JP3632162B2 - Skin cosmetics - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a skin cosmetic that is particularly excellent in a whitening effect, and further excellent in a rough skin preventing effect and an antiaging effect.
[0002]
[Prior Art and Problems to be Solved by the Invention]
Ultraviolet rays cause inflammation (erythema) and rough skin, and various factors are released to stimulate melanocytes and cause pigmentation. In addition, long-wavelength ultraviolet rays reach the dermis and cause skin aging by losing skin flexibility over a long period of time.
[0003]
Conventionally, anti-inflammatory agents such as whitening agents such as L-ascorbic acid and its derivatives, hydroquinone derivatives, pyrones such as kojic acid, placenta extracts such as placenta extract, and glycyrrhizins have been used for damage caused by ultraviolet rays. Formulated skin cosmetics have been used. However, these substances often have insufficient storage stability and the effect of preventing inflammation due to ultraviolet rays has not been sufficiently observed.
[0004]
On the other hand, it is known that specific biphenyl compounds have a tyrosinase activity inhibitory effect and a melanin production inhibitory effect (Japanese Patent Laid-Open Nos. 6-145040 and 7-25743). However, the whitening effect was not satisfactory even when this was blended alone.
[0005]
Accordingly, as a result of intensive studies, the present inventors have found that skin cosmetics containing at least one selected from glycyrrhizinate, glycyrrhetinic acid, and esters of glycyrrhetinic acid and at least one specific biphenyl compound are particularly whitening. The present invention has been completed by finding that it is excellent in effect, and further excellent in rough skin prevention and anti-aging effects.
[0006]
An object of the present invention is to provide a skin cosmetic that is particularly excellent in a whitening effect, and further excellent in a rough skin preventing effect and an antiaging effect.
[0007]
[Means for Solving the Problems]
The present invention that achieves the above object provides at least one selected from glycyrrhizinate, glycyrrhetinic acid, and esters of glycyrrhetinic acid, and at least one selected from biphenyl compounds represented by the following general formulas (1) and (2) A skin cosmetic containing
[0008]
[Chemical 3]
[0009]
(However, R ¹ is a substituent of CH ₃ , C ₂ H ₅ , C ₃ H ₇ , CH ₂ OH, C ₃ H ₆ OH, CH ₂ CH═CH ₂ )
[0010]
[Formula 4]
[0011]
(However, R ² is a hydrogen atom or a linear or branched saturated hydrocarbon group having 1 to 8 carbon atoms.)
[0012]
DETAILED DESCRIPTION OF THE INVENTION
Hereinafter, embodiments of the present invention will be described in detail.
[0013]
Examples of glycyrrhizinate used in the present invention include monosodium salt, monopotassium salt, monoammonium salt, dipotassium salt of 18α-glycyrrhizic acid, and monosodium salt, monopotassium salt, monoammonium salt of 18β-glycyrrhizic acid, Although a dipotassium salt etc. can be mentioned as a particularly preferable thing, it is not limited to these.
[0014]
Examples of glycyrrhetinic acid used in the present invention include 18α-glycyrrhetinic acid and 18β-glycyrrhetinic acid.
[0015]
Examples of the ester of glycyrrhetinic acid used in the present invention include stearyl of 18α-glycyrrhetinic acid and stearyl of 18β-glycyrrhetinic acid, which are not particularly limited.
[0016]
The content of these glycyrrhizinate, glycyrrhetinic acid, and esters of glycyrrhetinic acid is preferably 0.001 to 30.0% by weight based on the total amount of prescription ingredients of the cosmetic.
[0017]
The biphenyl compound used in the present invention is a known substance, and specific examples thereof include dehydrodichloroeosol, dehydrodioigenol, tetrahydromagnolol and the like (Journal of Organic Chemistry, 28, 1048, 1963). : Journal of the Chemical Society of Japan, Vol. 87, No. 6, 603, 1966).
[0018]
The blending amount is preferably 0.0001 to 20% by weight based on the total amount of the cosmetic.
In addition to the above raw materials, pigments, fragrances, preservatives, surfactants, antioxidants, moisturizers and the like can be appropriately blended in the cosmetic of the present invention within the scope of achieving the object of the present invention.
[0020]
Examples of the dosage form of the cosmetic of the present invention include creams, emulsions, lotions and packs. For example, in the case of a milky lotion, this cosmetic can be produced by an ordinary method in which an oil phase and an aqueous phase are each dissolved by heating and emulsified and cooled.
[0021]
【Example】
Hereinafter, the present invention will be described in detail based on examples and comparative examples. In addition,% shown in an Example is weight%. The skin color lightness recovery test method, wrinkle formation inhibition test method (anti-aging effect), measurement method for rough skin improvement effect, and sensory evaluation test described in Examples are as follows.
[0022]
In addition, the name of the biphenyl compound in an Example is described as follows with the difference of R < ¹ >, R < ² > of the said general formula.
Biphenyl compound 1 (R ¹ ; CH ₃ ), biphenyl compound 2 (R ¹ ; C ₂ H ₅ ), biphenyl compound 3 (R ¹ ; C ₃ H ₇ ), biphenyl compound 4 (R ¹ ; CH ₂ OH), biphenyl Compound 5 (R ¹ ; C ₃ H ₆ OH), biphenyl compound 6 (R ¹ ; CH ₂ CH═CH ₂ ), biphenyl compound 7 (R ² ; CH ₃ ), biphenyl compound 8 (R ² ; C ₂ H ₅ ), Biphenyl compound 9 (R ² ; C ₃ H ₇ ), biphenyl compound 10 (R ² ; iso-C ₃ H ₇ ), biphenyl compound 11 (R ² ; C ₈ H ₁₇ ), biphenyl compound 12 (R ² ; H).
[0023]
(1) Skin lightness recovery test method The back skin of 20 subjects was irradiated with UV rays in the UV-B region twice as much as the minimum erythema amount, the sample application site and the non-application site were set, and the standard brightness of each skin ( (V ₀ value, V ₀ ′ value) were measured. Subsequently, after continuously applying the sample to the application site twice a day for 15 weeks, the brightness of the skin at the application site and non-application site after 3, 6, 9, 12, 15 weeks (Vn value, Vn ′ value) The skin color recovery was evaluated according to the following criteria.
The lightness of the skin (Munsell color system V value) was calculated from X, Y, and Z values obtained by measurement with a high-speed spectral colorimeter. Moreover, evaluation was shown with the average value of the evaluation score after 20 weeks about 20 test subjects.
[0024]
(2) Wrinkle formation inhibition test using hairless mice Ten hairless mice (HR / ICR, 6 weeks of age at the start of the experiment) were used, and 80 μl of the sample was applied to the back. After 2 hours, wipe off the sample on the skin surface with 70% ethanol, prepare six health line lamps (Toshiba, SE20), and adjust the irradiation dose to 1 MED or less to UV-B. The sample was applied immediately after light irradiation. This operation was performed 5 times a week for 16 weeks. The amount of irradiation energy was measured using a UV-Radiometer (manufactured by TOKYO OPTICAL, UVR-305 / 365D). After the test, the frequency of wrinkles was evaluated with the naked eye according to the following criteria (wrinkle index). The test result was shown by the average of evaluation points.
[0025]
(3) Measurement test method for effect of improving rough skin The effect of continuous application was examined for 20 middle-aged and older subjects having rough skin on the lower leg for 4 weeks. About 1 g of a sample was applied to the subject's left lower leg test site twice a day, and the skin condition before and after the test was determined according to the following criteria. The lower right leg was used as a control with no sample applied.
The judgment results of the test site before and after the test and the control site are compared, and when the skin dryness is improved by two or more levels (for example, + → −, ++ → ±) is “effective”, and when the level is improved by 1 level, “Slightly effective” and “invalid” when there was no change. The test result was shown by the number of subjects who became “effective” and “slightly effective”.
[0026]
(4) Sensory test The characteristics of the sample after 20 test subjects were used for 10 days were evaluated. The evaluation was shown by the number of respondents who answered “Skin became smooth”, “I felt a whitening effect”, and “Skin was stretched” for questionnaire items on smoothness, whitening effect, and elasticity. .
[0027]
Examples 1-12, Comparative Examples 1-10
Glycyrrhizinate, glycyrrhetinic acid, esters of glycyrrhetinic acid and a biphenyl compound were blended in the composition shown in Table 1, and a skin cream was prepared based on the following preparation method. The above test was carried out for each, and the results are shown in Tables 2 and 3.
Composition [0028]
[Table 1]
[0029]
[Table 2]
[0030]
[Table 3]
[0031]
Preparation method (A) (B) is uniformly dissolved at 70 ° C., and (B) is injected into (A) while emulsifying and dispersing while stirring (A), and then cooled to 30 ° C. with stirring. Prepare.
[0032]
Characteristics The skin creams of Examples 1 to 12 of the present invention showed good results in the above tests. On the other hand, the skin creams of Comparative Examples 1 to 10 were inferior to the examples of the present invention because sufficient effects were not recognized.
[0033]
Example 13 [Skin Lotion]
The skin lotion of the present invention was prepared by the following production method according to the composition shown in Table 4.
Composition [0034]
[Table 4]
[0035]
The components of preparation methods (A) and (B) were mixed and dissolved, and (B) was added to (A) and mixed and stirred.
[0036]
Properties The skin lotion of Example 13 showed good results in the above tests.
[0037]
【The invention's effect】
As described above, it is apparent that the present invention provides a skin cosmetic that is particularly excellent in the whitening effect, and further excellent in the rough skin prevention effect and the antiaging effect.

Claims (1)

A skin cosmetic containing at least one selected from glycyrrhizinate, glycyrrhetinic acid, and esters of glycyrrhetinic acid and at least one selected from biphenyl compounds represented by the following general formulas (1) and (2).