JPS6239511A - Cosmetic for preventing aging of skin - Google Patents

Abstract

PURPOSE:A cosmetic which promotes skin function, prevents wrinkles on the skin, makes the skin with fineness and moisture, provides good touch after use and beautifies the body, contains vitamin E-gamma -linolenic acid. CONSTITUTION:A cosmetic containing vitamin E-gamma -linolenic acid, having good effects on the skin of gamma -linolenic acid as an essential fatty acid, developing simultaneously vasodilating action and aging preventing action of vitamin E, showing more improved effects than when vitamin E is used as a single com pound, and having extremely improved endermic permeation properties. The blending amount of the compound in the cosmetic is usually 0.01-10wt%, prefer ably 0.05-3wt% based on the total amount of the composition and the cosmetic is obtained by adding directly vitamin E-gamma -linolenic acid to cosmetic cream or milky lotion. EFFECT:Capable of increasing charm, keeping the skin healthy, exhibiting and providing preventing effect on aging of the skin, having improving effects on chapped skin and on keratin and accelerating effects on turnover rate.

Description

DETAILED DESCRIPTION OF THE INVENTION (Field of Industrial Application) The present invention relates to cosmetics for preventing skin aging (skin cosmetics used for preventing skin aging). More specifically, the present invention relates to skin cosmetics with excellent skin aging prevention effects (improving rough skin, keratin reforming effects, increasing the turnover rate of the stratum corneum, reducing wrinkles, etc.).

(Prior Art) Aging skin loses its flexibility and elasticity, wrinkles increase, and the skin becomes dry and rough without smoothness, and a phenomenon of exfoliation of keratin cells is observed.

Essential fatty acids such as α-linolenic acid and linoleic acid are not biosynthesized within the human body and must be ingested from the outside through meals. It is known that a deficiency of these essential fatty acids causes stunted growth, skin desquamation, etc., and significantly accelerates skin aging. As a countermeasure to this problem, it has been proposed to incorporate essential fatty acids or vegetable oils containing essential fatty acids, but the effect of preventing skin aging is not yet sufficient and there is a drawback that rancidity, discoloration, etc. are likely to occur.

On the other hand, vitamin E's effect on the skin is to regulate sexual function, and it has traditionally been used to treat skin diseases associated with irregular menstruation and women's skin diseases during menopause. It is used to treat chilblains, etc.

However, vitamin E alone has little effect on moisturizing skin and anti-aging effects, or has a so-called beautifying effect that eliminates wrinkles and makes skin fine and shiny and beautiful. It has drawbacks such as easily discoloring due to exposure to light and long-term storage, emitting A-like gas, and cannot be sufficiently concealed even when numbered.

(Disclosure of the Invention) In view of the above-mentioned problems, the inventors of the present invention have found that the stabilization of essential fatty acids, the permeability into the skin, the improvement effect on aging skin (as a result of many years of intensive investigation into the effects of 1 vitamin E-r-linolenic The present inventors have discovered that a skin cosmetic containing an acid ester exhibits an extremely significant anti-aging effect on the skin, leading to the completion of the present invention.

(Objective of the Invention) The object of the present invention is to provide an excellent skin cosmetic that beautifies the body while giving a good feeling when used, increases attractiveness, keeps the skin healthy, and expresses and imparts an anti-aging effect on the skin. Our goal is to provide the following.

(Structure of the Invention) (Specific Description of the Structure) The vitamin E-r-linolenic acid ester referred to in the present invention refers to γ-linolenic acid (also known as 6,9.12-octadecatrienoic acid) and α-tocopherol. (dl-α-tocopherol, d-α-tocopherol, ea-tocopherol), β-tocopherol, γ-tocopherol, mono-tocopherol, or a mixture thereof. Vitamin E-γ-linolenic acid ester combines γ-linolenic acid (also known as 9,12-octadecatrienoic acid) and tocopherol with N,N'-
It can be obtained by reaction in the presence of a condensing agent such as dicyclohexylcarbohydrate.

The amount of vitamin E-7-linolenic ester blended into cosmetics is not particularly limited and can be selected from a wide range, but it is usually 0.01 to 101 times the total weight of the liquid, preferably ゛0.05-8 weight.

The cosmetics of the present invention can be prepared by adding vitamin E-γ-linolenic acid ester directly to cosmetics, such as cosmetic creams and emulsions, or by pre-dissolving them in the oil phase thereof, or by adding vitamin E-γ-linolenic acid ester to cosmetics, such as cosmetic creams and emulsions, or by dissolving it in advance in the oil phase thereof, or by adding it to cosmetics, such as cosmetic creams and emulsions. For example, by adding and blending a pre-dissolved substance in ethanol) and performing processes such as emulsification, mixing, dispersion, and dissolution.

In addition to the above, pigments, fragrances, preservatives, surfactants, pigments, antioxidants, and the like may be appropriately incorporated into the skin cosmetic of the present invention within a range that achieves the object of the present invention.

(Effect of the invention) The cosmetic for preventing skin aging of the present invention accelerates skin function,
It prevents skin wrinkles, makes the skin smooth and moist, has excellent effects on improving rough skin and keratin, and has the effect of accelerating turnover rate.

As in the present invention, when γ-linolenic acid is used as an ester of vitamin E, γ-linolenic acid has the effect on the skin as an essential fatty acid, as well as the vasodilatory effect and anti-aging effect of vitamin E. The effect is far greater than when used alone. In addition, vitamin E has a function of stabilizing the unsaturated bonds in the γ-linolenic acid skeleton due to its heavy antioxidant function. Historically, since it is an ester derivative, it has extremely good transdermal permeability.

(Example) Examples will be described below.

In addition, the amount shown in Examples means weight %.

Method for measuring turnover rate of stratum corneum described in Examples,
The test method for measuring the rough skin improving effect, the measuring test method for the keratin improving effect, and the sensory effects are as follows.

(1) Method for measuring the turnover rate of the stratum corneum An ointment containing 5 parts by weight of the fluorescent dye danzyl chloride in white petrolatum was applied to the skin of the subject's forearm for 24 hours, and the ointment was applied to the skin of the subject's forearm for 24 hours. Osmotic bonding of diluchloride.

Thereafter, the test sample was applied to the same area twice a day (morning and evening), and the fluorescence of danzyl chloride was examined every day, and the number of days until the fluorescence disappeared was determined as the turnover rate of the skin stratum corneum. Note that the turnover rate of the normal skin stratum corneum is 14 to 16 days, but in aged skin it is 18 days.
It grows around the day. On the other hand, if the anti-aging effect appears, the time will be shortened to around 12 days.

(2) Test method for measuring the effect of improving rough skin The effect of continuous application for 4 weeks was investigated on 20 middle-aged and elderly subjects who had rough skin on their lower legs. Approximately 11 cosmetic samples were applied to the test site of the left lower leg of the test subject per day, and the condition of the skin at the start of the test and after the test was evaluated according to the criteria in Table 1. No sample was applied to the right lower leg, which served as a control.

Table 1 Judgment criteria for skin dryness - 2 Normal ± : @ Slight dryness, no scaling + : Dryness, mild scaling + : Dryness, moderate scaling + 10+ : Dryness, scaling Original test *m * Test site Compare the judgment results of the control area and if the skin dryness has improved by two or more levels (e.g. +-1,
+10-±) was considered "effective," one level of improvement was considered "slightly effective," and no change was considered "ineffective." There were no cases of skin dryness progressing during the test period.

(3) Peeling properties of keratinocytes Scotch tape (Tiban mending tape) was applied to the skin, and this was peeled off to remove the keratinocytes on the skin surface. The condition of the corneocytes was then observed in detail using a scanning electron microscope, and the exfoliation characteristics of the corneocytes were classified based on the criteria shown in Table 2, and their indices were determined.

Table 2 shows that when the difference between the evaluation score of the test site and that of the control site after 4 weeks of continuous application is 2 or more points, it is "valid", when it is 1 point, it is "slightly effective", and when it is 0 points, it is "invalid". ”.

The exfoliation property of these corneocytes is an indicator for determining the structural properties of the corneum, and in general, in dry skin and aging skin, the amount of intercellular bonds is weak, and the structure is less dense. It has been confirmed that the index is high because the index is also low.

(4) Sensory effect panel test Two samples were applied to the faces of 80 middle-aged (80-50 years old) female panelists twice a day for 4 months. Each panelist applied the sample before the start of the test and after the end of the test. The skin condition was evaluated for "wrinkle smoothing effect,""effect on firmness," and "effect on moist feeling."

Example 1, Comparative Examples 1 to 4 (skin cream) (1)
Prescription 51i! #l 1 Yusho 1 Kinsho 2 Yuka 18 Loss Kaj4-R An 0/W emulsion skin cream was prepared according to the above formulation in a conventional manner.

(2) Results The test results for each of the humiliated creams are shown in Table 3 below.

(Left below) Example 2, Comparative Examples 5 to 8 (Skin Milk) (1) Prescription'; MwA12 Shinsha 41 m12 mJ8 mM Scent
Fee a quantity appropriate-i at XI! ! it suitable
i Apply the O/W emulsion skin milk using the above recipe (using a trowel and the usual method).

(2) Results The test results for each skin milk obtained are shown in Table 4 below.

(margin below C) 1 / Example 3, Comparative Examples 9 to 12 (Lipstick) (1) Prescription After uniformly mixing and dissolving the required amounts of each component shown below at 80°C, pour into a lipstick mold. After cooling this to 30° C., each lipstick is taken out and inserted into a case to prepare a product.

Table 5 shows the results of using each lipstick sample twice a day (morning and evening) for three consecutive months on 20 test subjects (females aged 20 to 40) with rough lips.

Table 5 The vitamin E γ-linolenic acid ester used in Examples 1 to 8 is DL-α-tocopherol orotate, but other α-tocopherols (D-α
- Tocopherol, L-α-tocopherol), β-tocopherol, δ-tocopherol, etc.
-Linolenic acid esters also have excellent effects.

Claims (1)

[Claims] A cosmetic for preventing skin aging, characterized by containing vitamin E-γ-linolenic acid ester.