JP3632164B2 - Skin cosmetics - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a skin cosmetic that is particularly excellent in whitening effect, and that exhibits excellent skin roughness preventing effect, anti-aging effect and skin beautifying effect, and can keep skin healthy.
[0002]
[Prior Art and Problems to be Solved by the Invention]
Conventionally, cosmetics intended for prevention and treatment of skin spots, freckles, and the like have been formulated with L-ascorbic acid and its derivatives, hydroquinone derivatives such as arbutin, and pyrones such as kojic acid.
[0003]
These substances have effects such as inhibition of melanin production and light color bleaching of the produced melanin, and are widely known as substances having a whitening effect. However, in these substances, for example, L-ascorbic acid and its derivatives often meet with insufficient storage stability, and the anti-inflammatory effect by ultraviolet rays is often not sufficiently observed. Hydroquinone derivatives and pyrones have problems such as insufficient safety. As described above, it has been difficult to obtain a cosmetic material that is comprehensively excellent in whitening, such as a melanin production inhibitory effect, a melanin lightening effect, an inflammation prevention effect, and safety.
[0004]
On the other hand, it is known that specific biphenyl compounds have a tyrosinase activity inhibitory effect and a melanin production inhibitory effect (Japanese Patent Laid-Open Nos. 6-145040 and 7-25743). However, even when this was blended alone, the whitening effect was not satisfactory.
[0005]
Therefore, as a result of intensive studies, the present inventors have found that a skin cosmetic preparation containing an epidermal cell ceramide synthesis promoting substance and a specific biphenyl compound suppresses the production of melanin due to UV damage and synthesizes ceramide, a lipid of the epidermis. It was found that it promotes skin metabolism and, as a result, promotes melanin excretion and exhibits an excellent whitening effect. Furthermore, the present inventors have found that it exhibits excellent skin roughness prevention effects, anti-aging effects, and skin beautifying effects such as preventing skin dryness and preventing skin roughness and wrinkles, and has completed the present invention.
[0006]
An object of the present invention is to provide a skin cosmetic that is particularly excellent in whitening effect, and that exhibits excellent skin roughness prevention effect, anti-aging effect and skin beautifying effect, and can keep skin healthy.
[0007]
[Means for Solving the Problems]
The present invention that achieves the above object is a skin cosmetic containing an epidermal cell ceramide synthesis promoting substance and at least one selected from biphenyl compounds represented by the following general formulas (1) and (2).
[0008]
[Chemical 3]
[0009]
(However, R ¹ is a substituent of CH ₃ , C ₂ H ₅ , C ₃ H ₇ , CH ₂ OH, C ₃ H ₆ OH, CH ₂ CH═CH ₂ )
[0010]
[Formula 4]
[0011]
(However, R ² is a hydrogen atom or a linear or branched saturated hydrocarbon group having 1 to 8 carbon atoms.)
[0012]
DETAILED DESCRIPTION OF THE INVENTION
Hereinafter, embodiments of the present invention will be described in detail.
[0013]
Examples of nicotinic acid and derivatives thereof as epidermal cell ceramide synthesis promoting substances used in the present invention include nicotinic acid, nicotinic acid amide, methyl nicotinic acid, ethyl nicotinic acid, benzyl nicotinic acid, tocopherol nicotinate, and nitricate citrate. Examples of nicotinyl alcohol and salts thereof include nicotinyl alcohol and nicotinyl alcohol tartrate, but are not limited thereto.
[0014]
The content of the epidermal cell ceramide synthesis promoting substance is preferably 0.001 to 20.0% by weight based on the total amount of prescription ingredients of cosmetics.
The biphenyl compound used in the present invention is a known substance, and specific examples thereof include dehydrodichloroeosol, dehydrodioigenol, tetrahydromagnolol and the like (Journal of Organic Chemistry, 28, 1048, 1963). : Journal of the Chemical Society of Japan, Vol. 87, No. 6, 603, 1966).
[0016]
The blending amount is preferably 0.0001 to 20% by weight in the total amount of the cosmetic.
[0017]
In the cosmetic of the present invention, in addition to the above-mentioned raw materials, pigments, fragrances, preservatives, surfactants, antioxidants, moisturizers and the like can be appropriately blended within the scope of achieving the object of the present invention. .
[0018]
Examples of the dosage form of the cosmetic of the present invention include creams, emulsions, lotions and packs. For example, in the case of a milky lotion, this cosmetic can be produced by an ordinary method in which an oil phase and an aqueous phase are each dissolved by heating and emulsified and cooled.
[0019]
【Example】
Hereinafter, the present invention will be described in detail based on examples and comparative examples. In addition,% shown in an Example is weight%. The skin lightness recovery test method, wrinkle formation suppression test method (anti-aging effect), rough skin improvement effect measurement method, and sensory test (skin-beautifying effect) described in Examples are as follows.
[0020]
In addition, the name of the biphenyl compound in an Example is described as follows with the difference of R < ¹ >, R < ² > of the said general formula.
Biphenyl compound 1 (R ¹ ; CH ₃ ), biphenyl compound 2 (R ¹ ; C ₂ H ₅ ), biphenyl compound 3 (R ¹ ; C ₃ H ₇ ), biphenyl compound 4 (R ¹ ; CH ₂ OH), biphenyl Compound 5 (R ¹ ; C ₃ H ₆ OH), biphenyl compound 6 (R ¹ ; CH ₂ CH═CH ₂ ), biphenyl compound 7 (R ² ; CH ₃ ), biphenyl compound 8 (R ² ; C ₂ H ₅ ), Biphenyl compound 9 (R ² ; C ₃ H ₇ ), biphenyl compound 10 (R ² ; iso-C ₃ H ₇ ), biphenyl compound 11 (R ² ; C ₈ H ₁₇ ), biphenyl compound 12 (R ² ; H).
[0021]
(1) Skin lightness recovery test method The back skin of 20 subjects was irradiated with UV rays in the UV-B region twice as much as the minimum erythema amount, the sample application site and the non-application site were set, and the standard brightness of each skin ( (V ₀ value, V ₀ ′ value) were measured. Subsequently, after continuously applying the sample to the application site twice a day for 15 weeks, the brightness of the skin at the application site and non-application site after 3, 6, 9, 12, 15 weeks (Vn value, Vn ′ value) The skin color recovery was evaluated according to the following criteria.
The lightness of the skin (Munsell color system V value) was calculated from X, Y, and Z values obtained by measurement with a high-speed spectral colorimeter. The evaluation was shown as an average value of evaluation points after 6 weeks for 20 subjects.
[0022]
(2) Wrinkle formation inhibition test using hairless mice Ten hairless mice (HR / ICR, 6 weeks of age at the start of the experiment) were used, and 80 μl of the sample was applied to the back. After 2 hours, wipe off the sample on the skin surface with 70% ethanol, prepare 6 health line lamps (Toshiba, SE20), and adjust each dose to 1 MED or less, UV-B The sample was applied immediately after light irradiation. This operation was performed 5 times a week for 16 weeks. The irradiation energy charge was measured using a UV-Radiometer (manufactured by TOKYO OPTICAL, UVR-305 / 365D). After the test, the frequency of wrinkles was evaluated with the naked eye according to the following criteria (wrinkle index). The test result was shown by the average of evaluation points.
[0023]
(3) Measurement test method for effect of improving rough skin The effect of continuous application was examined for 20 middle-aged and older subjects having rough skin on the lower leg for 4 weeks. About 1 g of a sample was applied to the subject's left lower leg test site twice a day, and the skin condition before and after the test was determined according to the following criteria. The lower right leg was used as a control with no sample applied.
The judgment results of the test site before and after the test and the control site are compared, and when the skin dryness is improved by two or more levels (for example, + → −, ++ → ±) is “effective”, and when the level is improved by 1 level, “Slightly effective” and “invalid” when there was no change. The test result was shown by the number of subjects who became “effective” and “slightly effective”.
[0024]
(4) Sensory test The characteristics of the sample after 20 test subjects were used for 10 days were evaluated. The evaluation was shown by the number of respondents who answered “Skin became smooth”, “I felt a whitening effect”, and “Skin was stretched” for questionnaire items on smoothness, whitening effect, and elasticity. .
[0025]
Examples 1-12, Comparative Examples 1-10
An epidermal cell ceramide synthesis promoting substance and a biphenyl compound were blended in the composition shown in Table 1, and a skin cream was prepared based on the following preparation method. The above test was carried out for each, and the results are shown in Tables 2 and 3.
Composition [0026]
[Table 1]
[0027]
[Table 2]
[0028]
[Table 3]
[0029]
Preparation method (A) (B) is uniformly dissolved at 70 ° C., and (B) is injected into (A) while emulsifying and dispersing while stirring (A), and then cooled to 50 ° C. with stirring. (C) is added and cooled to a temperature of 30 ° C.
[0030]
Characteristics The skin creams of Examples 1 to 12 of the present invention showed good results in the above tests. On the other hand, the skin creams of Comparative Examples 1 to 10 were inferior to the examples of the present invention because sufficient effects were not recognized.
[0031]
Example 13 [Skin Lotion]
The skin lotion of the present invention was prepared by the following production method according to the composition shown in Table 4.
Composition [0032]
[Table 4]
[0033]
The components of preparation methods (A) and (B) were mixed and dissolved, and (B) was added to (A) and mixed and stirred.
[0034]
Properties The skin lotion of Example 13 showed good results in the above tests.
[0035]
【The invention's effect】
As described above, the present invention provides an excellent skin cosmetic that is particularly excellent in whitening effect, and that exhibits excellent skin roughness prevention effect, anti-aging effect and skin beautifying effect, and can keep the skin healthy. it is obvious.

Claims (1)

At least one epidermal cell ceramide synthesis promoter selected from the group consisting of nicotinic acid, nicotinic acid amide, methyl nicotinic acid, ethyl nicotinic acid, benzyl nicotinic acid, tocopherol nicotinate, nicamethate citrate, nicotinyl alcohol and salts thereof ; A skin cosmetic containing at least one selected from biphenyl compounds represented by the following general formulas (1) and (2).