NO960371L - Piperazine derivatives as ter - Google Patents

Piperazine derivatives as ter

Info

Publication number
NO960371L
NO960371L NO960371A NO960371A NO960371L NO 960371 L NO960371 L NO 960371L NO 960371 A NO960371 A NO 960371A NO 960371 A NO960371 A NO 960371A NO 960371 L NO960371 L NO 960371L
Authority
NO
Norway
Prior art keywords
group
compounds
ter
piperazine derivatives
sonh
Prior art date
Application number
NO960371A
Other languages
Norwegian (no)
Other versions
NO960371D0 (en
Inventor
Amedeo Leonardi
Carlo Riva
Gianni Motta
Rodolfo Testa
Original Assignee
Recordati Chem Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recordati Chem Pharm filed Critical Recordati Chem Pharm
Publication of NO960371D0 publication Critical patent/NO960371D0/en
Publication of NO960371L publication Critical patent/NO960371L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Det beskrives forbindelser med den generelle formel (I). Y betyr en bindingsgruppe, utvalgt fra et bredt spektrum, men omfattende -C00-, -CHCOO-, -CONH-, -CON(CH)-, -CHCONH-, -S0NH-, -S0N(CH)- og -PO(OCH)NH-. W betyr en alkylenkjede. A betyr en substituert fenylgruppe eller en benzofuran- eller benzodioksangruppe. R og Rx kan ha flere verdier, men R betyr fortrinnsvis en svær gruppe. Disse forbindelser og deres prodroger, enantiomerer, diastereo-isomerer, N-oksyder og farmasøytisk akseptable salter blokkerer a-adrenergiske receptorer, og er derfor nyttige ved forebyggelse av kontraksjoner i prostata, uretra og de lavere urinveier, uten å påvirke blod-trykket .Compounds of general formula (I) are described. Y represents a linking group, selected from a broad spectrum, but comprising -COO-, -CHCOO-, -CONH-, -CON (CH) -, -CHCONH-, -SONH-, -SON (CH) - and -PO ( AND) NH-. W represents an alkylene chain. A represents a substituted phenyl group or a benzofuran or benzodioxane group. R and Rx may have several values, but R preferably represents a large group. These compounds and their prodrugs, enantiomers, diastereoisomers, N-oxides and pharmaceutically acceptable salts block α-adrenergic receptors and are therefore useful in preventing contractions of the prostate, urethra and lower urinary tract, without affecting blood pressure.

NO960371A 1993-07-30 1996-01-29 Piperazine derivatives as ter NO960371L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT93MI001717A IT1266582B1 (en) 1993-07-30 1993-07-30 (DI) AZACYLO-HEXANIC AND DIAZACYLO-HEPTANIC DERIVATIVES
PCT/EP1994/002437 WO1995004049A1 (en) 1993-07-30 1994-07-22 PIPERAZINE DERIVATIVES AS α1A-ADRENERGIC RECEPTOR ANTAGONISTS

Publications (2)

Publication Number Publication Date
NO960371D0 NO960371D0 (en) 1996-01-29
NO960371L true NO960371L (en) 1996-03-29

Family

ID=11366733

Family Applications (1)

Application Number Title Priority Date Filing Date
NO960371A NO960371L (en) 1993-07-30 1996-01-29 Piperazine derivatives as ter

Country Status (14)

Country Link
EP (1) EP0711288A1 (en)
JP (1) JPH09500883A (en)
KR (1) KR960703884A (en)
CN (1) CN1132508A (en)
AU (1) AU680037B2 (en)
CA (1) CA2168443A1 (en)
IL (1) IL110348A0 (en)
IT (1) IT1266582B1 (en)
MX (1) MXPA94005805A (en)
NO (1) NO960371L (en)
NZ (1) NZ271634A (en)
SG (1) SG46281A1 (en)
WO (1) WO1995004049A1 (en)
ZA (1) ZA945625B (en)

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US5661163A (en) 1995-06-07 1997-08-26 Merck & Co., Inc. Alpha-1a adrenergic receptor antagonists
US5659033A (en) * 1995-09-13 1997-08-19 Neurogen Corporation N-aminoalkylfluorenecarboxamides; a new class of dopamine receptor subtype specific ligands
US5807856A (en) * 1995-11-15 1998-09-15 Merck & Co., Inc. Alpha 1a adrenergic receptor antagonist
PL326700A1 (en) * 1995-11-17 1998-10-26 Warner Lambert Co Sulphonamide-based inhibitors of intercellular substance metaloproteinases
JP4327249B2 (en) 1995-12-29 2009-09-09 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド Phenylthiazole derivatives with anti-herpesvirus properties
US6288091B1 (en) 1995-12-29 2001-09-11 Boehringer Ingelheim Ltd. Antiherpes virus compounds and methods for their preparation and use
CZ315098A3 (en) * 1996-04-05 1999-04-14 Société De Conseils De Recherches Et D'applications Scientifiques (S. C. R. A. S.) Antagonists of alpha1-adrenergic receptors
JP4150435B2 (en) * 1996-04-18 2008-09-17 株式会社資生堂 Alkylene diamine derivatives and anti-ulcer agents, antibacterial agents
ATE338754T1 (en) 1996-07-19 2006-09-15 Takeda Pharmaceutical HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE
AU2002300904B2 (en) * 1997-05-12 2004-12-23 Ortho-Mcneil Pharmaceutical, Inc. Arylsubstituted piperazines useful in the treatment of benign prostatic hyperplasia
DK0984777T3 (en) * 1997-05-12 2003-12-08 Ortho Mcneil Pharm Inc Aryl-substituted piperazines useful in the treatment of benign prostatic hyperplasia
WO1999006382A1 (en) * 1997-08-01 1999-02-11 Recordati S.A., Chemical And Pharmaceutical Company 1,4-disubstituted piperazines
US6271234B1 (en) 1997-08-01 2001-08-07 Recordati S.A., Chemical And Pharmaceutical Company 1,4-disubstituted piperazines
IT1293807B1 (en) * 1997-08-01 1999-03-10 Recordati Chem Pharm 1- (N-PHENYLAMINOALKYL) PIPERAZINE DERIVATIVES SUBSTITUTED AT POSITION 2 OF THE PHENYL RING
US6399614B1 (en) 1997-08-01 2002-06-04 Recordati S.A. Chemical And Pharmaceutical Company 1-(N-phenylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring
IT1293804B1 (en) 1997-08-01 1999-03-10 Recordati Chem Pharm DIARYLALKYL PIPERAZINS ACTIVE ON LOW URINARY TRACT
ZA991315B (en) * 1998-02-20 2000-11-20 Ortho Mcneil Pharm Inc Novel substituted pyridino arylpiperazines useful in the treatment of benign prostatic hyperplasia.
AU5467699A (en) 1998-08-07 2000-02-28 Chiron Corporation Substituted isoxazole as estrogen receptor modulators
IT1314191B1 (en) * 1999-10-18 2002-12-06 Recordati Chem Pharm ISOSSAZOLCARBOSSAMIDIC DERIVATIVES
US6365591B1 (en) 1999-10-18 2002-04-02 Recordati, S.A., Chemical And Pharmacueticals Company Isoxazolecarboxamide derivatives
AR027133A1 (en) * 1999-12-30 2003-03-12 Lundbeck & Co As H DERIVATIVES OF HETEROARILO, ITS PREPARATION AND USE.
JP3940290B2 (en) * 2000-12-22 2007-07-04 ザ・ヨルダニアン・フアーマシユーテイカル・エム・エフ・ジー・アンド・メデイカル・イクイツプメント・カンパニー・リミテツド New compounds
SE0004780D0 (en) 2000-12-22 2000-12-22 Jordanian Pharmaceutical Mfg & Novel compunds
JP2004520347A (en) * 2001-01-15 2004-07-08 グラクソ　グループ　リミテッド Arylpiperidine and piperazine derivatives as inducers of LDL-receptor expression
US7153858B2 (en) 2003-01-31 2006-12-26 Epix Delaware, Inc. Arylpiperazinyl compounds
EP2142506B1 (en) * 2007-03-30 2013-10-16 Council of Scientific & Industrial Research Novel benzophenone hybrids as potential anticancer agents and a process for the preparation thereof
ES2601856T3 (en) 2007-06-08 2017-02-16 Mannkind Corporation IRE-1A inhibitors
SG186229A1 (en) 2010-06-07 2013-01-30 Novomedix Llc Furanyl compounds and the use thereof
ES2631607T3 (en) 2011-12-09 2017-09-01 Research Triangle Institute, International 1-substituted 4-arylpiperazines as kappa opioid receptor antagonists
BR102012000187A2 (en) * 2012-01-05 2018-04-10 Univ Rio De Janeiro N-phenylpiperazine derivatives a1a, a1d and 5-ht1a receptor antagonist antagonists in the treatment of benign prostatic hyperplasia, pharmaceutical compositions containing the same
WO2023044364A1 (en) 2021-09-15 2023-03-23 Enko Chem, Inc. Protoporphyrinogen oxidase inhibitors

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Also Published As

Publication number Publication date
MXPA94005805A (en) 2004-08-20
EP0711288A1 (en) 1996-05-15
ZA945625B (en) 1995-03-07
NO960371D0 (en) 1996-01-29
JPH09500883A (en) 1997-01-28
AU7532394A (en) 1995-02-28
KR960703884A (en) 1996-08-31
SG46281A1 (en) 1998-02-20
WO1995004049A1 (en) 1995-02-09
ITMI931717A0 (en) 1993-07-30
ITMI931717A1 (en) 1995-01-30
NZ271634A (en) 1996-09-25
CN1132508A (en) 1996-10-02
CA2168443A1 (en) 1995-02-09
AU680037B2 (en) 1997-07-17
IL110348A0 (en) 1994-10-21
IT1266582B1 (en) 1997-01-09

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