JP2977750B2 - Anti-aging skin cosmetics - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a novel skin cosmetic containing γ-fatty acid amidobutyric acids. More specifically, a skin aging prevention effect (rough skin improvement effect, containing γ-fatty acid amide butyric acid, which is an acid amide compound formed by acid amide bond of γ-aminobutyric acid and fatty acid,
Skin cosmetics with excellent exfoliating effect, effect of increasing turnover speed, beautiful skin effect, etc.).

[0002]

2. Description of the Related Art Aged skin is dry and rough skin without keratinocyte exfoliation.
It is said that the aging skin has a slow turnover speed, and the turnover speed increases when the skin has an anti-aging effect. On the other hand, γ-aminobutyric acid is
It is abundant in the brain of animals and plays an important role in brain metabolism. That is, it is known that a GABA bypass is formed in the TCA cycle, and functions as an energy source instead of the TCA cycle when an abnormality occurs in the TCA cycle. Therefore, γ-aminobutyric acid is administered for the purpose of improving sequelae of cerebrovascular disorders, and is known to be effective for cerebral insufficiency. It is also known that the skin function is enhanced by the peripheral vasodilatory action of the skin, and the skin has an antiaging effect (Japanese Patent Publication No. 58-26726).

[0003]

Certainly, .gamma.-aminobutyric acid and its ester derivatives have an excellent skin activating effect, but they are water-soluble components, so there is still room for improvement from the viewpoint of transdermal absorption. It was the fact that was left.

In view of such circumstances, the inventor of the present invention has excellent skin aging prevention effects (rough skin improvement effect, keratin improvement effect,
As a result of intensive studies on a method for more effectively expressing the effect of increasing the speed of turnover, the beautiful skin effect, etc., the objective was to convert gamma-aminobutyric acid into a fatty acid amide to make it oil-soluble or almost oil-soluble. Have been achieved, and the present invention has been completed.

[0005]

That is, in order to achieve the above-mentioned object, the skin aging prevention cosmetic composition of the present invention is selected from the group of γ-fatty acid amide butyric acids in which the fatty acid has 6 to 24 carbon atoms. It is characterized by incorporating at least one compound.

[0006]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The configuration of the present invention will be described below in detail. The fatty acid component of the γ-fatty acid amidobutyric acid used in the present invention is a fatty acid having 6 to 24 carbon atoms. If the number of carbon atoms is less than 6, the oil solubility is poor and the skin aging prevention effect is small. Since the effect of preventing skin aging is reduced when the amount exceeds the above, it is necessary to appropriately select from fatty acids having 6 to 24 carbon atoms. For example, caproic acid, enanthic acid, caprylic acid, 2-ethylhexanoic acid, nonanoic acid, isononanoic acid , Capric acid, isodecanoic acid, dimethyloctanoic acid (neodecanoic acid), undecanoic acid, lauric acid, myristic acid, palmitic acid, isopalmitic acid, 2-heptyldecanoic acid, stearic acid, isostearic acid, oleic acid, linoleic acid, linolenic Straight- or branched-chain saturated or unsaturated fatty acids such as acid, arachidic acid, arachidonic acid and behenic acid. .

Preferably, lauric acid, myristic acid,
Palmitic acid, linear saturated fatty acids of stearic acid, oleic acid, linoleic acid, linear unsaturated fatty acids of linolenic acid, 2-ethylhexanoic acid, isodecanoic acid, isopalmitic acid, 2-heptyldecanoic acid, isostearic acid Γ-fatty acid amide butyric acid containing a branched saturated fatty acid as a fatty acid component, specifically γ-lauric amide butyric acid, γ
-Myristic amide butyric acid, γ-palmitic amide butyric acid, γ-stearic amide butyric acid, γ-oleic amide butyric acid, γ-linoleic amide butyric acid, γ-linoleic amide butyric acid, γ-2-ethylhexanoic amide butyric acid , Γ
-Isodecanoic amide butyric acid, γ-isopalmitic amide butyric acid, γ-2-heptyl decanoic amide butyric acid, and γ-isostearic amide butyric acid are preferred for more effectively exhibiting the effect of preventing skin aging. More preferably, acid amide compounds with unsaturated or branched chain fatty acids, such as γ-oleic amide butyric acid, γ-linoleic amide butyric acid, γ-linoleic amide butyric acid, γ-2-ethylhexanoic acid amide Butyric acid, γ-isodecanoic acid amidobutyric acid, γ-
Isopalmitic acid amidobutyric acid, γ-2-heptyldecanoic acid amidobutyric acid, and γ-isostearic acid amidobutyric acid are oil-soluble and soluble in water / alcohol, and are therefore more preferable because they have the advantage of easily producing various cosmetics.

As described above, the skin aging preventive cosmetic of the present invention comprises one selected from the group of γ-fatty acid amidobutyric acids, and acts on the skin to form a peripheral blood vessel of the skin. Enhance skin function, enhance skin function, prevent skin wrinkles, make the skin finer and more firm (skin effect), and have excellent skin aging prevention effect (rough skin improvement effect, keratin improvement) Effect and effect of increasing the turnover speed) in a short period of time, and persists.

The amount of γ-fatty acid amidobutyric acid is 0.05 to 14.0% by weight (hereinafter abbreviated as%) based on the total amount of the ingredients of the anti-aging skin cosmetics in view of the effect. Yes, more preferably 0.2 to 2.0%.

The cosmetic for preventing skin aging of the present invention includes, in addition to the above-mentioned raw materials, higher alcohol fatty acid esters, lanolin and its derivatives, hydrocarbons such as liquid paraffin and squalane, silicones, acrylic resins and cellulose resins. High molecular compounds, tar pigments, coloring pigments such as iron oxide, preservatives such as parabens, fatty acid soaps, anionic surfactants such as sodium cetyl sulfate, polyoxyethylene alkyl ethers, polyoxyethylene fatty acid esters, poly Nonionic surfactants such as oxyethylene polyhydric alcohol fatty acid ester, polyoxyethylene hydrogenated castor oil, polyhydric alcohol fatty acid ester, polyglycerin fatty acid ester, cationic surfactant such as tetraalkylammonium salt, betaine type, sulfobetaine Type, sulfo Amino acid type, N- stearoyl -L-
Amphoteric surfactants such as sodium glutamate, natural surfactants such as lecithin and lysophosphatidylcholine, pigments such as titanium oxide, humectants such as hyaluronic acid and chondroitin sulfate, and antioxidants such as vitamin-E Agents and the like can be appropriately compounded within a range that achieves the object of the present invention.

Examples of the dosage form of the skin aging preventive cosmetic of the present invention include creams, emulsions, lotions, packs and the like. This skin aging prevention cosmetic is, for example, in the case of an emulsion or the like,
It can be produced by a usual method of emulsifying and dispersing an oil phase and an aqueous phase, each of which is heated and dissolved, and cooling.

[0012]

The present invention will be described below in detail based on examples and comparative examples. In addition, the method of measuring the turnover speed of the stratum corneum described in the examples is a test method for measuring the effect of improving rough skin, and a test method for measuring the effect of improving stratum corneum.

Method for measuring the turnover rate of the stratum corneum 5% of a fluorescent dye, dansyl chloride, was added to white petrolatum.
% Ointment is prepared, and occlusively applied to the skin of the forearm of the subject for 24 hours to allow dansyl chloride to penetrate into the stratum corneum. Thereafter, the test sample was applied to the same site twice a day (morning and evening), and the fluorescence of dansyl chloride was examined every day. In addition, the turnover speed of the normal skin stratum corneum is 14 to 16 days, but it extends around 18 days in aged skin. On the other hand, when the anti-aging effect appears, it is reduced to around 12 days.

Measurement Test Method for Improving Rough Skin Effect The effect of continuous application for four weeks was examined on 20 middle-aged and elderly subjects having rough skin on the lower leg. About 1 g of the sample was applied to the test site of the left leg of the subject twice a day, and the skin condition before and after the test was judged according to the following criteria. The lower leg on the right side was used as a sample without application. [Skin dryness criteria]-: Normal ±: Slightly dry, no desquamation +: Dry, desquamation mild ++: Moderate, desquamation +++: Dried, desquamation remarkable Comparison of test results before and after test with control site If the degree of dryness of the skin is improved by two or more steps (for example, + →-,
++ → ±) was regarded as “valid”, the case where the signal was improved by one step was “slightly valid”, and the case where there was no change was “invalid”. The test results were indicated by the number of subjects who became “effective” and “slightly effective”.

[0015] Test method for measuring the effect of improving keratin (enhancing the exfoliative properties of keratinocytes) Scotch tape (Nichiban Mending tape) is applied to the skin of the test area before and after the above-mentioned test for measuring rough skin improvement.
Was peeled off and the state of the keratinous cells attached to the tape was examined in detail by a scanning electron microscope. The exfoliation properties of the keratinous layer of the skin were classified according to the following criteria, and the keratin-improving effect was determined. [Judgment criteria for keratin improvement (enhancement of exfoliative properties of keratinocytes)] Evaluation point 1: No scale was recognized Evaluation point 2: Small scale scattered Evaluation point 3: Small to medium scale remarkable Evaluation point 4: Large scale remarkable judgment Is “valid” when the difference between the evaluation point of the test site and that of the control site after continuous application for 4 weeks is 2 or more, “slightly effective” when 1 point, and “invalid” when 0 point . The test results were indicated by the number of subjects who became “effective” and “slightly effective”.

Sensory test (bare skin effect test) Female subjects complaining of rough skin, fine wrinkles, dry skin, etc.
A sample was applied twice a day (morning and evening) to 20 persons (55 years old) for 3 consecutive months, and the effect after 1, 2, and 3 months was evaluated. In the test results, for each item of skin wettability, smoothness, and elasticity, the respondents answered that "the skin was moistened", "the skin became smooth", and "the skin became taut" Indicated by the number of people.

Examples 1 to 13 and Comparative Examples 1 to 5 [Skin cream] γ-fatty acid amide butyric acid and the like were blended as shown in Table 2,
Each skin cream was prepared with the composition shown in Table 1 below, and the above-described tests were performed. In the examples, γ-caproamidobutyric acid was GABA-C2, γ-caprimidoamidobutyric acid was GABA-C3, and γ-lauric amidebutyric acid was GAB-C2.
AL, γ-myristate amidobutyric acid is GABA-M,
γ-palmitic amide butyric acid is GABA-P, γ-stearic amide butyric acid is GABA-S2, γ-oleic amide butyric acid is GABA-O, γ-linoleic amide butyric acid is GABA-L2, γ-linolenic amide butyric acid Is GAB
A-L3 and γ-behenamide butyric acid are GABA-B, γ
-2-ethylhexanoic acid amide butyric acid is GABA-EH,
The γ-aminobutyric acid compounded in the comparative example is GABA, γ-aminobutyric acid.
Acetamide amide butyrate is abbreviated as GABA-A, and γ-serotin amide butyrate is abbreviated as GABA-S3. (1) Composition

[0018]

[Table 1]

(2) Preparation Method The components (A) and (B) were each heated and dissolved at 80 ° C., mixed, and cooled to 30 ° C. with stirring to prepare each skin cream.

(3) Characteristics Table 2 shows the results of various tests performed on each skin cream.

[0021]

[Table 2]

[0022]

As described above, the present invention is a useful skin aging preventive cosmetic which can exhibit skin aging prevention effects (rough skin improvement effect, keratin improvement effect, effect of increasing turnover speed, beautiful skin effect, etc.) in a short period of time. It is clear that the fee is provided.

 ──────────────────────────────────────────────────続 き Continuation of the front page (56) References JP-A-51-148041 (JP, A) JP-A-60-184005 (JP, A) JP-A-63-150209 (JP, A) JP-A 62-184 138411 (JP, A) JP-A-62-87506 (JP, A) JP-A-5-117137 (JP, A) JP-A-6-145038 (JP, A) JP-A-7-242530 (JP, A)

Claims (1)

(57) [Claims] An anti-aging skin cosmetic comprising at least one member selected from the group consisting of γ-fatty acid amide butyric acid having 6 to 24 carbon atoms of a fatty acid.