RU97114956A - METHOD OF INHIBITING INTER CELL ADHESION AND METHOD OF INHIBITING THE INFLAMMATORY PROCESS - Google Patents
METHOD OF INHIBITING INTER CELL ADHESION AND METHOD OF INHIBITING THE INFLAMMATORY PROCESSInfo
- Publication number
- RU97114956A RU97114956A RU97114956/14A RU97114956A RU97114956A RU 97114956 A RU97114956 A RU 97114956A RU 97114956/14 A RU97114956/14 A RU 97114956/14A RU 97114956 A RU97114956 A RU 97114956A RU 97114956 A RU97114956 A RU 97114956A
- Authority
- RU
- Russia
- Prior art keywords
- inhibiting
- hydrochloride
- cell adhesion
- inflammatory process
- specified connection
- Prior art date
Links
- 230000002401 inhibitory effect Effects 0.000 title claims 4
- 230000004054 inflammatory process Effects 0.000 title claims 2
- 230000021164 cell adhesion Effects 0.000 title 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 230000001771 impaired Effects 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
- -1 pyrrolidino, hexamethyleneimino Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 210000003989 Endothelium, Vascular Anatomy 0.000 claims 1
- 230000017455 cell-cell adhesion Effects 0.000 claims 1
- 230000015271 coagulation Effects 0.000 claims 1
- 238000005345 coagulation Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
Claims (6)
где R1 и R3 независимо водород, -СН3, -С(O)(С1-С6 алкил), или -С(O)Аr, где Аr - необязательно замещенный фенил;
R2 выбирают из группы, состоящей из пирролидино, гексаметиленимино и пиперидино-групп; или их фармацевтически приемлемых солей и сольватов.1. A method of inhibiting cell-cell adhesion, comprising administering to an individual in need thereof an effective amount of a compound, a formula
where R 1 and R 3 are independently hydrogen, —CH 3 , —C (O) (C 1 -C 6 alkyl), or —C (O) Ar, where Ar is optionally substituted phenyl;
R 2 is selected from the group consisting of pyrrolidino, hexamethyleneimino and piperidino groups; or their pharmaceutically acceptable salts and solvates.
или его гидрохлорид.3. The method according to p. 2, in which the specified connection is
or its hydrochloride.
где R1 и R2 независимо водород, -СН3, -С(O)(С1-С6 алкил), или -С(O)Аr, где Аr - необязательно замещенный фенил;
R2 выбирают из группы, состоящей из пирролидино, гексаметиленимино и пиперидино-групп; или их фармацевтически приемлемых солей и сольватов.4. A method of inhibiting the inflammatory process and the process of impaired normal coagulation in patients with impaired vascular endothelium, comprising administering an effective amount of a compound of the formula
where R 1 and R 2 are independently hydrogen, —CH 3 , —C (O) (C 1 -C 6 alkyl), or —C (O) Ar, where Ar is optionally substituted phenyl;
R 2 is selected from the group consisting of pyrrolidino, hexamethyleneimino and piperidino groups; or their pharmaceutically acceptable salts and solvates.
или его гидрохлорид.6. The method according to p. 4, in which the specified connection is a
or its hydrochloride.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/385,934 US5484808A (en) | 1995-02-09 | 1995-02-09 | Methods of inhibiting cell-cell adhesion |
| US08/385,934 | 1995-02-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU97114956A true RU97114956A (en) | 1999-07-20 |
| RU2179021C2 RU2179021C2 (en) | 2002-02-10 |
Family
ID=23523494
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU97114956/14A RU2179021C2 (en) | 1995-02-09 | 1996-02-09 | Method of inhibition of intercellular adhesion and method of inhibition of inflammatory process |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US5484808A (en) |
| EP (1) | EP0726071A2 (en) |
| JP (1) | JPH10513475A (en) |
| KR (1) | KR19980702079A (en) |
| CN (1) | CN1072931C (en) |
| AU (1) | AU693021B2 (en) |
| CA (1) | CA2212339A1 (en) |
| CZ (1) | CZ286448B6 (en) |
| HU (1) | HUP9801323A3 (en) |
| IL (1) | IL117079A (en) |
| MY (1) | MY132251A (en) |
| NO (1) | NO973635L (en) |
| NZ (1) | NZ305072A (en) |
| RU (1) | RU2179021C2 (en) |
| UA (1) | UA43391C2 (en) |
| WO (1) | WO1996024384A1 (en) |
| ZA (1) | ZA961076B (en) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6515009B1 (en) | 1991-09-27 | 2003-02-04 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US5811447A (en) * | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US5770609A (en) | 1993-01-28 | 1998-06-23 | Neorx Corporation | Prevention and treatment of cardiovascular pathologies |
| US6251920B1 (en) | 1993-05-13 | 2001-06-26 | Neorx Corporation | Prevention and treatment of cardiovascular pathologies |
| US6491938B2 (en) | 1993-05-13 | 2002-12-10 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US6197789B1 (en) | 1995-06-07 | 2001-03-06 | Neorx Corporation | Prevention and treatment of cardiovascular pathologies with tamoxifen analogues |
| US20030083733A1 (en) * | 1997-10-10 | 2003-05-01 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US20020091433A1 (en) * | 1995-04-19 | 2002-07-11 | Ni Ding | Drug release coated stent |
| US5837313A (en) * | 1995-04-19 | 1998-11-17 | Schneider (Usa) Inc | Drug release stent coating process |
| US6099562A (en) * | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
| US5747509A (en) * | 1996-06-03 | 1998-05-05 | Schering Aktiengesellschaft | Method for lowering plasma levels of lipoprotein(a) |
| US5773432A (en) * | 1996-10-30 | 1998-06-30 | Schering Aktiengesellschaft | Method for lowering plasma levels of lipoprotein(a) |
| US6117911A (en) * | 1997-04-11 | 2000-09-12 | Neorx Corporation | Compounds and therapies for the prevention of vascular and non-vascular pathologies |
| US6008232A (en) * | 1997-08-20 | 1999-12-28 | Eli Lilly And Company | Methods for preventing headaches |
| WO1999051587A1 (en) * | 1998-04-01 | 1999-10-14 | Ono Pharmaceutical Co., Ltd. | Fused thiophene derivatives and drugs containing the same as the active ingredient |
| WO2000066612A1 (en) | 1999-05-04 | 2000-11-09 | Strakan Limited | Androgen glycosides and androgenic activity thereof |
| US6359015B1 (en) | 2000-02-28 | 2002-03-19 | The United States Of America As Represented By The Department Of Veterans Affairs | Method for antagonizing inhibition effects of alcohol on cell adhesion |
| US20040121313A1 (en) * | 2002-12-06 | 2004-06-24 | Ecker David J. | Methods for rapid detection and identification of bioagents in organs for transplantation |
| US7666588B2 (en) | 2001-03-02 | 2010-02-23 | Ibis Biosciences, Inc. | Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy |
| US20030027135A1 (en) * | 2001-03-02 | 2003-02-06 | Ecker David J. | Method for rapid detection and identification of bioagents |
| US6613083B2 (en) * | 2001-05-02 | 2003-09-02 | Eckhard Alt | Stent device and method |
| JP3887588B2 (en) * | 2002-08-30 | 2007-02-28 | 株式会社リガク | Stress measurement method by X-ray diffraction |
| US6977272B2 (en) * | 2002-10-16 | 2005-12-20 | President And Fellows Of Harvard College | Method for antagonizing inhibition effects of alcohol on cell adhesion |
| JP2006516193A (en) * | 2002-12-06 | 2006-06-29 | アイシス・ファーマシューティカルス・インコーポレーテッド | Rapid identification of pathogens in humans and animals |
| US7964343B2 (en) * | 2003-05-13 | 2011-06-21 | Ibis Biosciences, Inc. | Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture |
| US8097416B2 (en) | 2003-09-11 | 2012-01-17 | Ibis Biosciences, Inc. | Methods for identification of sepsis-causing bacteria |
| US8546082B2 (en) | 2003-09-11 | 2013-10-01 | Ibis Biosciences, Inc. | Methods for identification of sepsis-causing bacteria |
| US7956175B2 (en) | 2003-09-11 | 2011-06-07 | Ibis Biosciences, Inc. | Compositions for use in identification of bacteria |
| US20050266411A1 (en) * | 2004-05-25 | 2005-12-01 | Hofstadler Steven A | Methods for rapid forensic analysis of mitochondrial DNA |
| WO2006135400A2 (en) | 2004-08-24 | 2006-12-21 | Isis Pharmaceuticals, Inc. | Methods for rapid identification of recombinant organisms |
| AU2006272776B2 (en) * | 2005-07-21 | 2012-01-19 | Ibis Biosciences, Inc. | Methods for rapid identification and quantitation of nucleic acid variants |
| CN107412248A (en) | 2016-05-24 | 2017-12-01 | 中国医学科学院药物研究所 | Application of the THPA in treatment vascular inflammation or improvement function of vascular endothelium |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4133814A (en) * | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
| US4380635A (en) * | 1981-04-03 | 1983-04-19 | Eli Lilly And Company | Synthesis of acylated benzothiophenes |
| US4418068A (en) * | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
| US5395842A (en) * | 1988-10-31 | 1995-03-07 | Endorecherche Inc. | Anti-estrogenic compounds and compositions |
| JP3157882B2 (en) * | 1991-11-15 | 2001-04-16 | 帝国臓器製薬株式会社 | New benzothiophene derivatives |
| US5356926A (en) * | 1992-02-24 | 1994-10-18 | Warner-Lambert Company | 3-alkyloxy-, aryloxy-, or arylalkyloxy-benzo [β]thiophene-2-carboxamides as inhibitors of cell adhesion |
| TW383306B (en) * | 1992-12-22 | 2000-03-01 | Lilly Co Eli | New use of 2-phenyl-3-aroylbenzothiophenes in lowering serum cholesterol |
| US5457113A (en) * | 1993-10-15 | 1995-10-10 | Eli Lilly And Company | Methods for inhibiting vascular smooth muscle cell proliferation and restinosis |
| UA32427C2 (en) * | 1993-10-15 | 2000-12-15 | Елі Ліллі Енд Компані | The use of benzothiophene or pharmaceutical acceptable salts or solvate thereof for inhibition of angiogenesis and/or angiogenic diseases |
| US5441965A (en) * | 1993-12-21 | 1995-08-15 | Eli Lilly And Company | Methods of inhibiting thrombin |
| US5476862A (en) * | 1993-12-21 | 1995-12-19 | Eli Lilly And Company | Methods of increasing thrombomodulin expression |
| US5574047A (en) * | 1993-12-21 | 1996-11-12 | Eli Lilly And Company | Methods of inhibiting imperfect tissue repair |
-
1995
- 1995-02-09 US US08/385,934 patent/US5484808A/en not_active Expired - Fee Related
- 1995-04-14 US US08/422,295 patent/US5496851A/en not_active Expired - Fee Related
-
1996
- 1996-02-08 IL IL11707996A patent/IL117079A/en not_active IP Right Cessation
- 1996-02-09 UA UA97084166A patent/UA43391C2/en unknown
- 1996-02-09 JP JP8524495A patent/JPH10513475A/en not_active Withdrawn
- 1996-02-09 ZA ZA9601076A patent/ZA961076B/en unknown
- 1996-02-09 NZ NZ305072A patent/NZ305072A/en unknown
- 1996-02-09 KR KR1019970705474A patent/KR19980702079A/en not_active Application Discontinuation
- 1996-02-09 HU HU9801323A patent/HUP9801323A3/en unknown
- 1996-02-09 CN CN96191839A patent/CN1072931C/en not_active Expired - Fee Related
- 1996-02-09 RU RU97114956/14A patent/RU2179021C2/en active
- 1996-02-09 MY MYPI96000491A patent/MY132251A/en unknown
- 1996-02-09 CA CA002212339A patent/CA2212339A1/en not_active Abandoned
- 1996-02-09 WO PCT/US1996/002657 patent/WO1996024384A1/en not_active Application Discontinuation
- 1996-02-09 EP EP96300876A patent/EP0726071A2/en not_active Withdrawn
- 1996-02-09 AU AU52996/96A patent/AU693021B2/en not_active Ceased
- 1996-02-09 CZ CZ19972482A patent/CZ286448B6/en not_active IP Right Cessation
-
1997
- 1997-08-06 NO NO973635A patent/NO973635L/en not_active Application Discontinuation
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