smithkline Beecham Plc Heterocyclic compounds possessing 5ht2c receptor antagonist activity
GB9517559D0 (en) * 1995-08-26 1995-10-25 Smithkline Beecham Plc Novel compounds
CA2253941A1 (en) * 1996-05-16 1997-11-20 Sumanas Rakhit Thiophene- and furan-tryptamine derivatives
GB9612883D0 (en) * 1996-06-20 1996-08-21 Smithkline Beecham Plc Novel compounds
GB9612885D0 (en) * 1996-06-20 1996-08-21 Smithkline Beecham Plc Novel compounds
US6362009B1 (en) 1997-11-21 2002-03-26 Merck & Co., Inc. Solid phase synthesis of heterocycles
FR2778662B1 (fr) * 1998-05-12 2000-06-16 Adir Nouveaux composes cycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP1122252A4 (en) * 1998-10-16 2002-06-26 Takeda Chemical Industries Ltd CONDENSED HEREROCYCLIC NITROGEN COMPOUNDS; MANUFACTURING PROCESS AND AGENTS CONTAINING THEM
US6453357B1 (en) 1999-01-07 2002-09-17 Cisco Technology, Inc. Method and system for processing fragments and their out-of-order delivery during address translation
US6465467B1 (en) 1999-05-21 2002-10-15 Biovitrum Ab Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases
ES2252004T3 (es) * 1999-05-21 2006-05-16 Biovitrum Ab Nuevos compuestos, su uso y preparacion.
UA77650C2 (en) 1999-12-06 2007-01-15 Lundbeck & Co As H Use of serotonin reuptake inhibitor in combination with deramcyclane
FR2810979B1 (fr) * 2000-06-29 2002-08-23 Adir Nouveaux derives de diphenyluree, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
GB0019950D0 (en) * 2000-08-12 2000-09-27 Smithkline Beecham Plc Compounds
SE0004245D0 (sv) 2000-11-20 2000-11-20 Pharmacia Ab Novel compounds and their use
EP1304589A1 (en) * 2001-07-09 2003-04-23 Alcatel Connector for optical fibers
US6861440B2 (en) 2001-10-26 2005-03-01 Hoffmann-La Roche Inc. DPP IV inhibitors
FR2837823B1 (fr) * 2002-03-27 2005-04-08 Servier Lab Nouveaux derives d'indoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
NZ536664A (en) 2002-06-19 2007-07-27 Biovitrum Ab Piperazinylpyrazine derivative compounds, their use and preparation
BRPI0411509A (pt) 2003-06-20 2006-07-25 Hoffmann La Roche compostos, processo para a sua manufatura, composições farmacêuticas que compreendem os mesmos, método para tratamento e/ou profilaxia de enfermidades que estão associadas com dpp-iv e sua utilização
EA009591B1 (ru) 2003-06-20 2008-02-28 Ф.Хоффманн-Ля Рош Аг Производные пиридо[2,1-а]изохинолина в качестве ингибиторов dpp-iv
AR058040A1 (es) * 2005-09-13 2008-01-23 Bayer Cropscience Ag Derivados plaguicidas de fenilamidina sustituida con feniloxi
US8293100B2 (en) 2009-03-13 2012-10-23 Terrasep, Llc Methods and apparatus for centrifugal liquid chromatography
CN106278987A (zh) * 2016-08-16 2017-01-04 都创(上海)医药科技有限公司 吲哚啉类化合物的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4428881A (en) * 1977-12-23 1984-01-31 Gulf Oil Corporation Control of unwanted vegetation with N-carbamylindolines
KR930702334A (ko) * 1990-09-13 1993-09-08 데이비드 로버트 5 하이드록시트립타민 수용체 길항제로서의 인돌우레아
CA2142721A1 (en) * 1992-08-20 1994-03-03 Ian T. Forbes Condensed indole derivatives as 5ht and 5ht antagonists

Also Published As

Publication number Publication date
DE69401823D1 (de) 1997-04-03
EP0707581A1 (en) 1996-04-24
TW297023B (cg-RX-API-DMAC7.html) 1997-02-01
AP9400653A0 (en) 1994-07-31
ATE149163T1 (de) 1997-03-15
WO1995001976A1 (en) 1995-01-19
JPH08512299A (ja) 1996-12-24
US5834494A (en) 1998-11-10
IL110204A0 (en) 1995-01-24
CA2166624A1 (en) 1995-01-19
GB9313913D0 (en) 1993-08-18
DE69401823T2 (de) 1997-08-28
ZA944807B (en) 1996-01-04
EP0707581B1 (en) 1997-02-26
CN1129937A (zh) 1996-08-28
AP463A (en) 1996-02-19
MA23254A1 (fr) 1995-04-01

Similar Documents

Publication Publication Date Title
EP0707581B1 (en) Indoline derivatives as 5ht2c antagonists
CN101243068B (zh) 治疗多重耐药性细菌感染的化合物
CN1064358C (zh) 苄基哌啶衍生物
KR950010163B1 (ko) 신규 인돌 유도체
AU727608B2 (en) CBI analogs of CC-1065 and the duocarmycins
EP0690843B1 (en) Formyl- or cyano- substituted indole derivatives having dopaminergic activity
WO2003013510A1 (en) 3-arylsulfonyl-7-piperazinyl- indoles, -benzofurans and -benzothiophenes with 5-ht6 receptor affinity for treating cns disorders
EP1216239A1 (en) Piperazine derivatives as 5-ht1b antagonists
WO2008047831A1 (en) Jak inhibitor
KR20070114123A (ko) 염증 치료에 유용한 인돌
JPH0784462B2 (ja) ベンゾイミダゾ−ル誘導体
HU221193B1 (en) Neuroprotective indole, qinoline and benzoxazolone derivatives, pharmaceutical compositions comprising such compounds and process for producing them
US20040102418A1 (en) Compounds for the treatment of inflammatory disorders
FR2804114A1 (fr) Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant
CN1314904A (zh) 用作抗癌剂的炔基取代的喹啉－2－酮衍生物
CN1227841A (zh) 作为5－ht1a拮抗剂的哌嗪衍生物
CN101351446A (zh) 新的稠合吡咯衍生物
AU2006237920A1 (en) Nitrogen-containing heterocyclic compound
FR2805536A1 (fr) Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant
EP1487801A1 (en) 7-arylsulfonamido-2,3,4,5-tetrahydro-1h-benzo[d]azepine derivatives with 5-ht6 receptor affinity for the treatment of cns disorders
JPWO1998000400A1 (ja) テトラヒドロベンズインドール化合物
KR20070061569A (ko) Ｃｎｓ 장애 치료를 위한 5-ｈｔ6 수용체 길항제로서의5-술포닐-1-피페리디닐 치환된 인돌 유도체
CN107108575A (zh) 作为抗组胺剂的新型苯并咪唑衍生物
JPWO2009041559A1 (ja) インダゾールアクリル酸アミド化合物
KR100517387B1 (ko) 벤젠술폰아미드 화합물, 이의 제조 방법 및 이를 함유하는약제 조성물