JPH06256155A - Skin aging-preventing cosmetic - Google Patents

Abstract

PURPOSE:To provide useful skin aging-preventing cosmetic excellent in skin aging-preventing effects (e.g. skin roughness-improving effect, corneum-improving effect, turnover speed-increasing effect, skin-beautifying effect). CONSTITUTION:A cosmetic for preventing the aging of skin is characterized by containing at least one of gamma-amino-beta-hydroxybutyric acid (GABOB) and its salt and a yeast and/or its extract.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin aging-preventing cosmetic (a cosmetic used to prevent skin aging). More specifically, skin aging prevention effect (rough skin improvement effect, keratin improvement effect, effect of accelerating turnover speed, effect of beautiful skin, etc.)
Regarding excellent skin cosmetics.

[0002]

2. Description of the Related Art Aged skin is dry skin that is not smooth and has keratinocyte exfoliation phenomenon. And aging skin
It is said that the turnover speed is slow, and when the antiaging effect is imparted to the skin, the turnover speed is increased. Japanese Patent No. 1527136 discloses γ-amino-
It is disclosed that β-hydroxybutyric acid enhances the skin function by the peripheral vasodilatory action of the skin and has an antiaging effect.

However, the skin cosmetics containing γ-amino-β-hydroxybutyric acid alone have a slow effect of preventing aging. For example, in the case of cream, after 6 months of continuous use, in the case of lotion. Similarly, the effect appears after 8 months, which is not completely satisfactory, and there is room for improvement.

On the other hand, it is known to blend cosmetics by utilizing the moisturizing effect or yeast cosmetic effect of yeast, for example, Japanese Patent Publication No. 39-4 which uses yeast cells themselves in a pack.
There are 899 etc. However, when these are used alone, they retain water due to their water-retaining power and give a proper moisturization to the skin, and the effect of preventing skin aging is not positively obtained.

As a result of earnest studies in view of such circumstances, the present inventor has found that γ-amino-β-hydroxybutyric acid (hereinafter GA
When at least one of BOB) and a salt thereof and yeast and / or yeast extract are mixed in a cosmetic at the same time, due to their synergistic effect, excellent skin aging prevention effect (rough skin improving effect, keratin improving effect, It has been found that a rapid-acting anti-aging cosmetic composition is obtained in which the effect of accelerating turnover speed, the effect of skin beautification, etc.) is developed within a very short period of 1 to 2 months after the start of continuous use and is sustained. Has been completed.

[0006]

Means for Solving the Problems The skin anti-aging cosmetic composition of the present invention for achieving the above object is characterized by containing at least one of GABOB and a salt thereof, and yeast and / or yeast extract. It is what

GABOB used in the present invention is a known substance and is applied as a therapeutic agent for cerebral arteriosclerosis, and its chemical properties are as follows.

[0008]

[Table 1]

In addition, in Japanese Patent No. 1527136, G
It is described that ABOB has a skin aging preventing effect due to a skin tissue activating effect.

GAB obtained by neutralizing GABOB with caustic potash, caustic soda or calcium hydroxide, magnesium hydroxide
OB potassium salt, sodium salt, calcium salt,
Each of the magnesium salts has the same skin tissue activating effect, whitening effect, and wrinkle effect as free GABOB, and is applied to the skin anti-aging cosmetic composition of the present invention.

The amount of at least one of GABOB and its salt is 0.01 based on the total amount of the prescription components of the cosmetic.
˜2% by weight (hereinafter abbreviated as wt%). Even if the upper limit of each of these blending amounts is exceeded, an effect commensurate with the exceeding blending amount cannot be expected, and if the blending amount is less than the lower limit, the object of the present invention cannot be achieved.

The yeast and yeast extract used in the present invention include live yeast cells themselves, dried yeast cells in a dry powder form, and yeast cells such as self-digestion, hot water extraction, acid hydrolysis, and enzymatic decomposition. There are yeast extracts and the like that have been solubilized, extracted, and purified under appropriate conditions. Yeast generally include Saccharomyces genus and others such as brewer's yeast and baker's yeast, and when a yeast extract is obtained, it is physically and
Chemical and biochemical methods are applied. In the present invention, regardless of the bacterial species as a raw material, the origin, the extraction method, the purification method, the treatment method, and other manufacturing methods, they can be arbitrarily selected and used. Above all,
Commercially available yeast dry powder and yeast extract are easy to handle and easily available and convenient. The yeasts and yeast extracts described above contain useful components such as proteins, lipids, inorganic salts, organic acids, vitamins, amino acids, sugars and nucleic acid-related substances.

The amount of yeast and yeast extract to be blended is 0.0001 to 20 wt% based on the total amount of the prescription ingredients of the cosmetic. Even if the upper limit of each of these blending amounts is exceeded, an effect commensurate with the exceeding blending amount cannot be expected, and if the blending amount is less than the lower limit, the object of the present invention cannot be achieved.

In addition to the above, the skin anti-aging cosmetic composition of the present invention includes a pigment, a fragrance, an antiseptic, a surfactant, a pigment, an antioxidant, a pH adjusting agent, a thickener, etc. for the purpose of the present invention. It can be appropriately blended within the range to be achieved.

The skin anti-aging cosmetic composition of the present invention is, for example,
It can be applied to lotions, emulsions, creams, packs, etc.

[0016]

EXAMPLES The present invention will be described in detail below based on examples and comparative examples. The methods for measuring the turnover speed of the stratum corneum, the measurement test method for improving rough skin, the measurement test method for improving stratum corneum, and the sensory test described in Examples are as follows. GABOB potassium, sodium, calcium, and magnesium salts are GA
BOB-K, GABOB-Na, GABOB-Ca, G
Abbreviated as ABOB-Mg.

Method for measuring turnover rate of stratum corneum 5 wt% of dansyl chloride, a fluorescent dye, in white petrolatum
% Ointment is prepared and occluded and applied to the skin of the forearm of the subject for 24 hours, and dansyl chloride is osmotically bonded to the stratum corneum. Thereafter, the test sample was applied to the same site twice a day (morning and evening), and the fluorescence of dansyl chloride was examined every day. The number of days until the fluorescence disappeared was defined as the turnover rate of the stratum corneum of the skin. The normal turnover rate of the stratum corneum of the skin is 14 to 16 days, but in aged skin, the turnover speed extends to around 18 days. On the other hand, when the anti-aging effect appears, it is shortened to around 12 days.

Test Method for Rough Skin Improving Effect 20 middle-aged and elderly subjects who have rough skin on their lower legs were tested for the effect of continuous application for 4 weeks. About 1 g of the sample was applied to the left leg test site of the test subject twice a day, and the condition of the skin before and after the start of the test was evaluated according to the following criteria. The right lower leg was used as a target without applying the sample.

[0019]

[Table 2]

When the judgment results of the test site before and after the test and the control site are compared, and when the skin dryness is improved by two or more stages (for example, + → −, ++ → ±) is “effective”, when one stage is improved Is "slightly valid", and when there is no change, it is "invalid". The test results are shown by the number of subjects who were “effective” and “somewhat effective”.

Test method for keratin improvement (increased keratinocyte anti-exfoliation) effect Scotch tape (Nichiban Mending Tape) on the skin of the test area before and after the start of the rough skin improvement measurement test described above
After scrutinizing the state of the keratinocytes adhered to the tape when it is peeled off by a scanning electron microscope, the skin corneum layer peeling property is classified according to the following criteria,
A keratin improving effect was sought.

[0022]

[Table 3]

The judgment is "effective" when the difference between the evaluation point of the test site and that of the control site after continuous application for 4 weeks is 2 or more is "effective", 1 is "effective", and 0 is " Invalid ". The test results are shown by the number of subjects who were “effective” and “somewhat effective”.

Sensory test (bare skin effect test) Female subjects who complain of rough skin, fine wrinkles, dry skin (35-35)
The effect was evaluated after the sample was applied to 20 people (55 years old) twice a day (morning and evening) continuously for 2 months. The test results replied that "the skin was moisturized", "the skin was smooth", and "the skin was tense" with respect to each item of the wettability, smoothness, and elasticity of the skin. The number of people is shown.

Examples 1 to 5 and Comparative Examples 1 to 5 [Skin Cream] Tables 4 and 5 show the amounts of GABOB and at least one of its salts, yeast, yeast extract, and the composition of the skin cream in the skin cream. Shown in.

[0026]

[Table 4]

[0027]

[Table 5]

(2) Preparation Method The components (A) and (B) are dissolved by heating at 80 ° C., mixed, cooled with stirring, and added with (C) at about 50 ° C. to 30 ° C. Each skin cream was prepared by cooling to.

(3) Characteristics Tables 6 and 7 show the results of various tests performed on each skin cream.
Described in.

[0030]

[Table 6]

[0031]

[Table 7]

As shown in Tables 6 and 7, Example 1 of the present invention
The skin creams Nos. 5 to 5 showed remarkable effects in various properties with respect to Comparative Examples 1 to 5, and a sensory test showed an excellent skin beautifying effect 1 to 6 months after application of the sample.

Example 6 [two-layer type skin lotion] In the same manner as in Example 1, each two-layer type skin lotion was prepared in the following composition and various tests were carried out.

[0034]

[Table 8]

(2) Preparation method After the components (A) and (B) are uniformly dissolved, the components (A) and (B) are mixed and stirred to be dispersed, and then filled in a container. At the time of use, the contents should be evenly dispersed by shaking.

(3) Characteristics Example 6 showed good results in all the tests.

[0037]

Industrial Applicability As described above, the present invention provides a useful skin anti-aging cosmetic having excellent anti-aging effects (rough skin improving effect, keratin improving effect, turnover speed increasing effect, beautiful skin effect, etc.). It is clear to provide.

Claims (1)

[Claims] 1. A skin antiaging cosmetic comprising at least one of γ-amino-β-hydroxybutyric acid and a salt thereof, and yeast and / or a yeast extract.