IL110348A0 - Piperazine derivatives and pharmaceutical compositions containing them - Google Patents

Piperazine derivatives and pharmaceutical compositions containing them

Info

Publication number
IL110348A0
IL110348A0 IL11034894A IL11034894A IL110348A0 IL 110348 A0 IL110348 A0 IL 110348A0 IL 11034894 A IL11034894 A IL 11034894A IL 11034894 A IL11034894 A IL 11034894A IL 110348 A0 IL110348 A0 IL 110348A0
Authority
IL
Israel
Prior art keywords
pharmaceutical compositions
compositions containing
piperazine derivatives
piperazine
derivatives
Prior art date
Application number
IL11034894A
Original Assignee
Recordati Chem Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recordati Chem Pharm filed Critical Recordati Chem Pharm
Publication of IL110348A0 publication Critical patent/IL110348A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL11034894A 1993-07-30 1994-07-18 Piperazine derivatives and pharmaceutical compositions containing them IL110348A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT93MI001717A IT1266582B1 (en) 1993-07-30 1993-07-30 (DI) AZACYLO-HEXANIC AND DIAZACYLO-HEPTANIC DERIVATIVES

Publications (1)

Publication Number Publication Date
IL110348A0 true IL110348A0 (en) 1994-10-21

Family

ID=11366733

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11034894A IL110348A0 (en) 1993-07-30 1994-07-18 Piperazine derivatives and pharmaceutical compositions containing them

Country Status (14)

Country Link
EP (1) EP0711288A1 (en)
JP (1) JPH09500883A (en)
KR (1) KR960703884A (en)
CN (1) CN1132508A (en)
AU (1) AU680037B2 (en)
CA (1) CA2168443A1 (en)
IL (1) IL110348A0 (en)
IT (1) IT1266582B1 (en)
MX (1) MXPA94005805A (en)
NO (1) NO960371L (en)
NZ (1) NZ271634A (en)
SG (1) SG46281A1 (en)
WO (1) WO1995004049A1 (en)
ZA (1) ZA945625B (en)

Families Citing this family (32)

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US5661163A (en) * 1995-06-07 1997-08-26 Merck & Co., Inc. Alpha-1a adrenergic receptor antagonists
US5620993A (en) * 1995-06-07 1997-04-15 Merck & Co., Inc. Alpha-1a adrenergic receptor antagonists
US5659033A (en) * 1995-09-13 1997-08-19 Neurogen Corporation N-aminoalkylfluorenecarboxamides; a new class of dopamine receptor subtype specific ligands
US5807856A (en) * 1995-11-15 1998-09-15 Merck & Co., Inc. Alpha 1a adrenergic receptor antagonist
NZ321293A (en) * 1995-11-17 2001-04-27 Warner Lambert Co Sulfonamide inhibitors of matrix metalloproteinases
SK89398A3 (en) 1995-12-29 1998-11-04 Boehringer Ingelheim Pharma Phenyl thiazole derivatives with anti herpes virus properties
US6288091B1 (en) 1995-12-29 2001-09-11 Boehringer Ingelheim Ltd. Antiherpes virus compounds and methods for their preparation and use
DK0891344T3 (en) * 1996-04-05 2003-04-07 Sod Conseils Rech Applic Antagonists for alpha-1 adrenergic receptor
JP4150435B2 (en) * 1996-04-18 2008-09-17 株式会社資生堂 Alkylene diamine derivatives and anti-ulcer agents, antibacterial agents
CA2260999C (en) 1996-07-19 2006-07-11 Takeda Chemical Industries, Ltd. Heterocyclic compounds, their production and use in tyrosine kinase inhibition
TR199902971T2 (en) * 1997-05-12 2001-03-21 Ortho-Mcneil Pharmaceutical, Inc. Aryl substituted piperazines useful in the treatment of benign prostatic hyperplasia.
AU2002300904B2 (en) * 1997-05-12 2004-12-23 Ortho-Mcneil Pharmaceutical, Inc. Arylsubstituted piperazines useful in the treatment of benign prostatic hyperplasia
IT1293807B1 (en) * 1997-08-01 1999-03-10 Recordati Chem Pharm 1- (N-PHENYLAMINOALKYL) PIPERAZINE DERIVATIVES SUBSTITUTED AT POSITION 2 OF THE PHENYL RING
US6399614B1 (en) 1997-08-01 2002-06-04 Recordati S.A. Chemical And Pharmaceutical Company 1-(N-phenylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring
JP2001512110A (en) * 1997-08-01 2001-08-21 レコルダチ エッセ．ア．，ケミカル アンド ファーマシューティカル カンパニー 1,4-disubstituted piperazine
IT1293804B1 (en) 1997-08-01 1999-03-10 Recordati Chem Pharm DIARYLALKYL PIPERAZINS ACTIVE ON LOW URINARY TRACT
US6271234B1 (en) 1997-08-01 2001-08-07 Recordati S.A., Chemical And Pharmaceutical Company 1,4-disubstituted piperazines
US6218396B1 (en) * 1998-02-20 2001-04-17 Orth-Mcneil Pharmaceutical, Inc. Substituted pyridino arylpiperazines useful in the treatment of benign prostatic hyperplasia
WO2000008001A1 (en) 1998-08-07 2000-02-17 Chiron Corporation Substituted isoxazole as estrogen receptor modulators
IT1314191B1 (en) * 1999-10-18 2002-12-06 Recordati Chem Pharm ISOSSAZOLCARBOSSAMIDIC DERIVATIVES
US6365591B1 (en) 1999-10-18 2002-04-02 Recordati, S.A., Chemical And Pharmacueticals Company Isoxazolecarboxamide derivatives
AR027133A1 (en) * 1999-12-30 2003-03-12 Lundbeck & Co As H DERIVATIVES OF HETEROARILO, ITS PREPARATION AND USE.
JP3940290B2 (en) * 2000-12-22 2007-07-04 ザ・ヨルダニアン・フアーマシユーテイカル・エム・エフ・ジー・アンド・メデイカル・イクイツプメント・カンパニー・リミテツド New compounds
SE0004780D0 (en) 2000-12-22 2000-12-22 Jordanian Pharmaceutical Mfg & Novel compunds
WO2002055496A1 (en) * 2001-01-15 2002-07-18 Glaxo Group Limited Aryl piperidine and piperazine derivatives as inducers of ldl-receptor expression
US7153858B2 (en) 2003-01-31 2006-12-26 Epix Delaware, Inc. Arylpiperazinyl compounds
US8394954B2 (en) * 2007-03-30 2013-03-12 Council Of Scientific & Industrial Research Benzophenone hybrids as anticancer agents and processes for the preparation thereof
US7858666B2 (en) 2007-06-08 2010-12-28 Mannkind Corporation IRE-1α inhibitors
MX2012014273A (en) 2010-06-07 2013-03-22 Novomedix Llc Furanyl compounds and the use thereof.
WO2013086496A2 (en) 2011-12-09 2013-06-13 Research Triangle Institute 1-substituted 4-arylpiperazine as kappa opioid receptor antagonists
BR102012000187A2 (en) * 2012-01-05 2018-04-10 Univ Rio De Janeiro N-phenylpiperazine derivatives a1a, a1d and 5-ht1a receptor antagonist antagonists in the treatment of benign prostatic hyperplasia, pharmaceutical compositions containing the same
WO2023044364A1 (en) 2021-09-15 2023-03-23 Enko Chem, Inc. Protoporphyrinogen oxidase inhibitors

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2997472A (en) * 1961-08-22 Certificate of correction
FR6452M (en) * 1967-03-10 1968-11-12
FR1543944A (en) * 1967-03-10 1968-10-31 Bruneau & Cie Lab Salicylic acid amide derivatives and their preparation
US3557107A (en) * 1967-05-01 1971-01-19 Shulton Inc Phenylpiperazinylalkyl alkoxy anthranilates
FR1537901A (en) * 1967-07-19 1968-08-30 Bruneau & Cie Lab Amide derivatives of halogeno and nitro benzoic acids and their preparation
FR6924M (en) * 1967-10-18 1969-05-05
US3846430A (en) * 1968-01-12 1974-11-05 Bruneau & Cie Lab 1-(2-methoxy-phenyl)-4-{8 2-(4-fluoro-benzamido)-ethyl{9 -piperazine
NL8005133A (en) * 1980-09-12 1982-04-01 Duphar Int Res PHENYLPIPERAZINE DERIVATIVES WITH ANTIAGRESSIVE ACTION.
US4642291A (en) * 1982-09-01 1987-02-10 Sloan-Kettering Institute For Cancer Research Cell surface antigens of human astrocytoma
JPS5955878A (en) * 1982-09-24 1984-03-31 Chugai Pharmaceut Co Ltd Novel phenylpiperazine derivative
JPS60169467A (en) * 1984-02-10 1985-09-02 Chugai Pharmaceut Co Ltd Novel phenylpiperazine derivative
JP2556722B2 (en) * 1988-02-18 1996-11-20 興和株式会社 Novel sulfonamide compound
US4857644A (en) * 1988-06-09 1989-08-15 American Home Products Corporation Aryl sulfonopiperazines as anti-inflammatory agents
ES2027898A6 (en) * 1991-01-24 1992-06-16 Espanola Prod Quimicos 2-Methoxyphenylpiperazine derivatives.
HRP930210A2 (en) * 1992-02-25 1995-06-30 Recordati Chem Pharm Heterobicyclic compounds and pharmaceutical preparations containing them
SE9201138D0 (en) * 1992-04-09 1992-04-09 Astra Ab NOVEL PHTHALIMIDOALKYL PIPERAZINES

Also Published As

Publication number Publication date
JPH09500883A (en) 1997-01-28
NZ271634A (en) 1996-09-25
ITMI931717A0 (en) 1993-07-30
ITMI931717A1 (en) 1995-01-30
AU7532394A (en) 1995-02-28
MXPA94005805A (en) 2004-08-20
IT1266582B1 (en) 1997-01-09
AU680037B2 (en) 1997-07-17
KR960703884A (en) 1996-08-31
WO1995004049A1 (en) 1995-02-09
CA2168443A1 (en) 1995-02-09
ZA945625B (en) 1995-03-07
CN1132508A (en) 1996-10-02
EP0711288A1 (en) 1996-05-15
SG46281A1 (en) 1998-02-20
NO960371L (en) 1996-03-29
NO960371D0 (en) 1996-01-29

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