JP3121957B2 - Anti-aging skin cosmetics - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin cosmetic which has an excellent effect of preventing skin aging (effect of improving rough skin, effect of improving keratin, effect of increasing turnover speed, effect of beautiful skin, etc.).

[0002]

2. Description of the Related Art Aging skin is dry, rough, unsmooth skin with keratinocyte exfoliation. Conventionally, moisturizers such as glycerin and propylene glycol have been used to provide appropriate moisture to the skin in order to maintain healthy skin. However, these may instead cause loss of moisture in the stratum corneum, and not only do not improve rough skin, but also do not satisfy the feeling of use.

In general, it is known that aging skin has a low turnover rate of the stratum corneum due to a decrease in cell metabolism. Therefore, a skin cell activator or a blood circulation promoting agent for promoting skin cell metabolism and increasing the turnover rate of the stratum corneum is required to exhibit the above-mentioned skin aging prevention effect.

In such a background, γ-amino-β-
It has been disclosed that a skin cosmetic containing hydroxybutyric acid (hereinafter abbreviated as GABOB) enhances the skin function by the peripheral vasodilatory action of the skin and has an antiaging effect (Japanese Patent Application Laid-Open No. 62-255405).

[0005] However, a detailed examination of this skin cosmetic revealed that the skin cosmetic comprising GABOB alone as an active ingredient had an anti-aging effect of slow action. For example, in the case of cream, the effect appears after six months of continuous use, and in the case of lotion, the effect appears after eight months, so that it is not always satisfactory, and there is still room for improvement.

In view of such circumstances, as a result of intensive studies on the search for a skin aging preventive cosmetic which does not have such problems, the present invention was found. That is, the present invention provides an excellent skin aging prevention effect (rough skin improvement effect, keratin improvement effect, effect of increasing turnover speed, beautiful skin effect) in a very short time of 1 to 2 months after the start of continuous application, Another object of the present invention is to provide a long-acting, fast-acting skin aging preventive cosmetic.

[0007]

In order to achieve the above-mentioned object, the skin aging preventive cosmetic of the present invention comprises γ-amino-β
-Characterized by comprising at least one kind of hydroxybutyric acid and a salt thereof, and at least one kind of collagen and elastin.

[0008] GABOB used in the present invention is a known substance and has been applied as a therapeutic agent for cerebral arteriosclerosis.
Its chemical properties are as follows:

[0009]

[Table 1]

GABOB potassium salt (abbreviated as GABOB-K), sodium salt (abbreviated as GABOB-Na), GABOB obtained by neutralizing GABOB with caustic potash, caustic soda, calcium hydroxide or magnesium hydroxide. Both calcium salt (abbreviated as GABOB-Ca) and magnesium salt (abbreviated as GABOB-Ca) have the same skin tissue activating effect, whitening effect, and old wrinkle effect as free GABOB. Applied to the invention.

[0011] Collagen and elastin used in the skin aging preventive cosmetic of the present invention are also known substances, such as cartilage,
It is widely distributed in animals as a structural component of joints, eyes, skin and other connective tissues.

GABO in the anti-aging cosmetic composition of the present invention
Assuming that the compounding amounts of B and its salt (a), collagen and elastin are (a) and (b), respectively, (a) is 0.05 to 2.0% by weight (hereinafter referred to as wt%) based on the total amount. ) And (b) may be 0.001 to 1.0 wt%. If the amount is less than the lower limit of each compounding amount, the desired effect of the present invention is not sufficient. , It becomes difficult to hold individual dosage forms.

[0013] In addition to the above-mentioned raw materials, the cosmetic of the present invention includes tar pigments, coloring pigments such as iron oxide, preservatives such as paraben, fatty acid soap, sodium cetyl sulfate, sodium N-stearoyl-L-glutamate and the like. Nonionic surfactants such as anionic surfactants, polyoxyethylene alkyl ethers, polyoxyethylene fatty acid esters, polyoxyethylene polyhydric alcohol fatty acid esters, polyoxyethylene hydrogenated castor oil, polyhydric alcohol fatty acid esters, and polyglycerin fatty acid esters Agents, cationic surfactants such as tetraalkylammonium salts,
Betaine type, sulfobetaine type, amphoteric surfactants such as sulfoamino acid type, natural surfactants such as lecithin, lysophosphatidylcholine, pigments such as titanium oxide,
An antioxidant such as dibutylhydroxytoluene and the like can be appropriately compounded as long as the object of the present invention is achieved.

[0014]

The present invention will be described below with reference to examples. Prior to the examples, (1) a method for measuring the turnover speed of the stratum corneum, (2) a test method for measuring the effect of improving rough skin, (3) a test method for measuring the effect of improving stratum corneum, and a test method for (4) a sensory test are described. I do.

(1) Method for measuring the turnover rate of the stratum corneum 5 wt% of a fluorescent dye, dansyl chloride, was added to white petrolatum.
% Ointment is prepared and occluded in the skin of the subject's forearm for 24 hours, and dansyl chloride is penetrated into the stratum corneum. Thereafter, the test sample was applied to the same site twice a day (morning and evening), and the fluorescence of dansyl chloride was examined every day. The number of days until the fluorescence disappeared was defined as the turnover speed of the skin stratum corneum. The turnover speed of the normal skin stratum corneum is 14 to 16 days, but extends around 18 days in aged skin. In contrast, when the anti-aging effect appears, 1
It is shortened to around 2-3 days.

(2) Method for Measuring the Effect of Improving Rough Skin The effect of continuous application for four weeks was examined on 20 middle-aged and elderly subjects having rough skin on the lower leg. About 1 g of a sample was applied to the test site of the left lower leg of the subject twice a day, and the skin condition before and after the test was judged according to the following criteria.
The lower right leg served as a control without the application of the sample.

[0017]

[Table 2]

By comparing the results of judgment between the test site before and after the test and the control site, if the degree of dryness of the skin is improved by two or more stages (eg; + →-, ++ → ±), “effective” is improved by one stage. "Slightly valid" for cases, "Disabled" for no change
And The test results were indicated by the number of subjects who became “effective” and “slightly effective”.

(3) Method for measuring the effect of improving keratin (enhancing the anti-peeling properties of keratinocytes) A scotch tape (Nichiban Mending tape) is adhered to the skin of the test area before and after the test of the above-described effect of improving rough skin and after the test is completed. When this was peeled off, the state of the keratinocytes attached to the tape was examined in detail by a scanning electron microscope,
The stratum corneum exfoliating property was classified according to the following criteria, and the effect of improving the keratin was determined.

[0020]

[Table 3]

Judgment was made when the difference between the evaluation point of the test site and that of the control site after continuous application for 4 weeks was 2 or more, “valid”, 1 or more, “slightly effective”, and 0 point. "Invalid". The test results were indicated by the number of subjects who became “effective” and “slightly effective”.

(4) Sensory test (Beauty skin effect test) Female subjects complaining of rough skin, fine wrinkles, dry skin, etc.
The sample was applied twice a day (morning and evening) to 20 persons (55 years old) for 3 consecutive months, and the effect after 1, 2, and 3 months was evaluated. The test results answered that "skin was moistened", "skin became smooth", and "skin became tight" for each item of skin wettability, smoothness, and elasticity. Indicated by the number of people.

Examples 1 to 5 and Comparative Examples 1 to 7 [Skin Cream] γ-amino-β-hydroxybutyric acid and a salt thereof, and at least one of collagen and elastin are blended as shown in Table 4, Each skin cream was prepared with the composition shown in Table 5, and the above-described experiments were performed.

[0024]

[Table 4]

(1) Composition

[Table 5]

(2) Preparation method The components (B) and (C) are uniformly heated and dissolved to a temperature of 8
After the temperature is reduced to 0 ° C., the component (A) is mixed and dissolved in the component (C), and then the component (B) is charged and mixed with stirring. afterwards,
The temperature was cooled to 30 ° C. with stirring to obtain the desired cream.

(3) Characteristics Table 4 shows the results of various tests conducted on each skin cream. As shown in Table 4, the skin creams of Comparative Examples 1 to 7 containing only collagen, elastin, or γ-amino-β-hydroxybutyric acid and a salt thereof alone cannot provide sufficient effects in various properties. Embodiment 1 of the invention
~ 5 collagen, at least one of elastin and γ-
At least one of amino-β-hydroxybutyric acid and salts thereof
The skin cream containing the seed showed a remarkable effect on various properties, and showed an excellent skin effect 1 to 2 months after the sample application in the sensory test.

Examples 6 and 7 [Two-layer lotion] In the same manner as in the above examples, various tests were carried out by preparing each two-layer lotion with the following composition.

(1) Composition

[Table 6]

(2) Preparation Method After the component (A) is mixed and dissolved in the component (B), the mixture is stirred with the component (C), dispersed and then filled into a container. When used, the contents are shaken and dispersed uniformly.

(3) Characteristics Also in Examples 6 and 7, good results were shown in all of the above tests.

[0032]

As described above, the present invention provides a useful skin aging preventive cosmetic which is excellent in skin aging prevention effect (rough skin improvement effect, keratin improvement effect, effect of increasing turnover speed, beautiful skin effect, etc.). It is clear to offer.

Claims (1)

(57) [Claims] 1. A skin anti-aging cosmetic comprising at least one of γ-amino-β-hydroxybutyric acid and a salt thereof, and at least one of collagen and elastin.