JPH0539484A - Liquid crystal composition and cosmetic containing the same - Google Patents

Abstract

PURPOSE:To provide the subject composition of intense and broad color developability, excellent in aesthetic feeling, containing a hydrophilic surfactant, sterol, alpha-glyceryl alkyl ether, and polysaccharide galenical drug extract and/or low-molecular weight compound each at specified amount. CONSTITUTION:The objective liquid crystal composition stable with time, containing (A) 0.01-3wt.% of a hydrophilic surfactant such as a sucrose fatty acid ester or sulfuric ester salt, (B) 0.01-1wt.% of a sterol such as cholesterol or cholestanol, (C) 0.01-3wt.% of an alpha-glyceryl alkyl ether such as diglyceryl monostearyl ether, and (D) 0.0001-0.05wt.% of a polysaccharide galenical drug (e.g. hamamelis) extract and/or 0.0001-10wt.% of a low-molecular weight compound such as alanine or NaCl.

Description

Detailed Description of the Invention

[0001]

INDUSTRIAL APPLICABILITY The present invention has a strong and wide color-developing property, is excellent in aesthetics, imparts good usability and a pharmacological effect, and is stable over time. Liquid crystal composition and cosmetics containing the same.

[0002]

2. Description of the Related Art Conventionally, liquid crystal compositions have been prepared by using various surfactants and sterols as raw materials. Also,
Among them, those having particularly excellent color developability have been attempted to be used in various ornaments and cosmetics because they have a mysterious appearance.

[0003]

However, the conventional liquid crystal compositions are not only sufficiently weak in color development, but also have a narrow color width and are not sufficiently satisfactory in terms of stability over time.

[0004]

Under such circumstances, the present inventors have conducted diligent research and as a result, have found that a hydrophilic surfactant,
If a specific amount of sterols, α-glyceryl alkyl ether and polysaccharide crude drug extract or low molecular weight compound is blended,
A liquid crystal composition that is extremely rich in color developability and has an excellent aesthetic feeling, is provided with good usability and a pharmacological effect, and is stable over time. The present invention has been completed by finding that a cosmetic having the above characteristics can be obtained.

That is, the present invention provides the following components (a), (b),
(c) and (d) (a) Hydrophilic surfactant 0.01 to 3% by weight (b) Sterols 0.01 to 1% by weight (c) α-glyceryl alkyl ether 0.01 to 3% by weight (d) Polysaccharide crude drug extraction The present invention provides a liquid crystal composition containing 0.0001 to 0.05% by weight of a compound and / or 0.0001 to 10% by weight of a low molecular weight compound, and a cosmetic containing the same.

The hydrophilic surfactant as the component (a) used in the present invention is a surfactant having an HLB of 8 or higher, and specific examples thereof include nonionic surfactants such as sucrose fatty acid ester and polyglycerin fatty acid ester. Agents: Anionic surfactants such as sulfate ester salts and phosphate ester salts; Cationic surfactants such as quaternary ammonium salts; Amphoteric surfactants such as egg yolk lecithin, soybean lecithin and hydrogenated products thereof and derivatives thereof And so on. These hydrophilic surfactants may be used alone or in combination of two or more.

Examples of the sterols as the component (b) used in the present invention include animal sterols such as cholesterol, cholestanol, lanosterol, selegrosterol, dehydrocholesterol and coprostanol; β-sitosterol, stigma Examples thereof include plant sterols such as sterols, campesterols and ergosterols; sterols derived from microorganisms such as mycosterols and timosterols, and cholesterol and cholestanol are particularly preferable. These sterols can be blended alone or in combination of two or more.

Examples of the (c) component α-glyceryl alkyl ether used in the present invention include batyl alcohol, chimyl alcohol, ceracyl alcohol, behenyl α-monoglyceryl ether, diglyceryl monostearyl ether and triglyceryl monopal. Examples thereof include mityl ether, diglyceryl mono-2-ethyldecyl ether, diglyceryl monooleyl ether and the like. These α-glyceryl alkyl ethers can be blended alone or in combination of two or more.

The component (d) used in the present invention improves the color development of the liquid crystal composition and controls the color tone by adjusting the concentration thereof, and imparts good usability and pharmacological effect. It is mixed for the purpose.

In the present invention, the term “polysaccharide crude drug” refers to a plant containing a polysaccharide and having a pharmacological effect, and specifically, Hamamelis (Antiaceae), Salvia, Birch (Lamiaceae), Sophoraceae, Hop ( Mulberry family), quince, simoke (rose family), aloe vera, lily bulb, arrow cape (lily family), carrot (Ulinaceae family), flax (Lamiaceae family), chamomile, dandelion, chamomile (Asteraceae family), korori (legume family) ), Psyllium (Plantain), mallow,
Amteia, Birodo Aoi (Mallowaceae), Western Bodhi Tree, Bodhi Tree (lindenaceae), Hypericum (Hypericaceae), Elderberry (Lonicerae), Papaver (Papaceae), Amber (Rutaceae), Horse chestnut (Acupunctaceae), Cucumber family), witch hazel (Lamiaceae family), rosemary (Lamiaceae family), red-crowned tree (Buckthorn family), Kaiso (Hibama family family), Yahazunonomata (Ceriaceae family) and the like.

The polysaccharide crude drug extract is obtained by extracting from the leaves, flowers, branches, fruits, etc. of the above-mentioned polysaccharide crude drugs. The extraction method is not particularly limited, and examples thereof include water, primary alcohols such as methyl alcohol and ethyl alcohol, liquid polyhydric alcohols such as propylene glycol and 1,3-butylene glycol, and lower alkyl esters such as ethyl acetate. A method using a known solvent such as hydrocarbons such as benzene and hexane, ethyl ether, acetone and the like is adopted, and these solvents can be used alone or in combination of two or more kinds. Among them, the preferable extraction solvent includes an aqueous solution of an organic solvent miscible with water, particularly an aqueous solution of ethyl alcohol, methyl alcohol, acetone and the like. As the extract, the polysaccharide crude drug is immersed in the above extraction solvent, and this may be extracted at room temperature or under heating, and the extract obtained by filtration may be used as it is, but further concentrated if necessary. May be used. Also, these extracts can be purified and used.

Further, as low molecular weight compounds, NaCl, KC
l, CaCl ₂ , MgSO ₄ , NaH ₂ PO ₄ · H ₂ O and other alkali or alkaline earth metal salts; alanine, glycine and other amino acids;
Organic acids such as pyrrolidonecarboxylic acid, lactic acid, citric acid, malic acid, tartaric acid and salts thereof; glucose, fructose, xylose, sucrose, mannitol, N-acetylglucosamine, N-acetylneuraminic acid (sialic acid), colominic acid , Monosaccharides or oligomers such as chitin oligomers and salts thereof.

Table 1 below shows the results of visual observation of how representative of the component (d) in the present invention the color tone of the liquid crystal composition changes depending on its concentration. The polysaccharide crude drug extract was prepared as follows. Aloe Vera: Aloe [Aloe barbadenisis Miller (Aloe
Vera Linne)] fresh leaves are squeezed, and leaf piece cell tissues and the like are removed from the obtained juice by filtration. Isopropanol was added to this liquid and the mixture was stirred, and the resulting precipitate was washed with ethanol, and then ethanol was removed under reduced pressure to obtain the present extract. Quinceseed [Cydonia Vulgaris Pers (Ro
saceae)) and extracted with purified water, and then the seed pieces and the like are filtered to obtain the present extract. Sohakuhi: Sohakuhi (mulberry bark) [Kuwa Morus bombyc
is Koidzumi or other root bark of the same genus plant (Moraceae)], finely chopped, added with ethanol, extracted by heating, and then the cell tissue is filtered off to remove ethanol under reduced pressure to obtain the present extract. Salvia: 1,3-butylene glycol was added to the dried whole plant of Salvia [Salvia officinalis L.] and extracted,
The leaf extract, cell tissue and the like are filtered to obtain the present extract. Hypericum perforatum: 1,3-butylene glycol is added to the dried whole grass of Hypericum perforatum or Hypericum perforatum to extract and then the leaf pieces, cell tissues and the like are filtered to obtain the present extract. Mallow: mallow oil [Malva Silvestris] dried flowers and leaves with 1,3-butylene glycol after extraction,
The leaf extract, cell tissue and the like are filtered to obtain the present extract. Horse chestnut: horse chestnut [Aesculus hip
ocastanum L.)] dried fruit is extracted with 1,3-butylene glycol, and then the fruit pieces, cell tissues and the like are filtered off to obtain the present extract. Witch Hazel: Hamamelidaceae (Hamam
elis Virginiana Witchhazel)] and purified by adding purified water to the leaves and bark, and then the leaf pieces, cell tissues, etc. are filtered to obtain the present extract.

[0014]

[Table 1]

In the liquid crystal composition of the present invention, the above (a)
The components (a), (b), (c) and (d) are each contained in the composition of the present invention in an amount of 0.01 to 3% by weight (hereinafter referred to simply as%).
(Preferably 0.1-1%), (b) 0.01-1% (preferably 0.05-0.5%), (c) 0.01-3% (preferably 0.1%).
2 to 2%), (d) is 0.0001 in the case of polysaccharide herbal extract
~ 0.05% (preferably 0.001 to 0.02%), and 0.0001 to 10% in the case of low molecular weight compounds. The component (d) is shown in terms of the solid content of the extract. If the content of the component (a) is less than this, the liquid crystal composition of the present invention cannot be obtained, and if it exceeds this, the system is emulsified, which is not preferable; if the content of the component (b) is less than this. If so, the liquid crystal composition of the present invention cannot be obtained, and if it exceeds this, crystals of sterols are precipitated, which is not preferable; if the compounding amount of the component (c) is less than this, the liquid crystal composition of the present invention is obtained. Stability becomes worse, and if it exceeds this, a liquid crystal composition cannot be obtained, which is not preferable;
If the compounding amount of the component (d) is less than this, the liquid crystal composition of the present invention swells and whitens or the stability is poor, and good usability and pharmacological effects cannot be expected. Color development of the composition is hindered, which is not preferable. The sterols as the component (b) and the α-glyceryl alkyl ether as the component (c) are preferably blended in a weight ratio of (b) :( c) = 1: 20 to 2: 1. When the amount of the component (b) exceeds this range, the solubility of the component (b) deteriorates, and when the amount of the component (c) exceeds this range, the color developability of the liquid crystal composition deteriorates, which is not preferable.

In the liquid crystal composition of the present invention, the components (a), (b) and (c) are dissolved by heating and then added to purified water containing the component (d), or this is further mixed and stirred. Although it can be obtained by the method, purified water containing the component (d) and (a) to (c)
Powdered components may be mixed at the time of use. Here, (a), (b), (c) added to purified water
And the amount of the component (d) is 0.00 with respect to the entire liquid crystal composition.
5 to 5%, particularly 0.1 to 3.5% is preferable. (a), (b),
When the total amount of the components (c) and (d) exceeds 5%, the liquid crystal composition does not swell sufficiently and the color developability deteriorates.
When it is less than 1, the liquid crystal composition becomes too thin, and the color development is deteriorated, which is not preferable.

Further, the liquid crystal composition of the present invention is as it is,
Alternatively, it can be used as a cosmetic such as a lotion, a cream, a beauty essence or the like by appropriately blending a cosmetic component generally used in a cosmetic within a range that does not impair the effects of the present invention. Here, as the cosmetic ingredient, triglyceride,
Hydrocarbon oil, ester oil, oil component such as wax or higher alcohol, powder component such as coloring pigment, extender pigment or pearl luster imparting agent, pH adjusting agent, preservative, antioxidant, chelating agent, moisturizing agent, beauty Ingredients, fragrances and the like can be mentioned.

[0018]

The present invention will be further described with reference to examples, but the present invention is not limited to these examples.

Examples 1 to 6 and Comparative Examples 1 to 7 Compositions having the compositions shown in Table 2 below were prepared, and the presence or absence of liquid crystal formation and the stability and color development after storage at 40 ° C. for 2 months were visually observed. It was evaluated by. The results are shown in Table 2. (Production method) A. 1-5 is melted by heating. B. Add 6 to 10 and A to 11 and mix uniformly. (Evaluation) Presence or absence of liquid crystal formation: ◯: Liquid crystal can be formed ×: Liquid crystal cannot be formed Stability of liquid crystal: ◯: System separation and crystal precipitation do not occur even if left in an environment of 40 ° C. for 2 months Stable ×: When left in an environment of 40 ° C for 2 months, system separation and crystal precipitation occur −: Liquid crystal is not formed and evaluation is not possible Coloring property of liquid crystal: ○: Significant color formation ×: No color formation −: Liquid crystal Was not generated, and evaluation was not possible Usability: The above-mentioned composition was applied to the skin of 20 professional panels, and judged by the average value of the following evaluation points. Evaluation After application to the skin, it feels moist and refreshing feeling 2 After application to the skin, it does not feel moist and refreshing feeling 1 Judgment 1.7 to 2.0 ○ 1.0 to 1.7 × Pharmacological effect: 20 people for 1 month with the above composition It was applied to the skin of the professional panel of No. 1 and evaluated by the average value of the following evaluation points. Evaluation Moisturizing effect 1 month after the skin feels moisturized 2 After 1 month does not feel the skin moisturizes 1 Prevents skin roughening 1 month feels improvement in the rough skin 2 1 month feels no improvement in the rough skin 1 judgment Same as usability

[0020]

[Table 2]

Examples 1 to 6 according to the present invention exhibited light purple to red coloring. Further, as is clear from the results in Table 2, Examples 1 to 6 were remarkably rich in color developability, and their usability, pharmacological effect and stability were also good. Further, in Comparative Examples 1 to 7, no generation of liquid crystal was observed,
Alternatively, its stability was poor, and almost no coloring was observed, which was not satisfactory.

Example 7 Lotion (composition) (% by weight) (1) Hydrogenated soybean lecithin 0.34 (2) Cholesterol 0.17 (3) Batyl alcohol 0.23 (4) Quince 0.014 (5) Arrow cape 0.002 (6) Glycerin 3 ( 7) 1,3-butylene glycol 4 (8) Methylparaben 0.2 (9) Perfume 0.01 (10) Purified water plus 100% (Production method) (1) to (3) are heated and dissolved. B. (4) to (9) are added to (10), and they are uniformly mixed and stirred. C. Add A to B, mix and stir uniformly. The lotion obtained has a purple aesthetic appearance,
Even when left at room temperature for 6 months, neither separation nor color deterioration was observed, and it was stable over time. Further, this lotion had a moist and refreshing feeling of use, and was also excellent in the effects of moisturizing and protecting the skin from ultraviolet rays.

Example 8 Beauty essence (composition) (% by weight) (1) Hydrogenated soybean lecithin 0.2 (2) Cholesterol 0.1 (3) Batyl alcohol 0.3 (4) Souakuhi 0.025 (5) Methylparaben 0.05 (6) Perfume 0.01 ( 7) Purified water plus 100% (Manufacturing method) (1) to (3) are heated and dissolved. B. (4) to (6) are added to (7), and they are uniformly mixed and stirred. C. A is added dropwise to B. The obtained beauty essence has an aesthetic appearance in which liquid crystal pieces colored in purple are dispersed in the cosmetic solution, and even when left at room temperature for 6 months, the liquid crystal pieces are not decomposed and the coloration is not deteriorated. It was stable. In addition to having a moisturizing and refreshing feeling, the present beauty essence was also excellent in whitening effect.

Example 9 Rinse agent (composition) (% by weight) (1) Stearyl trimethyl ammonium chloride 0.05 (2) Cholesterol 0.1 (3) Batyl alcohol 0.4 (4) Glycerin 2.5 (5) 1,3-Butylene glycol 2.5 ( 6) Aloe vera 0.0036 (7) Paraben 0.05 (8) Perfume 0.01 (9) Purified water plus 100% (Production method) (1) to (3) are heated and dissolved. B. (4) to (8) are added to (9), and they are uniformly mixed and stirred. C. Add A to B, mix and stir uniformly. The resulting rinse agent has a blue-violet aesthetic appearance,
Even when left at room temperature for 6 months, neither separation nor color deterioration was observed, and it was stable over time. Further, this rinse agent was excellent in the effect of preventing dandruff and itchiness as well as providing a smooth and silky texture to the hair.

Example 10 Serum (composition) (% by weight) (1) Sodium stearoylethyl taurate 0.06 (2) Cholesterol 0.2 (3) Batyl alcohol 0.74 (4) Sodium pyrrolidonecarboxylate 0.001 (5) Paraben 0.05 (6) ) Fragrance 0.01 (7) Purified water plus 100% (Manufacturing method) A. (1) to (3) are heated and dissolved. B. (4) to (6) are added to (7), and they are uniformly mixed and stirred. C. Add A to B, mix and stir uniformly. The obtained beauty essence had a purple aesthetic appearance, and even when left at room temperature for 6 months, neither separation nor color deterioration was observed, and it was stable over time. Further, the present beauty essence has a moisturizing and refreshing feeling of use, and is also excellent in moisturizing effect and its durability.

Example 11 Lotion (composition) (% by weight) (1) Sodium stearoylethyl taurate 0.07 (2) Cholesterol 0.3 (3) Batyl alcohol 1.2 (4) Glycerin 0.5 (5) 1,3-Butylene glycol 1.0 ( 6) Salvia 0.0015 (7) Sodium lactate 0.0013 (8) Paraben 0.05 (9) Perfume 0.01 (10) Purified water In addition 100% (Production method) (1) to (3) are heated and dissolved. B. (4) to (9) are added to (10), and they are uniformly mixed and stirred. C. Add A to B, mix and stir uniformly. The lotion thus obtained had a blue-violet aesthetic appearance, and even after being left at room temperature for 6 months, no separation or deterioration in color formation was observed and it was stable over time. Further, this lotion had a smooth feeling of use and was excellent in promoting blood circulation.

Example 12 Serum (composition) (% by weight) (1) Hydrogenated soybean lecithin 0.3 (2) Cholesterol 0.2 (3) Batyl alcohol 0.8 (4) Glucose 10 (5) Methylparaben 0.2 (6) Perfume 0.01 ( 7) Purified water plus 100% (Manufacturing method) (1) to (3) are heated and dissolved. B. (4) to (6) are added to (7), and they are uniformly mixed and stirred. C. Add A to B, mix and stir uniformly. The obtained serum has a blue-purple aesthetic appearance and is 6
Even if left at room temperature for a month, no separation or deterioration in color was observed,
It was stable over time. Further, the beauty essence had a moisturizing and refreshing feeling, and was excellent in moisturizing effect and its durability.

Example 13 Beauty essence (composition) (% by weight) (1) Hydrogenated soybean lecithin 0.2 (2) Cholesterol 0.1 (3) Batyl alcohol 0.3 (4) Souakuhi 0.012 (5) Alanine 1 (6) Methylparaben 0.05 ( 7) Fragrance 0.01 (8) Purified water plus 100% (Manufacturing method) (1) to (3) are heated and dissolved. B. (4) to (7) are added to (8), and they are uniformly mixed and stirred. C. Add A to B, mix and stir uniformly. The obtained serum has a blue-purple aesthetic appearance and is 6
Even if left at room temperature for a month, no separation or deterioration in color was observed,
It was stable over time. Further, the beauty essence had a moisturizing and refreshing feeling, and was excellent in moisturizing effect and its durability.

[0029]

EFFECTS OF THE INVENTION The liquid crystal composition of the present invention and the cosmetics containing the same are excellent in color developability and excellent in aesthetics, and are excellent in usability, pharmacological effect and stability over time.
It is extremely useful as cosmetics and the like.

Claims (3)

[Claims] 1. The following components (a), (b), (c) and (d) (a) hydrophilic surfactant 0.01 to 3% by weight (b) sterols 0.01 to 1% by weight (c) α -Glyceryl alkyl ether 0.01 to 3% by weight (d) A liquid crystal composition containing 0.0001 to 0.05% by weight of a herbal crude drug extract and / or 0.0001 to 10% by weight of a low molecular weight compound. 2. The liquid crystal composition according to claim 1, wherein the mixing ratio of the sterols and the α-glyceryl alkyl ether is 1:20 to 2: 1 by weight. 3. A cosmetic containing the liquid crystal composition according to claim 1.