JPH08507767A - 管脈形成を抑制する方法および組成物 - Google Patents

管脈形成を抑制する方法および組成物

Info

Publication number
JPH08507767A
JPH08507767A JP6520046A JP52004694A JPH08507767A JP H08507767 A JPH08507767 A JP H08507767A JP 6520046 A JP6520046 A JP 6520046A JP 52004694 A JP52004694 A JP 52004694A JP H08507767 A JPH08507767 A JP H08507767A
Authority
JP
Japan
Prior art keywords
angiogenesis
compound
human
group
animal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP6520046A
Other languages
English (en)
Japanese (ja)
Inventor
ダマト，ロバート
Original Assignee
ザ・チルドレンズ・メデイカル・センター・コーポレーシヨン
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26699202&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JPH08507767(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ザ・チルドレンズ・メデイカル・センター・コーポレーシヨン filed Critical ザ・チルドレンズ・メデイカル・センター・コーポレーシヨン
Publication of JPH08507767A publication Critical patent/JPH08507767A/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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JP6520046A 1993-03-01 1994-02-24 管脈形成を抑制する方法および組成物 Withdrawn JPH08507767A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US2504693A 1993-03-01 1993-03-01
US08/025,046 1993-12-15
US08/168,817 US5629327A (en) 1993-03-01 1993-12-15 Methods and compositions for inhibition of angiogenesis
US08/168,817 1993-12-15
PCT/US1994/001971 WO1994020085A1 (en) 1993-03-01 1994-02-24 Methods and compositions for inhibition of angiogenesis

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2001050214A Division JP4065373B2 (ja) 1993-03-01 2001-02-26 サリドマイドを有効成分とする医薬品製剤

Publications (1)

Publication Number Publication Date
JPH08507767A true JPH08507767A (ja) 1996-08-20

Family

ID=26699202

Family Applications (4)

Application Number Title Priority Date Filing Date
JP6520046A Withdrawn JPH08507767A (ja) 1993-03-01 1994-02-24 管脈形成を抑制する方法および組成物
JP2001050214A Expired - Lifetime JP4065373B2 (ja) 1993-03-01 2001-02-26 サリドマイドを有効成分とする医薬品製剤
JP2004220584A Pending JP2004359693A (ja) 1993-03-01 2004-07-28 サリドマイドを有効成分とする医薬品製剤
JP2007289175A Pending JP2008088182A (ja) 1993-03-01 2007-11-07 サリドマイドを有効成分とする医薬品製剤

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2001050214A Expired - Lifetime JP4065373B2 (ja) 1993-03-01 2001-02-26 サリドマイドを有効成分とする医薬品製剤
JP2004220584A Pending JP2004359693A (ja) 1993-03-01 2004-07-28 サリドマイドを有効成分とする医薬品製剤
JP2007289175A Pending JP2008088182A (ja) 1993-03-01 2007-11-07 サリドマイドを有効成分とする医薬品製剤

Country Status (20)

Country Link
US (18) US5629327A (US20020061911A1-20020523-C00023.png)
EP (4) EP1245229A3 (US20020061911A1-20020523-C00023.png)
JP (4) JPH08507767A (US20020061911A1-20020523-C00023.png)
KR (1) KR100506043B1 (US20020061911A1-20020523-C00023.png)
AT (2) ATE304356T1 (US20020061911A1-20020523-C00023.png)
AU (1) AU676722B2 (US20020061911A1-20020523-C00023.png)
BR (1) BR9400764A (US20020061911A1-20020523-C00023.png)
CA (3) CA2342974C (US20020061911A1-20020523-C00023.png)
CO (1) CO4230017A1 (US20020061911A1-20020523-C00023.png)
DE (3) DE69434490T2 (US20020061911A1-20020523-C00023.png)
DK (2) DK0688211T3 (US20020061911A1-20020523-C00023.png)
ES (2) ES2245711T3 (US20020061911A1-20020523-C00023.png)
FR (1) FR08C0036I2 (US20020061911A1-20020523-C00023.png)
HK (1) HK1052865A1 (US20020061911A1-20020523-C00023.png)
LU (1) LU91471I2 (US20020061911A1-20020523-C00023.png)
NL (1) NL300358I2 (US20020061911A1-20020523-C00023.png)
NZ (4) NZ262676A (US20020061911A1-20020523-C00023.png)
PE (1) PE10095A1 (US20020061911A1-20020523-C00023.png)
PT (1) PT688211E (US20020061911A1-20020523-C00023.png)
WO (1) WO1994020085A1 (US20020061911A1-20020523-C00023.png)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002506861A (ja) * 1998-03-16 2002-03-05 コルジーン コーポレイション ２−（２，６−ジオキソピペリジン−３−イル）イソインドリン誘導体、その製剤および炎症性サイトカイン阻害剤としてのその使用
JP2002514578A (ja) * 1998-05-11 2002-05-21 エントレメッド インコーポレイテッド ２−フタルイミジノグルタル酸の類似体および血管新生の阻害剤としてのそれらの使用
JP2004538322A (ja) * 2001-08-06 2004-12-24 ザ チルドレンズ メディカル センター コーポレイション 窒素置換サリドマイド誘導体の合成及び抗腫瘍活性
JP2009509945A (ja) * 2005-09-27 2009-03-12 天津和美生物技▲術▼有限公司 細胞の腫瘍壊死因子の放出を抑制できる５Ｈ−チエノ［３，４−ｃ］ピロール−４，６ジオン誘導物
JP2009538318A (ja) * 2006-05-26 2009-11-05 セルジーン・コーポレーション 併用療法において免疫調節化合物を用いる方法及び組成物

Families Citing this family (286)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6582959B2 (en) 1991-03-29 2003-06-24 Genentech, Inc. Antibodies to vascular endothelial cell growth factor
US5629327A (en) * 1993-03-01 1997-05-13 Childrens Hospital Medical Center Corp. Methods and compositions for inhibition of angiogenesis
US6228879B1 (en) * 1997-10-16 2001-05-08 The Children's Medical Center Methods and compositions for inhibition of angiogenesis
US6114355A (en) * 1993-03-01 2000-09-05 D'amato; Robert Methods and compositions for inhibition of angiogenesis
US8143283B1 (en) * 1993-03-01 2012-03-27 The Children's Medical Center Corporation Methods for treating blood-born tumors with thalidomide
US6805865B1 (en) 1993-05-27 2004-10-19 Entremed, Inc. Compositions and methods for treating cancer and hyperproliferative disorders
US20040248799A1 (en) * 1993-05-27 2004-12-09 Holaday John W. Compositions and methods for treating cancer and hyperproliferative disorders
DE4422237A1 (de) * 1994-06-24 1996-01-04 Gruenenthal Gmbh Verwendung von Lactamverbindungen als pharmazeutische Wirkstoffe
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JP2009509945A (ja) * 2005-09-27 2009-03-12 天津和美生物技▲術▼有限公司 細胞の腫瘍壊死因子の放出を抑制できる５Ｈ−チエノ［３，４−ｃ］ピロール−４，６ジオン誘導物
JP2009538318A (ja) * 2006-05-26 2009-11-05 セルジーン・コーポレーション 併用療法において免疫調節化合物を用いる方法及び組成物

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US20020061911A1 (en) 2002-05-23
ATE304356T1 (de) 2005-09-15
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US6977268B2 (en) 2005-12-20
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US20020161024A1 (en) 2002-10-31
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US6071948A (en) 2000-06-06
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US6469045B1 (en) 2002-10-22
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