JP3441166B2 - Anti-aging skin cosmetics - Google Patents

Description

Description: BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin aging preventive cosmetic (a cosmetic used for preventing skin aging). More specifically, skin aging prevention effect (rough skin improvement effect, keratin improvement effect, effect of increasing turnover speed, beautiful skin effect, etc.)
The present invention relates to a skin cosmetic which is excellent in operability and further excellent in usability. BACKGROUND OF THE INVENTION [0002] Aging skin is skin that is dry and has no smoothness, and in which keratinocyte exfoliation is observed. And aging skin,
It is said that the turnover speed is low when the skin has an anti-aging effect, and the turnover speed is high. The present applicant has previously found that diisopropylamine dichloroacetate enhances skin function by activating skin tissue and has an antiaging effect, and has proposed the same (Japanese Patent Publication No. Sho 62-18523). [0003] However, skin cosmetics comprising diisopropylamine dichloroacetate alone are not satisfactory enough that the effects of preventing aging and the like are delayed, and the effects appear only after long-term continuous use. In fact, there was room for improvement. [0004] In view of such circumstances, the present inventor has proposed an excellent skin aging prevention effect (rough skin improvement effect, keratin improvement effect, effect of increasing turnover speed, effect of beautiful skin, etc.). ) Was developed in a very short time of 1 to 2 months after the start of use, and as a result of diligent research, it was determined that there was no rapid-acting skin aging preventive cosmetic that was persistent. As a result, diisopropylamine dichloroacetate was added to glycyrrhizic acid. Glycyrrhetinic acid and derivatives thereof and a compound having at least two or more hydroxyl groups have been found to achieve this object by a synergistic effect, thereby completing the present invention. Namely, diisopropylamine dichloroacetate, glycyrrhizic acid, and at least one selected from glycyrrhetinic acid and derivatives thereof, and ethylene glycol, a compound having at least two hydroxyl groups selected from di glycerin or Ranaru group And a skin anti-aging cosmetic. [0006] Glycyrrhizic acid, glycyrrhetinic acid and derivatives thereof are known substances and only have an anti-inflammatory effect. Like diisopropylamine dichloroacetate, glycyrrhizic acid, glycyrrhizic acid and glycyrrhetinic acid are known to enhance skin functions and have an antiaging effect. Had not been found. Furthermore, compounds having at least two or more hydroxyl groups are also known substances and are usually used as humectants. However, like diisopropylamine dichloroacetate, they enhance skin functions and have an antiaging effect. Had not been found. However, the inventor of the present invention has found that the combination of the above-mentioned substances acts synergistically on the skin, enhances the skin function by activating the skin tissue, prevents wrinkles on the skin, and improves the texture of the skin. In addition to making fine and moist skin (beautifying skin effect), it also has excellent skin aging prevention effect (rough skin improving effect, keratin improving effect, effect of increasing turnover speed) in a short period of time, and more. It has been found that it exhibits remarkable effects such as excellent usability. Hereinafter, the configuration of the present invention will be described in detail. The glycyrrhizic acid and derivatives thereof used in the present invention are known compounds, such as 18α-glycyrrhizic acid (abbreviated as α-Gi), 18β-glycyrrhizic acid (abbreviated as β-Gi), and salts thereof, 18α. Trisodium glycyrrhizinate (abbreviated as α-Gi-Na3), 18α-monopotassium glycyrrhizinate (α
-Gi-K), dipotassium 18α-glycyrrhizinate (abbreviated as α-Gi-K2), monoammonium 18α-glycyrrhizinate (abbreviated as α-Gi-NH3), trisodium 18β-glycyrrhizinate (β -Gi-Na3), 18 monopotassium β-glycyrrhizinate (abbreviated as β-Gi-K), 18
β-glycyrrhizic acid dipotassium (abbreviated as β-Gi-K2), and 18α-glycyrrhizic acid methyl ester (α-
Gimethyl), 18β-glycyrrhizic acid methyl ester (abbreviated as β-Gimethyl) and the like can be particularly preferred, but are not limited thereto. Glycyrrhetinic acid and its derivatives used in the present invention are known compounds, and include α-glycyrrhetinic acid (abbreviated as α-Ge), β-glycyrrhetinic acid (abbreviated as β-Ge), and glycyrrhetinic acid derivatives. As the salt, disodium 3-succinyloxyglycyrrhetinate (abbreviated as 3-succinyl-Ge-Na2)
And the like can be mentioned as particularly preferable, but the present invention is not limited to these. Further, esters of glycyrrhetinic acid derivatives include stearyl α-glycyrrhetinate (abbreviated as α-Ge-stearyl), β
-Stearyl glycyrrhetinate (abbreviated as β-Ge-stearyl), pyridoxine α-glycyrrhetinate (α
-Ge-pyridoxine), β-glycyrrhetinic acid pyridoxine (abbreviated as β-Ge-pyridoxine), α-glycyrrhetinic acid glycerin (abbreviated as α-Ge-glycerin), β-glycyrrhetinic acid (β-Ge) -Abbreviated as glycerin) and the like, but are not limited thereto. Furthermore, compounds having two or more hydroxyl groups used in the present invention are known compounds, ethylene glycol, di-glycerin. The compounding amount of diisopropylamine dichloroacetate is 0.0
The content is preferably 1 to 50% by weight (hereinafter abbreviated as wt%), and more preferably 0.05 to 10% by weight. The amount of glycyrrhizic acid, glycyrrhetinic acid and their derivatives is 0.005 to 2% by weight based on the total amount of the cosmetic ingredients. The compounding amount of the compound having at least two or more hydroxyl groups is 0.1% based on the total amount of the components of the cosmetic.
1 to 50 wt%. The cosmetic of the present invention includes, in addition to the above-mentioned raw materials, tar pigments, coloring pigments such as iron oxide, preservatives such as paraben, anionic surfactants such as fatty acid soap and sodium cetyl sulfate, and polyoxyethylene. Nonionic surfactants such as alkyl ethers, polyoxyethylene fatty acid esters, polyoxyethylene polyhydric alcohol fatty acid esters, polyoxyethylene hydrogenated castor oil, polyhydric alcohol fatty acid esters, and polyglycerin fatty acid esters; Ionic surfactants, amphoteric surfactants such as betaine type, sulfobetaine type, sulfoamino acid type, sodium N-stearoyl-L-glutamate, natural surfactants such as lecithin and lysophosphatidylcholine, titanium oxide and the like Pigment, dibutyl hydroxy And antioxidants such as toluene, may be appropriately blended within the range to achieve the object of the present invention. Examples of the dosage form of the cosmetic of the present invention include creams, milky lotions, jellyy milky lotions, lotions, packs and the like. The present invention will be described below in detail based on examples and comparative examples. The methods for measuring the turnover speed of the stratum corneum, the method for measuring the effect of improving the rough skin, the method for measuring the effect of improving the stratum corneum, and the sensory test described in the examples are as follows. Method for measuring the turnover speed of the stratum corneum 5% of dansyl chloride, a fluorescent dye, was added to white petrolatum.
% Ointment was prepared, and the ointment was occlusively applied to the skin of the forearm of the subject for 24 hours, and dansyl chloride was penetrated into the stratum corneum. Thereafter, a test sample was applied to the same site twice a day (morning and evening), the fluorescence of dansyl chloride was examined every day, and the number of days until the fluorescence disappeared was defined as the turnover speed of the stratum corneum of the skin. Measurement Test Method for Improvement Effect of Rough Skin The effect of continuous application for four weeks was examined on 20 middle-aged and elderly subjects having rough skin on the lower leg. About 1 g of the sample was applied to the test site of the left leg of the subject twice a day, and the skin condition before and after the start of the test was determined according to the criteria shown in Table 1. The lower leg on the right side was used as a target without applying the sample. [Table 1] The test results before and after the test are compared with those of the control site. The skin dryness is improved by two or more stages (for example, + →-, ++ → ±). Is "Slightly valid", and the case where there is no change is "Invalid". The test results were indicated by the number of subjects who became “effective” and “slightly effective”. Measuring test method for keratin improvement (enhancement of exfoliative properties of keratinocytes) Scotch tape (Nichiban Mending tape) is applied to the skin of the test part before and after the above-mentioned measurement test for measuring rough skin improvement.
Was adhered to the tape, and when the tape was peeled off, the state of the keratinous cells attached to the tape was examined in detail by a scanning electron microscope. [Table 2] The judgment was "valid" when the difference between the evaluation point of the test site and that of the control site after continuous application for 4 weeks was 2 or more, "valid" when it was 1 point, and "valid" when it was 0 point. Invalid ". The test results were indicated by the number of subjects who became “effective” and “slightly effective”. Sensory test (Beauty skin effect test) and feeling of use Female subjects complaining of rough skin, fine wrinkles, dry skin, etc.
A sample was applied twice a day (morning and evening) to 20 persons (55 years old) for 3 consecutive months, and the effect after 1, 2, and 3 months was evaluated. The test results showed that the skin was moistened, the skin became smooth, and the skin became taut for each item of skin wettability, smoothness, elasticity, and feeling of use. , "The growth is good" Examples 1-4, Comparative Examples 1-13 [Skin cream] Diisopropylamine dichloroacetate, glycyrrhizic acid, glycyrrhetinic acid and derivatives thereof,
Compounds having at least two or more hydroxyl groups are shown in Tables 4 and 5
And a skin cream was prepared with the composition shown in Table 3 below, and the above-described experiments were performed. In the table, diisopropylamine dichloroacetate is abbreviated as DADA. (1) Composition [Table 3] (2) Preparation Method The components (A) and (B) were each heated and dissolved at 80 ° C., mixed, and cooled to 30 ° C. with stirring to prepare each skin cream. (3) Characteristics The results of various tests conducted on each skin cream are shown in Tables 4 to 6. As shown in Tables 4 to 6, skin creams containing glycyrrhizic acid, glycyrrhetinic acid and derivatives of Comparative Examples 1 to 13, diisopropylamine dichloroacetate, or a compound having at least two or more hydroxyl groups, alone or in combination of two kinds are available. Sufficient effects cannot be obtained in the properties, and glycyrrhizic acid, glycyrrhetinic acid and derivatives of Examples 1 to 4 of the present invention and diisopropylamine dichloroacetate, a skin cream in which a compound having at least two or more hydroxyl groups is blended, have various properties. A remarkable effect was observed, and in the sensory test, an excellent skin effect was exhibited within one to two months after application of the sample, and the feeling in use was also excellent. [Table 4] [Table 5] [Table 6] Examples 5 to 8 [Skin Lotion] Skin lotions were prepared according to the compositions shown in Table 7, and various tests were carried out. (1) Composition [Table 7] (2) Preparation method After the components (A) and (B) were each dissolved uniformly, the components (A) and (B) were mixed, stirred and dispersed, and then filled in a container. At the time of use, the contents were uniformly shaken and used. (3) Characteristics Examples 5 to 8 all showed good results in the above-mentioned tests. The cosmetic composition for preventing skin aging according to the present invention has excellent skin aging preventing effects (rough skin improving effect, keratin improving effect, fast turnover speed effect, beautiful skin effect, etc.) Also excellent.

Claims (1)

(57) and Patent Claims 1 diisopropylamine dichloroacetate, glycyrrhizic acid, and at least one selected from glycyrrhetinic acid and derivatives thereof, ethylene glycol, at least selected from di glycerin or Ranaru group A cosmetic composition for preventing skin aging, comprising a compound having two or more hydroxyl groups.