JPH0776513A - Cosmetic for preventing skin aging - Google Patents

Abstract

PURPOSE:To obtain a valuable cosmetic for preventing skin aging having excellent inhibitory effect on skin aging (improving effect on chapped skin, improving effect on keratin increasing effect on turnover, beautifying effect on skin, etc.). CONSTITUTION:This cosmetic is a cosmetic mixed with at least one selected from a group of gamma-amino-beta-hydroxybutyric acid and its salt and an essence of Swertia japonica and/or essence of Panax ginseng.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin aging-preventing cosmetic (a cosmetic used to prevent skin aging). More specifically, skin aging prevention effect (rough skin improvement effect, keratin improvement effect, effect of accelerating turnover speed, effect of beautiful skin, etc.)
Regarding excellent skin cosmetics.

[0002]

2. Description of the Related Art Aged skin is dry skin that is not smooth and has keratinocyte exfoliation phenomenon. And aging skin
It is said that the turnover speed is slow, and when the antiaging effect is imparted to the skin, the turnover speed is increased. The present applicant has previously found and proposed that γ-amino-β-hydroxybutyric acid enhances skin function and has an antiaging effect (Japanese Patent Publication No. 13685/1990).

On the other hand, assemblage extract, carrot extract and the like are known substances and only have a blood circulation-promoting effect, and they promote skin function similar to γ-amino-β-hydroxybutyric acid and its salts and prevent aging. It has not been found to have any effect.

[0004] However, the skin cosmetics prepared by blending these skin stimulants, which are the components for enhancing the skin function, alone are
In all cases, the effects such as aging prevention are slow-acting, and it takes a long time for the effects to appear. Therefore, they are not completely satisfactory, and there is a room for improvement.

In view of such circumstances, the present inventor has an excellent effect of preventing skin aging (rough skin improving effect, keratin improving effect,
The effect of accelerating turnover speed, the effect of beautiful skin, etc.)
As a result of intensive research into whether or not there is a rapid-acting skin anti-aging cosmetic that develops in a very short period of 1 to 2 months after the start of use and lasts, γ-amino-β-hydroxybutyric acid and its salts The present invention has been completed by finding that this object can be achieved by blending at least one member selected from the group (i) with a seaweed extract and / or a carrot extract.

[0006]

That is, the present invention provides γ
-Amino-β-hydroxybutyric acid and at least one selected from the group of salts thereof, and a combination extract and / or carrot extract are blended to provide a skin anti-aging cosmetic composition.

The structure of the present invention will be described in detail below. In order to achieve the above object, the skin anti-aging cosmetic composition of the present invention comprises (i) at least one member selected from the group of γ-amino-β-hydroxybutyric acid and salts thereof, and (b) assembly extract and / or It is characterized by containing a carrot extract. The present inventor, as a result of exploring the blending ratio that maximizes the synergistic effect of the above-mentioned constituents to be blended in the skin anti-aging cosmetic, (a) from the group of γ-amino-β-hydroxybutyric acid and salts thereof. In a combination of at least one selected and (b) assembly extract and / or carrot extract, it is preferable that the ratio (weight ratio) of the respective compounding amounts is (a) :( b) = 1: 1-30. The excellent effect of the present invention was confirmed.

The skin anti-aging cosmetic composition of the present invention comprises, as described above, at least one member selected from the group consisting of γ-amino-β-hydroxybutyric acid and salts thereof, and an assembly extract and / or carrot extract. Both of them act synergistically on the skin to expand the peripheral blood vessels of the skin, enhance skin function, prevent wrinkles on the skin, and make the skin fine and firm. (Beautiful skin effect), excellent anti-aging effect (rough skin improving effect, keratin improving effect, quick turnover speed increasing effect) is manifested in a short time, and lasting and other remarkable effects are exhibited.

[0009] As described above, γ-amino-β-hydroxybutyric acid and salts thereof applied to the present invention are known compounds and are described in detail in the above publication. γ-amino-
Examples of the β-hydroxybutyric acid salt include potassium salt, sodium salt, calcium salt, and magnesium salt of γ-amino-β-hydroxybutyric acid neutralized with caustic potash, caustic soda, calcium hydroxide, or magnesium hydroxide. Is applied.

The assembly (Swertia) used in the present invention.
Japonica Makino) is a known substance, and is an extract obtained by digesting a dry pulverized product of whole flowering plants in ethanol or hydrous ethanol and filtering. The extract obtained by the following method was applied to Examples and Comparative Examples. 50 g of crushed assembly product was added to 250 ml of water-containing ethanol (90% by weight of ethanol) at a temperature of 40 to 50 ° C.
After the mixture was digested with and filtered off, the residue was digested again in the same manner several times to obtain 1.5 l of the extract. 100 ml of purified water was added to the residue which was concentrated under reduced pressure, the mixture was aged for 1 week, the insoluble portion was filtered off and the obtained extract was concentrated under reduced pressure, and then ethanol was added to bring the ethanol content of the extract to 40% by weight. The mixture was adjusted so that 100 ml of the assembly extract was obtained. (After 100 g of this extract was concentrated under reduced pressure, it was extracted with 200 ml of ethyl acetate (40 ml x 5 times), and ethyl acetate was distilled off from this extract under reduced pressure to give 0.95 to 1.05 g. It was.)

The ginseng used in the present invention is also a known substance, and ginseng (Panax gin) is used.
seng C. A. It is an extract obtained by cold-soaking a dried pulverized product of 5 to 6-year-old roots of Meyer) in ethanol or hydrous ethanol and filtering. The extract obtained by the following method was applied to Examples and Comparative Examples. 50 g of ginseng ginseng was soaked in 200 ml of water-containing ethanol (90% by weight of ethanol) for 1 week, and the ethanol of the extract obtained by filtration was distilled off. Purified water was added to bring the ethanol content of the extract to 50% by weight. The resulting mixture was aged for 7 to 10 weeks in a cold place, and then filtered to obtain 100 ml of ginseng extract. (Note that this extract 10.0
g was concentrated under reduced pressure, 30 ml of purified water was added and dissolved, and this aqueous solution was filtered. Then, ether 40 was added to the filtrate.
After adding ml, shake gently and leave for a while,
The lower layer aqueous solution was separated. In addition, water saturation n
-Butanol 120 ml (40 ml x 3 times) was added and shaken vigorously, left for a while, the butanol layer was separated, and the butanol solution was heated on a water bath to remove n-butanol. It was 1.2 g. )

The blending amount of γ-amino-β-hydroxybutyric acid and its salt is 0.
It is 1 to 2% by weight (hereinafter abbreviated as wt%).

The amount of the assembly extract is preferably 0.1 to 5.0 wt% based on the total amount of the prescription components of the cosmetic composition.
It is within the range of%.

The content of the carrot extract is preferably 0.1 to 5.0 wt% based on the total amount of the prescription ingredients of the cosmetic.
It is within the range of%.

In the cosmetics of the present invention, in addition to the above-mentioned raw materials, tar-based pigments, coloring pigments such as iron oxide, preservatives such as parabens, fatty acid soaps, anionic surfactants such as sodium cetyl sulfate, and polyoxyethylene. Nonionic surfactants such as alkyl ethers, polyoxyethylene fatty acid esters, polyoxyethylene polyhydric alcohol fatty acid esters, polyoxyethylene hydrogenated castor oil, polyhydric alcohol fatty acid esters, polyglycerin fatty acid esters, tetraalkylammonium salts, etc. Ionic surfactants, betaine type, sulfobetaine type, sulfoamino acid type, amphoteric surfactants such as sodium N-stearoyl-L-glutamate, natural surfactants such as lecithin and lysophosphatidylcholine, and titanium oxide Pigment, dibutyl hydroxy And antioxidants such as toluene, may be appropriately blended within the range to achieve the object of the present invention.

The dosage form of the cosmetic of the present invention includes creams, emulsions, lotions, packs and the like. For example, in the case of cream or the like, this cosmetic can be produced by a usual method of emulsifying and dispersing an oil phase and an aqueous phase, which are melted by heating, and cooling.

[0017]

EXAMPLES The present invention will be described in detail below based on examples and comparative examples. The methods for measuring the turnover speed of the stratum corneum, the measurement test method for improving rough skin, the measurement test method for improving stratum corneum, and the sensory test described in Examples are as follows.

Method for measuring turnover speed of stratum corneum 5 wt% of fluorescent dye dansyl chloride in white petrolatum
% Ointment is prepared and occluded and applied to the skin of the forearm of the subject for 24 hours, and dansyl chloride is osmotically bonded to the stratum corneum. Thereafter, the test sample was applied to the same site twice a day (morning and evening), and the fluorescence of dansyl chloride was examined every day. The number of days until the fluorescence disappeared was defined as the turnover rate of the stratum corneum of the skin. The normal turnover rate of the stratum corneum of the skin is 14 to 16 days, but in aged skin, it increases around 18 days. On the other hand, when the anti-aging effect appears, it is shortened to around 12 days.

Measurement Test Method for Rough Skin Improvement Effect The application effect for 20 consecutive weeks was examined for 20 middle-aged and elderly subjects who have rough skin on their lower legs. About 1 g of the sample was applied to the left leg test site of the test subject twice a day, and the skin condition before the start of the test and after the test was judged according to the criteria shown in Table 1. The right lower leg was used as a target without applying the sample.

[0020]

[Table 1]

When the judgment results of the test site before and after the test and the control site are compared, when the skin dryness is improved by two stages or more (for example, + → −, ++ → ±) is “effective”, when one stage is improved Is "slightly valid", and when there is no change, it is "invalid". The test results are shown by the number of subjects who were “effective” and “somewhat effective”.

Test method for measuring the effect of improving keratin (increasing anti-peeling property of keratinocytes) Scotch tape (Nichiban Mending Tape) on the skin of the test area before and after the start of the rough skin improvement measurement test described above
Was adhered and the state of keratinocytes adhered to the tape when peeled off was examined in detail by a scanning electron microscope, and the keratin layer cell exfoliation property was classified according to the criteria in Table 2 to obtain a keratin improving effect.

[0023]

[Table 2]

The judgment is "effective" when the difference between the evaluation points of the test site and the control site after continuous application for 4 weeks is 2 points or more, "effective" when 1 point, "slightly effective", and when 0 point. Invalid ". The test results are shown by the number of subjects who were “effective” and “somewhat effective”.

Sensory test (bare skin effect test) Female subjects who complain of rough skin, fine wrinkles, dry skin (35-35)
The sample was applied to 20 people (55 years old) twice a day (morning and evening) for 3 consecutive months, and the effect after 1, 2 and 3 months was evaluated. The test results replied that "the skin was moisturized", "the skin was smooth", and "the skin was tense" with respect to each item of the skin wettability, smoothness, and elasticity. The number of people is shown.

Examples 1 to 8 and Comparative Examples 1 to 7 [skin cream] γ-amino-β-hydroxybutyric acid and its salt, and assembly extract and / or carrot extract were blended as shown in Tables 4 and 5. Then, a skin cream having the composition shown in Table 3 below was prepared, and the above-mentioned various experiments were carried out. In addition, γ-amino-β-hydroxybutyric acid is GAB
As salts of OB and γ-aminobutyric acid-β-hydroxybutyric acid, potassium salt is GABOB-K and sodium salt is G
ABOB-N and calcium salt are abbreviated as GABOB-C and magnesium salt as GABOB-M.

(1) Composition

[0028]

[Table 3]

(2) Preparation Method Each of the components (A) and (B) was heated and dissolved at 80 ° C., then mixed and cooled to 30 ° C. with stirring to prepare each skin cream.

(3) Properties The results of various tests of each skin cream are shown in Tables 4-6. As shown in Tables 4 to 6, the assembly extract, carrot extract, or γ-amino-β-of Comparative Examples 1 to 7.
The skin cream containing only hydroxybutyric acid and its salt alone did not provide sufficient effects in various properties, and the assembly extract and / or carrot extract and γ-amino-β-of Examples 1 to 8 of the present invention were not obtained. A skin cream containing at least one selected from the group of hydroxybutyric acid and its salts showed remarkable effects in various properties, and a sensory test showed an excellent skin-beautifying effect 1-2 months after application of the sample. .

[0031]

[Table 4]

[0032]

[Table 5]

[0033]

[Table 6]

Examples 9 to 11 [Skin lotion] Skin lotions having the compositions shown in Table 7 were prepared and various tests were carried out.

(1) Composition

[0036]

[Table 7]

(2) Preparation Method After the components (A) and (B) were uniformly dissolved, the components (A) and (B) were mixed and stirred to be dispersed, and then filled in a container. At the time of use, the content was uniformly dispersed by shaking before use.

(3) Characteristics Examples 9 to 11 all showed good results in the above tests.

[0039]

Industrial Applicability As described above, the present invention provides a useful skin anti-aging cosmetic having excellent anti-aging effects (rough skin improving effect, keratin improving effect, turnover speed increasing effect, beautiful skin effect, etc.). It is clear to provide.

Claims (1)

[Claims] 1. A skin anti-aging cosmetic composition comprising at least one selected from the group consisting of γ-amino-β-hydroxybutyric acid and salts thereof, and an assembly extract and / or carrot extract.