IL110033A0 - Bis-imide derivatives and pharmaceutical compositions containing them - Google Patents
Bis-imide derivatives and pharmaceutical compositions containing themInfo
- Publication number
- IL110033A0 IL110033A0 IL11003394A IL11003394A IL110033A0 IL 110033 A0 IL110033 A0 IL 110033A0 IL 11003394 A IL11003394 A IL 11003394A IL 11003394 A IL11003394 A IL 11003394A IL 110033 A0 IL110033 A0 IL 110033A0
- Authority
- IL
- Israel
- Prior art keywords
- bis
- pharmaceutical compositions
- compositions containing
- imide derivatives
- imide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B11/00—Diaryl- or thriarylmethane dyes
- C09B11/28—Pyronines ; Xanthon, thioxanthon, selenoxanthan, telluroxanthon dyes
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B15/00—Acridine dyes
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B5/00—Dyes with an anthracene nucleus condensed with one or more heterocyclic rings with or without carbocyclic rings
- C09B5/002—Dyes with an anthracene nucleus condensed with one or more heterocyclic rings with or without carbocyclic rings the heterocyclic rings being condensed in peri position and in 1-2 or 2-3 position
- C09B5/004—Dyes with an anthracene nucleus condensed with one or more heterocyclic rings with or without carbocyclic rings the heterocyclic rings being condensed in peri position and in 1-2 or 2-3 position only O-containing hetero rings
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B57/00—Other synthetic dyes of known constitution
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B57/00—Other synthetic dyes of known constitution
- C09B57/08—Naphthalimide dyes; Phthalimide dyes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/080,862 US5416089A (en) | 1993-06-24 | 1993-06-24 | Polycyclic and heterocyclic chromophores for bis-imide tumoricidals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL110033A0 true IL110033A0 (en) | 1994-10-07 |
Family
ID=22160120
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11003394A IL110033A0 (en) | 1993-06-24 | 1994-06-16 | Bis-imide derivatives and pharmaceutical compositions containing them |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US5416089A (en:Method) |
| EP (1) | EP0705250A1 (en:Method) |
| JP (1) | JPH08511802A (en:Method) |
| KR (1) | KR960703113A (en:Method) |
| CN (1) | CN1125943A (en:Method) |
| AU (1) | AU7171294A (en:Method) |
| BR (1) | BR9407265A (en:Method) |
| CA (1) | CA2165765A1 (en:Method) |
| CZ (1) | CZ336795A3 (en:Method) |
| FI (1) | FI956231A0 (en:Method) |
| HR (1) | HRP940367A2 (en:Method) |
| HU (1) | HUT75121A (en:Method) |
| IL (1) | IL110033A0 (en:Method) |
| NO (1) | NO955257L (en:Method) |
| PL (1) | PL312272A1 (en:Method) |
| SK (1) | SK163095A3 (en:Method) |
| TW (1) | TW263506B (en:Method) |
| WO (1) | WO1995000490A1 (en:Method) |
| ZA (1) | ZA944370B (en:Method) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5703089A (en) * | 1994-04-28 | 1997-12-30 | Knoll Aktiengesellschaft | Dihydrodibenzisoquinolinediones |
| US5641782A (en) * | 1995-02-16 | 1997-06-24 | The Dupont Merck Pharmaceutical Company | 3-aromatic and 3-heteroaromatic substituted bisnaphthalimides |
| FR2751655B1 (fr) * | 1996-07-26 | 1998-08-28 | Adir | Nouveaux derives de bis-imides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| EP1053237B1 (en) * | 1998-02-04 | 2003-07-02 | The Board Of Regents, The University Of Texas System | Inhibition of human telomerase by a g-quadruplex-interaction compound |
| ES2191532B1 (es) * | 2001-05-28 | 2005-02-16 | Fundacion Universitaria San Pablo - Ceu | Derivados de naftalimidas heterociclicas como agentes antiproliferativos. |
| US20040082788A1 (en) * | 2002-07-08 | 2004-04-29 | Chemgenex Therapeutics, Inc. | Naphthalimide synthesis including amonafide synthesis and pharmaceutical preparations thereof |
| US20050192312A1 (en) * | 2004-01-30 | 2005-09-01 | Brown Dennis M. | Naphthalimide dosing by N-acetyl transferase genotyping |
| CA2569279A1 (en) * | 2004-06-04 | 2005-12-15 | Chemgenex Pharmaceuticals, Inc. | Methods of treating cellular proliferative disease using naphthalimide and parp-1 inhibitors |
| JP4993645B2 (ja) | 2004-12-01 | 2012-08-08 | ジェネンテック， インコーポレイテッド | 抗体薬剤結合体および方法 |
| US7947839B2 (en) * | 2004-12-01 | 2011-05-24 | Genentech, Inc. | Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use |
| KR20100074288A (ko) * | 2007-10-22 | 2010-07-01 | 오키드 리서치 레버라토리즈 리미티드 | 히스톤 디아세틸라제 억제제 |
| CN101638389B (zh) * | 2008-03-03 | 2012-09-05 | 河南大学 | 一种含萘酰亚胺结构的多胺衍生物及其制备方法和应用 |
| US9060776B2 (en) | 2009-10-09 | 2015-06-23 | Ethicon Endo-Surgery, Inc. | Surgical generator for ultrasonic and electrosurgical devices |
| CN106167490B (zh) * | 2016-08-10 | 2018-11-09 | 大连理工大学 | 一类含吲哚的咪唑并萘酰亚胺类衍生物及其合成和应用 |
| CZ308568B6 (cs) | 2018-12-03 | 2020-12-09 | Univerzita Karlova | Naftalimidofurany pro aplikace v molekulární biologii |
| JP6884920B2 (ja) * | 2019-04-02 | 2021-06-09 | 旭化成株式会社 | 錠剤の保存安定性を向上させる方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3604827A1 (de) * | 1986-02-15 | 1987-08-20 | Bayer Ag | Elektrophotographische toner |
| DE3707651A1 (de) * | 1987-03-10 | 1988-09-22 | Knoll Ag | Bis-naphthalimide, ihre herstellung und verwendung |
| US5290931A (en) * | 1990-02-21 | 1994-03-01 | Hoechst Mitsubishi Kasei Co., Ltd. | Water-insoluble naphthalic acid imide dyestuffs |
| US5086059A (en) * | 1990-06-07 | 1992-02-04 | Du Pont Merck Pharmaceutical Company | Bis-naphthalimides as anticancer agents |
| US5206249A (en) * | 1991-03-27 | 1993-04-27 | Du Pont Merck Pharmaceutical Company | Bis-naphthalimides containing amino-acid derived linkers as anticancer agents |
| US5206250A (en) * | 1991-03-27 | 1993-04-27 | Du Pont Merck Pharmaceutical Company | Bis-naphthalimides containing amide and thioamide linkers as anticancer agents |
-
1993
- 1993-06-24 US US08/080,862 patent/US5416089A/en not_active Expired - Fee Related
-
1994
- 1994-06-15 CA CA002165765A patent/CA2165765A1/en not_active Abandoned
- 1994-06-15 PL PL94312272A patent/PL312272A1/xx unknown
- 1994-06-15 KR KR1019950705888A patent/KR960703113A/ko not_active Withdrawn
- 1994-06-15 FI FI956231A patent/FI956231A0/fi not_active Application Discontinuation
- 1994-06-15 SK SK1630-95A patent/SK163095A3/sk unknown
- 1994-06-15 AU AU71712/94A patent/AU7171294A/en not_active Abandoned
- 1994-06-15 JP JP7502870A patent/JPH08511802A/ja active Pending
- 1994-06-15 CN CN94192573A patent/CN1125943A/zh active Pending
- 1994-06-15 HU HU9503759A patent/HUT75121A/hu unknown
- 1994-06-15 EP EP94920709A patent/EP0705250A1/en not_active Withdrawn
- 1994-06-15 BR BR9407265A patent/BR9407265A/pt not_active Application Discontinuation
- 1994-06-15 CZ CZ953367A patent/CZ336795A3/cs unknown
- 1994-06-15 WO PCT/US1994/006442 patent/WO1995000490A1/en not_active Ceased
- 1994-06-16 IL IL11003394A patent/IL110033A0/xx unknown
- 1994-06-20 ZA ZA944370A patent/ZA944370B/xx unknown
- 1994-06-23 TW TW083105732A patent/TW263506B/zh active
- 1994-06-23 HR HR08/080,862A patent/HRP940367A2/hr not_active Application Discontinuation
-
1995
- 1995-02-21 US US08/392,018 patent/US5585382A/en not_active Expired - Lifetime
- 1995-12-22 NO NO955257A patent/NO955257L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US5585382A (en) | 1996-12-17 |
| BR9407265A (pt) | 1996-10-01 |
| PL312272A1 (en) | 1996-04-15 |
| ZA944370B (en) | 1996-01-04 |
| TW263506B (en:Method) | 1995-11-21 |
| HU9503759D0 (en) | 1996-02-28 |
| EP0705250A1 (en) | 1996-04-10 |
| CA2165765A1 (en) | 1995-01-05 |
| CN1125943A (zh) | 1996-07-03 |
| KR960703113A (ko) | 1996-06-19 |
| FI956231L (fi) | 1995-12-22 |
| US5416089A (en) | 1995-05-16 |
| AU7171294A (en) | 1995-01-17 |
| JPH08511802A (ja) | 1996-12-10 |
| HRP940367A2 (en) | 1997-04-30 |
| FI956231A7 (fi) | 1995-12-22 |
| FI956231A0 (fi) | 1995-12-22 |
| HUT75121A (en) | 1997-04-28 |
| SK163095A3 (en) | 1996-09-04 |
| WO1995000490A1 (en) | 1995-01-05 |
| NO955257D0 (no) | 1995-12-22 |
| CZ336795A3 (en) | 1996-06-12 |
| NO955257L (no) | 1996-02-26 |
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