JPS62226910A - Skin cosmetic - Google Patents
Skin cosmeticInfo
- Publication number
- JPS62226910A JPS62226910A JP6951986A JP6951986A JPS62226910A JP S62226910 A JPS62226910 A JP S62226910A JP 6951986 A JP6951986 A JP 6951986A JP 6951986 A JP6951986 A JP 6951986A JP S62226910 A JPS62226910 A JP S62226910A
- Authority
- JP
- Japan
- Prior art keywords
- skin
- cosmetic
- ascorbic acid
- alkyl
- effects
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002537 cosmetic Substances 0.000 title claims abstract description 28
- 229960005070 ascorbic acid Drugs 0.000 claims abstract description 15
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Natural products OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 14
- 235000000069 L-ascorbic acid Nutrition 0.000 claims abstract description 13
- 239000002211 L-ascorbic acid Substances 0.000 claims abstract description 12
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 3
- 239000000126 substance Substances 0.000 claims description 3
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 14
- 206010040880 Skin irritation Diseases 0.000 abstract description 4
- 230000009759 skin aging Effects 0.000 abstract description 4
- 230000036556 skin irritation Effects 0.000 abstract description 4
- 231100000475 skin irritation Toxicity 0.000 abstract description 4
- 230000007774 longterm Effects 0.000 abstract description 3
- 239000006210 lotion Substances 0.000 abstract description 3
- 230000003405 preventing effect Effects 0.000 abstract description 3
- 239000006071 cream Substances 0.000 abstract description 2
- 239000002552 dosage form Substances 0.000 abstract description 2
- 239000000843 powder Substances 0.000 abstract description 2
- 230000010757 Reduction Activity Effects 0.000 abstract 1
- 206010040849 Skin fissures Diseases 0.000 abstract 1
- 238000002156 mixing Methods 0.000 abstract 1
- 238000004321 preservation Methods 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 35
- 238000012360 testing method Methods 0.000 description 14
- 230000002087 whitening effect Effects 0.000 description 8
- 239000000203 mixture Substances 0.000 description 6
- 235000019645 odor Nutrition 0.000 description 5
- 230000003712 anti-aging effect Effects 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 238000002845 discoloration Methods 0.000 description 4
- 210000000434 stratum corneum Anatomy 0.000 description 4
- 230000007306 turnover Effects 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 3
- 239000011668 ascorbic acid Substances 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 150000000996 L-ascorbic acids Chemical class 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 210000000245 forearm Anatomy 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000001953 sensory effect Effects 0.000 description 2
- 239000002884 skin cream Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 230000037303 wrinkles Effects 0.000 description 2
- OIRQROBVKNWIIW-RBBKRZOGSA-N (2r)-2-[(1s)-1,2-dihydroxyethyl]-3-hydroxy-4-octadecoxy-2h-furan-5-one Chemical compound CCCCCCCCCCCCCCCCCCOC1=C(O)[C@@H]([C@@H](O)CO)OC1=O OIRQROBVKNWIIW-RBBKRZOGSA-N 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- 206010042496 Sunburn Diseases 0.000 description 1
- 102000003425 Tyrosinase Human genes 0.000 description 1
- 108060008724 Tyrosinase Proteins 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 238000010531 catalytic reduction reaction Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000004299 exfoliation Methods 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 239000000542 fatty acid esters of ascorbic acid Substances 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000008099 melanin synthesis Effects 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Furan Compounds (AREA)
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】
(産業上の利用分野)
本発明は、後記特定のアスコルビン酸誘導体を含有する
皮膚化粧料に関し、更に詳しくは、人体に好ましくない
副作用や皮膚刺激を有さず、長期保存しても安定で、し
かも優れた肌荒れ防止効果、皮膚の老化防止効果および
優れた美白効果を同時に発現、付与し得る皮膚化粧料に
関する。Detailed Description of the Invention (Industrial Application Field) The present invention relates to a skin cosmetic containing a specific ascorbic acid derivative described below, and more specifically, it has no undesirable side effects or skin irritation on the human body, and has a long-term use. The present invention relates to a skin cosmetic that is stable even when stored and can simultaneously exhibit and impart excellent skin roughness prevention effects, skin aging prevention effects, and excellent skin whitening effects.
(従来の技術)
老化した皮膚は柔軟性、弾力性を失い、皮膚のシワが増
大し、乾燥して滑らかさのない荒れ肌で、角質細胞剥離
現象が認められる。(Prior Art) Aging skin loses its flexibility and elasticity, wrinkles increase, and the skin becomes dry and rough without smoothness, and a phenomenon of exfoliation of keratin cells is observed.
最近、皮膚老化防止に関する化粧料が僅かに提案されて
いるが、十分な効果を有するものが見あたらない。Recently, a few cosmetics have been proposed for preventing skin aging, but none have been found to have sufficient effects.
一方、日焼けした肌を健常な肌色に回復するには、増加
形成しているメラニン色素の淡色漂白やメラニン生成過
程でのチロシナーゼ活性の阻害等が必要であるとされて
いる。On the other hand, in order to restore sunburned skin to a healthy complexion, it is said that it is necessary to lighten the increasing amount of melanin pigment formed and inhibit tyrosinase activity during the melanin production process.
これらの原理を応用した美白化粧料の活性物質として、
いくつかのアスコルビン酸誘導体が研究され、アスコル
ビン酸の8−モノ直鎮脂肪酸エステル、2,6−ジ直鎮
脂肪酸エステル等が提案されている(特公昭45−16
891号、特公昭46−28684号)。しかしながら
、化粧料に応用した場合、経口安定性に問題があったり
、変色、変臭の原因となったり、また優れた美白効果が
得られないという欠点がある。As an active substance for whitening cosmetics that apply these principles,
Several ascorbic acid derivatives have been researched, and 8-mono-di-butyrate fatty acid esters and 2,6-di-di-diylene fatty acid esters of ascorbic acid have been proposed (Japanese Patent Publication No. 45-16
No. 891, Special Publication No. 46-28684). However, when applied to cosmetics, there are drawbacks such as problems with oral stability, causing discoloration and odor, and failure to obtain excellent whitening effects.
このように、皮膚老化防止効果と美白効果を発現、付与
し得る優れた皮膚化粧料は未だ見られない。As described above, an excellent skin cosmetic that can exhibit and provide skin anti-aging effects and whitening effects has not yet been found.
(発明が解決しようとする問題点)
本発明の目的は、長期保存しても安定で、変色、変臭、
活性低下等を起こすことなく、使用時には皮膚刺激なく
良好な感触を与えながら身体を美化し、魅力を増し、皮
膚をすこやかに保ち、皮膚老化防止効果と美白効果とを
同時に発現、付与し得る優れた皮膚化粧料を提供するこ
とにある。(Problems to be Solved by the Invention) The object of the present invention is to be stable even when stored for a long period of time, and to prevent discoloration and odor.
An excellent product that can beautify the body, increase attractiveness, keep the skin healthy, and simultaneously express and impart skin anti-aging effects and whitening effects while giving a good feel without causing skin irritation, without causing a decrease in activity, etc. The purpose of the present invention is to provide skin cosmetics with improved skin care.
(問題点を解決するための手段)
上述の目的は、
(式中、Rは炭素数10〜22のアルキル基)で表ワさ
れる2−0−アルキルL−アスコルビン酸の少なくとも
一つを含有することを特徴とする皮膚化粧料によって達
成される。(Means for solving the problem) The above-mentioned object contains at least one of 2-0-alkyl L-ascorbic acids represented by (wherein R is an alkyl group having 10 to 22 carbon atoms) This is achieved by a skin cosmetic product characterized by the following.
本発明に使用する2−0−アルキルト−アスコルビン酸
は公知の物質であって、例えば8−o−メトキシメチル
−2−0−アルキルアスコルビン酸を加水分解反応させ
る事により、更にまた、8−〇−ベンジルー2−0−ア
ルキルアスコルビン酸を接触還元反応させる・ことによ
って得られる。The 2-0-alkyl-ascorbic acid used in the present invention is a known substance. - Obtained by subjecting benzy-2-0-alkyl ascorbic acid to a catalytic reduction reaction.
前記一般式で表わされる2−0−アルキルト−アスコル
ビン酸としては、例えば2−0−デシルL−アスコルビ
ン酸、2−o−ウンデシルL−7スコルビン+*、2−
o−ドデシルL−アスコルビン酸、2−0−)リゾシル
L−アスコルビン酸。Examples of the 2-0-alkyl-ascorbic acid represented by the above general formula include 2-0-decyl L-ascorbic acid, 2-o-undecyl L-7scorbin+*, and 2-0-decyl L-ascorbic acid.
o-dodecyl L-ascorbic acid, 2-0-)lysosyl L-ascorbic acid.
2−0−テトラデシルL−アスコルビン酸、2−0−ペ
ンタデシルL−アスコルビン酸、2−0−ヘキサデシル
L−アスコルビン酸、2−0−ヘプタデシルL−アスコ
ルビン酸、2−o−オクタデシルL−アスコルビンi、
2−0−ノナデシルL一アスコルビンl、2−0−エイ
コシルL−アスコルビン9.2−0−ヘネイコシルL−
アスコルビンM、2−0−トコシルL−7スコルビン酸
等が挙げられる。2-0-tetradecyl L-ascorbic acid, 2-0-pentadecyl L-ascorbic acid, 2-0-hexadecyl L-ascorbic acid, 2-0-heptadecyl L-ascorbic acid, 2-o-octadecyl L-ascorbic acid,
2-0-nonadecyl L-ascorbin 1, 2-0-eicosyl L-ascorbin 9.2-0-heneicosyl L-
Examples include ascorbic M, 2-0-tocosyl L-7 scorbic acid, and the like.
本発明において、前記の2−0−アルキルト−アスコル
ビン酸は、各々単独でもしくはその2つ以上の混合物と
して皮膚化粧料基剤に配合される。In the present invention, the above-mentioned 2-0-alkyl-ascorbic acids are blended into the skin cosmetic base either singly or as a mixture of two or more thereof.
その配合量は、皮膚化粧料の形H(種類)によって異な
るけれども、総括的な配合量は、当該化粧料の処方成分
全量を基準として(以下同様)、通常0.05〜10重
量優、好ましくは0゜5〜8重星チの範囲内である。The amount to be blended varies depending on the form H (type) of the skin cosmetic, but the overall amount to be blended is usually 0.05 to 10% by weight, preferably 0.05 to 10% by weight, based on the total amount of prescription ingredients of the cosmetic. is within the range of 0°5 to 8 double star Chi.
本発明の皮膚化粧料の剤型は、特に限定されるものでな
く、クリーム状、乳液状、ローシ1ン状。The dosage form of the skin cosmetic of the present invention is not particularly limited, and may be cream, emulsion, or lotion.
パウダー状等々の通常の化粧料の剤型を適用することが
できる。Usual cosmetic formulations such as powder form can be applied.
本発明の化粧料は、他の成分として、乳化剤。The cosmetic of the present invention includes an emulsifier as another component.
油性物質、保湿剤、香料、防腐剤9着色料、皮膚栄養剤
などを本発明の目的を達成する範囲内で適宜配合し得る
。Oily substances, humectants, perfumes, preservatives, coloring agents, skin nutrients, and the like may be incorporated as appropriate within the scope of achieving the object of the present invention.
(発明の効果)
本発明の皮膚化粧料は、長期保存しても安定で、変色、
変臭、活性低下等を起こすことなく、使用時には皮膚刺
激なく良好な感触を与えながら身体を美化し、魅力を増
し、皮膚をすこやかに保ち、皮膚老化防止効果と美白効
果とを同時に発現、付与し得る。(Effects of the invention) The skin cosmetics of the present invention are stable even after long-term storage, and do not cause discoloration.
It does not cause odor or decrease in activity, and when used, gives a good feel without irritating the skin while beautifying the body, increasing attractiveness, keeping the skin healthy, and simultaneously exhibiting and imparting skin anti-aging effects and whitening effects. It is possible.
(作 用)
本発明における2−0−アルキルL−アスコルビン酸は
、特に化粧料の系中での安定性が高く、また化粧料基材
との相溶性、乳化性1人体に対する安全性が高く、良好
であるので、皮膚化粧料の処方設計が容易となり、そし
て経口安定性が良好で、皮膚刺激なくフィーリングの良
い良好な感触を与える化粧料を提供することができる。(Function) The 2-0-alkyl L-ascorbic acid of the present invention has particularly high stability in a cosmetic system, and also has high compatibility with cosmetic base materials, emulsifying properties, and safety for the human body. , it is possible to easily design a formulation for a skin cosmetic, and it is possible to provide a cosmetic that has good oral stability and provides a good feeling without irritating the skin.
以下、実施例について説明する。Examples will be described below.
なお、実施例に示す優とは重11%を意味する。In addition, "excellent" shown in Examples means a weight of 11%.
実施例に記載の角質層のターンオーバー速度測定方法、
官能効果のパネルテスト、美白効果のパネルテスト、皮
膚)1: 回復試験法は下記の通りである。Method for measuring turnover rate of stratum corneum described in Examples,
Sensory effect panel test, whitening effect panel test, skin) 1: Recovery test method is as follows.
(1)角質層のターンオーバー速度測定方法蛍光色素の
ダンジルクロライドを白色ワセリン中に5重量チ配合し
た軟膏を作り、被検者の前腕部の皮膚に24時間閉塞貼
布し、角質層にダンジルクロライドを浸透結合させる。(1) Method for measuring the turnover rate of the stratum corneum An ointment containing 5 parts by weight of the fluorescent dye danzyl chloride in white petrolatum was prepared and applied to the skin of the subject's forearm for 24 hours, and the ointment was applied to the skin of the forearm of the subject. Osmotic binding of danzyl chloride.
その後同じ部位に1日2回(朝・夕)被検試料を塗布し
、毎日ダンジルクロライドの蛍光をしらべ、その蛍光が
消滅するまでの日数を皮膚角質層のターンオーバー速度
とした。なお、通常の皮膚角質層のターンオーバー速度
は14〜16日であるが、老化した皮膚においては18
日前後にのびる。それに対して老化防止効果が現われる
と12日前後にまで短縮される。今回は被検者5名によ
り行ない、平均値を算出した。Thereafter, the test sample was applied to the same area twice a day (morning and evening), and the fluorescence of danzyl chloride was examined every day.The number of days until the fluorescence disappeared was defined as the turnover rate of the skin stratum corneum. Note that the turnover rate of the normal skin stratum corneum is 14 to 16 days, but in aged skin it is 18 days.
It grows around the day. On the other hand, once the anti-aging effect appears, the time is shortened to around 12 days. This time, the test was conducted on 5 subjects, and the average value was calculated.
(2)官能効果のパネルテスト
20名の中年(80〜50才)女子パネラ−の顔面に試
料を1日2回、2ケ月間連続塗布し、パネラ一本人が試
験開始前および終了後の皮膚の状態を、「しわ伸ばし効
果」、「はりに対する効果」、1きめに対する効果」に
つきそれぞれ評価した。(2) Sensory effect panel test: Samples were applied to the faces of 20 middle-aged (80-50 years old) female panelists twice a day for 2 months, and each panelist tested the test before and after the test. The skin condition was evaluated for "wrinkle smoothing effect,""effect on firmness," and "effect on first texture."
(3)美白効果のパネルテスト
日焼けに悩む被検者(女子)20名のパネラ−に試料を
毎日朝・ター回2ケ月塗布し、「有効」、「ややイl°
効」または「無効」のいずれかをパネラ一本人が判定し
た。(3) Panel test of skin whitening effect Samples were applied to a panel of 20 test subjects (female) suffering from sunburn, once every morning and evening for two months.
Panera himself judged either "effective" or "ineffective."
(4)皮膚色明度回復試験
被試験者20名の背部皮膚にUV−B領域の紫外線を最
小紅斑量の2倍量照射し、1週間の後、その照射部に試
料塗布部位と非塗布部位とを設定して各々の皮膚の基準
明度(Vo値、vo′値)を測定した。引続いて塗布部
位には試料を1日1回ずつ8ケ月間連続塗布し、18週
間後の塗布部位及び非塗布部位の皮膚の明度(Vn・・
・値、vn′・・・値)を測定して、第1表の判定基準
により、皮膚色の回復評価を実施した。(4) Skin color brightness recovery test The back skin of 20 test subjects was irradiated with ultraviolet rays in the UV-B region at twice the minimum amount of erythema, and after one week, the irradiated areas were covered with sample application areas and unapplied areas. The reference brightness (Vo value, vo' value) of each skin was measured. Subsequently, the sample was continuously applied to the application site once a day for 8 months, and the skin brightness (Vn...
・value, vn'... value) was measured, and skin color recovery evaluation was performed according to the criteria shown in Table 1.
尚、皮膚の明度(V値)は高速分光色彩d[で測定して
得られたマンセル値より算出した。また、評価は被試験
者20名の18週間後の評価点の平均値で示した。In addition, the brightness of the skin (V value) was calculated from the Munsell value obtained by measurement with a high-speed spectral colorimeter d[. Moreover, the evaluation was shown as the average value of the evaluation scores of 20 test subjects after 18 weeks.
第1表
(5)保存安定性試験(40°C,6ケ月後の化粧料の
安定性)
化粧料の試料を40°Cの恒温室に6ケ月間保存した後
の外観変化(分離、着色の有無等)、変臭の有無等を専
門検査員8人によってしらべた。Table 1 (5) Storage stability test (stability of cosmetics after 6 months at 40°C) Appearance changes (separation, discoloration, etc.) after storing cosmetic samples in a constant temperature room at 40°C for 6 months Eight specialized inspectors examined the presence or absence of odor, etc.) and the presence or absence of strange odors.
実施例1〜6、比較例1〜4
〔スキンクリーム〕
下記の組成に於いて絹2,8表に示すとうりに7スコル
ビン酸の誘導体を変えて、実施例、比較例であるスキン
クリームを調製して諸試験を実施した。その結果を第2
.8表に示した。Examples 1 to 6, Comparative Examples 1 to 4 [Skin Cream] Skin creams as Examples and Comparative Examples were prepared by changing the derivative of 7-scorbic acid in the following composition as shown in Tables 2 and 8. We prepared and conducted various tests. The second result is
.. It is shown in Table 8.
組 成
実施例6〜9、比較例5
〔二層型ローシdン〕
実施例1と同様に、下記の組成に於いて抽々の実施例、
比較例の二層型ローシMンを調製して諸試験を実施した
。その結果を第4表に示した。Composition Examples 6 to 9, Comparative Example 5 [Two-layered low-density] Similar to Example 1, the following compositions were used as examples,
A comparative example of two-layer ROSHI M was prepared and various tests were carried out. The results are shown in Table 4.
組 成Assembling
Claims (1)
の少なくとも一つを含有することを特徴とする皮膚化粧
料。(1) Contains at least one of 2-O-alkyl L-ascorbic acid represented by the following general formula ▲ Numerical formula, chemical formula, table, etc. ▼ (wherein R is an alkyl group having 10 to 22 carbon atoms) A skin cosmetic product characterized by:
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP61069519A JPH07112966B2 (en) | 1986-03-26 | 1986-03-26 | Skin cosmetics |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP61069519A JPH07112966B2 (en) | 1986-03-26 | 1986-03-26 | Skin cosmetics |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS62226910A true JPS62226910A (en) | 1987-10-05 |
JPH07112966B2 JPH07112966B2 (en) | 1995-12-06 |
Family
ID=13405050
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP61069519A Expired - Fee Related JPH07112966B2 (en) | 1986-03-26 | 1986-03-26 | Skin cosmetics |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPH07112966B2 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008094774A (en) * | 2006-10-13 | 2008-04-24 | Nikko Chemical Co Ltd | Nitrogen monoxide production promoter and use thereof |
WO2008090717A1 (en) * | 2007-01-26 | 2008-07-31 | Shiseido Company, Ltd. | Adam inhibitor |
JP2013541960A (en) * | 2010-10-29 | 2013-11-21 | 株式會社アモーレパシフィック | Kit for searching for skin active substance containing Klotho gene and method for searching for skin active substance using the same |
WO2015190505A1 (en) * | 2014-06-10 | 2015-12-17 | 味の素株式会社 | Cosmetic composition containing 3-o-alkyl-l-ascorbic acid or salt thereof |
JP2019064990A (en) * | 2017-10-05 | 2019-04-25 | ピアス株式会社 | RhoGDIβ INHIBITOR AND COSMETIC |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61236772A (en) * | 1983-12-19 | 1986-10-22 | Takeda Chem Ind Ltd | Antioxidant for food, ascorbic acid derivative and production thereof |
-
1986
- 1986-03-26 JP JP61069519A patent/JPH07112966B2/en not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61236772A (en) * | 1983-12-19 | 1986-10-22 | Takeda Chem Ind Ltd | Antioxidant for food, ascorbic acid derivative and production thereof |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008094774A (en) * | 2006-10-13 | 2008-04-24 | Nikko Chemical Co Ltd | Nitrogen monoxide production promoter and use thereof |
WO2008090717A1 (en) * | 2007-01-26 | 2008-07-31 | Shiseido Company, Ltd. | Adam inhibitor |
JP2008184387A (en) * | 2007-01-26 | 2008-08-14 | Shiseido Co Ltd | Adam inhibitor |
JP2013541960A (en) * | 2010-10-29 | 2013-11-21 | 株式會社アモーレパシフィック | Kit for searching for skin active substance containing Klotho gene and method for searching for skin active substance using the same |
WO2015190505A1 (en) * | 2014-06-10 | 2015-12-17 | 味の素株式会社 | Cosmetic composition containing 3-o-alkyl-l-ascorbic acid or salt thereof |
US10322078B2 (en) | 2014-06-10 | 2019-06-18 | Ajinomoto Co., Inc. | Cosmetic composition containing 3-O-alkyl-L-ascorbic acid or salt thereof |
JP2019064990A (en) * | 2017-10-05 | 2019-04-25 | ピアス株式会社 | RhoGDIβ INHIBITOR AND COSMETIC |
Also Published As
Publication number | Publication date |
---|---|
JPH07112966B2 (en) | 1995-12-06 |
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