JP2000001421A - Cosmetic for preventing skin aging - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a useful cosmetic for preventing skin aging having excellently preventing effects on skin aging (improving effect on chapped skin, improving effect on keratin, quickening effect on overturn, skin lightening effect, etc.). SOLUTION: This cosmetic for preventing skin aging is obtained by formulating at least one selected from the group consisting of sodium γ-hydroxy butyrate and its salt with at least one selected from glycyrrhizic acid, glycyrrhetinic acid and their derivatives.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic for preventing skin aging (a skin aging prevention effect, an effect of improving rough skin, an effect of improving keratin, an effect of increasing the speed of turnover, and a beautiful skin effect). Cosmetics used).

[0002]

2. Description of the Related Art Aged skin is rough skin that is dry and has no smoothness and in which keratinocyte exfoliation is observed. And aging skin,
It is said that the turnover speed is low when the skin has an anti-aging effect, and the turnover speed is high. The present applicant has previously found that γ-hydroxybutyric acid and salts thereof enhance the skin function by the peripheral vasodilatory action of the skin and have an antiaging effect, and have proposed the same (JP-A-4-26606). .

[0003] However, skin cosmetics comprising γ-hydroxybutyric acid and a salt thereof alone have a slow effect of preventing aging and the like. For example, in the case of cream, after six months of continuous use,
In the case of a lotion, the effect was apparent after eight months of continuous use, and was not sufficiently satisfactory, and in fact, there was room for improvement.

[0004]

In view of such circumstances, the present inventor has found that excellent skin aging prevention effects (rough skin improvement effect, keratin improvement effect, effect of increasing turnover speed, beautiful skin effect, etc.) As a result of intensive studies as to whether there is a fast-acting skin aging preventive cosmetic that develops in a very short time of 1-2 months after the start of use and lasts, it is selected from the group of γ-hydroxybutyric acid and salts thereof. The present inventors have found that this object can be achieved by blending glycyrrhizic acid, glycyrrhetinic acid and their derivatives with at least one of them, and have completed the present invention.

[0005] Glycyrrhizic acid, glycyrrhetinic acid and derivatives thereof are known substances and have only been recognized as having an anti-inflammatory effect. Like γ-hydroxybutyric acid and its salts, it improves the deterioration of skin function and prevents aging. It has not been found to have any effect.

However, the inventor of the present invention has found that the combination of the aforementioned substances acts synergistically on the skin to dilate peripheral blood vessels of the skin, enhance skin function, improve skin wrinkles, and smooth skin. In addition to providing a plump and moist skin (beautifying skin effect), it also has an excellent effect of improving rough skin, improving keratin and increasing the speed of turnover in a short period of time. I found it to work.

[0007] That is, the present invention provides a method for treating skin aging, comprising mixing at least one selected from the group consisting of γ-hydroxybutyric acid and salts thereof and at least one selected from glycyrrhizic acid, glycyrrhetinic acid and derivatives thereof. Prevent cosmetics.

[0008]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The configuration of the present invention will be described below in detail.

Examples of the γ-hydroxybutyric acid and its salts applicable to the present invention include known commercially available compounds. Examples of the salts of γ-hydroxybutyric acid include potassium hydroxide, sodium hydroxide and calcium hydroxide. And potassium salts, sodium salts, calcium salts, and magnesium salts of γ-hydroxybutyric acid neutralized with either magnesium hydroxide.

The glycyrrhizic acid and its derivatives used in the present invention are known compounds.
18α-glycyrrhizic acid (abbreviated as α-Gi), 1
8β-glycyrrhizic acid (abbreviated as β-Gi), their salts 18α-glycyrrhizic acid trisodium (abbreviated as α-Gi-Na3), and 18α-glycyrrhizinate monopotassium (abbreviated as α-Gi-K) ), 18
dipotassium α-glycyrrhizinate (abbreviated as α-Gi-K2), 18α-monoammonium glycyrrhizinate (abbreviated as α-Gi-NH3), trisodium 18β-glycyrrhizinate (abbreviated as β-Gi-Na3), 18β-Glycyrrhizinate monopotassium (β-G
i-K), 18 β-glycyrrhizic acid dipotassium (abbreviated as β-Gi-K2), and 18α-glycyrrhizic acid methyl ester (abbreviated as α-Gi methyl), which are esters of glycyrrhizic acid derivatives, 18
β-glycyrrhizic acid methyl ester (abbreviated as β-Gi methyl) and the like are preferred.

The glycyrrhetinic acid and its derivatives used in the present invention are known compounds, specifically, α-glycyrrhetinic acid (abbreviated as α-Ge),
As salts of β-glycyrrhetinic acid (abbreviated as β-Ge) and glycyrrhetinic acid derivatives, disodium 3-succinyloxyglycyrrhetinate (3-succinyl-Ge)
-Na2) and the like are preferred.

Further, esters of glycyrrhetinic acid derivatives include, for example, stearyl α-glycyrrhetinate (abbreviated as α-Ge-stearyl), stearyl β-glycyrrhetinate (abbreviated as β-Ge-stearyl), α-glycyrrhetin Pyridoxine acid (α-Ge-
Pyridoxine), β-glycyrrhetinic acid pyridoxine (abbreviated as β-Ge-pyridoxine), α-
Glycerin glycyrrhetinate (abbreviated as α-Ge-glycerin), glyceryl β-glycyrrhetinate (β-G
e-glycerin) and the like.

The amount of γ-hydroxybutyric acid and a salt thereof is 0.01 to 0.01% based on the total amount of the ingredients of the cosmetic.
2.0% by weight (hereinafter abbreviated as wt%) is preferred.

The amount of glycyrrhizic acid, glycyrrhetinic acid and their derivatives is preferably 0.01 to 2.0% by weight based on the total amount of the cosmetic ingredients.

The cosmetics of the present invention include, in addition to the above-mentioned raw materials, tar pigments, coloring pigments such as iron oxide, preservatives such as paraben, anionic surfactants such as fatty acid soap and sodium cetyl sulfate, polyoxyethylene. Nonionic surfactants such as alkyl ethers, polyoxyethylene fatty acid esters, polyoxyethylene polyhydric alcohol fatty acid esters, polyoxyethylene hydrogenated castor oil, polyhydric alcohol fatty acid esters, and polyglycerin fatty acid esters; Ionic surfactants, betaine-type, sulfobetaine-type, sulfoamino acid-type, amphoteric surfactants such as N-stearoyl-L-glutamate, natural surfactants such as lecithin, lysophosphatidylcholine, and titanium oxide Pigment, dibutyl hydroxy And antioxidants such as toluene, may be appropriately blended within the range to achieve the object of the present invention.

The cosmetic preparation of the present invention includes creams, emulsions, lotions, packs and the like.

[0017]

The present invention will be described below in detail based on examples and comparative examples. The methods for measuring the turnover speed of the stratum corneum, the method for measuring the effect of improving rough skin, the method for measuring the effect of improving stratum corneum, and the sensory test described in the examples are as follows.

Method for measuring the turnover speed of the stratum corneum 5 wt% of the fluorescent dye dansyl chloride was added to white petrolatum.
% Ointment was prepared, and the ointment was occlusively applied to the skin of the forearm of the subject for 24 hours, and dansyl chloride was penetrated into the stratum corneum. Thereafter, a test sample was applied to the same site twice a day (morning and evening), the fluorescence of dansyl chloride was examined every day, and the number of days until the fluorescence disappeared was defined as the turnover speed of the stratum corneum of the skin.

Measurement Test Method for Improvement of Rough Skin The effect of continuous application for 20 weeks was examined on 20 middle-aged and elderly subjects having rough skin on the lower leg. About 1 g of the sample was applied to the test site of the left leg of the subject twice a day, and the skin condition before and after the start of the test was determined according to the criteria shown in Table 1. The lower leg on the right side was used as a target without applying the sample.

[0020]

[Table 1]

The test results before and after the test and the control site are compared, and when the degree of dryness of the skin is improved by two or more stages (for example, + →-, ++ → ±), “effective” and one stage of improvement Is "Slightly valid", and the case where there is no change is "Invalid". The test results were indicated by the number of subjects who became “effective” and “slightly effective”.

Measurement test method of keratin improvement (enhancement of exfoliation of keratinocytes) effect Scotch tape (Nichiban Mending tape) is applied to the skin of a test part before and after the above-mentioned measurement test for measuring rough skin improvement.
Was adhered to the tape, and when the tape was peeled off, the state of the keratinous cells attached to the tape was examined in detail by a scanning electron microscope.

[0023]

[Table 2]

The judgment is "valid" when the difference between the evaluation point of the test site and that of the control site after continuous application for 4 weeks is 2 or more, "valid" when it is 1 point, and "moderately" when it is 0 point. Invalid ". The test results were indicated by the number of subjects who became “effective” and “slightly effective”.

Sensory test (bare skin effect test) Female subjects complaining of rough skin, fine wrinkles, dry skin, etc.
A sample was applied twice a day (morning and evening) to 20 persons (55 years old) for 3 consecutive months, and the effect after 1, 2, and 3 months was evaluated. The test results were as follows: for each item of skin wettability, smoothness, elasticity, and thickness, "skin was moistened", "skin became smooth", "skin became taut" and The number of respondents who answered that "the skin had a feeling of volume" was indicated.

Examples 1-4, Comparative Examples 1-9 [Skin cream] γ-hydroxybutyric acid and its salt, glycyrrhizic acid,
Glycyrrhetinic acid and their derivatives were blended as shown in Tables 4 and 5, skin creams were prepared with the compositions shown in Table 3 below, and the above-described experiments were performed. The salts of γ-hydroxybutyric acid are abbreviated as GOB, and the salts of γ-hydroxybutyric acid are abbreviated as GOB-K, the sodium salt as GOB-N, and the calcium salt as GOB-C.

(1) Composition

[0028]

[Table 3]

(2) Preparation Method The components (A) and (B) were each dissolved by heating to 80 ° C., mixed, and cooled to 30 ° C. with stirring to prepare each skin cream.

(3) Characteristics Tables 4 to 6 show the results of various tests conducted on each skin cream. As shown in Tables 4 to 6, glycyrrhizic acid, glycyrrhetinic acid and derivatives of Comparative Examples 1 to 9, or a skin cream containing only γ-hydroxybutyric acid and its salt alone could not obtain sufficient effects in various properties, The skin creams containing the glycyrrhizic acid, glycyrrhetinic acid and derivatives thereof of Examples 1 to 4 of the present invention and at least one selected from the group of γ-hydroxybutyric acid and salts thereof show remarkable effects in various properties, In the test, excellent skin effect (skin wettability, smoothness, elasticity and thickness) was shown 1 to 2 months after application of the sample.

[0031]

[Table 4]

[0032]

[Table 5]

[0033]

[Table 6]

Examples 5 to 10 [Skin lotion] Skin lotions were prepared according to the compositions shown in Table 7, and various tests were carried out. In addition, as a salt of γ-hydroxybutyric acid, the sodium salt is abbreviated as GOB-N, and the magnesium salt is abbreviated as GOB-M.

(1) Composition

[0036]

[Table 7]

(2) Preparation method After the components (A) and (B) were uniformly dissolved, the components (A) and (B) were mixed, dispersed by stirring, and then charged into a container. At the time of use, the contents were uniformly shaken and used.

(3) Characteristics Examples 5 to 10 all showed good results in the above tests.

[0039]

As described above, the present invention provides a useful skin aging preventive cosmetic composition having excellent skin aging preventing effects (rough skin improving effect, keratin improving effect, effect of increasing turnover speed, beautiful skin effect, etc.). It is clear to offer.

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Claims (1)

[Claims] 1. A skin aging preventive cosmetic comprising: at least one selected from the group consisting of γ-hydroxybutyric acid and salts thereof; and at least one selected from glycyrrhizic acid, glycyrrhetinic acid and derivatives thereof.