JPH08511802A - ビス−イミド抗腫瘍剤のための多環式および複素環式発色団 - Google Patents

ビス−イミド抗腫瘍剤のための多環式および複素環式発色団

Info

Publication number
JPH08511802A
JPH08511802A JP7502870A JP50287095A JPH08511802A JP H08511802 A JPH08511802 A JP H08511802A JP 7502870 A JP7502870 A JP 7502870A JP 50287095 A JP50287095 A JP 50287095A JP H08511802 A JPH08511802 A JP H08511802A
Authority
JP
Japan
Prior art keywords
azaphenanthrene
propylamino
independently
nmr
nitro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP7502870A
Other languages
English (en)
Japanese (ja)
Inventor
パツテン，アーサー・デイビツド
パコフスキー，グレゴリー・ジエイムズ
サイツ，ステイーブン・ポール
アカミーケ，エメカ・アミーチ
チヤーニー，ロバート・ジヨーゼフ
カルテンバツチ，ロバート・フランク・ザサード
オーウオツト，マイクル・ジエイムズ
Original Assignee
ザ・デュポン・メルク・ファーマシュウティカル・カンパニー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ザ・デュポン・メルク・ファーマシュウティカル・カンパニー filed Critical ザ・デュポン・メルク・ファーマシュウティカル・カンパニー
Publication of JPH08511802A publication Critical patent/JPH08511802A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B11/00—Diaryl- or thriarylmethane dyes
    • C09B11/28—Pyronines ; Xanthon, thioxanthon, selenoxanthan, telluroxanthon dyes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B15/00—Acridine dyes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B5/00—Dyes with an anthracene nucleus condensed with one or more heterocyclic rings with or without carbocyclic rings
    • C09B5/002—Dyes with an anthracene nucleus condensed with one or more heterocyclic rings with or without carbocyclic rings the heterocyclic rings being condensed in peri position and in 1-2 or 2-3 position
    • C09B5/004—Dyes with an anthracene nucleus condensed with one or more heterocyclic rings with or without carbocyclic rings the heterocyclic rings being condensed in peri position and in 1-2 or 2-3 position only O-containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution
    • C09B57/08—Naphthalimide dyes; Phthalimide dyes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP7502870A 1993-06-24 1994-06-15 ビス−イミド抗腫瘍剤のための多環式および複素環式発色団 Pending JPH08511802A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/080,862 US5416089A (en) 1993-06-24 1993-06-24 Polycyclic and heterocyclic chromophores for bis-imide tumoricidals
US08/080,862 1993-06-24
PCT/US1994/006442 WO1995000490A1 (en) 1993-06-24 1994-06-15 Bis-imide polycyclic and heterocyclic chromophores useful as tumoricidals

Publications (1)

Publication Number Publication Date
JPH08511802A true JPH08511802A (ja) 1996-12-10

Family

ID=22160120

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7502870A Pending JPH08511802A (ja) 1993-06-24 1994-06-15 ビス−イミド抗腫瘍剤のための多環式および複素環式発色団

Country Status (19)

Country Link
US (2) US5416089A (en:Method)
EP (1) EP0705250A1 (en:Method)
JP (1) JPH08511802A (en:Method)
KR (1) KR960703113A (en:Method)
CN (1) CN1125943A (en:Method)
AU (1) AU7171294A (en:Method)
BR (1) BR9407265A (en:Method)
CA (1) CA2165765A1 (en:Method)
CZ (1) CZ336795A3 (en:Method)
FI (1) FI956231A0 (en:Method)
HR (1) HRP940367A2 (en:Method)
HU (1) HUT75121A (en:Method)
IL (1) IL110033A0 (en:Method)
NO (1) NO955257L (en:Method)
PL (1) PL312272A1 (en:Method)
SK (1) SK163095A3 (en:Method)
TW (1) TW263506B (en:Method)
WO (1) WO1995000490A1 (en:Method)
ZA (1) ZA944370B (en:Method)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011500783A (ja) * 2007-10-22 2011-01-06 オーキッド リサーチ ラボラトリーズ リミテッド ヒストンデアセチラーゼ阻害剤

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703089A (en) * 1994-04-28 1997-12-30 Knoll Aktiengesellschaft Dihydrodibenzisoquinolinediones
US5641782A (en) * 1995-02-16 1997-06-24 The Dupont Merck Pharmaceutical Company 3-aromatic and 3-heteroaromatic substituted bisnaphthalimides
FR2751655B1 (fr) * 1996-07-26 1998-08-28 Adir Nouveaux derives de bis-imides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP1053237B1 (en) * 1998-02-04 2003-07-02 The Board Of Regents, The University Of Texas System Inhibition of human telomerase by a g-quadruplex-interaction compound
ES2191532B1 (es) * 2001-05-28 2005-02-16 Fundacion Universitaria San Pablo - Ceu Derivados de naftalimidas heterociclicas como agentes antiproliferativos.
US20040082788A1 (en) * 2002-07-08 2004-04-29 Chemgenex Therapeutics, Inc. Naphthalimide synthesis including amonafide synthesis and pharmaceutical preparations thereof
US20050192312A1 (en) * 2004-01-30 2005-09-01 Brown Dennis M. Naphthalimide dosing by N-acetyl transferase genotyping
CA2569279A1 (en) * 2004-06-04 2005-12-15 Chemgenex Pharmaceuticals, Inc. Methods of treating cellular proliferative disease using naphthalimide and parp-1 inhibitors
JP4993645B2 (ja) 2004-12-01 2012-08-08 ジェネンテック， インコーポレイテッド 抗体薬剤結合体および方法
US7947839B2 (en) * 2004-12-01 2011-05-24 Genentech, Inc. Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use
CN101638389B (zh) * 2008-03-03 2012-09-05 河南大学 一种含萘酰亚胺结构的多胺衍生物及其制备方法和应用
US9060776B2 (en) 2009-10-09 2015-06-23 Ethicon Endo-Surgery, Inc. Surgical generator for ultrasonic and electrosurgical devices
CN106167490B (zh) * 2016-08-10 2018-11-09 大连理工大学 一类含吲哚的咪唑并萘酰亚胺类衍生物及其合成和应用
CZ308568B6 (cs) 2018-12-03 2020-12-09 Univerzita Karlova Naftalimidofurany pro aplikace v molekulární biologii
JP6884920B2 (ja) * 2019-04-02 2021-06-09 旭化成株式会社 錠剤の保存安定性を向上させる方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3604827A1 (de) * 1986-02-15 1987-08-20 Bayer Ag Elektrophotographische toner
DE3707651A1 (de) * 1987-03-10 1988-09-22 Knoll Ag Bis-naphthalimide, ihre herstellung und verwendung
US5290931A (en) * 1990-02-21 1994-03-01 Hoechst Mitsubishi Kasei Co., Ltd. Water-insoluble naphthalic acid imide dyestuffs
US5086059A (en) * 1990-06-07 1992-02-04 Du Pont Merck Pharmaceutical Company Bis-naphthalimides as anticancer agents
US5206249A (en) * 1991-03-27 1993-04-27 Du Pont Merck Pharmaceutical Company Bis-naphthalimides containing amino-acid derived linkers as anticancer agents
US5206250A (en) * 1991-03-27 1993-04-27 Du Pont Merck Pharmaceutical Company Bis-naphthalimides containing amide and thioamide linkers as anticancer agents

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011500783A (ja) * 2007-10-22 2011-01-06 オーキッド リサーチ ラボラトリーズ リミテッド ヒストンデアセチラーゼ阻害剤

Also Published As

Publication number Publication date
US5585382A (en) 1996-12-17
BR9407265A (pt) 1996-10-01
PL312272A1 (en) 1996-04-15
ZA944370B (en) 1996-01-04
TW263506B (en:Method) 1995-11-21
HU9503759D0 (en) 1996-02-28
EP0705250A1 (en) 1996-04-10
CA2165765A1 (en) 1995-01-05
CN1125943A (zh) 1996-07-03
IL110033A0 (en) 1994-10-07
KR960703113A (ko) 1996-06-19
FI956231L (fi) 1995-12-22
US5416089A (en) 1995-05-16
AU7171294A (en) 1995-01-17
HRP940367A2 (en) 1997-04-30
FI956231A7 (fi) 1995-12-22
FI956231A0 (fi) 1995-12-22
HUT75121A (en) 1997-04-28
SK163095A3 (en) 1996-09-04
WO1995000490A1 (en) 1995-01-05
NO955257D0 (no) 1995-12-22
CZ336795A3 (en) 1996-06-12
NO955257L (no) 1996-02-26

Similar Documents

Publication Publication Date Title
Dallavalle et al. Novel 7-oxyiminomethyl derivatives of camptothecin with potent in vitro and in vivo antitumor activity
JPH08511802A (ja) ビス−イミド抗腫瘍剤のための多環式および複素環式発色団
JP7557890B2 (ja) 免疫抑制剤、その製造方法及び応用
JPH09501442A (ja) 免疫抑制剤として有用な炭素環式および複素環式縮合環キノリンカルボン酸
JPH09504519A (ja) ピリダジノキノリン化合物
AU716435B2 (en) Novel indole-2,3-dione-3-oxime derivatives
JP7611934B2 (ja) ピラゾロピリダジノン化合物、その医薬組成物及びその用途
US6737424B2 (en) Alpha-substituted pyridazino quinoline compounds
RU2162089C2 (ru) Новые пирролокарбазолы
CH633796A5 (fr) Dipyridoindoles therapeutiquement actifs.
JPH0311067A (ja) 興奮性アミノ酸拮抗剤
PT87604B (pt) Processo para a preparacao de agentes anti-alergicos e anti-inflamatorios di-hidropiridinicos
KR20180128456A (ko) 에스트로겐 수용체 하향 조절제로서의 치환된 인돌 화합물
JPH06508104A (ja) 抗真菌剤及び抗ミコバクテリア剤として有用な新規化合物および組成物
JPH08502037A (ja) ４環性化合物、これらを調整するための方法及び中間体並びに抗腫瘍剤としてのこれらの使用
JP2005530691A (ja) 新規なチロインジシンとその関連プロセス、薬学的組成物および方法
JP2023538405A (ja) 新規ｎ－複素環ｂｅｔブロモドメイン阻害剤、その調製方法及び医薬応用
FR2761071A1 (fr) Derives de quinolein-2(1h)-one et de dihydroquinolein-2(1h)- one, leur preparation et leur application en therapeutique
CN1325476C (zh) 通过偶氮甲碱叶立德的闭环制备稠多环生物碱,其新化合物和其作为化疗剂的应用
JPH05508639A (ja) １，２―ジヒドロ―３ｈ―ジベンズイソキノリン―１，３―ジオン抗ガン剤
JPS61254565A (ja) ６−フエニル−１，２，３，４，４ａ，５，６，１０ｂ−オクタヒドロベンゾ（ｈ）イソキノリン
ES2367968T3 (es) Sales de quino[4,3,2-kl]acridinio n8,n13-disustituidas utilizadas como agentes terapéuticos.
KR100199299B1 (ko) 벤조(c)페난트리디늄 유도체 제조방법 및 이 방법으로 제조된 신규화합물
FR2953838A1 (fr) Derives de 9h-beta-carboline (ou 9h-pyridino[3,4-b]indole) trisubstitues, leur preparation et leur utilisation therapeutique
WO2022171126A1 (zh) 作为Wee-1抑制剂的稠环化合物