EA199800678A1 - METHOD OF INHIBITING MUSCULAR-APONURROTIC FIBROMATOSIS (DEMOID TUMORS) - Google Patents

METHOD OF INHIBITING MUSCULAR-APONURROTIC FIBROMATOSIS (DEMOID TUMORS)

Info

Publication number
EA199800678A1
EA199800678A1 EA199800678A EA199800678A EA199800678A1 EA 199800678 A1 EA199800678 A1 EA 199800678A1 EA 199800678 A EA199800678 A EA 199800678A EA 199800678 A EA199800678 A EA 199800678A EA 199800678 A1 EA199800678 A1 EA 199800678A1
Authority
EA
Eurasian Patent Office
Prior art keywords
fibromatosis
demoid
aponurrotic
tumors
inhibiting muscular
Prior art date
Application number
EA199800678A
Other languages
Russian (ru)
Inventor
Мария Л. Брэнди
Франческо Тонелли
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9603148.9A external-priority patent/GB9603148D0/en
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA199800678A1 publication Critical patent/EA199800678A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Способ ингибирования мышечно-апоневротических фиброматозов, включающий введение млекопитающему, которое в этом нуждается, эффективного количества соединения, имеющего формулу (I), где Rи Rнезависимо представляют собой водород, -CH, (a) или (b), где Ar представляет собой необязательно замещенный фенил; Rвыбирается из группы, состоящей из пирролидино, гексаметиленимино и пиперидино; или их фармацевтически приемлемой соли или сольвата.Международная заявка была опубликована вместе с отчетом о международном поиске.A method of inhibiting muscular aponeurotic fibromatosis, comprising administering to a mammal in need thereof an effective amount of a compound having formula (I), wherein R and R are independently hydrogen, —CH, (a) or (b), where Ar is an optionally substituted phenyl; R selected from the group consisting of pyrrolidino, hexamethyleneimino and piperidino; or a pharmaceutically acceptable salt or solvate thereof. The international application was published along with an international search report.

EA199800678A 1996-01-29 1997-01-27 METHOD OF INHIBITING MUSCULAR-APONURROTIC FIBROMATOSIS (DEMOID TUMORS) EA199800678A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1077396P 1996-01-29 1996-01-29
GBGB9603148.9A GB9603148D0 (en) 1996-02-15 1996-02-15 Methods of inhibiting musculoaponeurotic fibromatoses (desmoid tumors)
PCT/US1997/002287 WO1997026878A1 (en) 1996-01-29 1997-01-27 Methods of inhibiting musculoaponeurotic fibromatoses (desmoid tumors)

Publications (1)

Publication Number Publication Date
EA199800678A1 true EA199800678A1 (en) 1999-02-25

Family

ID=26308707

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800678A EA199800678A1 (en) 1996-01-29 1997-01-27 METHOD OF INHIBITING MUSCULAR-APONURROTIC FIBROMATOSIS (DEMOID TUMORS)

Country Status (11)

Country Link
EP (1) EP0907361A4 (en)
JP (1) JP2000503995A (en)
KR (1) KR19990082055A (en)
CN (1) CN1209746A (en)
AU (1) AU707675B2 (en)
CZ (1) CZ235398A3 (en)
EA (1) EA199800678A1 (en)
IL (1) IL125523A0 (en)
NO (1) NO983452L (en)
PL (1) PL328127A1 (en)
WO (1) WO1997026878A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2135195C1 (en) * 1998-12-17 1999-08-27 Овсюк Валерий Григорьевич Method for producing material containing prostate cells and treating the cases of uterine fibromatosis, chronic prostatitis and male sexual function disorders by applying transplantation method
AU781168B2 (en) * 2001-01-26 2005-05-12 Pfizer Products Inc. Method of treating certain cancers using an estrogen agonist/antagonist

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW366342B (en) * 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
US5552162A (en) * 1993-02-09 1996-09-03 Arch Development Corporation Method for improvement of scar size and appearance
ATE220323T1 (en) * 1993-10-15 2002-07-15 Lilly Co Eli METHOD OF TREATING RESISTANT NEOPLASMS
US5457116A (en) * 1993-10-15 1995-10-10 Eli Lilly And Company Methods of inhibiting uterine fibrosis
US5574047A (en) * 1993-12-21 1996-11-12 Eli Lilly And Company Methods of inhibiting imperfect tissue repair

Also Published As

Publication number Publication date
JP2000503995A (en) 2000-04-04
AU2124097A (en) 1997-08-20
NO983452D0 (en) 1998-07-27
KR19990082055A (en) 1999-11-15
PL328127A1 (en) 1999-01-18
AU707675B2 (en) 1999-07-15
EP0907361A1 (en) 1999-04-14
WO1997026878A1 (en) 1997-07-31
IL125523A0 (en) 1999-03-12
CZ235398A3 (en) 1999-02-17
CN1209746A (en) 1999-03-03
NO983452L (en) 1998-07-27
EP0907361A4 (en) 2002-05-02

Similar Documents

Publication Publication Date Title
KR950010888A (en) How to inhibit smooth muscle cell proliferation and restenosis
RU97114956A (en) METHOD OF INHIBITING INTER CELL ADHESION AND METHOD OF INHIBITING THE INFLAMMATORY PROCESS
MY132056A (en) Methods of inhibiting physiological conditions associated with an excess of neuropeptide y.
ATE216582T1 (en) INHIBITION OF UTERINE FIBROSIS
MX9701325A (en) Methods of inhibiting ulcerative mucositis.
EA199700450A1 (en) METHODS OF SUPPORTING MIGRATION OF VASCULAR SMOOTH-COMBIN CELLS
MX9701360A (en) Methods of inhibiting demyelinating and dysmyelinating diseases.
DE69412049D1 (en) Inhibition of dysfunctional uterine bleeding
DK0652004T3 (en) Methods for treating resistant neoplasms
RU98113525A (en) The use of 2-phenyl-3-aroylbenzothiophenes for the inhibition of thrombotic disorder, to increase the activation of protein C
DK0652002T3 (en) Use of 2-phenyl-3-aroylebenzothiophenes in the manufacture of a drug for inhibiting cartilage degradation
EA199800015A1 (en) METHOD OF INHIBITING MELANOMA
ATE207748T1 (en) INHIBITING OVARIAN MISDEVELOPMENT, DELAYED PUBERTY OR SEXUAL INFANTILISM
EA199800019A1 (en) METHOD OF INCREASING THE DENSITY OF CALCIUM CHANNELS
KR950016734A (en) Inhibition of sexual prematurity
EA199800366A1 (en) METHODS OF INHIBITING INHIBITOR 1 PLASMINOGEN ACTIVATOR
EA199700136A1 (en) METHODS OF INHIBITING EXOGENOUS ESTROGENS
EA199800678A1 (en) METHOD OF INHIBITING MUSCULAR-APONURROTIC FIBROMATOSIS (DEMOID TUMORS)
EA200000243A1 (en) METHODS TO REDUCE THE NUMBER OF PLATELETS
EA199700200A1 (en) METHODS TO INHIBIT OCTIC CANCER
EA199800676A1 (en) WAYS TO IMPROVE THE COMPETENCE OF THE SPHINKTER
EA199800677A1 (en) METHOD FOR INHIBITING TUMOR INHIBITS
MX9701327A (en) Methods of inhibiting endometrial cancer.
MX9702148A (en) Methods of inhibiting endometrial mitoses.
ATE200623T1 (en) USE OF 2-PHENYL-3-AROYLBENZOTHIOPHENE DERIVATIVES FOR PRODUCING A MEDICATION FOR INHIBITING PRIMARY ENDOMETRIAL HYPERPLASIA