JPS6156114A - Cosmetic for preventing skin aging - Google Patents

Abstract

PURPOSE:The titled cosmetic having immediate effect and dulability, comprising a specific alicyclic compound and a specified substance such as gamma-aminobutyric acid, water-soluble collagen, etc. CONSTITUTION:The titled cosmetic comprising (A) a compound selected from 6-(50methylxyhept-1-yl)-bicyclo-[3,3,0]octan-3-one, 6-(5-ethyoxyhept-1-yl)bycylo- [3,3,0]octan-3-one, and 6-(5-hydroxyhept-1-yl)-bicyclo-[3,3,0]octan-3-yl, and (B) a blood circulation promoter or a cell activator selected from gamma-aminobutyric acid, vitamin E orotate, diisopropylamini dichloroacetate, hyaluronic acid, elastin, water-soluble collagen, extract of Japanese green gentian, ginseng ectract. Synergistic effect of both the components shows effects such s improvement in chapped skin, improvement in keratin, reduction in wrinkles, increase in turnover rate of skin or keratin layer, etc. in a short period.

Description

Detailed Description of the Invention (Industrial Application Field) The present invention relates to cosmetics for preventing skin aging (skin cosmetics used for preventing skin aging). +1:1 reforming effect, effect of increasing the turnover rate of the stratum corneum, reduction of wrinkles, etc.).

(Conventional technology)

Aging skin is dry, smooth, rough, and rough skin with peeling of corneocytes, a high collagen/elastin ratio, and many wrinkles in the connective phase. It is said that aging skin has a slow turnover rate due to a decrease in cell metabolism, and therefore, when an anti-aging effect is imparted to the skin, the turnover rate becomes faster. Special edition 1986-5007
Publication No. 70 describes that certain alicyclic compounds have the effect of reducing wrinkles in the skin by reducing the production of collagen and promoting the production of elastin.

However, the specific alicyclic compound alone only has an effect of promoting elastin formation, and has a satisfactory effect on skin aging. It is difficult to obtain, and the effect is temporary.

10,000, Japanese Patent Publication No. 58-26726 discloses that amine acetic acid compounds enhance skin functions by dilating the skin's peripheral blood vessels and have an anti-aging effect.

However, with γ-aminobutyric acid compounds alone, the anti-aging effect on the skin is slow-acting, and in the case of creams, after 6 months,
In the case of lotions, the effects do not appear until three months later, and they do not have the effect of lowering the collagen/elastin ratio of connective tissue to reduce wrinkles in the skin.

(Problems to be Solved by the Invention) The present inventors, in an attempt to improve the drawbacks of the prior art,
After extensive research, we found that when both the specific alicyclic compound listed below and the specific compound listed below are used together in the base of skin cosmetics, The synergistic effect of both of them results in excellent anti-aging effects on the skin (improves rough skin, improves keratin, lowers the collagen/elastin ratio of connective tissue, reduces wrinkles, and speeds up turnover rate). The present invention was completed based on the discovery that it is possible to obtain a cosmetic product for preventing skin aging that is fast-acting and long-lasting, and which develops in a very short period of time, such as one month after the start of use.

(First Means to Solve the Problems) That is, the present invention provides 6-(5-methoxyhept-1-
yl)-bicyclo-[3,3,01 octane-3-one (hereinafter referred to as 1 of the alicyclic compound), 6-(5-ethoxyhept-1-yl)-bicyclo-[3,3,03 octane- 3-one 0] octan-3-one f (hereinafter referred to as alicyclic compound 3); ) is a cosmetic for preventing skin aging.

The amount of the specific alicyclic compound blended is 0.0001 to 3.0 weight λ%, preferably 0.001 to 0.5 weight M%, based on the total weight of the cosmetic composition. The blending amount is 0.01
At 101% by weight, the effect aimed at by the present invention is not sufficient, and on the other hand, even if it exceeds 3.0% by weight, no improvement in the effect can be expected in proportion to the increase.

Among the above-mentioned specific blood circulation promoters or cell activators, the manufacturing method for the natural product extracts such as Oriental japonica extract and Korean ginseng extract is not specified, but a summary of each manufacturing method is as follows. It is.

[Production method of Aspergillus japonica extract]

Swertia Japonica Mak
This is an extract obtained by digesting the dry and pulverized whole plant of P. ino) in the flowering stage in ethanol or aqueous ethanol and filtering it. In the examples, an extract obtained by the method described below was used.

50 pe of crushed Aspergillus aqueous ethanol (ethanol 9
0wt%) 250 ml was digested at a temperature of 40 to 50°C, filtered and separated, and the residue was digested in the same manner several times. I got it. This was concentrated under reduced pressure, 100 m/ml of purified water was added to the residue, and after aging for 1 week, the insoluble portion was filtered off, and the extract was concentrated under reduced pressure.
Next, ethanol was added to adjust the ethanol content of the extract to 40 wt%, and the volume was adjusted to 100 ml! Obtain 1 piece of Aspergillus japonica extract.

[Production method of Korean ginseng extract] Panax ginseng (Panax ginseng CA,
This is an extract obtained by cold soaking a 5- to 6-year-old dried and crushed root of A. Meyer) in ethanol or water-containing ethanol and filtering it. In the examples, an extract obtained by the following method was used.

50 y of crushed Panax carrots were cold soaked in 200 ml of aqueous ethanol (90 wt% ethanol) for 1 week, filtered, and the ethanol of the resulting extract was distilled off, and purified water was added to make the ethanol content of the extract 50 wt%. This was further aged in a cold place for 7 to 10 weeks, and then filtered to obtain 100 ml of Korean carrot extract.
child.

The amount of the specific blood circulation promoter or cell activator to be blended into the cosmetic of the present invention is adjusted as appropriate depending on its effect or the dosage form of the cosmetic, but is usually shown in Table 1 below. The blending amount is suitable. The amount of compounding is 1 part based on the company's cosmetic composition.

Table 1 The cosmetics for preventing skin aging of the present invention are as specified above!
The alicyclic compound and the specific blood circulation promoter or cell activator may be directly added to a skin cosmetic base such as a cream, emulsion, or lotion, or these compounds may be added to an oil phase component or an aqueous phase component. It is prepared by dissolving and blending ingredients in a solvent such as alcohol, and performing treatments such as emulsification, mixing, dispersion, dissolution, and solubilization.

(Effect of the invention) The cosmetic for preventing skin aging of the present invention is
- JRt = Ruf # Bu Enhances skin function, prevents skin wrinkles, makes skin smooth and moisturized, and has excellent skin aging prevention effects (improving rough skin, improving keratin) It can produce remarkable effects, such as synergistically developing and sustaining the effect of increasing the turnover rate and speeding up the turnover rate.

(Example) Examples will be described below.

Note that % shown in Examples means % of weight.

Method for measuring turnover rate of stratum corneum described in Examples,
The test method for measuring the rough skin improvement effect and the measurement test method for the keratin improvement effect are as follows.

(1) Method for measuring turnover rate of stratum corneum Mix 5% by weight of tanzyl chloride, a fluorescent dye, in white vaseline = 7- to make one ointment, and apply it to the skin of the subject's forearm for 24 hours as an occlusive patch. and allows danzyl chloride to penetrate and bind to the stratum corneum. After that, apply to the same area twice a day (morning and
Evening) Apply the test sample, check the fluorescence of danzyl chloride every day, and count the number of days until the fluorescence disappears as the turnover rate of the skin's stratum corneum. Note that the normal turnover rate of the stratum corneum of the skin is 14 to 16 days, but in aged skin, the turnover rate increases to around 18 days. On the other hand, if the anti-aging effect appears, the time will be shortened to around 12 days.

(2) Test method for measuring the effect of improving rough skin.
The condition of the skin before and after the test was evaluated according to the criteria in Table 2. No sample was applied to the right lower leg as a control.
child.

Table 2 Judgment criteria for skin dryness -: Normal ±: Slight dryness, no flaking 12 Dryness, mild flaking ++: Moderate dryness, flaking 10+10: Dryness, marked desquamation Judgment of test and control areas before and after the test Compare the results and if the skin dryness has improved by two or more levels (e.g. +-1,
10 + → ±) is "valid", 1 step improved y, = case is "
If there is no change, it is considered ``slightly effective'', and if there is no change, it is ``invalid''.

Additionally, there were no cases of skin dryness during the test period.

(3) Test method for measuring the effect of improving keratin (increasing the anti-peeling properties of keratinocytes) A scotch tape (Tiban mending tape) is adhered to the test area skin before and after the above-mentioned rough skin improvement measurement test, and this is peeled off. The condition of the keratinocytes attached to the tape was examined in detail using a full-scanning electron microscope.
According to the criteria in the table, the skin keratin cell anti-exfoliation property is separated [7], and the keratin improving effect is determined.

Table 3 Judgment criteria for keratin education effect (increased anti-desquamation property of keratinocytes) Evaluation points 1 Two scales not recognized # 2: Small scale scattered 1 3: Small to medium scale noticeable # 4: Large scale noticeable Table 3 is 4 If the difference between the evaluation score of the test site and that of the control site after weekly continuous application is 2 points or more, it is considered "effective", if it is 1 point, it is "slightly effective", and if it is 0 points, it is "invalid".

In addition, each skin milk with the formulation shown in Table 3 above in Table 4 was prepared by the above-mentioned method and the evaluation score of the test site was higher than that of the control site. Test results of skin anti-aging effects (improving effect on rough skin, improving effect on dead skin cells, turnover rate of stratum corneum) of each skin cream of Example 1 and Comparative Example 3 are shown in Tables 5 to 7. Regarding the test results of the skin aging prevention effect of Comparative Example 1 and Comparative Example 2, see Part 8.
Shown in the table.

Table 5: Skin anti-aging effects of one skin milk containing one of the alicyclic compounds 1 Table 6: Skin anti-aging effects of one skin milk containing one of the alicyclic compounds 2 Table 7; Table 8: Anti-aging effect on the skin of skin milk containing one of the alicyclic compounds 3: Preventing skin aging effect of skin milk containing no alicyclic compound Table 5 to Table 8 Summary 11t! As is clear from the above □ specific alicyclic compound
~3) and the aforementioned blood circulation promoter or cell activator elastin, water-soluble collagen, Oriental japonica extract, ω'' fresh carrot extract) and the skin milk of the present invention (Example 1-1 to Example 1). 1-24), the skin aging prevention effects (improving rough skin, improving keratin, and increasing the turnover rate of the stratum corneum by 5%) are synergistically improved and expressed.

On the other hand, if only the specific alicyclic compound is blended, f
The skin milk of Comparative Example 3 (Comparative Examples 3-1 to 3-3) and the above-mentioned blood circulation promoter or cell activator were blended together. In Example 2-8), the effect of preventing skin aging is low. and,
The skin milk (skin milk base) of Comparative Example 1 that does not contain (combined) both the specific alicyclic compound and the blood circulation promoter or cell activator has no skin aging prevention effect.

Next, each of the skin milks mentioned above was given to 50 subjects (women aged 25 to 45) who had problems with fine lines twice a day (in the morning,
Evening) Continuous: Apply the application for 3 months, and the results (practical test results) after 1 month and 3 months are shown in Tables 9 to 16.
The table shows T,=.

Table 9: Practical test results of 1 skin milk containing 1 of the above alicyclic compound (after 1 month) Table 10: Results of practical test of 1 skin milk containing 1 of the above alicyclic compound Results (after 3 months) Table 11: Practical test results of skin milk containing 2 of the above alicyclic compounds (after 1 month) Table 12: Previous il[l! Results of next month's test of 1 skin milk containing 2 (after 3 months) Table 13: Practical test results of 1 skin milk containing 3 of the above alicyclic compound (after 1 month) Table 14 :Results of a practical test of skin milk containing 3 of the above alicyclic compounds (after 3 months) ~ +l Table 15 2 Results of a practical test of skin milk containing no alicyclic compounds mentioned above (after 1 month) Table 16: Practical test results of the skin milk without the alicyclic compound (after 3 months) Skin cream of the present invention (Example 1-1)
In Examples 1 to 24), the effects of smoothing out wrinkles, improving texture, and improving moisturizing sensation were all visible after one month of use, with remarkable rapid effects and long-lasting effects. The effects of C) are also significantly superior.

In contrast, when only the specific alicyclic compound is blended,
Comparative Example 3 (Comparative Examples 3-1 to 3-3) and Comparative Example 2 (Comparative Examples 2-1 to 2-8) containing only the blood circulation promoter or cell activator. Skin milk has relatively low and slow-acting effects. In addition, the above-mentioned effect was not observed with skin milk base (base) as a control product.

Claims (1)

[Claims] 6-(5-methoxyhept-1-yl)-bicyclo-[
3,3,0]octan-3-one, 6-(5-ethoxyhept-1-yl)-bicyclo-[3,3,0]octan-3-one, 6-(5-hydroxyhept-1-yl) yl)-bicyclo-[3,3,0]octan-3-one, and at least one alicyclic compound selected from the group consisting of γ-aminobutyric acid, vitamin E orotate, diisopropylamine dichloroacetate, hyaluronic acid, A cosmetic for preventing skin aging, which is formulated with at least one substance selected from the group consisting of elastin, water-soluble collagen, Jasmine japonica extract, and Korean ginseng extract.