JP2003221315A - Skin care preparation for external use to be used for hair growth - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a highly safe skin care preparation for external use to be used for hair growth having an excellent usability, wherein the hair-growing, hair-nourishing and hair loss-preventing actions are promoted on hair loss, hair thinning and baldness caused by age-related hormone reduction. <P>SOLUTION: This skin care preparation for external use to be used for hair growth is allowed to contain at least one crude drug essence having a body-fluid action (Chuling, Hoelen, Ginseng, Dong quai, capsicum, Chen pi, bitter orange peel, Tao Ren, or the like), at least one plant sterol or plant sterol glucoside (stigmastanol maltoside, ergosterol glucoside, or the like) and at least one crude drug essence promoting enzymatic activities in hair roots (castor bean, howthorn, Ampelopsis, or the like). <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a skin external preparation for hair growth, and more specifically, 1) an extract of a crude drug having a tsu liquid action based on the tsu liquid theory and its active ingredient, and 2) an angiogenic activity. Stigmasteranol maltosid plant (Evolvulus) extract, and further, 3) by containing a plant sterol and / or a plant sterol glycoside, the peripheral blood vessels around the hair root are reduced due to the decrease of hormones and aging, and the formation of peripheral blood vessels, The present invention relates to a skin external preparation for hair growth, which is excellent in usability and has a remarkable hair growth effect by improving and promoting physiological functions of living tissues by synergistic effect of the extract to promote hair root enzyme activity and maintenance and promotion of nutritional supplementation.

[0002]

2. Description of the Related Art It is a desire for men and women of all ages to maintain abundant black hair forever. However, aging and genetic predisposition,
Furthermore, due to social stress, etc., hair gradually falls off, causing thinning hair and baldness. In order to prevent such alopecia, various manufacturers have been working hard to develop hair regrowth agents. Developed so far are minoxidil, ginkgo, ginger and other crude drug extracts, and hair growth agents such as pantothenyl ethyl ether, alloxazine, adenosine 3 ', 5'-cyclic monophosphate (c-AMP). .

However, the hair-growth agents that have been developed so far may be insufficient in promoting hair growth and may cause side effects such as skin irritation, so that they are sufficiently effective and safe at present. The current situation was that nothing was obtained. Therefore, there has been a demand for a hair nourishing agent which is excellent in hair growth promoting action and highly safe.

Tsuji action is the influence of qi, blood,
Of the concept of water, which relates to water, the present inventor has clarified that several kinds of herbal extracts promote the metabolism of body fluids such as digestive fluid, saliva, and urine. There is. Basically, the Tsu liquid theory is a concept that the body fluid containing nutrients is normally distributed from blood vessels or lymph vessels to peripheral tissues. It controls this distribution, supplies nutrients and removes waste products, and maintains and improves the physiological functions of living tissues. By the action of maintaining and improving the physiological function of the biological tissue, for example, skin beautifying action and atopic dermatitis,
It is recognized that skin diseases such as psoriasis vulgaris, senile xerosis, and burns are improved, hair growth is promoted, sweating is promoted, digestive juice secretion is promoted, diuretic action, and bowel movement is promoted. In addition, it is known that the herb medicine having a sucrose action has a hair-growth-promoting action on bukuro, sekibukuryo, bukushin, bukurohihi and chorei.

On the other hand, on the other hand, herbal medicines such as Taxit, castor bean, Kamala, Kissoukkon, juniper, Kotonikku, hawthorn, Sayo, Renjisou, and Reishi are known to have hair root enzyme activity.

On the other hand, plant-derived or synthetic phytosterols (β-sitosterol, campesterol,
It was also known that sterol glycosides such as stigmasteranol) and stigmasteranol maltoside are effective for hair loss and baldness due to instability of male hormone.

[0007] However, there is known a skin external preparation for hair growth containing 1) a crude drug extract having a sucrose action, 2) a crude drug extract having angiogenic activity and 3) a plant-derived or synthetic phytosterol. However, following the angiogenesis around the hair root, the synergistic effect of normal distribution of body fluid due to tsu fluid action from blood vessels or lymph vessels to peripheral tissues causes hair loss / thinning hair caused by hormonal decrease associated with aging.
With respect to baldness, etc., by further significantly promoting the hair root enzyme activity, the synergistic effect remarkably promotes the hair-growth / hair-growth effect and the hair loss-prevention effect, which is highly safe and has excellent usability. It was not known at all that a drug could be obtained.

[0008]

SUMMARY OF THE INVENTION The present invention has been made under such circumstances, and has a hair-growing / hair-promoting effect and a hair-removing effect on hair loss, thinning hair, baldness, etc. caused by hormonal decrease due to aging. It is an object of the present invention to provide a skin external preparation for hair growth, which has a significantly enhanced preventive effect, high safety, and excellent usability.

[0009]

[Means for Solving the Problems] In view of such circumstances, the present inventors have remarkably promoted the hair-restoring / hair-restoring effect and the hair-loss preventing effect on hair loss / thinning hair / bald etc. due to hormone reduction due to aging. As a result of earnest studies for a skincare external preparation for hair growth that is highly safe and has excellent usability, 1) a crude drug extract having a tsu liquid action, 2) a crude drug extract having angiogenic activity, and 3) By incorporating a plant sterol and a plant sterol glycoside in a skin external preparation for hair growth and the like,
With the synergistic effect, hair loss, thinning hair, baldness, etc. caused by hormonal decrease due to aging are remarkably promoted, and hair growth, nourishing effect and hair loss prevention effect are significantly promoted, and it is highly safe and easy to use. It came to completion. That is, the present invention relates to the following technology. (1) 1) One or more kinds selected from crude drug extracts having an action of syrup and its active ingredient, and 2) One or more kinds selected from plant sterols and / or plant sterol glycosides, and / or Or, 3) a skin external preparation for hair growth, which comprises an extract of a crude drug having hair root enzyme activity and one or more active ingredients thereof. (2) The hair-growth treatment according to (1), characterized in that the sap action is a maintenance / improvement action of physiological functions of biological tissues by controlling nutrients from the vascular system and / or lymphatic system. External skin preparation. (3) The skin external preparation for hair growth according to (1) or (2), characterized in that the plant sterol and / or the plant sterol glycoside has an inhibitory action on androgen production around the hair root. (4) Herbal medicines that have a sap action include butterbur, sesame burs, bukshin, butterburhi, chorei, taksha, inchinko, mokuboui, kanbowi, kaseki, yokuinin, toukanin, toukahi, mokutou, tsusou, toshinshinku, tokusaku, kubaku, jakubaku, jakubaku, jakubaku, jakubaku, jakubaku, jakubaku. , Chazenshi, Chazensou, Tokihi, Hikai,
Calendula, Sekisho, Hanpenren, Gokmaishu, Shajin, Seijin, Tenmondou, Bakuromontou, Ginkgo, Ginkgo sycamore, Ganoderma lucidum, Ganoderma lucidum, Joteishi, Sesame, Kokuzuku, Kouzuki, Kouzuki, Bakukou, Bekko, Shikoku, Bekko, Bekko. Keigai, Kyoukatsu, Kouhon, juniper, sausage, ginger, soupaku, koju, gensui, seiryuka, shinui,
Mint, burdock, centai, soybean, chrysanthemum, burrower, mankeishi, huhei, mokuzo, kokuseiso,
Cuckoo, Psycho, rhubarb, bowfish, banshayo, rokai, machinin, ikrinin, kengoshi, genka, shouriku, terexi, eucalyptus, gypsum, chimo, sanshin, anchovy, swordfish, kansueseki, lensin, locon, ketsumeishi, seisoushi,
Mitsumouka, Yamyousha, Yutan, Seitenki, Saikaku, Shojiou, Genjin, Buttonpi, Sikon,
Zikoppi, sandalwood, ginkgo, dragonfly, weeping, psyllium, ryutan, kujin, sympi, kouren, goldfish, forsythia, pacificus, lantern, pearl oyster, lion butterflies, pacific psyllium, pearl oyster, pearl syrup, sardine, pearl syrup, pearl syrup, pearl syrup, sardine. One or more selected from extracts of herbal medicines of atassin, bashiken, dobukuro, kanju, babotsu, sanzkon, yakan, dogoshitu, kenjin, kinkaran, kayo, ryokuzu, seika, hakens, zuken, and eucommia. A skin external preparation for hair growth according to any one of (1) to (3), which is characterized. (5) Crude drugs having a sucrose action include chorei, bukuro, carrot, spruce, capsicum, chimpi, spruce,
The skin external preparation for hair growth according to any one of (1) to (4), characterized in that it is one or two or more kinds selected from the extract of Chinese herb medicine. (6) The plant sterol and / or the plant sterol glycoside is stigmasteranol, stigmasteranol glucoside, stigmasteranol maltoside, stigmasteranol maltotrioside, stigmasteranol maltotetraoside, stigmasteranol maltoside. Pentaoside,
One or more selected from campesterol, campesterol glucoside, campesterol maltoside, ergosterol glucoside, ergosterol maltoside, ergosterol maltotrioside, ergosterol maltotetraoside, ergosterol malpentaoside (1) to
A skin external preparation for hair growth according to any one of (5). (7) The plant sterol and / or plant sterol glycoside is one or more selected from stigmasteranol maltoside, stigmasteranol maltotrioside, ergosterol maltoside, and ergosterol maltotrioside. (1)-
A skin external preparation for hair growth according to any one of (6). (8) The herb medicine having hair root enzyme activity is characterized by being selected from one or two or more kinds of herbal extracts selected from Taxus, Castor bean, Kamala, Kissoukkon, Sandalwood, Kotonikku, Hawthorn, Sayo, Renjisou, and Reishi. The external preparation for hair growth according to any one of (1) to (7). (9) The skin external preparation for hair growth according to any one of (1) to (8), wherein the extract is an extract of a whole plant with a polar solvent. (10) The external preparation for hair growth according to any one of (1) to (9), which is a cosmetic or a pharmaceutical product. (11) 1) Bukryou, Sekibukyou, Bukshin, Bukryuhi, Chorei, Taksha, Inchinko, Mokuboui, Kanbowi, Kaseki, Yokuinin,
Tounin, Toukahi, Mokutou, Tsuso, Tousen, Kubaku, Jifushi, Hentiku, Sekii, Shazenshi,
Chazensou, Tokihi, Hikai, Calendula, Sekishos, Hampenren, Gokmaiche, Shajin,
Ginseng, Tenmondou, Bakumontou, Ginkgo, Ginkgo syrup, Ganoderma lucidum, Censored, Joteishi, Sesame seeds, Kokuzu, Kouzukii, Kiban, Kibankyo, Bekko, Bekko, Kouou, Mahou, Keishi, Shisoyo, Kaigai, Pleinoptera, Kouki Ginger, Sohaku, Koju,
Gensui, Seiryuka, Shini, peppermint, burdock,
Centai, soyo, chrysanthemum, daisies, mankei,
Fuhei, Mokuzo, Kosoiso, Cuckoo, Psycho,
Rhinoceros, bow show, banshayou, lokai, machinin, ikrinin, kengoshi, genka, shoulik, terexi, ukyu compi, gypsum, chimo, sanshin,
Tantricius, Kagosou, Kanseki Seki, Rensin, Locon, Ketsumeishi, Seisoushi, Mitsumouka, Yamyousha, Yutan, Seitenki, Psychiatry, Ginger, Gingin, Buttonpi, Sikon, Zikoppi, Juniper, Ginkgo, Gourmet, Gourd, Gourd, Gourd, Gourmeta. Coleoptera, Goldfish, Forsythia, Atlantic Ocean, Banglancon, Houkouei,
Deer butterflies, birch, juniper, quince, senchinren, juniper, juniper, juniper, broom, atasin, bashiken, dobukuryo, kanju, babotsu, sandcon, yakan, dogoshitu, kenjin, quincalin, kayo, rye dove, sardine, sardine One or more selected from extracts of ginseng herbs and 2) one or more selected from plant sterols and / or plant sterol glycosides 3) Taxus, castor beans, Kamala, Kissoucon, sandalwood , Kotonik, Hawthorn, Sayo,
A skin external preparation for hair growth containing one or more selected from extracts of herbal medicines such as spinach, weeping plants, and mint. (12) 1) One or more selected from herbal extracts of chorei, bukuro, carrot, touki, capsicum, chimpi, spruce, and tounin, and 2) plant sterol and / or plant sterol glycoside, Stigmasteranol, stigmasteranol glucoside, stigmasteranol maltoside, stigmasteranol maltotrioside, stigmasteranol maltotetraoside, stigmasteranol maltopentaoside, campesterol, campesterol glucoside, campesterol maltoside, Ergosterol glucoside, ergosterol maltoside, ergosterol maltotrioside,
One or more selected from ergosterol maltotetraoside and ergosterol malpentaoside, and 3) a herbal medicine for taxis, castor bean, camara, kissing turmeric, sandy mildew, kotonikku, hawthorn, soybean, lotus root, weeping beetle, sansha The skin external preparation for hair growth according to (11), containing one or more selected from extracts. Hereinafter, the present invention will be described in detail centering on the embodiment.

[0010]

BEST MODE FOR CARRYING OUT THE INVENTION (1) An extract of a herbal medicine having a tsu liquid action, which is an essential component of the external preparation for skin for hair growth of the present invention, and its active ingredient. The present invention is characterized in that it contains one or more kinds of extracts of a crude drug having a tsu liquid action, which is an essential component of the external preparation for skin growth of the present invention, and its active ingredient. As a crude drug extract having an action of syrup used in the present invention and its active ingredient, in the classification of Chinese herbal medicines, diuretic moisturizer, saxine drug,
Preferable examples are extracts and active ingredients of crude drugs that are classified into a table medicine, an antipyretic drug, and a supplemental drug. The herbal medicine names are Bukuryo, Sekibukuryo, Bukushin, Bukuryohi, Chorei, Takusha, Inchinko, Mokuboui, Kambowi, Kaseki, Yokuinin, Tokanin, Toukahi, Mokutou, Tsuyusou, Toshinsou, Tokisou, Weeping, Sensitive, Weeping, Sensitive, Weeping, Sensitive, Weeping, Weeping, Sensitive. Toukihi, hikai, calendula, budgerigar, hampenlen, gokmaiche, shajin, jingen, tenmondou, bakumonto, ginkgo, ginkgo biloba, ginkgo, cornflower, japonicus, sesame, kokuzu, kokui, kiban, kibankoku, kobuki, kobuki, kobe Keishi, Shisoyo, Keigai,
Kyoukatsu, kouhon, juniper, sausage, ginger, weeping, koju, ginsui, seiryuka,
Shinyi, peppermint, burdock, centai, soybean, chrysanthemum, burdock, mankeishi, fuhei, mozozo, kosoiso, kakkon, psycho, rhinoceros, rhinoceros, bonsai, banshayou, rokai, machinin, ikurinin, kengoshi, kansui, genka, taigeki, sukuriku, sakuriku, sardine Terexi, succulent, gypsum, chimo, sanshin, tanchiyo, kagosou, kansuiseki, lensin, locon, ketsumeishi, seizoushi, mitsumoka, yamyosha, yutan, seitenki, rye kulk, ginkgo, ginkgo, ginkgo biloba, ginkgo biloba, ginkgo biloba, ginkgo biloba, ginkgo biloba, ginkgo biloba, ginkgo biloba, ginkgo biloba, ginkgo biloba, ginkgo biloba, biloba Coptis, Cucumber, Ryutan, Kujin, Sympi, Coptis, Kingfish, Forsythia, Atlantic Ocean, Banglancon,
White-spotted whale, deer butterfly, gypsophila, juniper, kinshato, sengren, juniper, juniper, dianthus, balsam, attasin, bashiken,
Hakusenpi, Dobukuryo, Kanju, Babotsu, Sandscon, yakan, Dogositsu, Kenjin, Quinkaran, Kayo, Ryokuzu, Seika, Hakuhens, Soken, Seikou, and the like can be mentioned. Among them, herbal medicines that have a sap action are chorei, bukuro, carrots, sugar cane, capsicum,
Since the extracts of Chinpi, spruce and pearl oyster are excellent in the effect of promoting hair growth, it is preferably used as a crude drug extract to be added to the external skin treatment agent for hair growth of the present invention. or,
As the active ingredient of the herbal medicine, those already known may be used, for example, isoflavones which are the active ingredients of Cuckon and Tantoushi, anthraquinones which are the active ingredients of rhubarb and rokai, other anthocyanins, alkaloids and glycosides. Preferred examples thereof include phytosterols, flavones and tannins. Of these, crude drug extracts are preferably used in the present invention. this is,
This is because there is a synergistic effect due to components other than the active ingredient.
The content of the herbal medicine extract having a sucrose action, which is used in the external preparation for skin growth of the present invention, is 0.01 to 70% by weight, preferably 0.1 to 20% by weight, and more preferably 0.1.
It is 5 to 5% by weight. This is because if the amount is too small, the hair-growth effect due to the action of tsu liquid does not sufficiently appear, and if the amount is too large, the degree of freedom in formulation preparation is impaired or the effect reaches a ceiling. The inclusion of a crude drug extract having a sucrose action in a skin external preparation for hair growth promotes the action of maintaining and improving the physiological function of the skin tissue by controlling the nutrients from the vascular system and lymphatic system, and nourishes the hair root tissue. By promoting supply, it is excellent in promoting hair growth, and thus has an action of preventing or improving baldness, thinning hair, and hair loss.

(2) Plant sterols and plant sterol glycosides The present invention contains one or more plant sterols and plant sterol glycosides which are essential components of the skin external preparation for hair growth of the present invention. Characterize. Plant sterol glycosides such as plant-derived or synthesized plant sterols (β-sitosterol, campesterol, stigmasterol, etc.) and plant sterol glycosides (stigmasteranol glucoside, ergosterol glucoside, etc.) The kind is effective for hair loss and baldness due to instability of hormone balance. Sterol is a kind of alcohol and is a generic term for steroids having a hydroxyl group at the 3-position and having 27 to 29 carbon atoms. Free,
It is widely distributed in the plant kingdom in the form of esters and glycosides, and is an important constituent of biological membranes. The plant sterols used here include stigmasterol and β-
Sitosterol, campesterol, α-spinasterol, 3-betaol, ergosterol charantine, cholic acid and the like can be mentioned. The types of sugars in plant glycosides include monosaccharides, disaccharides, trisaccharides, tetrasaccharides and polysaccharides. 1) Monosaccharides such as dicarbose, tricarbose, tetracarbose, pentose, D-ribose, D-deoxyribose, D-xylose, D-arabinose, hexose, heptasaccharide, octose , A nine-carbon sugar, and the like (conformation) has a pyranose type (pyranoside),
Furanose type (furanoside), arabinose type (arabinoside) and the like can be mentioned. Examples of the derivative of glucose, galactose, rhamnose, fructose, mannose, and hexose, include amino sugars (glucosamine, chondrosamine) and the like. 2) As disaccharides, maltose, lactose, 3) As trisaccharides, maltotriose, 4) As tetrasaccharides, maltohexaose, 5) As polysaccharides, starch, dextrin, glycogen, amylose, Amylopectin, cellulose, pectin, galacturonic acid, fructan (polymer of fructose), konnyakumannn
ann) and the like. In the external preparation for skin growth for hair growth of the present invention, plant sterol glycosides are preferable from the viewpoint of the degree of freedom in prescribing to the external base. The types of plant sterol glycosides used here include stigmasteranol glucoside,
Stigmasteranol maltoside, stigmasteranol maltotrioside, stigmasteranol maltotetraoside, stigmasteranol maltopentaoside, stigmasterol glucoside, stigmasterol maltoside, stigmasterol maltotrioside, stigmasterol Maltotetraoside, stigmasterol malpentaoside, ergostanol glucoside, ergostanol glucoside, ergostanol maltoside, ergostanol maltotrioside, ergostanol maltotetraoside, ergostanol malpentaside, ergosterol glucoside, Ergosterol maltoside, ergosterol maltotrioside, ergosterol maltotetraoside, ergosterol malpentaoside, campe Tanol glucoside, Campestanol maltoside, Campestanol maltotrioside, Campestanol maltotetraoside, Campestanol malpentaoside, Campesterol glucoside, Campesterol maltoside, Campesterol maltotrioside, Campesterol maltotetraoside, campesterol malpentaoside, β-sitostanol glucoside, β-sitostanol maltoside, β
-Sitostanol maltotrioside, β-sitostanol maltotetraoside, β-sitostanol malpentaoside, β-sitosterol glucoside, β-sitosterol maltoside, β-sitosterol maltotrioside, β-sitosterol maltotetraoside , Β-sitosterol malpentaoside, and the like, and among them, stigmasteranol glucoside, stigmasteranol maltoside, ergosterol glucoside, and ergosterol maltoside are preferable. This is because the hair growth promoting effect is particularly excellent. A preferred substance as the plant sterol and plant sterol glycoside used in the external skin treatment agent for hair growth of the present invention is stigmasteranol maltoside. The content of the plant sterol and the plant sterol glycoside in the external preparation for skin growth of the present invention is 0.01 to.
70% by weight, preferably 0.1 to 20% by weight, more preferably 0.5 to 5% by weight. This is because when the amount is too small, the hair-growing effect of the plant sterol and the plant sterol glycoside is not sufficiently exhibited, and when the amount is too large, the degree of freedom in preparation of the formulation is impaired or the effect reaches a ceiling. By including plant sterols and plant sterol glycosides in the skin external preparation for hair growth, maintenance of physiological functions of skin tissue by controlling nutrients from the vascular system and lymphatic system
By promoting the improving action and promoting the nutritional supply to the hair root tissue and the like, it is excellent in promoting hair growth and, therefore, has the action of preventing or improving baldness, thinning hair, and hair loss.

(3) Crude drug extract having hair root enzyme activity-accelerating activity of the present invention An extract of a crude drug having hair root enzyme activity-promoting activity, which is an essential component of the external preparation for skin for hair growth of the invention, and one or more of its active ingredients. It is characterized by containing two or more kinds. Preferred examples of the hair root enzyme activity promoter include crude drug extracts that promote the activity of hair root enzymes such as sulfhydryl oxidase disclosed in JP-A-8-43375.
In an experimental animal, the activity of such an enzyme at the site of the skin to which a sample or the like is administered is measured by, for example, collecting the skin of the experimental animal and adding 50 mM of EDTA containing 1 mmol.
Using a supernatant obtained by adding an M sodium dihydrogen phosphate aqueous solution and homogenizing the homogenate obtained by centrifugation at 27,000 G, the enzyme activity of SH oxidase contained in the homogenate was measured as usual. Color was developed by dithiothreitol (DTT) and 7-fluoro-4-sulfamoyl-benzoxadiazole (ABD-F) and the fluorescence intensity thereof was measured, and DTT and 5,5′-
Examples thereof include a method in which color is developed with dithiobis-2-nitrobenzoic acid (DNTB) and the absorbance is measured. Examples of crude drug names that promote such enzyme activity include taxi, castor beans, Kamala, Kissoukon, sandalwood,
Examples thereof include Kotonikku, hawthorn, soybean, lotus root, and weeping plants. Among them, the extract of hawthorn and castor beans is excellent in the action of promoting hair root enzyme activity, and therefore it is preferably used as a crude drug extract to be incorporated in the external preparation for hair growth of the present invention. The content of the crude drug extract having the activity of promoting hair root enzyme activity used in the external preparation for skin growth of the present invention is 0.01 to 70% by weight, preferably,
It is 0.1 to 20% by weight, and more preferably 0.5 to 5% by weight. This is because if the amount is too small, the hair-growth effect due to the action of tsu liquid does not sufficiently appear, and if the amount is too large, the degree of freedom in formulation preparation is impaired or the effect reaches a ceiling. By incorporating a herbal medicine extract having a sucrose action into a skin external preparation for hair growth, it significantly promotes hair root enzyme activity and is excellent in promoting hair growth and hair growth, and thus has an effect of preventing or improving baldness, thinning hair, and hair loss. Have.

(4) Crude drug extract of the present invention The extract referred to in the present invention means the plant itself of such a plant, a processed product obtained by processing such as drying, shredding or crushing, or a plant or a processed product thereof. Extract extracted with solvent,
It means a generic term for a solvent-removed product obtained by removing the solvent of the extract, or an extract or a purified fractionated product obtained by purifying the solvent-removed product by column chromatography or liquid-liquid extraction. Among these, as the hair-growth promoting agent of the present invention, a solvent extract of whole grass or a solvent-removed product thereof can be preferably exemplified, and as such a solvent, a polar solvent can be preferably exemplified. Examples of such a polar solvent include water, ethanol, methanol,
Alcohols such as 1,3-butanediol and propylene glycol, esters such as ethyl acetate and methyl formate, ketones such as acetone and methyl ethyl ketone, halogenated hydrocarbons such as chloroform and methylene chloride,
One or more selected from nitriles such as acetonitrile and ethers such as diethyl ether and tetrahydrofuran can be preferably exemplified. Of these, more preferable are water and / or alcohols. A particularly preferred solvent is 50% ethanol. To make such an extract, add 1 to the plant or its processed product.
A 10-fold amount of solvent may be added, and the solution may be immersed at room temperature for several days, and at a temperature near the boiling point for several hours. After that, the insoluble matter can be removed by filtration and the solvent can be removed by concentration under reduced pressure or freeze-drying, if necessary.

(5) Skincare external preparation for hair growth according to the present invention 1) One or more kinds of crude drug extracts having a swelling action, and 2) One or two kinds of crude drug extracts having angiogenic activity. Or more and 3) one or two or more of plant sterols and plant sterol glycosides are mixed and contained in a skin external preparation for hair growth, thereby exhibiting a hair growth promoting effect by its synergistic effect, Excellent for preventing and improving baldness, thinning hair, hair loss, etc. Here, the hair restorer in the present invention means
It is a general term for compositions to be applied externally to the skin, and skin external medicines including patches and cosmetics including detergents can be preferably exemplified. Among these, tonic dosage forms, lotion dosage forms, cream dosage forms Is particularly preferable. The hair nourishing promoter of the present invention is highly safe, has excellent usability, and has a remarkable hair-growth effect. In the cosmetic for promoting hair nourishment of the present invention, the content of the extract containing the hair nourishing promoter is preferably 0.001 to 50% by weight, more preferably 0. It is 1 to 20% by weight. This is because, if the amount is too small, the hair-growth promoting action may not be exhibited, and if the amount is too large, the effect may reach the ceiling and the freedom of other prescription ingredients may be impaired.

A cosmetic containing the hair nourishing agent of the present invention is
Minoxidil, pantothenyl ethyl ether and alloxazine, adenosine-3 ', known as hair growth promoters,
5'-cyclic monophosphate (c-AM
P), vitamin E acetate, carpronium chloride, D
L-α-tocopherol, DL-α-tocopherol,
When combined with nicotinic acid and its derivatives (nicotinic acid, benzyl nicotinate, ethyl nicotinate, methyl nicotinate, etc.), the hair growth promoting effect is excellent due to the synergistic effect.
In order to maintain good hair growth effect, stigmasteranol and its derivatives, vitamin E and its derivatives, pantothenol and its derivatives, pantothenic acid and its derivatives, glycyrrhizinic acid and its derivatives, glycyrrhetinic acid and Derivatives thereof, nicotinic acid and its derivatives, salicylic acid and its derivatives, glutathione peroxidase, porphyrin derivatives, folic acid, vitamin C, vitamin H, cepharanthin, ethinyl estradiol, prednisolone, placenta extract (placenta extract), royal jelly, pyridoxine hydrochloride, photosensitizer. , One or more of diphenhydramine hydrochloride and allantoin. As the concentration to be included, 0.01
˜70 wt%, preferably 0.1 to 20 wt%, more preferably 0.5 to 5 wt%. This is because if the added concentration is too low, the effect is not exhibited, and if it is too high, unfavorable effects such as irritation occur. Further, for the purpose of imparting a refreshing feeling to the scalp and refreshing the background, one or more of l-menthol, l-menthyl glyceryl ether, and ethanol are contained as a texture improving agent.
The concentration to be contained is 0.001 to 70% by weight, preferably 0.01 to 20% by weight. This is because if the added concentration is too low, the effect is not exhibited, and if it is too high, unfavorable effects such as irritation occur. In particular, ethanol is preferable because it reduces irritation by suppressing it to 50% by weight or less, preferably 40% by weight or less.

In addition to the above-mentioned essential components, any components usually used in cosmetics and external medicines for skin can be contained. Such optional components include hydrocarbons such as squalane, petrolatum, microcrystalline wax, jojoba oil, carnauba wax, esters such as octyldodecyl oleate, triglycerides such as olive oil, lard, and coconut oil, stearic acid, Fatty acids such as oleic acid and lithinoleic acid, higher alcohols such as oleyl alcohol, stearyl alcohol and octyldodecanol, anionic surfactants such as sulfosuccinate and sodium polyoxyethylene alkyl sulfate, and amphoteric surfactants such as alkyl betaine salts , Cationic surfactants such as dialkyl ammonium salts, sorbitan fatty acid esters, fatty acid monoglycerides, polyoxyethylene adducts thereof, polyoxyethylene alkyl ethers, polyoxyethylene fats Nonionic surfactants such as esters, polyethylene glycol, glycerine,
Polyhydric alcohols such as 1,3-butanediol, thickening
Gelling agent, antioxidant, UV absorber, coloring agent, preservative,
It may contain powder and the like.

(6) Evaluation method by mouse hair-growth test (hair-growth evaluation method using C3H mouse) A crude drug extract having Tsuyo Sayo, plant sterols and plant sterol glycosides, and an extract having an activity to promote hair root enzyme activity are decompressed. After concentrating, freeze-dry, and dry the solid in 5% 70% ethanol.
It was dissolved at a concentration of 10% and used as a test sample. As a control, vehicle 70% ethanol and comparative control example 1% minoxidil were used. A 7-week-old male C3H mouse (Charles River) was purchased, acclimated for 2 weeks, and then subjected to the experiment. The back surface of the mouse was shaved with an electric clipper, and the half surface facing the tail was shaved with a shaver (National High Spin ES467). As a group of 7 animals, 40 μl of the sample was applied to the shaved site every day for 5 days a week. The growth of hair is observed with the naked eye and a color difference meter (Minolta CR
It was evaluated by objective measurement by measuring the lightness value (L) according to -200). The results were judged from the results of 5 animals excluding the animals showing the minimum and maximum effects in consideration of the variation among the 7 animals.

[0018]

EXAMPLES The present invention will be described in more detail below with reference to Examples, but it goes without saying that the present invention is not limited to these Examples.

<Examples 1 to 14> As crude drugs having a tsuru action, 1) Chorei, 2) Touki, 3) Bukuro,
As the plant sterol glycosides, A) stichmasteranol maltosid, B) ergosterol glucosid, and a) castor bean and a) hawthorn were selected as crude drugs having an effect of promoting hair root enzyme activity. 100 g of the whole herb of the above crude drug was extracted with 1 L of 50% ethanol at room temperature for 7 to 10 days, concentrated under reduced pressure and freeze-dried to obtain an extract of the dried solid product. As a test sample, each dry solid was dissolved in 70% ethanol to a concentration of 10%. As examples, Example 1: Chorei + Stigma Mustanol Maltoshi + Castor Bean, Example 2: Chorei + Stigma Mustanol Maltoshi + Hawthorn, Example 3: Touki + Stigma Masteranol Maltoshi +
Castor bean, Example 4: Touki + Stigma Mustanol Malt Shit + Hawthorn, Example 5: Bukyou + Stigma Mustanol Maltoshi + Castor Bean, Example 6: Bukyou + Stigma Mustanol Malt Shit + Hawthorn, Example 7: Chorei + Ergosterol glucoside + castor beans,
Example 8: Chorei + ergosterol glucosid + hawthorn, Example 9: Touki + ergosterol glucosid + castor bean, Example 1
0: Touki + Erukosterol Glucosid + Hawthorn, Example 11:
Bukuryo + Erukosterol Glucose + Castor bean, Example 12:
Bukuryo + ergosterol glucoside + hawthorn was used. In addition, as Comparative Examples, Comparative Example 1: Chorei, Comparative Example 2: Touki, Comparative Example 3: Bukuro, Comparative Example 4: Stigmaster Mustanol Maltosit, Comparative Example 5: Elcosterrol Glucosit, Comparative Example 6: Hawthorn, Comparative Example 7: Castor bean, Comparative Example 6: Chorei + Stigma Mustanol Maltosit, Comparative Example 7: Touki + Stigma Mustanol Maltosit, Comparative Example 8: Bukyou + Stigma Mustanol Maltosit, Comparative Example 9: Chorei + Shiroganegara, Comparative Example 10: Touki + Shiroganegarasa, Comparative Example 11: Bukuro + Shiroganegarasa, Comparative Example 12: Hawthorn + Chorei, Comparative Example 1
3: Hawthorn + Touki, Comparative Example 14: Hawthorn + Bucurry, Comparative Example 15: Castor beans + Chorei, Comparative Example 1
6: Castor bean + Touki, Comparative Example 17: Castor bean + Bukyou, Comparative Example 18: Hawthorn + Stigma Mustanol Maltosit, Comparative Example 19: Hawthorn + Stigma Mustanol Malt Sit, Comparative Example 2
0: Hawthorn + White Squirrel Galaxa, Comparative Example 21: Hawthorn + White Squirrel Galaxa, Comparative Example 22: Castor + Stigma Mustanol Maltosit, Comparative Example 23: Castor + Sticuma Mustanol Malt Citrate, Comparative Example 24: Castor + White Scallop Quercus, Comparative Example 25: Castor beans + Spodoptera punctata were used. on the other hand,
As a control, 70% ethanol of vehicle was used, and as a comparative control example 1, 1% minoxidil was used. C3H
The back of the mouse is shaved with an electric hair clipper, and the half face toward the tail is shaved (National High Spin ES
467) and the hair was shaved. As a group of 7 animals, 40 μl of the sample was applied to the shaved site every day for 5 days a week. The growth of hair was evaluated by visual observation and objective measurement by measuring the lightness value (L) with a colorimeter (Minolta CR-200).
Table 1 shows the test results of the mouse hair nourishing effect after 20 days. As can be seen from Table 1, a crude drug extract having a tsu liquid action,
By combining and combining a plant sterol glycoside and a crude drug having an effect of promoting hair root enzyme activity (Examples 1 to 1)
2), the synergistic effect for promoting hair growth was superior to each of them (Comparative Examples 1 to 7) and the combination of two kinds (Comparative Examples 8 to 25). The hair growth-promoting effect of the crude drug extract having a sucrose action, the plant sterol glycoside and the hair root enzyme activity-promoting effect of the crude drug extract is superior to that of the minoxidil administration group, and it can be seen that it is an excellent hair-growth promoting agent. .
(The results show the average value and SEM)

[0020]

[Table 1]

<Example 12> Using the extract of a crude drug having a syrup action, the plant sterol glycoside and the extract of a crude drug having an effect of promoting hair root enzyme activity, which were extracted by the above-mentioned methods of Examples 1 to 14, The tonic shown in Figure 2 was created and the effect of promoting hair growth in humans was investigated. As Example 12, a hair tonic in which 2% Chorei extract + 2% Stigmas Mustanol Maltoshi extract + 2% Hawthorn extract were simultaneously mixed, Comparative Example 26: 6.
Hair Tonic with% Chorei Extract, Comparative Example 2
Hair tonic containing 7: 6% Stigma Mustanol Maltoside Extract, Comparative Example 28: Hair tonic containing 6% Hawthorn Extract, Comparative Example 29: 3% Chorei Extract + 3% Stigma Masteranol Maltosit Extract Hair Tonic, Comparative Example 3
Hair tonic containing 0: 3% chorei extract + 3% hawthorn extract, Comparative Example 3 1: 3% hawthorn extract +3
% Tonic masterol maltosid extract was added, and as a comparative control example 2, a tonic to which 3% minoxidil was added was prepared. Furthermore, as a control, we also created a tonic that does not contain a hair-growth material. Each of the above tonics was collected by a panelist and a hair growth promoting effect test was conducted. That is,
A total of 90 subjects with androgenetic alopecia having an average age of 46.6 were collected and divided into 9 groups of 10 persons. I had him use it twice a day for 6 months in a row. After 6 months, the degree of improvement due to hair nourishment was examined. The results are expressed as ++ for a group that significantly improved compared to before use, + for a group that slightly improved compared to before use, and ± for a group that did not improve compared to before use. From the results of Table 2, the hair-growth promoting effect of the tonic containing the herbal medicine extract is superior to that of the control, and among them, the herbal extract having the tsu liquid action of Example 12, the plant sterol glycoside and the hair root enzyme activity promoting effect are present. Tonic (2% Chorei extract + 2% Stigma Mustanol Maltoshito extract + 2% Hawthorn extract combined at the same time) is a tonic that contains all the extracts of herbal medicines, and the hair growth promoting effect is excellent due to the synergistic action of the three herbal extracts. However, it was found to be more effective for androgenetic alopecia than tonics containing minoxidil. * Hair-growth material (herbal medicine extract) 6 parts by weight 1-menthol 0.15 parts by weight dipotassium glycyrrhizinate 0.05 parts by weight sorbitan monolaurate 0.2 parts by weight POE (20) POP (6) 2-decyltetradecyl ether 0 ． 7 parts by weight Soybean phospholipids 0.2 parts by weight 1,3 pentanediol 3 parts by weight Glycerin 2 parts by weight Citric acid 0.1 parts by weight Sodium citrate 0.1 parts by weight Methylparaben 0.1 parts by weight Ethanol 40 parts by weight Water 47 .40 parts by weight

[0022]

[Table 2]

<Example 13> Using the crude drug extract having the action of syrup, the plant sterol glycoside and the extract of the crude drug having the activity of promoting hair root enzyme activity, which were extracted by the above-mentioned methods of Examples 1 to 14, The tonic shown in Figure 2 was created and the effect of promoting hair growth in humans was investigated. As Example 12, a hair tonic in which 2% Touki extract + 2% Stigma Mustanol maltoside extract + 2% hawthorn extract were simultaneously mixed, Comparative Example 26: 6%
Hair tonic containing Toki extract, Comparative Example 27: 6
% Stigmasteranol Maltosit extract blended hair tonic, Comparative Example 28: 6% hawthorn extract blended hair tonic, Comparative Example 29: 3% Sugimasterol maltosit extract blended hair tonic, Comparative Example 30: 3%
Hair Tonic with Touki Extract + 3% Hawthorn Extract, Comparative Example 31: Hair Tonic with 3% Hawthorn Extract + 3% Stigmaster Mustanol Maltoshi Extract, and Tonic with 3% Minoxidil as Comparative Control Example 2 did. Furthermore, as a control, we also created a tonic that does not contain a hair-growth material. Each of the above tonics was collected by a panelist and a hair growth promoting effect test was conducted. That is, 90 subjects with male pattern baldness with an average age of 42.9 were collected and 10
The people were divided into 9 groups. I had him use it twice a day for 6 months in a row. After 6 months, the degree of improvement due to hair nourishment was examined. The results are expressed as ++ for a group that significantly improved compared to before use, + for a group that slightly improved compared to before use, and ± for a group that did not improve compared to before use. From the results of Table 3, the hair-growth promoting effect of the tonic containing the herbal medicine extract is superior to that of the control, and among them, the herbal medicine extract having the tsu liquid action of Example 12, the herbal medicine extract having the angiogenic activity and the hair root enzyme. A tonic (a hair tonic containing 2% Touki extract + 2% Stigma Mustanol Maltoshito extract + 2% Hawthorn extract at the same time) that contains all the extracts of herbal medicines that have an activity-promoting effect is a hair growth promotion by the synergistic action of the three herbal extracts. It was found to be excellent in the effect and more effective for androgenetic alopecia than the tonic containing minoxidil. * Hair-growth material (herbal medicine extract) 6 parts by weight 1-menthol 0.15 parts by weight dipotassium glycyrrhizinate 0.05 parts by weight sorbitan monolaurate 0.2 parts by weight POE (20) POP (6) 2-decyltetradecyl ether 0 ． 7 parts by weight Soybean phospholipids 0.2 parts by weight 1,3 pentanediol 3 parts by weight Glycerin 2 parts by weight Citric acid 0.1 parts by weight Sodium citrate 0.1 parts by weight Methylparaben 0.1 parts by weight Ethanol 40 parts by weight Water 47 .40 parts by weight

[0024]

[Table 3]

Example 14 By treating the components of the emulsion base shown below by a conventional method, a milky lotion containing 3% each of bukuro butter extract, stigmastanol maltosit extract and taxus extract was prepared, and a panelist suffering from thinning hair was prepared. Five people in one group were used twice a day for 6 months in the morning and evening, and the effect of preventing and improving thinning hair was evaluated. The criteria for evaluation are as follows: grade 2: significant improvement, grade 1: clear improvement, grade 0.5: slight improvement, grade 0: no improvement. The average score was 1.69. The milky lotion extract having a liquor action having a hair growth promoting effect of the present invention, the stigmasteranol maltosit extract which is a plant sterol glycoside, and the Taxus extract having a hair root enzyme activity promoting effect are excellent effects for improving thinning hair. It was recognized that Behenyl alcohol 0.2 parts by weight 1,2-pentanediol 10 parts by weight 2-ethylhexanoate cetyl 2 parts by weight squalane 7 parts by weight dipotassium glycyrrhizinate 0.0 1 parts by weight methyl paraoxybenzoate 0.2 parts by weight lipophilic mono Glycerin stearate 2.5 parts by weight Polyoxyethylene hydrogenated castor oil (50 E.O.) 1.5 parts by weight beeswax 1. 5 parts by weight ethanol 3. 0 parts by weight essence extract 3. 0 parts by weight Taxit extract 3.0 parts by weight Stigmasteranol maltoside extract 5.0 parts by weight l-menthol 0.15 parts by weight Fragrance 0.3 parts by weight purified water 24 60. 64 parts by weight

Example 15 An emulsion containing 3% each of a carrot extract, a stigmastanol maltosit extract and a sandalwood extract was prepared by treating the components of the emulsion base shown below by a conventional method to give thin hair. Five panelists, one group of whom were worried, were used twice a day in the morning and evening for 6 months to evaluate the effect of preventing and improving thinning hair. The criteria for evaluation are as follows: grade 2: significant improvement, grade 1: clear improvement, grade 0.5: slight improvement, grade 0: no improvement. The average score was 1.51. A milk lotion containing a carrot extract having a liquor action having a hair growth promoting effect, a stigmasteranol maltoside extract which is a plant sterol glycoside, and a sandalwood extract having a hair root enzyme activity promoting effect of the present invention is excellent in improving thinning hair. It was confirmed that there was an effect. Behenyl alcohol 0.2 parts by weight 1,3-butylene glycol 10 parts by weight 2-ethylhexanoate cetyl 2 parts by weight squalane 7 parts by weight dipotassium glycyrrhizinate 0.0 1 parts by weight methyl paraoxybenzoate 0.2 parts by weight lipophilic mono Glycerin stearate 2.5 parts by weight Polyoxyethylene hydrogenated castor oil (50 E.O.) 1.5 parts by weight beeswax 1. 5 parts by weight ethanol 5. 0 parts by weight carrot extract 3.0 parts by weight stichmasteranol maltoside extract 3.0 parts by weight juniper extract 3.0 parts by weight l-menthol 0.15 parts by weight perfume 0.3 parts by weight purified water 59. 64 parts by weight

<Example 16> A lotion type drug was prepared according to the following formulation. That is, the prescription ingredients were stirred and solubilized at room temperature to obtain a lotion. About this lotion type drug, using 5 panelists from 1 group suffering from thinning hair for 6 months,
I had them use twice a day in the morning and evening and evaluated the effect of preventing and improving thinning hair. The criteria for evaluation are as follows: grade 2: significant improvement, grade 1: clear improvement, grade 0.5: slight improvement, grade 0: no improvement. The average score was 1.69. A lotion-type pharmaceutical product is produced by a combination of a bougainberry extract having a liquorice action with a hair growth promoting effect of the present invention, a stigmasteranol maltoside extract which is a plant sterol glycoside, and a hawthorn extract having a hair root enzyme activity promoting effect. By doing so, a synergistic effect was obtained in promoting hair growth, and it was confirmed that the lotion-type drug has an excellent effect in improving thinning hair. Stigmasteranol maltosid extract 5 parts by weight Bukyou extract 5 parts by weight hawthorn extract 5 parts by weight l-menthol 0.15 parts by weight 1,3 butanediol 5 parts by weight glycerin 3 parts by weight citric acid 0.1 parts by weight sodium citrate 0.1 parts by weight methylparaben 0.2 Parts by weight ethanol 20 parts by weight polyoxyethylene hydrogenated castor oil (40 E.O.) 1 part by weight water 55.45 parts by weight

<Example 17> A scalp cream was prepared according to the following formulation. That is, (a), (b) and (c) were each heated and dissolved at 80 ° C., (a) and (b) were gradually added, and after further adding (c), the emulsified particles were homogenized with a homomixer and cooled to obtain a scalp cream. . This scalp cream had an excellent effect in preventing and improving hair loss. B) Squalane 10 parts by weight Cetanol 3 parts by weight Sorbitan sesquistearate 2 parts by weight Polyoxyethylene (20) behenyl ether 2 parts by weight Vitamin E acetate 0. 1 part by weight b) Propylene glycol 5 parts by weight ergosterol glucosid extract 5 parts by weight chimpi extract 5 parts by weight soybean extract 5 parts by weight l-menthol 0.15 parts by weight carboxyvinyl polymer 0.3 parts by weight methylparaben 0. 2 parts by weight water 35 parts by weight c) water 2 7.05 parts by weight potassium hydroxide 0. 2 parts by weight

[0029]

EFFECTS OF THE INVENTION According to the present invention, for hair loss, thinning hair, baldness, etc. caused by hormonal decrease due to aging, hair growth / hair nourishing effect and hair loss prevention effect are remarkably promoted, and safety is high,
It is possible to provide a skin external preparation for hair growth having excellent usability.

─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) A61K 35/78 A61K 35/78 W 35/84 35/84 A A61P 17/14 A61P 17/14 (72) Inventor Hitoshi Ishida 5-7-23 Sena, Shizuoka City, Shizuoka Prefecture (72) Inventor Yasuhiro Obara 27 27 Takashimadai, Kanagawa-ku, Kanagawa Yokohama City Pola Chemical Industry Co., Ltd. Pola Yokohama Laboratory (72) Inventor Maeda Tetsuo 560 Kashio-cho, Totsuka-ku, Yokohama, Kanagawa Pola Chemical Industry Co., Ltd. at Pola Totsuka Research Laboratory (72) Inventor Katsuo Matsumoto 560, Kashio-cho, Totsuka-ku, Yokohama City, Kanagawa Prefecture Pola Totsuka Research Laboratory (72) Inventor Yamamoto Takuya 560 Kashio-cho, Totsuka-ku, Yokohama-shi, Kanagawa Pola Kasei Kogyo Co., Ltd. F-term in Pola Totsuka Laboratory (reference) 4C083 AA082 AA 111 AA112 AC072 AC102 AC112 AC122 AC182 AC302 AC342 AC422 AC432 AC442 AC482 AD092 AD491 AD492 AD532 CC37 EE22 4C086 AA01 AA02 EA10 MA03 MA17 MA63 NA14 ZA92 4C088 AA04 AA05 AB12 AB40 AB41 AB46 AB51 BA08 MA07 MA92 MA63 NA14 ZA

Claims (12)

[Claims] 1. A kind or two or more kinds selected from 1) a herbal medicine extract having a sucrose action and its active ingredient, and a kind and one or more kinds selected from 2) a plant sterol and / or a plant sterol glycoside. And / or 3) a skin external preparation for hair growth, which comprises an extract of a crude drug having hair root enzyme activity and one or more active ingredients thereof. 2. The hair-growth according to claim 1, characterized in that the sap action is a maintenance / improvement action of physiological functions of biological tissues by controlling nutrients from vascular system and / or lymphatic system. External preparation for skin. 3. The skin external preparation for hair growth according to claim 1, wherein the plant sterol and / or the plant sterol glycoside has an action of suppressing androgen production around the hair root. 4. A crude drug having a tsu liquid action is bukuro,
Sekibukuryo, Bukushin, Bukuryuhi, Chorei,
Takusha, Inchinko, Mokuboi, Kanbowi, Kaseki, Yokuinin, Toukanin, Tokahi, Mokutsu, Tsutsuso, Ginseng, Kubaku, Jifushi, Henchiku, Sekii, Chariscens, Chardanthus, Penis, Penis, Hakushoku, Sekisou, Sekishou, Sekisou. , Tenmondou, Bakumonto, Ginkgo, Gyokuchikkuyakugou,
Duckweed, Spinach, Juteishi, Sesame, Kokuzu, Kokuzui, Kiban, Kibankyo, Bekko, Bekkokyo, Maou, Keishi, Perilla, Kaigai, Kyoukatsu, Kouhon, Byakushi, Saishin, Gyosu, Sohaku, Kojuu, Genius, Gensui, Gensui Peppermint, burdock, centai, soybean, chrysanthemum, burdock, mankeishi, fuhei, mokuzo, kokisoiso, kakkon, psycho, rhinoceros, rhubarb, bonsai, banshayo, rokai, machinin, ikurinin, kengoshi, genka, gyoza, taerexi, nakushi konpi, ginkgo Sanshin, Tanchikuo, Kagosou, Kansuiseki, Rensin, Locon, Ketsumeishi, Seisoushi, Mitsumouka, Yamyousha, Yutan, Seitenki, Saikaku, Shaw Ou, gendine, moutan bark, tooth root Jikoppi, Byakubi, Ginsaiko, Scutellaria, Coptis, cork tree bark, Ryuutan, Sophora root, the dermis, Koouren, Kinginka, forsythia, Atlantic, radix isatidis, dandelion, Shikajichou, Baishousou, executive position Kinshatou, Andrographis paniculata,
A kind of herbal extract selected from medaka, juniper, dianthus, balsam, atasin, bashiken, burdock, kanju, babotsu, sandscon, yakan, dogoshiti, kenjin, kinkaran, kayo, ryokkusu, seika, hakensu, kenzo, seikou Or 2 or more types, The external preparation for skin growth of any one of Claims 1-3 characterized by the above-mentioned. 5. The herb medicine having a sucrose action is one or more kinds selected from chorei, bukuro, carrot, touki, capsicum, chimpi, spruce, and bukuro herb extracts. Item 5. A skin external preparation for growing hair according to any one of Items 1 to 4. 6. A plant sterol and / or a plant sterol glycoside is stigmasteranol, stigmasteranol glucoside, stigmasteranol maltoside, stigmasteranol maltotrioside, stigmasteranol maltotetraoside, stigma. Selected from stanol maltopentaoside, campesterol, campesterol glucoside, campesterol maltoside, ergosterol glucoside, ergosterol maltoside, ergosterol maltotrioside, ergosterol maltotetraoside, ergosterol malpentaoside One or two or more types, The skin external preparation for hair growth according to any one of claims 1 to 5. 7. The plant sterol and / or plant sterol glycoside is one or two kinds selected from stigmasteranol maltoside, stigmasteranol maltotrioside, ergosterol maltoside and ergosterol maltotrioside. It is above, The skin external preparation for hair growth as described in any one of Claims 1-6 characterized by the above-mentioned. 8. The herb medicine having hair root enzyme activity is selected from one or two or more kinds selected from the extract of herb medicine of Taxus, castor bean, Kamala, Kissoukon, sandalgrass, kotonikku, hawthorn, soybean, lotus root, and ground beetle. A skin external preparation for hair growth according to any one of claims 1 to 7, characterized in that: 9. The skin external preparation for hair growth according to claim 1, wherein the extract is an extract of a whole grass with a polar solvent. 10. The external skin treatment agent for hair growth according to claim 1, which is a cosmetic or a pharmaceutical product. 11. 1) Bukuryou, coughing Bukuryou, Bukushin, Bukuryouhi, Chorei, Takusha, Intin-koo, Mokuboui, Kanboui, talc, Coix, the person, Toukahi, Mokutsuu, continuo, Toushinsou, Kubaku, Jifushi, Henchiku, Sekii, Shazenshi, Chasen, Tokihi, Hikai, Calendula,
Sekishos, Hampenren, Gokmaishu, Shajin, Seijin, Tenmondou, Bakumonto, Ginkgo, Ginkgo sycamore, Ganoderma lucidum, Ginseng, Kiban, Ginkgo, Kokuzuku, Kouzukii, Kiban, Kibankyo, Bekko, Bekkosouki, Koubou, Maou Kyoukatsu, Kouhon, Jakushi, Saishin, Gyosho, Souaku, Koju,
Gensui, Seiryuka, Shini, peppermint, burdock,
Centai, soyo, chrysanthemum, daisies, mankei,
Fuhei, Mokuzo, Kosoiso, Cuckoo, Psycho,
Rhinoceros, bow show, banshayou, lokai, machinin, ikrinin, kengoshi, genka, shoulik, terexi, ukyu compi, gypsum, chimo, sanshin,
Tantricius, Kagosou, Kanseki Seki, Rensin, Locon, Ketsumeishi, Seisoushi, Mitsumouka, Yamyousha, Yutan, Seitenki, Psychiatry, Ginger, Gingin, Buttonpi, Sikon, Zikoppi, Juniper, Ginkgo, Gourmet, Gourd, Gourd, Gourd, Gourmeta. Coleoptera, Goldfish, Forsythia, Atlantic Ocean, Banglancon, Houkouei,
Deer butterflies, birch, juniper, quince, senchinren, juniper, juniper, juniper, broom, atasin, bashiken, dobukuryo, kanju, babotsu, sandcon, yakan, dogoshitu, kenjin, quincalin, kayo, rye dove, sardine, sardine One or two or more species selected from the extract of crude drug of Gypsophila and 2) one or more species selected from plant sterol and / or glycosides of plant sterols 3) Taxus, castor bean, Kamala, Kissoukkon, sandalwood , Kotonik, Hawthorn, Sayo,
A skin external preparation for hair growth, which comprises one or more selected from extracts of herbal medicines of spinach, weeds, and sansha. 12. 1) One or two or more kinds selected from Chorei, Bukuro, Carrot, Toki, Capsicum, Chinpi, Spruce, and Tonin herb extracts, and 2).
Plant sterol and / or plant sterol glycoside,
Stigmasteranol, Stigmasteranol glucoside,
Stigmasteranol maltoside, stigmasteranol maltotrioside, stigmasteranol maltotetraoside, stigmasteranol maltopentaoside, campesterol, campesterol glucoside, campesterol maltoside, ergosterol glucoside, ergosterol maltoside, One or more selected from ergosterol maltotrioside, ergosterol maltotetraoside, ergosterol malpentaoside, and 3) taxit, castor bean, camara, kissweed turmeric, sandgrass, kotokuniku, hawthorn, sayou, lotus root, The external preparation for skin growth for hair growth according to claim 11, which contains one or more selected from extracts of herbal medicine and Chinese herb medicine.