JPH07291848A - Skin aging-preventing cosmetic - Google Patents

Abstract

PURPOSE:To prepare the skin aging-preventing cosmetic containing at least one kind selected from a bovine bone marrow extract, vitamin E or its ester, and diisopropylamine dichloroacetate. CONSTITUTION:This skin aging-preventing agent contains at least one kind selected from 0.001-10wt.% (based on the whole amount of the cosmetic) of a bovine bone marrow extract, 0.005-2wt.% of vitamin E or its ester compound, and 0.1-2wt.% of diisopropylamine dichloroacetate. The ingredients synergistically act on the skin to dilate skin peripheral blood vessels, stimulate skin functions, prevent skin wrinkles, and form a strong and fine skin. Simultaneously, an excellent rough skin-improving effect, a keratin-improving effect, and a turnover rate-increasing effect can be manifested in a short time and are maintained. The cosmetic can be prepared into a cream, an emulsion, a beauty wash, a pack, etc.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin aging-preventing cosmetic (a cosmetic used to prevent skin aging). More specifically, skin aging prevention effect (rough skin improvement effect, keratin improvement effect, effect of accelerating turnover speed, skin beauty effect, etc.)
Relating to excellent skin anti-aging cosmetics.

[0002]

2. Description of the Related Art Aged skin is dry skin that is not smooth and has keratinocyte exfoliation phenomenon. And aging skin
It is said that the turnover speed is slow, and when the antiaging effect is imparted to the skin, the turnover speed is increased.

The present inventors have previously found that the bone marrow extract of cattle enhances the water-retaining function originally possessed by the skin to maintain or restore the skin in a healthy state, thereby making the skin wettable and soft. To impart elasticity, elasticity and luster and find an excellent skin-beautifying effect. Especially, when applied to aged skin, the effect is remarkably observed. 63-66108).

Further, since vitamin E and its ester compound have a vasodilatory effect, they are used for the treatment of frostbite, exudative antierythema, frostburn, etc., and like the bone marrow extract of cattle, they promote skin function and aging. It is expected to have a preventive effect.

On the other hand, diisopropylamine dichloroacetate is a known substance, and it has been proposed (Japanese Patent Publication No. 62-18523) to enhance the skin function by activating the skin tissue and have the effect of preventing skin aging.

[0006] However, the skin cosmetics containing the skin activating agent, which is a component for enhancing these skin functions, alone are
In both cases, the effects such as aging prevention are delayed, and it takes time for the effects to appear, so they are not sufficiently satisfactory,
The reality is that there is room for improvement.

In view of such circumstances, the present inventors have an excellent effect of preventing skin aging (effect of improving rough skin, effect of improving keratin, effect of accelerating turnover speed, effect of beautiful skin, etc.).
However, as a result of extensive research into whether there is a rapid-acting skin anti-aging cosmetic that appears for a very short period of time, which is the first month after the start of use, as a result, bovine bone marrow extract and vitamin E have been obtained.
The present invention has been completed by finding that this object can be achieved by a synergistic effect by blending the compound and its ester compound, and at least one selected from the group of diisopropylamine dichloroacetate.

[0008]

That is, the present invention is characterized in that at least one selected from the group of vitamin E and its ester compound, diisopropylamine dichloroacetate, and bovine bone marrow extract are blended. An anti-aging cosmetic is provided.

The structure of the present invention will be described in detail below. In order to achieve the above-mentioned object, the skin anti-aging cosmetic composition of the present invention contains at least one selected from the group consisting of vitamin E and its ester compound, diisopropylamine dichloroacetate, and bovine bone marrow extract. It is a feature.

Vitamin E and its ester compound used in the present invention are known substances such as vitamin E, vitamin E acetate, vitamin E nicotinate,
Vitamin E succinate, vitamin E linoleate, vitamin E orotate and the like can be mentioned. What is Vitamin E?
-Tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, etc., or a mixture thereof. Any of these vitamin E and its ester compound can be applied to the anti-aging cosmetic composition of the present invention, and they are each incorporated alone or as a mixture of two or more thereof in the anti-aging cosmetic composition.

Further, since the vitamin E and its ester compound used in the present invention have an antioxidant effect, it is expected that the deterioration of bovine bone marrow extract and other components is suppressed.

The amount of vitamin E and its ester compound to be blended is 0.005 based on the total amount of the prescription components of the cosmetic as a result of studying the range in which the object of the present invention can be achieved.
It is 2.0% by weight.

The diisopropylamine dichloroacetate used in the present invention is described in detail in the above publication. Hereinafter, diisopropylamine dichloroacetate is abbreviated as DADA.

As a result of studying the range in which the object of the present invention can be achieved, the content of DADA is 0.1 to 2.0% by weight based on the total amount of the prescription components of the cosmetic.

The extraction method of bovine bone marrow extract applied to the present invention is as follows. That is, the crushed cow spine,
To 100 kg of hip bone and femur, 500 liter of acetone was added, stirred for 1 hour, and then filtered. To this residue, 100 liters of methanol and 200 liters of chloroform were added, stirred for 4 hours and then filtered. To the residue was added 200 liters of a chloroform-methanol mixture, the temperature was kept at 50 ° C., the mixture was extracted for 2 hours, then filtered and combined with each of the above extracts. The extract was evaporated to dryness with a rotary evaporator to obtain 8.6 kg of bovine bone marrow extract. However, the analysis results are as follows. : Lipid: 87.8% Protein: 3.6% Ash: 0.3% Carbohydrate: 0.4% Moisture: 7.9% Total nitrogen: 0.6%

The amount of bovine bone marrow extract blended was 0.001 to 1 in terms of dry residue, based on the total amount of the prescription components of the cosmetic, as a result of studying the range in which the object of the present invention can be achieved.
It is 0.0% by weight.

As described above, the skin anti-aging cosmetic composition of the present invention is characterized by blending bovine bone marrow extract with at least one selected from the group consisting of vitamin E, its ester compound and DADA. So, these act synergistically on the skin, expand peripheral blood vessels of the skin, enhance skin function, prevent wrinkles of the skin, and make the skin fine and firm (( (Beautiful skin effect)
It exerts outstanding effects of preventing skin aging (rough skin improving effect, keratin improving effect, effect of accelerating turnover speed) in a short period of time and lastingly.

In the cosmetics of the present invention, in addition to the above-mentioned raw materials, tar pigments, coloring pigments such as iron oxide, preservatives such as parabens, fatty acid soaps, anionic surfactants such as sodium cetylsulfate, polyoxyethylene. Nonionic surfactants such as alkyl ethers, polyoxyethylene fatty acid esters, polyoxyethylene polyhydric alcohol fatty acid esters, polyoxyethylene hydrogenated castor oil, polyhydric alcohol fatty acid esters, polyglycerin fatty acid esters, tetraalkylammonium salts, etc. Ionic surfactants, betaine-type, sulfobetaine-type, sulfoamino acid-type, amphoteric surfactants such as sodium N-stearoyl-L-glutamate, natural surfactants such as lecithin and lysophosphatidylcholine, and titanium oxide Pigment, dibutyl hydroxy And antioxidants such as toluene, may be appropriately blended within the range to achieve the object of the present invention.

The dosage form of the cosmetic of the present invention includes creams, emulsions, lotions, packs and the like.

[0020]

The present invention will be described in detail below with reference to examples and comparative examples, but the present invention is not limited to these. The test method used in the present invention is as follows.

Method for measuring turnover rate of stratum corneum An ointment was prepared by mixing 5% by weight of fluorescent dye dansyl chloride in white petrolatum, and applied occlusion on the skin of the forearm of a subject for 24 hours, and the horny layer was penetrated with dansyl chloride. Combined. Thereafter, the test sample was applied to the same site twice a day (morning and evening), and the fluorescence of dansyl chloride was examined every day. The number of days until the fluorescence disappeared was defined as the turnover rate of the stratum corneum of the skin.

Measurement Test Method for Rough Skin Improvement Effect The effect of continuous application for 4 weeks was investigated for 20 middle-aged and elderly subjects who have rough skin on their lower legs. About 1 g of the sample was applied to the test site of the left leg of the test subject twice a day, and the condition of the skin before and after the start of the test was evaluated according to the following criteria. The right lower leg was used as a target without applying the sample. Criteria for skin dryness −: Normal ±: Minor dryness, no desquamation +: Dry, mild desquamation ++: Dry, moderate desquamation +++: Dryness, remarkable desquamation Compare the determination results of the test site before and after the test and the control site, When the skin dryness is improved by two or more stages (for example, + →-,
++ → ±) is defined as “valid”, a case of improvement by 1 level is defined as “slightly valid”, and a case of no change is defined as “invalid”. The test results are shown by the number of subjects who were “effective” and “somewhat effective”.

Test method for measuring the effect of improving keratin (increasing the anti-peeling property of keratinocytes) Scotch tape (Nichiban Mending Tape) on the skin of the test area before and after the start of the rough skin improvement measurement test described above
The state of keratinocytes adhering to the tape was peeled off and the state of the keratinocytes adhered to the tape was examined in detail by a scanning electron microscope. Criteria for improving keratin (increasing anti-peeling properties of keratinocytes) Evaluation point 1: No scale is recognized Evaluation point 2: Small scale interspersed evaluation point 3: Small to medium scale outstanding Evaluation point 4: Large scale outstanding When the difference between the evaluation points of the test site after weekly continuous application and that of the control site was 2 points or more, "effective" was given, 1 point was "somewhat effective", and 0 point was "ineffective". The test results are shown by the number of subjects who were “effective” and “somewhat effective”.

Sensory test (bare skin effect test) Female subjects who complain of rough skin, fine wrinkles, dry skin (35-35)
The sample was applied to 20 people (55 years old) twice a day (morning and evening) for 3 consecutive months, and the effect after 1, 2 and 3 months was evaluated. The test results replied that "the skin was moisturized", "the skin was smooth", and "the skin was tense" with respect to each item of the skin wettability, smoothness, and elasticity. The number of people is shown.

Examples 1 to 4, Comparative Examples 1 to 4 [Skin cream] Bovine bone marrow extract, vitamin E and its ester compound were blended as shown in Tables 2 and 3, and each skin was prepared with the composition shown in Table 1. Creams were prepared and the above experiments were carried out. Vitamin E is VE, Vitamin E acetate is VE-
A, vitamin E nicotinate is abbreviated as VE-N. (1) Composition

[0026]

[Table 1]

(2) Preparation Method Each of the components (A) and (B) was heated and dissolved at 80 ° C., then mixed and cooled to 30 ° C. with stirring to prepare each skin cream.

(3) Characteristics Tables 2 to 4 show the results of various tests conducted on each skin cream.

[0029]

[Table 2]

[0030]

[Table 3]

[0031]

[Table 4]

As shown in Tables 2 to 4, the skin creams of Comparative Examples 1 to 4 in which the bovine bone marrow extract, vitamin E and the ester compound thereof were blended alone did not show sufficient effects in various characteristics, and thus the skin creams of the present invention were obtained. The skin creams of Examples 1 to 4 in which the bovine bone marrow extract and at least one selected from the group of vitamin E and its ester compound were mixed showed remarkable effects in various properties. It showed an excellent skin-beautifying effect for a month.

Examples 5 and 6 [Skin lotion] Each skin lotion having the following composition was prepared and various tests were carried out. (1) Composition

[0034]

[Table 5]

(2) Preparation Method After the components (A) and (B) were uniformly dissolved, the component (A) and the component (B) were mixed and dispersed by stirring, and then filled in a container. At the time of use, the content was uniformly dispersed by shaking before use.

(3) Characteristics Examples 5 and 6 all showed good results in the above tests.

Examples 7 to 10 and Comparative Examples 5 to 7 [Skin cream] Bovine bone marrow extract and DADA were blended as shown in Tables 7 and 8 to prepare each skin cream with the composition shown in Table 6, The above experiments were carried out. (1) Composition

[0038]

[Table 6]

(2) Preparation Method Each of the components (A) and (B) was heated and dissolved at 80 ° C., then mixed and cooled to 30 ° C. with stirring to prepare each skin cream.

(3) Properties The results of various tests of each skin cream are shown in Tables 7-9.

[0041]

[Table 7]

[0042]

[Table 8]

[0043]

[Table 9]

As shown in Tables 7-9, the skin creams of Comparative Examples 5-7 in which the bovine bone marrow extract and DADA were blended alone did not show sufficient effects in various properties, and the skin creams of Examples 7-10 of the present invention were obtained. The skin cream containing the bovine bone marrow extract and DADA showed remarkable effects on various properties, and a sensory test showed excellent skin-beautifying effect 1-2 months after application of the sample.

Examples 11 and 12 [Skin lotion] Each skin lotion having the following composition was prepared and various tests were carried out. (1) Composition

[0046]

[Table 10]

(2) Preparation method After the components (A) and (B) were uniformly dissolved, the components (A) and (B) were mixed and stirred to be dispersed, and then filled in a container. At the time of use, the content was uniformly dispersed by shaking before use.

(3) Characteristics Examples 11 and 12 all showed good results in the above-mentioned tests.

[0049]

Industrial Applicability As described above, the present invention provides a useful skin anti-aging cosmetic having excellent anti-aging effects (rough skin improving effect, keratin improving effect, turnover speed increasing effect, beautiful skin effect, etc.). It is clear to provide.

Claims (1)

[Claims] 1. Vitamin E and its ester compound,
A skin anti-aging cosmetic composition comprising at least one selected from the group of diisopropylamine dichloroacetate and bovine bone marrow extract.