JPH07118140A - Cosmetic for preventing aging of skin - Google Patents

Cosmetic for preventing aging of skin

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Publication number
JPH07118140A
JPH07118140A JP28567693A JP28567693A JPH07118140A JP H07118140 A JPH07118140 A JP H07118140A JP 28567693 A JP28567693 A JP 28567693A JP 28567693 A JP28567693 A JP 28567693A JP H07118140 A JPH07118140 A JP H07118140A
Authority
JP
Japan
Prior art keywords
skin
acid
effect
amino
cosmetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP28567693A
Other languages
Japanese (ja)
Inventor
Kyotaro Hasunuma
喬太郎 蓮沼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanebo Ltd
Original Assignee
Kanebo Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanebo Ltd filed Critical Kanebo Ltd
Priority to JP28567693A priority Critical patent/JPH07118140A/en
Publication of JPH07118140A publication Critical patent/JPH07118140A/en
Pending legal-status Critical Current

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Abstract

PURPOSE:To obtain a cosmetic for preventing aging of skin having excellent preventing effect on aging of skin (improving effect on chapped skin, improving effect on keratin, increasing effect on rate of turnover, beatifying effect on skin, etc.). CONSTITUTION:This cosmetic for preventing aging of skin is obtained by blending at least one selected from a group consisting of gamma-amino-beta-hydroxybutyric acid and its salt with at least one selected from glycyrrhizic acid, glycyrrhetinic acid and their derivatives and is obtained by mixing at least one selected from gamma-amino-beta-hydroxybutyric acid and its salt with an extract of bovine placenta.

Description

【発明の詳細な説明】Detailed Description of the Invention

【0001】[0001]

【産業上の利用分野】本発明は皮膚老化防止化粧料(皮
膚の老化防止に用いる化粧料)に関する。更に詳しく
は、皮膚老化防止効果(荒れ肌改善効果、角質改善効
果、ターンオーバー速度を早くする効果、美肌効果等)
の優れた皮膚化粧料に関する。
BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin aging-preventing cosmetic (a cosmetic used to prevent skin aging). More specifically, skin aging prevention effect (rough skin improvement effect, keratin improvement effect, effect of accelerating turnover speed, effect of beautiful skin, etc.)
Regarding excellent skin cosmetics.

【0002】[0002]

【従来の技術および発明が解決しようとする課題】老化
皮膚とは、乾燥して滑らかさのない荒れ肌で、角質細胞
剥離現象が認められる皮膚である。そして老化皮膚は、
ターンオーバー速度が遅く、また皮膚に老化防止効果が
付与発現するとターンオーバー速度が早くなると言われ
ている。本出願人は、先に、γ−アミノ−β−ヒドロキ
シ酪酸及びその塩が、皮膚の末梢血管拡張作用により皮
膚機能を亢進し、老化防止効果を有することを見出し、
提案した(特公平1−13685号公報)。
2. Description of the Related Art Aged skin is dry and non-smooth rough skin in which keratinocyte exfoliation phenomenon is observed. And aging skin
It is said that the turnover speed is slow, and when the antiaging effect is imparted to the skin, the turnover speed is increased. The present applicant has previously found that γ-amino-β-hydroxybutyric acid and salts thereof enhance skin function by peripheral vasodilatory action of skin, and have an antiaging effect,
Proposed (Japanese Patent Publication No. 1-13685).

【0003】しかし、γ−アミノ−β−ヒドロキシ酪酸
及びその塩を単独で配合してなる皮膚化粧料は、老化防
止等の効果は遅効性で、例えばクリームの場合では連用
6ケ月後に、ローションの場合は連用8か月後に効果が
現れるというように、充分満足し得るものではなく、改
良の余地を残しているのが実情であった。
[0003] However, the skin cosmetics containing γ-amino-β-hydroxybutyric acid and its salt alone have a slow effect of preventing aging. For example, in the case of creams, the lotion is applied after 6 months of continuous use. In some cases, the effect appears after 8 months of continuous use, which is not completely satisfactory, and there is room for improvement.

【0004】[0004]

【課題を解決するための手段】本発明者は、このような
実情に鑑み、優れた皮膚老化防止効果(荒れ肌改善効
果、角質改善効果、ターンオーバー速度を早くする効
果、美肌効果等)が、使用開始後1〜2ケ月目という極
く短時間に発現し、かつ持続する速効性の皮膚老化防止
化粧料がないものかと鋭意研究を重ねた結果、γ−アミ
ノ−β−ヒドロキシ酪酸及びその塩の群から選ばれる少
なくとも一種に、グリチルリチン酸、グリチルレチン酸
及びそれらの誘導体を配合することによって、あるいは
γ−アミノ−β−ヒドロキシ酪酸及びその塩の群から選
ばれる少なくとも一種に、牛胎盤抽出物を配合すること
によって、この目的が達成されることを見出して本発明
を完成するに至った。
In view of such circumstances, the present inventor has an excellent effect of preventing skin aging (rough skin improving effect, keratin improving effect, effect of increasing turnover speed, beautiful skin effect, etc.), As a result of intensive research into whether or not there is a rapid-acting skin anti-aging cosmetic that develops in a very short period of 1 to 2 months after the start of use and lasts, γ-amino-β-hydroxybutyric acid and its salts At least one selected from the group of, glycyrrhizic acid, by blending glycyrrhetinic acid and derivatives thereof, or at least one selected from the group of γ-amino-β-hydroxybutyric acid and salts thereof, bovine placenta extract. The present invention has been completed by finding that this object can be achieved by compounding.

【0005】グリチルリチン酸、グリチルレチン酸及び
それらの誘導体は公知物質であり、抗炎症作用が認めら
れているのみであり、γ−アミノ−β−ヒドロキシ酪酸
及びその塩と同様に皮膚機能を亢進し、老化防止効果を
有することは見いだされていなかった。
Glycyrrhizic acid, glycyrrhetinic acid and their derivatives are known substances and only have an anti-inflammatory action, and like the γ-amino-β-hydroxybutyric acid and its salts, enhance the skin function, It has not been found to have an anti-aging effect.

【0006】さらに、牛胎盤抽出物も公知物質であり皮
膚賦活作用および皮膚美白作用が認められているが、γ
−アミノ−β−ヒドロキシ酪酸及びその塩と同様に牛胎
盤抽出物単独では充分満足し得るものではなかった。
Furthermore, bovine placenta extract is a known substance, and its skin activating action and skin whitening action are recognized.
Similar to -amino-β-hydroxybutyric acid and its salts, bovine placenta extract alone was not fully satisfactory.

【0007】しかしながら、本発明者は、前述の物質の
組み合わせによって相乗的に皮膚に作用して、皮膚の末
梢血管を拡張し、皮膚機能を亢進して、肌のしわを防止
し、肌目(きめ)こまかな、かつしっとりとした皮膚に
する(美肌効果)と共に、優れた皮膚老化防止効果(荒
れ肌改善効果、角質改善効果、ターンオーバー速度を早
くする効果)を短時間に発現し、持続する等、顕著な効
果を現すことを見いだしたのである。
However, the present inventor synergistically acts on the skin by the combination of the aforementioned substances, expands peripheral blood vessels of the skin, enhances the skin function, prevents wrinkles of the skin, and Fine texture and smooth and moisturized skin (beautiful skin effect), as well as excellent skin aging prevention effects (rough skin improvement effect, keratin improvement effect, effect of accelerating turnover speed) are maintained and maintained in a short time It has been found that such a remarkable effect is exhibited.

【0008】本発明の請求項1は、γ−アミノ−β−ヒ
ドロキシ酪酸及びその塩の群から選ばれる少なくとも一
種と、グリチルリチン酸、グリチルレチン酸及びそれら
の誘導体から選ばれる少なくとも一種とを配合すること
を特徴とする皮膚老化防止化粧料である。
According to claim 1 of the present invention, at least one selected from the group of γ-amino-β-hydroxybutyric acid and salts thereof and at least one selected from glycyrrhizic acid, glycyrrhetinic acid and their derivatives. A skin aging prevention cosmetic characterized by:

【0009】また、本発明の請求項2は、γ−アミノ−
β−ヒドロキシ酪酸及びその塩の群から選ばれる少なく
とも一種と、牛胎盤抽出物とを配合することを特徴とす
る皮膚老化防止化粧料である。
The second aspect of the present invention provides γ-amino-
A skin anti-aging cosmetic composition comprising at least one selected from the group of β-hydroxybutyric acid and salts thereof and a bovine placenta extract.

【0010】以下、本発明の構成について詳述する。The structure of the present invention will be described in detail below.

【0011】本発明に適用されるγ−アミノ−β−ヒド
ロキシ酪酸及びその塩は、公知の化合物であって、前記
公報に詳細に記載されている。γ−アミノ−β−ヒドロ
キシ酪酸の塩としては、水酸化カリウム、水酸化ナトリ
ウム、水酸化カルシウムまたは水酸化マグネシウムのい
ずれかで中和したγ−アミノ−β−ヒドロキシ酪酸のカ
リウム塩、同ナトリウム塩、同カルシウム塩、同マグネ
シウム塩が適用される。
Γ-Amino-β-hydroxybutyric acid and salts thereof applicable to the present invention are known compounds and are described in detail in the above publication. Examples of the salt of γ-amino-β-hydroxybutyric acid include potassium salt of γ-amino-β-hydroxybutyric acid and sodium salt thereof, which are neutralized with potassium hydroxide, sodium hydroxide, calcium hydroxide or magnesium hydroxide. , The same calcium salt and the same magnesium salt are applied.

【0012】本発明に用いるグリチルリチン酸及びその
誘導体は公知化合物であり、18α−グリチルリチン酸
(α−Giと略記する)、18β−グリチルリチン酸
(β−Giと略記する)、それらの塩である18α−グ
リチルリチン酸トリナトリウム(α−Gi−Na3と略
記する)、18α−グリチルリチン酸モノカリウム(α
−Gi−Kと略記する)、18α−グリチルリチン酸ジ
カリウム(α−Gi−K2と略記する)、18α−グリ
チルリチン酸モノアンモニウム(α−Gi−NH3と略
記する)、18β−グリチルリチン酸トリナトリウム
(β−Gi−Na3と略記する)、18β−グリチルリ
チン酸モノカリウム(β−Gi−Kと略記する)、18
β−グリチルリチン酸ジカリウム(β−Gi−K2と略
記する)、及びグリチルリチン酸誘導体のエステル類で
ある18α−グリチルリチン酸メチルエステル(α−G
iメチルと略記する)、18β−グリチルリチン酸メチ
ルエステル(β−Giメチルと略記する)等が特に好ま
しいものとして挙げることができるが、これらに限定さ
れるものではない。
Glycyrrhizic acid and its derivatives used in the present invention are known compounds such as 18α-glycyrrhizinic acid (abbreviated as α-Gi), 18β-glycyrrhizinic acid (abbreviated as β-Gi) and salts thereof, 18α. -Trisodium glycyrrhizinate (abbreviated as α-Gi-Na3), 18α-monopotassium glycyrrhizinate (α
-Gi-K), 18α-glycyrrhizinate dipotassium (abbreviated as α-Gi-K2), 18α-monoammonium glycyrrhizinate (abbreviated as α-Gi-NH3), 18β-trisodium glycyrrhizinate (β). -Gi-Na3), 18 β-glycyrrhizinate monopotassium (abbreviated as β-Gi-K), 18
β-Glycyrrhizic acid dipotassium (abbreviated as β-Gi-K2) and 18α-glycyrrhizinic acid methyl ester (α-G) which are esters of glycyrrhizinic acid derivatives.
i-methyl), 18β-glycyrrhizinic acid methyl ester (abbreviated as β-Gi-methyl), and the like can be mentioned as particularly preferable ones, but not limited thereto.

【0013】また、本発明に用いるグリチルレチン酸及
びその誘導体は公知化合物であり、α−グリチルレチン
酸(α−Geと略記する)、β−グリチルレチン酸(β
−Geと略記する)、グリチルレチン酸誘導体の塩とし
ては、3−サクシニルオキシグリチルレチン酸二ナトリ
ウム(3−サクシニル−Ge−Na2と略記する)等が
特に好ましいものとして挙げることができるが、これら
に限定されるものではない。さらに、グリチルレチン酸
誘導体のエステル類としては、α−グリチルレチン酸ス
テアリル(α−Ge−ステアリルと略記する)、β−グ
リチルレチン酸ステアリル(β−Ge−ステアリルと略
記する)、α−グリチルレチン酸ピリドキシン(α−G
e−ピリドキシンと略記する)、β−グリチルレチン酸
ピリドキシン(β−Ge−ピリドキシンと略記する)、
α−グリチルレチン酸グリセリン(α−Ge−グリセリ
ンと略記する)、β−グリチルレチン酸グリセリン(β
−Ge−グリセリンと略記する)等が特に好ましいもの
として挙げることができるが、これらに限定されるもの
ではない。
Glycyrrhetinic acid and its derivatives used in the present invention are known compounds, and α-glycyrrhetinic acid (abbreviated as α-Ge) and β-glycyrrhetinic acid (β
-Ge)), as the salt of the glycyrrhetinic acid derivative, 3-succinyloxyglycyrrhetinic acid disodium (abbreviated as 3-succinyl-Ge-Na2) and the like can be mentioned as particularly preferred, but are not limited thereto. It is not something that will be done. Furthermore, as esters of glycyrrhetinic acid derivatives, α-glycyrrhetinic acid stearyl (abbreviated as α-Ge-stearyl), β-glycyrrhetinic acid stearyl (abbreviated as β-Ge-stearyl), α-glycyrrhetinic acid pyridoxine (α) -G
abbreviated as e-pyridoxine), β-glycyrrhetinic acid pyridoxine (abbreviated as β-Ge-pyridoxine),
Glycerin α-glycyrrhetinate (abbreviated as α-Ge-glycerin), β-glycyrrhetinate glycerin (β
-Ge-glycerin) and the like can be mentioned as particularly preferable ones, but the present invention is not limited thereto.

【0014】本発明に用いる牛胎盤抽出物は、公知の物
質であって、妊娠3〜4ケ月の新鮮な牛胎盤を凍結、融
解し、細切後低温下で脂溶性成分を繰り返し除去したの
ち、水溶性成分を抽出して得られる。牛胎盤抽出物とし
ては、水溶性プラセンタエキス等が挙げられる。
The bovine placenta extract used in the present invention is a known substance, and fresh bovine placenta from 3 to 4 months of gestation is frozen and thawed, and the fat-soluble components are repeatedly removed at low temperature after cutting into small pieces. , Obtained by extracting the water-soluble component. Examples of the bovine placenta extract include water-soluble placenta extract and the like.

【0015】γ−アミノ−β−ヒドロキシ酪酸及びその
塩の配合量は、化粧料の処方成分全量を基準として0.
01〜2.0重量%(以下、wt%と略記する)であ
る。
The blending amount of γ-amino-β-hydroxybutyric acid and its salt is 0.
01 to 2.0 wt% (hereinafter abbreviated as wt%).

【0016】グリチルリチン酸、グリチルレチン酸及び
それらの誘導体の配合量は、化粧料の処方成分全量を基
準として0.005〜2.0wt%である。
The amount of glycyrrhizic acid, glycyrrhetinic acid and their derivatives to be blended is 0.005 to 2.0 wt% based on the total amount of the prescription components of the cosmetic.

【0017】牛胎盤抽出物の配合量は、化粧料の処方成
分全量を基準として0.1〜3.0wt%である。
The amount of the cow placenta extract blended is 0.1 to 3.0 wt% based on the total amount of the prescription ingredients of the cosmetic.

【0018】本発明の化粧料には、上記原料の他にター
ル系色素、酸化鉄などの着色顔料、パラベンなどの防腐
剤、脂肪酸セッケン、セチル硫酸ナトリウムなどの陰イ
オン界面活性剤、ポリオキシエチレンアルキルエーテ
ル、ポリオキシエチレン脂肪酸エステル、ポリオキシエ
チレン多価アルコール脂肪酸エステル、ポリオキシエチ
レン硬化ヒマシ油、多価アルコール脂肪酸エステル、ポ
リグリセリン脂肪酸エステルなどの非イオン界面活性
剤、テトラアルキルアンモニウム塩などの陽イオン界面
活性剤、ベタイン型、スルホベタイン型、スルホアミノ
酸型、N−ステアロイル−L−グルタミン酸ナトリウム
などの両性界面活性剤、レシチン、リゾフォスファチジ
ルコリンなどの天然系界面活性剤、酸化チタンなどの顔
料、ジブチルヒドロキシトルエンなどの抗酸化剤など
を、本発明の目的を達成する範囲内で適宜配合すること
ができる。
In the cosmetics of the present invention, in addition to the above raw materials, tar dyes, coloring pigments such as iron oxide, preservatives such as parabens, fatty acid soaps, anionic surfactants such as sodium cetylsulfate, polyoxyethylene, etc. Nonionic surfactants such as alkyl ethers, polyoxyethylene fatty acid esters, polyoxyethylene polyhydric alcohol fatty acid esters, polyoxyethylene hydrogenated castor oil, polyhydric alcohol fatty acid esters, polyglycerin fatty acid esters, tetraalkylammonium salts, etc. Ionic surfactants, betaine type, sulfobetaine type, sulfoamino acid type, amphoteric surfactants such as sodium N-stearoyl-L-glutamate, natural surfactants such as lecithin and lysophosphatidylcholine, and titanium oxide Pigment, dibutyl hydroxy And antioxidants such as toluene, may be appropriately blended within the range to achieve the object of the present invention.

【0019】本発明の化粧料の剤型としては、クリー
ム、乳液、化粧水、パックなどが挙げられる。
The dosage form of the cosmetic of the present invention includes creams, emulsions, lotions, packs and the like.

【0020】[0020]

【実施例】以下、実施例及び比較例に基づいて本発明を
詳細に説明する。尚、実施例に記載の角質層のターン
オーバー速度測定方法、荒れ肌改善効果の測定試験
法、角質改善効果の測定試験法、官能テストは下記
の通りである。
EXAMPLES The present invention will be described in detail below based on examples and comparative examples. The methods for measuring the turnover speed of the stratum corneum, the measurement test method for improving rough skin, the measurement test method for improving stratum corneum, and the sensory test described in Examples are as follows.

【0021】角質層のターンオーバー速度測定方法 蛍光色素のダンシルクロリドを白色ワセリン中に5wt
%配合した軟膏を作り、被験者の前腕部の皮膚に24時
間閉塞塗布し、角質層にダンシルクロリドを浸透結合さ
せた。その後同じ部位に1日2回(朝、夕)被験試料を
塗布し、毎日ダンシルクロリドの蛍光を調べ、その蛍光
が消滅するまでの日数を皮膚角質層のターンオーバー速
度とした。
Method for measuring turnover rate of stratum corneum 5 wt% of dansyl chloride, a fluorescent dye, in white petrolatum
% Ointment was prepared and occluded and applied to the skin of the forearm of the subject for 24 hours, and dansyl chloride was osmotically bonded to the stratum corneum. After that, the test sample was applied to the same site twice a day (morning and evening), the fluorescence of dansyl chloride was examined every day, and the number of days until the fluorescence disappeared was defined as the turnover rate of the stratum corneum of the skin.

【0022】荒れ肌改善効果の測定試験法 下脚に荒れ肌を有する中高年被験者20名を対象として
4週間連続塗布効果を調べた。被験者の左側脚試験部位
に1日2回約1gの試料を塗布し、試験開始前および終
了後の皮膚の状態を表1の判定基準により判定した。な
お、右側下脚は試料を塗布せず対象とした。
Measurement Test Method for Rough Skin Improvement Effect The effect of continuous application for 4 weeks was investigated for 20 middle-aged and elderly subjects who have rough skin on their lower legs. About 1 g of the sample was applied to the left leg test site of the test subject twice a day, and the skin condition before the start of the test and after the test was judged according to the criteria shown in Table 1. The right lower leg was used as a target without applying the sample.

【0023】[0023]

【表1】 [Table 1]

【0024】試験前後の試験部位と対照部位の判定結果
を比較し、皮膚乾燥度が2段階以上改善された場合(例
えば+→−,++→±)を「有効」、1段階改善された
場合を「やや有効」、変化がなかった場合を「無効」と
した。試験結果は「有効」、「やや有効」となった被験
者の人数で示した。
When the skin dryness is improved by two or more stages (for example, + →-, ++ → ±) by comparing the determination results of the test site before and after the test with the control site, it is "effective" and when it is improved by one stage. Is "slightly valid", and when there is no change, it is "invalid". The test results are shown by the number of subjects who were “effective” and “somewhat effective”.

【0025】角質改善(角質細胞の抗剥離性増大)効
果の測定試験法 前述の荒れ肌改善測定試験開始前および終了後の被験部
皮膚にスコッチテープ(ニチバンメンディングテープ)
を接着し、これを剥離した時テープに付着した角質細胞
の状態を走査型電子顕微鏡によって詳細に調べ、表2の
判定基準によって皮膚角質層細胞剥離性を分類し、角質
改善効果を求めた。
Test method for measuring effect of improving keratin (increasing anti-peeling property of keratinocytes) Scotch tape (Nichiban Mending Tape) is applied to the skin of the test area before and after the start of the rough skin improvement measurement test described above.
Was adhered and the state of keratinocytes adhered to the tape when peeled off was examined in detail by a scanning electron microscope, and the keratin layer cell exfoliation property was classified according to the criteria in Table 2 to obtain a keratin improving effect.

【0026】[0026]

【表2】 [Table 2]

【0027】判定は4週間連続塗布後の試験部位の評価
点と対照部位のそれとの差が2点以上の場合を「有
効」、1点の場合を「やや有効」、0点の場合を「無
効」とした。試験結果は「有効」、「やや有効」となっ
た被験者の人数で示した。
The judgment is "effective" when the difference between the evaluation point of the test site and that of the control site after continuous application for 4 weeks is 2 points or more, "effective", 1 point "slightly effective", 0 point " Invalid ". The test results are shown by the number of subjects who were “effective” and “somewhat effective”.

【0028】官能テスト(素肌効果試験) 荒れ肌、小じわ、乾燥肌等を訴える女子被験者(35〜
55才)20人に試料を1日2回(朝、夕)連続3ケ月
間塗布して、1,2,3ケ月後の効果を評価した。試験
結果は、皮膚の湿潤性、平滑性、弾力性の各項目に対し
て、「皮膚に潤いが生じた」、「皮膚が滑らかになっ
た」、「皮膚に張りが生じた」と回答した人数で示し
た。
Sensory test (bare skin effect test) Female subjects who complain of rough skin, fine wrinkles, dry skin (35-35)
The sample was applied to 20 persons (55 years old) twice a day (morning and evening) for 3 consecutive months, and the effect after 1, 2 and 3 months was evaluated. The test results replied that "the skin was moisturized", "the skin was smooth", and "the skin was tense" with respect to each item of the skin wettability, smoothness, and elasticity. The number of people is shown.

【0029】実施例1〜4、比較例1〜9[スキンクリ
ーム] γ−アミノ−β−ヒドロキシ酪酸及びその塩と、グリチ
ルリチン酸、グリチルレチン酸及びそれらの誘導体とを
表4、5に記載の通りに配合し、下記表3の組成でスキ
ンクリームを調製し、前記の諸実験を実施した。尚、γ
−アミノ−β−ヒドロキシ酪酸はGABOB、γ−アミ
ノ酪酸−β−ヒドロキシ酪酸の塩としては、カリウム塩
はGABOB−K、同ナトリウム塩はGABOB−N、
同カルシウム塩はGABOB−Cのごとく略記する。
Examples 1 to 4 and Comparative Examples 1 to 9 [Skin cream] γ-amino-β-hydroxybutyric acid and its salts, glycyrrhizic acid, glycyrrhetinic acid and their derivatives are shown in Tables 4 and 5. The skin cream having the composition shown in Table 3 below was prepared, and the above-mentioned various experiments were carried out. Note that γ
-Amino-β-hydroxybutyric acid is GABOB, γ-aminobutyric acid-β-hydroxybutyric acid salt is potassium salt GABOB-K, sodium salt GABOB-N,
The calcium salt is abbreviated as GABOB-C.

【0030】(1)組成(1) Composition

【0031】[0031]

【表3】 [Table 3]

【0032】(2)調製法 (A)成分及び(B)成分を各々80℃に加熱溶解した
後混合して、攪拌しつつ30℃まで冷却して、各スキン
クリームを調製した。
(2) Preparation Method Each of the components (A) and (B) was heated and dissolved at 80 ° C., then mixed and cooled to 30 ° C. with stirring to prepare each skin cream.

【0033】(3)特性 各スキンクリームの諸試験を実施した結果を表4〜6に
記載した。表4〜6に示すごとく、比較例1〜9のグリ
チルリチン酸、グリチルレチン酸及び誘導体、あるいは
γ−アミノ−β−ヒドロキシ酪酸及びその塩のみを単独
で配合したスキンクリームは諸特性において充分なる効
果は得られず、本発明の実施例1〜4のグリチルリチン
酸、グリチルレチン酸及び誘導体とγ−アミノ−β−ヒ
ドロキシ酪酸及びその塩の群から選ばれる少なくとも1
種とを配合したスキンクリームは諸特性において顕著な
効果が見られ、官能テストでは試料塗布後1〜2ケ月で
優れた美肌効果を示した。
(3) Characteristics Tables 4 to 6 show the results of various tests performed on each skin cream. As shown in Tables 4 to 6, the skin creams of Comparative Examples 1 to 9 in which only glycyrrhizinic acid, glycyrrhetinic acid and derivatives, or γ-amino-β-hydroxybutyric acid and its salt alone are blended are not sufficiently effective in various properties. At least one selected from the group consisting of glycyrrhizic acid, glycyrrhetinic acid and derivatives of Examples 1 to 4 of the present invention and γ-amino-β-hydroxybutyric acid and salts thereof, which was not obtained.
The skin cream containing the seeds showed remarkable effects in various properties, and a sensory test showed an excellent skin-beautifying effect 1-2 months after application of the sample.

【0034】[0034]

【表4】 [Table 4]

【0035】[0035]

【表5】 [Table 5]

【0036】[0036]

【表6】 [Table 6]

【0037】実施例5〜8[スキンローション] 表7の組成でスキンローションを調製し、諸試験を実施
した。なお、、γ−アミノ酪酸−β−ヒドロキシ酪酸の
塩として、マグネシウム塩はGABOB−Mのごとく略
記する。
Examples 5 to 8 [Skin lotion] Skin lotions having the compositions shown in Table 7 were prepared and various tests were carried out. In addition, a magnesium salt is abbreviated as GABOB-M as a salt of γ-aminobutyric acid-β-hydroxybutyric acid.

【0038】(1)組成(1) Composition

【0039】[0039]

【表7】 [Table 7]

【0040】(2)調製法 (A)、(B)成分を各々均一に溶解した後、(A)成
分と(B)成分を混合攪拌分散し、次いで容器に充填し
た。使用時には内容物を均一に振盪分散して使用した。
(2) Preparation Method After the components (A) and (B) were uniformly dissolved, the components (A) and (B) were mixed and dispersed by stirring, and then filled in a container. At the time of use, the content was uniformly dispersed by shaking before use.

【0041】(3)特性 実施例5〜8は、前記諸試験において全て良好な結果を
示した。
(3) Characteristics Examples 5 to 8 all showed good results in the above tests.

【0042】実施例9〜15、比較例10〜15[スキ
ンクリーム] γ−アミノ−β−ヒドロキシ酪酸及びその塩と、牛胎盤
抽出物とを表9、10に記載の通りに配合し、下記表8
の組成でスキンクリームを調製し、前記の諸実験を実施
した。なお、牛胎盤抽出物はプラセンタエキスのごとく
略記する。
Examples 9 to 15 and Comparative Examples 10 to 15 [skin cream] γ-amino-β-hydroxybutyric acid and its salt and bovine placenta extract were blended as shown in Tables 9 and 10, and Table 8
A skin cream was prepared with the above composition and the above-mentioned experiments were carried out. The placenta extract is abbreviated as placenta extract.

【0043】(1)組成(1) Composition

【0044】[0044]

【表8】 [Table 8]

【0045】(2)調製法 (A)成分及び(B)成分を各々80℃に加熱溶解した
後混合して、攪拌しつつ30℃まで冷却して、各スキン
クリームを調製した。
(2) Preparation Method Each of the components (A) and (B) was heated and dissolved at 80 ° C., then mixed and cooled to 30 ° C. with stirring to prepare each skin cream.

【0046】(3)特性 各スキンクリームの諸試験を実施した結果を表9〜11
に記載した。表9〜11に示すごとく、比較例10〜1
5のプラセンタエキス、あるいはγ−アミノ−β−ヒド
ロキシ酪酸及びその塩のみを単独で配合したスキンクリ
ームは諸特性において充分なる効果は得られず、本発明
の実施例9〜15の牛胎盤抽出物とγ−アミノ−β−ヒ
ドロキシ酪酸及びその塩の群から選ばれる少なくとも1
種とを配合したスキンクリームは諸特性において顕著な
効果が見られ、官能テストでは試料塗布後1〜2ケ月で
優れた美肌効果を示した。
(3) Properties Tables 9 to 11 show the results of various tests performed on each skin cream.
Described in. As shown in Tables 9 to 11, Comparative Examples 10 to 1
The placenta extract of No. 5 or the skin cream containing only γ-amino-β-hydroxybutyric acid and its salt alone does not show sufficient effects in various properties, and the bovine placenta extracts of Examples 9 to 15 of the present invention are not obtained. And at least 1 selected from the group of γ-amino-β-hydroxybutyric acid and salts thereof.
The skin cream containing the seeds showed remarkable effects in various properties, and a sensory test showed an excellent skin-beautifying effect 1-2 months after application of the sample.

【0047】[0047]

【表9】 [Table 9]

【0048】[0048]

【表10】 [Table 10]

【0049】[0049]

【表11】 [Table 11]

【0050】実施例16〜18[スキンローション] 表12の組成でスキンローションを調製し、諸試験を実
施した。尚、γ−アミノ酪酸−β−ヒドロキシ酪酸の塩
として、マグネシウム塩はGABOB−Mのごとく略記
する。
Examples 16 to 18 [Skin lotion] Skin lotions having the compositions shown in Table 12 were prepared and various tests were carried out. The magnesium salt as a salt of γ-aminobutyric acid-β-hydroxybutyric acid is abbreviated as GABOB-M.

【0051】(1)組成(1) Composition

【0052】[0052]

【表12】 [Table 12]

【0053】(2)調製法 (A)、(B)成分を各々均一に溶解した後、(A)成
分と(B)成分を混合攪拌分散し、次いで容器に充填し
た。使用時には内容物を均一に振盪分散して使用した。
(2) Preparation Method After the components (A) and (B) were uniformly dissolved, the component (A) and the component (B) were mixed and dispersed by stirring, and then filled in a container. At the time of use, the content was uniformly dispersed by shaking before use.

【0054】(3)特性 実施例17〜19は、前記諸試験に於いてすべて良好な
結果を示した。
(3) Characteristics Examples 17 to 19 all showed good results in the above tests.

【0055】[0055]

【発明の効果】以上記載のごとく、本発明が、皮膚老化
防止効果(荒れ肌改善効果、角質改善効果、ターンオー
バー速度を早くする効果、美肌効果等)の優れた有用な
る皮膚老化防止化粧料を提供することは明らかである。
Industrial Applicability As described above, the present invention provides a useful skin anti-aging cosmetic having excellent anti-aging effects (rough skin improving effect, keratin improving effect, turnover speed increasing effect, beautiful skin effect, etc.). It is clear to provide.

Claims (2)

【特許請求の範囲】[Claims] 【請求項1】 γ−アミノ−β−ヒドロキシ酪酸及びそ
の塩の群から選ばれる少なくとも一種と、グリチルリチ
ン酸、グリチルレチン酸及びそれらの誘導体から選ばれ
る少なくとも一種とを配合することを特徴とする皮膚老
化防止化粧料。
1. Skin aging, characterized by blending at least one selected from the group of γ-amino-β-hydroxybutyric acid and salts thereof and at least one selected from glycyrrhizinic acid, glycyrrhetinic acid and their derivatives. Preventive cosmetics.
【請求項2】 γ−アミノ−β−ヒドロキシ酪酸及びそ
の塩の群から選ばれる少なくとも一種と、牛胎盤抽出物
とを配合することを特徴とする皮膚老化防止化粧料。
2. A skin anti-aging cosmetic composition comprising at least one selected from the group of γ-amino-β-hydroxybutyric acid and salts thereof and a bovine placenta extract.
JP28567693A 1993-10-20 1993-10-20 Cosmetic for preventing aging of skin Pending JPH07118140A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP28567693A JPH07118140A (en) 1993-10-20 1993-10-20 Cosmetic for preventing aging of skin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP28567693A JPH07118140A (en) 1993-10-20 1993-10-20 Cosmetic for preventing aging of skin

Publications (1)

Publication Number Publication Date
JPH07118140A true JPH07118140A (en) 1995-05-09

Family

ID=17694614

Family Applications (1)

Application Number Title Priority Date Filing Date
JP28567693A Pending JPH07118140A (en) 1993-10-20 1993-10-20 Cosmetic for preventing aging of skin

Country Status (1)

Country Link
JP (1) JPH07118140A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10194956A (en) * 1997-01-14 1998-07-28 Kanebo Ltd Skin cosmetic
JP2001072567A (en) * 1999-09-07 2001-03-21 Sunstar Inc Skin cosmetic
KR100332031B1 (en) * 1999-06-03 2002-04-10 서경배 A composition for external application having effects of improving wrinkle and suppressing wrinkle formation
KR102204495B1 (en) * 2020-02-14 2021-01-20 주식회사 미래셀바이오 Cosmetic composition comprising Jeju black cattle placenta extract as and effective component and preparation method thereof

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10194956A (en) * 1997-01-14 1998-07-28 Kanebo Ltd Skin cosmetic
KR100332031B1 (en) * 1999-06-03 2002-04-10 서경배 A composition for external application having effects of improving wrinkle and suppressing wrinkle formation
JP2001072567A (en) * 1999-09-07 2001-03-21 Sunstar Inc Skin cosmetic
KR102204495B1 (en) * 2020-02-14 2021-01-20 주식회사 미래셀바이오 Cosmetic composition comprising Jeju black cattle placenta extract as and effective component and preparation method thereof

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