HUT75121A - Bis-imide derivatives of tri-and tetraamines and pharmaceutical compositions containing them - Google Patents

Bis-imide derivatives of tri-and tetraamines and pharmaceutical compositions containing them Download PDF

Info

Publication number
HUT75121A
HUT75121A HU9503759A HU9503759A HUT75121A HU T75121 A HUT75121 A HU T75121A HU 9503759 A HU9503759 A HU 9503759A HU 9503759 A HU9503759 A HU 9503759A HU T75121 A HUT75121 A HU T75121A
Authority
HU
Hungary
Prior art keywords
nitro
propylamino
dicarboximido
azafenanthrene
formula
Prior art date
Application number
HU9503759A
Other languages
English (en)
Hungarian (hu)
Other versions
HU9503759D0 (en
Inventor
Emeka Amaechi Akamike
Robert Joseph Cherney
Robert Frank Kaltenbach Iii
Michael James Orwat
Gregory James Pacofsky
Arthur David Patten
Steven Paul Seitz
Original Assignee
Du Pont Merck Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Merck Pharma filed Critical Du Pont Merck Pharma
Publication of HU9503759D0 publication Critical patent/HU9503759D0/hu
Publication of HUT75121A publication Critical patent/HUT75121A/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B11/00—Diaryl- or thriarylmethane dyes
    • C09B11/28—Pyronines ; Xanthon, thioxanthon, selenoxanthan, telluroxanthon dyes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B15/00—Acridine dyes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B5/00—Dyes with an anthracene nucleus condensed with one or more heterocyclic rings with or without carbocyclic rings
    • C09B5/002—Dyes with an anthracene nucleus condensed with one or more heterocyclic rings with or without carbocyclic rings the heterocyclic rings being condensed in peri position and in 1-2 or 2-3 position
    • C09B5/004—Dyes with an anthracene nucleus condensed with one or more heterocyclic rings with or without carbocyclic rings the heterocyclic rings being condensed in peri position and in 1-2 or 2-3 position only O-containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution
    • C09B57/08—Naphthalimide dyes; Phthalimide dyes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HU9503759A 1993-06-24 1994-06-15 Bis-imide derivatives of tri-and tetraamines and pharmaceutical compositions containing them HUT75121A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/080,862 US5416089A (en) 1993-06-24 1993-06-24 Polycyclic and heterocyclic chromophores for bis-imide tumoricidals

Publications (2)

Publication Number Publication Date
HU9503759D0 HU9503759D0 (en) 1996-02-28
HUT75121A true HUT75121A (en) 1997-04-28

Family

ID=22160120

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9503759A HUT75121A (en) 1993-06-24 1994-06-15 Bis-imide derivatives of tri-and tetraamines and pharmaceutical compositions containing them

Country Status (19)

Country Link
US (2) US5416089A (en:Method)
EP (1) EP0705250A1 (en:Method)
JP (1) JPH08511802A (en:Method)
KR (1) KR960703113A (en:Method)
CN (1) CN1125943A (en:Method)
AU (1) AU7171294A (en:Method)
BR (1) BR9407265A (en:Method)
CA (1) CA2165765A1 (en:Method)
CZ (1) CZ336795A3 (en:Method)
FI (1) FI956231A0 (en:Method)
HR (1) HRP940367A2 (en:Method)
HU (1) HUT75121A (en:Method)
IL (1) IL110033A0 (en:Method)
NO (1) NO955257L (en:Method)
PL (1) PL312272A1 (en:Method)
SK (1) SK163095A3 (en:Method)
TW (1) TW263506B (en:Method)
WO (1) WO1995000490A1 (en:Method)
ZA (1) ZA944370B (en:Method)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703089A (en) * 1994-04-28 1997-12-30 Knoll Aktiengesellschaft Dihydrodibenzisoquinolinediones
US5641782A (en) * 1995-02-16 1997-06-24 The Dupont Merck Pharmaceutical Company 3-aromatic and 3-heteroaromatic substituted bisnaphthalimides
FR2751655B1 (fr) * 1996-07-26 1998-08-28 Adir Nouveaux derives de bis-imides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP1053237B1 (en) * 1998-02-04 2003-07-02 The Board Of Regents, The University Of Texas System Inhibition of human telomerase by a g-quadruplex-interaction compound
ES2191532B1 (es) * 2001-05-28 2005-02-16 Fundacion Universitaria San Pablo - Ceu Derivados de naftalimidas heterociclicas como agentes antiproliferativos.
US20040082788A1 (en) * 2002-07-08 2004-04-29 Chemgenex Therapeutics, Inc. Naphthalimide synthesis including amonafide synthesis and pharmaceutical preparations thereof
US20050192312A1 (en) * 2004-01-30 2005-09-01 Brown Dennis M. Naphthalimide dosing by N-acetyl transferase genotyping
CA2569279A1 (en) * 2004-06-04 2005-12-15 Chemgenex Pharmaceuticals, Inc. Methods of treating cellular proliferative disease using naphthalimide and parp-1 inhibitors
JP4993645B2 (ja) 2004-12-01 2012-08-08 ジェネンテック， インコーポレイテッド 抗体薬剤結合体および方法
US7947839B2 (en) * 2004-12-01 2011-05-24 Genentech, Inc. Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use
KR20100074288A (ko) * 2007-10-22 2010-07-01 오키드 리서치 레버라토리즈 리미티드 히스톤 디아세틸라제 억제제
CN101638389B (zh) * 2008-03-03 2012-09-05 河南大学 一种含萘酰亚胺结构的多胺衍生物及其制备方法和应用
US9060776B2 (en) 2009-10-09 2015-06-23 Ethicon Endo-Surgery, Inc. Surgical generator for ultrasonic and electrosurgical devices
CN106167490B (zh) * 2016-08-10 2018-11-09 大连理工大学 一类含吲哚的咪唑并萘酰亚胺类衍生物及其合成和应用
CZ308568B6 (cs) 2018-12-03 2020-12-09 Univerzita Karlova Naftalimidofurany pro aplikace v molekulární biologii
JP6884920B2 (ja) * 2019-04-02 2021-06-09 旭化成株式会社 錠剤の保存安定性を向上させる方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3604827A1 (de) * 1986-02-15 1987-08-20 Bayer Ag Elektrophotographische toner
DE3707651A1 (de) * 1987-03-10 1988-09-22 Knoll Ag Bis-naphthalimide, ihre herstellung und verwendung
US5290931A (en) * 1990-02-21 1994-03-01 Hoechst Mitsubishi Kasei Co., Ltd. Water-insoluble naphthalic acid imide dyestuffs
US5086059A (en) * 1990-06-07 1992-02-04 Du Pont Merck Pharmaceutical Company Bis-naphthalimides as anticancer agents
US5206249A (en) * 1991-03-27 1993-04-27 Du Pont Merck Pharmaceutical Company Bis-naphthalimides containing amino-acid derived linkers as anticancer agents
US5206250A (en) * 1991-03-27 1993-04-27 Du Pont Merck Pharmaceutical Company Bis-naphthalimides containing amide and thioamide linkers as anticancer agents

Also Published As

Publication number Publication date
US5585382A (en) 1996-12-17
BR9407265A (pt) 1996-10-01
PL312272A1 (en) 1996-04-15
ZA944370B (en) 1996-01-04
TW263506B (en:Method) 1995-11-21
HU9503759D0 (en) 1996-02-28
EP0705250A1 (en) 1996-04-10
CA2165765A1 (en) 1995-01-05
CN1125943A (zh) 1996-07-03
IL110033A0 (en) 1994-10-07
KR960703113A (ko) 1996-06-19
FI956231L (fi) 1995-12-22
US5416089A (en) 1995-05-16
AU7171294A (en) 1995-01-17
JPH08511802A (ja) 1996-12-10
HRP940367A2 (en) 1997-04-30
FI956231A7 (fi) 1995-12-22
FI956231A0 (fi) 1995-12-22
SK163095A3 (en) 1996-09-04
WO1995000490A1 (en) 1995-01-05
NO955257D0 (no) 1995-12-22
CZ336795A3 (en) 1996-06-12
NO955257L (no) 1996-02-26

Similar Documents

Publication Publication Date Title
CA2736097C (en) Carbazole compounds for inhibition of nf-kb activity
HUT75121A (en) Bis-imide derivatives of tri-and tetraamines and pharmaceutical compositions containing them
KR20160103986A (ko) N-벤질 트립탄트린 유도체, 및 이의 제조 방법 및 적용
HUP0202758A2 (hu) Izomer kondenzált pirrolokarbazolok és izoindolok és intermedierjeik, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
EP0091241A2 (en) Condensed pyrrolinone derivatives, and their production
WO1999042442A1 (en) Aminoguanidine hydrazone derivatives, process for producing the same and drugs thereof
CH633796A5 (fr) Dipyridoindoles therapeutiquement actifs.
NZ560354A (en) Androgen receptor modulator compounds and methods
HU204052B (en) Process for producing imidazopyridazines and pharmaceutical comprising such compounds
AU2015311362B2 (en) Pyrazolo[3,4-c]pyridine derivatives
PT95646A (pt) Processo para a preparacao de derivados de isotiazolo-quinolina e de composicoes farmaceuticas que os contem
AU2003217373B2 (en) Novel tyloindicines and related processes, pharmaceutical compositions and methods
SI9300390A (en) Pyrolo :3,2-b: carbazones, 1h benzofuro :3,2-f: indoles and 1h-:1: benzothieno :2,3-f: indoles and their use as anti-tumour agents
DK172753B1 (da) N-(5,6,7,8-tetrahydropyrido[2,3--d]pyrimidin-6-yl-alkanoyl)-glutaminsyrederivater, deres anvendelse, farmaceutiske præparat
CA2007529A1 (en) 3-phenyl-5, 6-dihydrobenz [c] acridine-7-carboxylic acids and related compounds as cancer chemotherapeutic agents
JPH05508639A (ja) １，２―ジヒドロ―３ｈ―ジベンズイソキノリン―１，３―ジオン抗ガン剤
KR19980032504A (ko) 포유류 세포의 성장 억제 방법
AU680431B2 (en) 2,5-disubstituted isoquindazole-6-(2H)-ones
CN102584679B (zh) 一类苯并咔唑酰胺类化合物、其制备方法和用途
US5641782A (en) 3-aromatic and 3-heteroaromatic substituted bisnaphthalimides
EP1330456B1 (en) N8,n13 -disubstituted quino[4,3,2-kl]acridinium salts as therapeutic agents
WO2019228170A1 (zh) 八氢戊搭烯类化合物、其制备方法及其在医药学上的应用
IE65462B1 (en) (1,2,3,4-Tetrahydro-9-acridimino)cyclohexane carboxylic acid and related compounds a process for their preparation and their use as medicaments
CN108430987A (zh) Pi3k抑制剂及其药学上可接受的盐和多晶型物及其应用
NO774216L (no) Fremgangsmaate for fremstilling av benzimidazolderivater