JPH07118140A - Cosmetic for preventing aging of skin - Google Patents

Abstract

PURPOSE:To obtain a cosmetic for preventing aging of skin having excellent preventing effect on aging of skin (improving effect on chapped skin, improving effect on keratin, increasing effect on rate of turnover, beatifying effect on skin, etc.). CONSTITUTION:This cosmetic for preventing aging of skin is obtained by blending at least one selected from a group consisting of gamma-amino-beta-hydroxybutyric acid and its salt with at least one selected from glycyrrhizic acid, glycyrrhetinic acid and their derivatives and is obtained by mixing at least one selected from gamma-amino-beta-hydroxybutyric acid and its salt with an extract of bovine placenta.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin aging-preventing cosmetic (a cosmetic used to prevent skin aging). More specifically, skin aging prevention effect (rough skin improvement effect, keratin improvement effect, effect of accelerating turnover speed, effect of beautiful skin, etc.)
Regarding excellent skin cosmetics.

[0002]

2. Description of the Related Art Aged skin is dry and non-smooth rough skin in which keratinocyte exfoliation phenomenon is observed. And aging skin
It is said that the turnover speed is slow, and when the antiaging effect is imparted to the skin, the turnover speed is increased. The present applicant has previously found that γ-amino-β-hydroxybutyric acid and salts thereof enhance skin function by peripheral vasodilatory action of skin, and have an antiaging effect,
Proposed (Japanese Patent Publication No. 1-13685).

[0003] However, the skin cosmetics containing γ-amino-β-hydroxybutyric acid and its salt alone have a slow effect of preventing aging. For example, in the case of creams, the lotion is applied after 6 months of continuous use. In some cases, the effect appears after 8 months of continuous use, which is not completely satisfactory, and there is room for improvement.

[0004]

In view of such circumstances, the present inventor has an excellent effect of preventing skin aging (rough skin improving effect, keratin improving effect, effect of increasing turnover speed, beautiful skin effect, etc.), As a result of intensive research into whether or not there is a rapid-acting skin anti-aging cosmetic that develops in a very short period of 1 to 2 months after the start of use and lasts, γ-amino-β-hydroxybutyric acid and its salts At least one selected from the group of, glycyrrhizic acid, by blending glycyrrhetinic acid and derivatives thereof, or at least one selected from the group of γ-amino-β-hydroxybutyric acid and salts thereof, bovine placenta extract. The present invention has been completed by finding that this object can be achieved by compounding.

Glycyrrhizic acid, glycyrrhetinic acid and their derivatives are known substances and only have an anti-inflammatory action, and like the γ-amino-β-hydroxybutyric acid and its salts, enhance the skin function, It has not been found to have an anti-aging effect.

Furthermore, bovine placenta extract is a known substance, and its skin activating action and skin whitening action are recognized.
Similar to -amino-β-hydroxybutyric acid and its salts, bovine placenta extract alone was not fully satisfactory.

However, the present inventor synergistically acts on the skin by the combination of the aforementioned substances, expands peripheral blood vessels of the skin, enhances the skin function, prevents wrinkles of the skin, and Fine texture and smooth and moisturized skin (beautiful skin effect), as well as excellent skin aging prevention effects (rough skin improvement effect, keratin improvement effect, effect of accelerating turnover speed) are maintained and maintained in a short time It has been found that such a remarkable effect is exhibited.

According to claim 1 of the present invention, at least one selected from the group of γ-amino-β-hydroxybutyric acid and salts thereof and at least one selected from glycyrrhizic acid, glycyrrhetinic acid and their derivatives. A skin aging prevention cosmetic characterized by:

The second aspect of the present invention provides γ-amino-
A skin anti-aging cosmetic composition comprising at least one selected from the group of β-hydroxybutyric acid and salts thereof and a bovine placenta extract.

The structure of the present invention will be described in detail below.

Γ-Amino-β-hydroxybutyric acid and salts thereof applicable to the present invention are known compounds and are described in detail in the above publication. Examples of the salt of γ-amino-β-hydroxybutyric acid include potassium salt of γ-amino-β-hydroxybutyric acid and sodium salt thereof, which are neutralized with potassium hydroxide, sodium hydroxide, calcium hydroxide or magnesium hydroxide. , The same calcium salt and the same magnesium salt are applied.

Glycyrrhizic acid and its derivatives used in the present invention are known compounds such as 18α-glycyrrhizinic acid (abbreviated as α-Gi), 18β-glycyrrhizinic acid (abbreviated as β-Gi) and salts thereof, 18α. -Trisodium glycyrrhizinate (abbreviated as α-Gi-Na3), 18α-monopotassium glycyrrhizinate (α
-Gi-K), 18α-glycyrrhizinate dipotassium (abbreviated as α-Gi-K2), 18α-monoammonium glycyrrhizinate (abbreviated as α-Gi-NH3), 18β-trisodium glycyrrhizinate (β). -Gi-Na3), 18 β-glycyrrhizinate monopotassium (abbreviated as β-Gi-K), 18
β-Glycyrrhizic acid dipotassium (abbreviated as β-Gi-K2) and 18α-glycyrrhizinic acid methyl ester (α-G) which are esters of glycyrrhizinic acid derivatives.
i-methyl), 18β-glycyrrhizinic acid methyl ester (abbreviated as β-Gi-methyl), and the like can be mentioned as particularly preferable ones, but not limited thereto.

Glycyrrhetinic acid and its derivatives used in the present invention are known compounds, and α-glycyrrhetinic acid (abbreviated as α-Ge) and β-glycyrrhetinic acid (β
-Ge)), as the salt of the glycyrrhetinic acid derivative, 3-succinyloxyglycyrrhetinic acid disodium (abbreviated as 3-succinyl-Ge-Na2) and the like can be mentioned as particularly preferred, but are not limited thereto. It is not something that will be done. Furthermore, as esters of glycyrrhetinic acid derivatives, α-glycyrrhetinic acid stearyl (abbreviated as α-Ge-stearyl), β-glycyrrhetinic acid stearyl (abbreviated as β-Ge-stearyl), α-glycyrrhetinic acid pyridoxine (α) -G
abbreviated as e-pyridoxine), β-glycyrrhetinic acid pyridoxine (abbreviated as β-Ge-pyridoxine),
Glycerin α-glycyrrhetinate (abbreviated as α-Ge-glycerin), β-glycyrrhetinate glycerin (β
-Ge-glycerin) and the like can be mentioned as particularly preferable ones, but the present invention is not limited thereto.

The bovine placenta extract used in the present invention is a known substance, and fresh bovine placenta from 3 to 4 months of gestation is frozen and thawed, and the fat-soluble components are repeatedly removed at low temperature after cutting into small pieces. , Obtained by extracting the water-soluble component. Examples of the bovine placenta extract include water-soluble placenta extract and the like.

The blending amount of γ-amino-β-hydroxybutyric acid and its salt is 0.
01 to 2.0 wt% (hereinafter abbreviated as wt%).

The amount of glycyrrhizic acid, glycyrrhetinic acid and their derivatives to be blended is 0.005 to 2.0 wt% based on the total amount of the prescription components of the cosmetic.

The amount of the cow placenta extract blended is 0.1 to 3.0 wt% based on the total amount of the prescription ingredients of the cosmetic.

In the cosmetics of the present invention, in addition to the above raw materials, tar dyes, coloring pigments such as iron oxide, preservatives such as parabens, fatty acid soaps, anionic surfactants such as sodium cetylsulfate, polyoxyethylene, etc. Nonionic surfactants such as alkyl ethers, polyoxyethylene fatty acid esters, polyoxyethylene polyhydric alcohol fatty acid esters, polyoxyethylene hydrogenated castor oil, polyhydric alcohol fatty acid esters, polyglycerin fatty acid esters, tetraalkylammonium salts, etc. Ionic surfactants, betaine type, sulfobetaine type, sulfoamino acid type, amphoteric surfactants such as sodium N-stearoyl-L-glutamate, natural surfactants such as lecithin and lysophosphatidylcholine, and titanium oxide Pigment, dibutyl hydroxy And antioxidants such as toluene, may be appropriately blended within the range to achieve the object of the present invention.

The dosage form of the cosmetic of the present invention includes creams, emulsions, lotions, packs and the like.

[0020]

EXAMPLES The present invention will be described in detail below based on examples and comparative examples. The methods for measuring the turnover speed of the stratum corneum, the measurement test method for improving rough skin, the measurement test method for improving stratum corneum, and the sensory test described in Examples are as follows.

Method for measuring turnover rate of stratum corneum 5 wt% of dansyl chloride, a fluorescent dye, in white petrolatum
% Ointment was prepared and occluded and applied to the skin of the forearm of the subject for 24 hours, and dansyl chloride was osmotically bonded to the stratum corneum. After that, the test sample was applied to the same site twice a day (morning and evening), the fluorescence of dansyl chloride was examined every day, and the number of days until the fluorescence disappeared was defined as the turnover rate of the stratum corneum of the skin.

Measurement Test Method for Rough Skin Improvement Effect The effect of continuous application for 4 weeks was investigated for 20 middle-aged and elderly subjects who have rough skin on their lower legs. About 1 g of the sample was applied to the left leg test site of the test subject twice a day, and the skin condition before the start of the test and after the test was judged according to the criteria shown in Table 1. The right lower leg was used as a target without applying the sample.

[0023]

[Table 1]

When the skin dryness is improved by two or more stages (for example, + →-, ++ → ±) by comparing the determination results of the test site before and after the test with the control site, it is "effective" and when it is improved by one stage. Is "slightly valid", and when there is no change, it is "invalid". The test results are shown by the number of subjects who were “effective” and “somewhat effective”.

Test method for measuring effect of improving keratin (increasing anti-peeling property of keratinocytes) Scotch tape (Nichiban Mending Tape) is applied to the skin of the test area before and after the start of the rough skin improvement measurement test described above.
Was adhered and the state of keratinocytes adhered to the tape when peeled off was examined in detail by a scanning electron microscope, and the keratin layer cell exfoliation property was classified according to the criteria in Table 2 to obtain a keratin improving effect.

[0026]

[Table 2]

The judgment is "effective" when the difference between the evaluation point of the test site and that of the control site after continuous application for 4 weeks is 2 points or more, "effective", 1 point "slightly effective", 0 point " Invalid ". The test results are shown by the number of subjects who were “effective” and “somewhat effective”.

Sensory test (bare skin effect test) Female subjects who complain of rough skin, fine wrinkles, dry skin (35-35)
The sample was applied to 20 persons (55 years old) twice a day (morning and evening) for 3 consecutive months, and the effect after 1, 2 and 3 months was evaluated. The test results replied that "the skin was moisturized", "the skin was smooth", and "the skin was tense" with respect to each item of the skin wettability, smoothness, and elasticity. The number of people is shown.

Examples 1 to 4 and Comparative Examples 1 to 9 [Skin cream] γ-amino-β-hydroxybutyric acid and its salts, glycyrrhizic acid, glycyrrhetinic acid and their derivatives are shown in Tables 4 and 5. The skin cream having the composition shown in Table 3 below was prepared, and the above-mentioned various experiments were carried out. Note that γ
-Amino-β-hydroxybutyric acid is GABOB, γ-aminobutyric acid-β-hydroxybutyric acid salt is potassium salt GABOB-K, sodium salt GABOB-N,
The calcium salt is abbreviated as GABOB-C.

(1) Composition

[0031]

[Table 3]

(2) Preparation Method Each of the components (A) and (B) was heated and dissolved at 80 ° C., then mixed and cooled to 30 ° C. with stirring to prepare each skin cream.

(3) Characteristics Tables 4 to 6 show the results of various tests performed on each skin cream. As shown in Tables 4 to 6, the skin creams of Comparative Examples 1 to 9 in which only glycyrrhizinic acid, glycyrrhetinic acid and derivatives, or γ-amino-β-hydroxybutyric acid and its salt alone are blended are not sufficiently effective in various properties. At least one selected from the group consisting of glycyrrhizic acid, glycyrrhetinic acid and derivatives of Examples 1 to 4 of the present invention and γ-amino-β-hydroxybutyric acid and salts thereof, which was not obtained.
The skin cream containing the seeds showed remarkable effects in various properties, and a sensory test showed an excellent skin-beautifying effect 1-2 months after application of the sample.

[0034]

[Table 4]

[0035]

[Table 5]

[0036]

[Table 6]

Examples 5 to 8 [Skin lotion] Skin lotions having the compositions shown in Table 7 were prepared and various tests were carried out. In addition, a magnesium salt is abbreviated as GABOB-M as a salt of γ-aminobutyric acid-β-hydroxybutyric acid.

(1) Composition

[0039]

[Table 7]

(2) Preparation Method After the components (A) and (B) were uniformly dissolved, the components (A) and (B) were mixed and dispersed by stirring, and then filled in a container. At the time of use, the content was uniformly dispersed by shaking before use.

(3) Characteristics Examples 5 to 8 all showed good results in the above tests.

Examples 9 to 15 and Comparative Examples 10 to 15 [skin cream] γ-amino-β-hydroxybutyric acid and its salt and bovine placenta extract were blended as shown in Tables 9 and 10, and Table 8
A skin cream was prepared with the above composition and the above-mentioned experiments were carried out. The placenta extract is abbreviated as placenta extract.

(1) Composition

[0044]

[Table 8]

(2) Preparation Method Each of the components (A) and (B) was heated and dissolved at 80 ° C., then mixed and cooled to 30 ° C. with stirring to prepare each skin cream.

(3) Properties Tables 9 to 11 show the results of various tests performed on each skin cream.
Described in. As shown in Tables 9 to 11, Comparative Examples 10 to 1
The placenta extract of No. 5 or the skin cream containing only γ-amino-β-hydroxybutyric acid and its salt alone does not show sufficient effects in various properties, and the bovine placenta extracts of Examples 9 to 15 of the present invention are not obtained. And at least 1 selected from the group of γ-amino-β-hydroxybutyric acid and salts thereof.
The skin cream containing the seeds showed remarkable effects in various properties, and a sensory test showed an excellent skin-beautifying effect 1-2 months after application of the sample.

[0047]

[Table 9]

[0048]

[Table 10]

[0049]

[Table 11]

Examples 16 to 18 [Skin lotion] Skin lotions having the compositions shown in Table 12 were prepared and various tests were carried out. The magnesium salt as a salt of γ-aminobutyric acid-β-hydroxybutyric acid is abbreviated as GABOB-M.

(1) Composition

[0052]

[Table 12]

(2) Preparation Method After the components (A) and (B) were uniformly dissolved, the component (A) and the component (B) were mixed and dispersed by stirring, and then filled in a container. At the time of use, the content was uniformly dispersed by shaking before use.

(3) Characteristics Examples 17 to 19 all showed good results in the above tests.

[0055]

Industrial Applicability As described above, the present invention provides a useful skin anti-aging cosmetic having excellent anti-aging effects (rough skin improving effect, keratin improving effect, turnover speed increasing effect, beautiful skin effect, etc.). It is clear to provide.

Claims (2)

[Claims] 1. Skin aging, characterized by blending at least one selected from the group of γ-amino-β-hydroxybutyric acid and salts thereof and at least one selected from glycyrrhizinic acid, glycyrrhetinic acid and their derivatives. Preventive cosmetics. 2. A skin anti-aging cosmetic composition comprising at least one selected from the group of γ-amino-β-hydroxybutyric acid and salts thereof and a bovine placenta extract.