JPH07507549A - 味の良い医薬組成物 - Google Patents
味の良い医薬組成物Info
- Publication number
- JPH07507549A JPH07507549A JP6500885A JP50088594A JPH07507549A JP H07507549 A JPH07507549 A JP H07507549A JP 6500885 A JP6500885 A JP 6500885A JP 50088594 A JP50088594 A JP 50088594A JP H07507549 A JPH07507549 A JP H07507549A
- Authority
- JP
- Japan
- Prior art keywords
- drug
- coating
- coated
- poly
- pct
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims (10)
- 1.不快な味の薬剤を含有する芯材料からなる経口投与用の味をマスクした医薬 顆粒組成物であって、該芯は、1:2:0.2の割合のポリ(アクリル酸エチル ーメタクリル酸メチル)トリメチルアンモニオエチルメタクリラートクロリドか らなる高透過性内部ポリマー性被覆および1:2:0.1の割合のポリ(アクリ ル酸エチル−メタクリル酸メチル)トリメチルアンモニオエチルメタクリラート クロリドからなる低透過性外部ポリマー性被覆を有し、該被覆により薬剤が胃中 で即時放出される医薬顆粒組成物。
- 2.該ポリマー性被覆が可塑剤を含有している請求項1記載の組成物。
- 3.可塑剤が約5%ないし約30%の量で存在し、被覆顆粒が約200ないし約 400ミクロンの最終粒子サイズを有する請求項2記載の組成物。
- 4.該薬剤が、シメチジン、ラニチジン、カフェイン、アセトアミノフェン、デ キストロメトルファン、クロルフェニラミン、ジフェンヒドラミン、テオフィリ ン、ペニシリン、アンピシリンおよびエリスロマイシンからなる群より選択され る請求項1、2または3記載の組成物。
- 5.請求項1記載の医薬顆粒組成物を含有し、さらに所望により医薬賦形剤を含 有していてもよい咀嚼可能な錠剤。
- 6.請求項4記載の顆粒組成物を含有する咀嚼可能な錠剤。
- 7.薬剤がシメチジンであって、それが約100mgないし約400の量で存在 する請求項6記載の咀嚼可能な錠剤。
- 8.薬剤芯材料の流動床上に高透過性の内部ポリマー性被覆の水性分散物を噴霧 し、被覆芯材料を回収し、除塵し、除塵した材料の流動床に低透過性の外部ポリ マー性被覆を適用し、被覆粒子を除塵し、ついで、乾燥することからなる、味を マスクした医薬顆粒組成物の製造方法。
- 9.内部ポリマー性被覆が1:2:0.2の割合のポリ(アクリル酸エチル−メ タクリル酸メチル)トリメチルアンモニオエチルメタクリラートクロリドであり 、ポリマー性外部被覆が1:2:0.1の割合のポリ(アクリル酸エチル−メタ クリル酸メチル)トリメチルアンモニオエチルメタクリラートクロリドであって 、被覆された物質を除塵して最終粒子サイズを約200ないし約400ミクロン とした請求項8記載の方法。
- 10.薬剤がシメチジンまたはカフェインである請求項8記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US89328892A | 1992-06-04 | 1992-06-04 | |
US893,288 | 1992-06-04 | ||
PCT/US1993/005423 WO1993024109A1 (en) | 1992-06-04 | 1993-06-04 | Palatable pharmaceutical compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH07507549A true JPH07507549A (ja) | 1995-08-24 |
JP3839467B2 JP3839467B2 (ja) | 2006-11-01 |
Family
ID=25401342
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50088594A Expired - Fee Related JP3839467B2 (ja) | 1992-06-04 | 1993-06-04 | 味の良い医薬組成物 |
Country Status (8)
Country | Link |
---|---|
US (1) | US5578316A (ja) |
EP (1) | EP0650353B1 (ja) |
JP (1) | JP3839467B2 (ja) |
AT (1) | ATE217789T1 (ja) |
CA (1) | CA2137265C (ja) |
DE (1) | DE69331948T2 (ja) |
ES (1) | ES2174849T3 (ja) |
WO (1) | WO1993024109A1 (ja) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000509399A (ja) * | 1996-05-07 | 2000-07-25 | エフ・エイチ・フォールディング・アンド・カンパニー・リミテッド | 味隠蔽された懸濁液 |
JP2001253826A (ja) * | 2000-03-09 | 2001-09-18 | Maruzen Pharmaceut Co Ltd | 内服用剤 |
JP2001527526A (ja) * | 1996-11-23 | 2001-12-25 | エルティエス ローマン テラピー−ズュステーメ アーゲー | 消化管内での作用物質調整放出用トローチ |
JP2005506323A (ja) * | 2001-09-05 | 2005-03-03 | ベクトゥラ・リミテッド | 経口送達用機能性散剤 |
JP2005526756A (ja) * | 2002-03-11 | 2005-09-08 | ノバルティス アクチエンゲゼルシャフト | 味をマスクした獣医用固体組成物 |
JP2013537896A (ja) * | 2010-09-27 | 2013-10-07 | ビーエーエスエフ ソシエタス・ヨーロピア | 酸性有効成分のための保護コーティング |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5837277A (en) * | 1992-06-04 | 1998-11-17 | Smithkline Beecham Corporation | Palatable pharmaceutical compositions |
AU1655595A (en) * | 1994-04-29 | 1995-11-09 | Mcneil-Ppc, Inc. | Solid pharmaceutical dosage form containing flavored film coating |
US5853756A (en) * | 1995-01-11 | 1998-12-29 | J. B. Chemicals & Pharmaceuticals Limited | Controlled release formulations of Ranitidine |
FR2752732B1 (fr) * | 1996-08-28 | 1998-11-20 | Pf Medicament | Forme galenique a liberation prolongee de milnacipran |
IL129242A0 (en) * | 1996-10-01 | 2000-02-17 | Cima Labs Inc | Taste-masked microcapsule compositions and methods of manufacture |
UA65607C2 (uk) | 1998-03-04 | 2004-04-15 | Орто-Макнейл Фармацевтикал, Інк. | Фармацевтична композиція (варіанти) та спосіб її приготування |
US8231899B2 (en) * | 1998-09-10 | 2012-07-31 | Nycomed Danmark Aps | Quick release pharmaceutical compositions of drug substances |
AU9664498A (en) * | 1998-09-24 | 2000-04-10 | Procter & Gamble Company, The | Chewable compositions containing dextromethorphan |
US6270807B1 (en) | 1999-03-02 | 2001-08-07 | L. Perrigo Company | Taste-masked pharmaceutical composition |
IN191482B (ja) * | 1999-03-19 | 2003-12-06 | Ranbaxy Lab Ltd | |
WO2001035930A1 (en) * | 1999-11-16 | 2001-05-25 | Ranbaxy Laboratories Limited | Taste masked oral compositions |
CZ20023167A3 (cs) * | 2000-02-29 | 2003-10-15 | Teva Pharmaceutical Industries Ltd. | Způsob přípravy klaritromycinu a klaritromycinového meziproduktu, v podstatě prostého oximu a farmaceutický prostředek, který jej obsahuje |
AU2001278673A1 (en) * | 2000-10-30 | 2002-05-15 | Lupin Limited | Rapidly disintegrating sustained release cefuroxime axetil composition |
KR100510356B1 (ko) * | 2001-02-27 | 2005-08-24 | 룀 게엠베하 운트 콤파니 카게 | 저장 안정성이 개선된 피복제 및 결합제를 포함하는 약제학적 제형 및 이의 제조방법 |
US7914811B2 (en) * | 2001-06-29 | 2011-03-29 | Mcneil-Ppc, Inc. | Brittle-coating, soft core dosage form |
US7838026B2 (en) | 2001-09-28 | 2010-11-23 | Mcneil-Ppc, Inc. | Burst-release polymer composition and dosage forms comprising the same |
US7122143B2 (en) | 2001-09-28 | 2006-10-17 | Mcneil-Ppc, Inc. | Methods for manufacturing dosage forms |
US6723348B2 (en) * | 2001-11-16 | 2004-04-20 | Ethypharm | Orodispersible tablets containing fexofenadine |
US20030220351A1 (en) * | 2002-05-24 | 2003-11-27 | Gilbert Gonzales | Enteric coated caffeine tablet |
US7632521B2 (en) * | 2003-07-15 | 2009-12-15 | Eurand, Inc. | Controlled release potassium chloride tablets |
EP1673064A1 (en) * | 2003-08-28 | 2006-06-28 | Sandoz AG | Pharmaceutical composition comprising anticonvulsant with taste mask coating |
US20050181050A1 (en) * | 2004-01-28 | 2005-08-18 | Collegium Pharmaceutical, Inc. | Dosage forms using drug-loaded ion exchange resins |
US8609198B2 (en) * | 2004-07-21 | 2013-12-17 | Hewlett-Packard Development Company, L.P. | Pharmaceutical dose form with a patterned coating and method of making the same |
WO2006081518A2 (en) * | 2005-01-28 | 2006-08-03 | Collegium Pharmaceutical, Inc. | Non-ionic non-aqueous vehicles for topical and oral administration of carrier-complexed active agents |
JP2009541337A (ja) * | 2006-06-19 | 2009-11-26 | マクニール−ピーピーシー・インコーポレーテツド | 活性成分を含有する腸溶性の被覆された粒子 |
US20130005874A1 (en) * | 2010-03-15 | 2013-01-03 | Taisho Pharmaceutical Co., Ltd | Pigment composition |
US9795576B2 (en) | 2010-09-27 | 2017-10-24 | Basf Se | Protective coatings for acidic active ingredients |
DK2637668T3 (en) | 2010-11-08 | 2016-08-29 | Albireo Ab | Ibat inhibitors for the treatment of liver diseases |
US10525010B2 (en) | 2012-05-02 | 2020-01-07 | Capsugel Belgium Nv | Aqueous dispersions of controlled release polymers and shells and capsules thereof |
WO2015065848A1 (en) | 2013-11-04 | 2015-05-07 | Capsugel Belgium Nv | Methods and systems for improved bioavailability of active pharmaceutical ingredients including esomeprazole |
WO2015130760A1 (en) | 2014-02-25 | 2015-09-03 | Orbis Biosciences, Inc. | Taste masking drug formulations |
JP6751020B2 (ja) | 2014-06-25 | 2020-09-02 | Eaファーマ株式会社 | 固形製剤及びその着色防止又は着色低減方法 |
US10441604B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Cholestyramine pellets and methods for preparation thereof |
US10441605B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Oral cholestyramine formulation and use thereof |
US10786529B2 (en) * | 2016-02-09 | 2020-09-29 | Albireo Ab | Oral cholestyramine formulation and use thereof |
WO2019032026A1 (en) | 2017-08-09 | 2019-02-14 | Albireo Ab | CHOLESTYRAMINE GRANULES, ORAL FORMULATIONS OF CHOLESTYRAMINE AND THEIR USE |
US10793534B2 (en) | 2018-06-05 | 2020-10-06 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
WO2019245448A1 (en) | 2018-06-20 | 2019-12-26 | Albireo Ab | Crystal modifications of odevixibat |
US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
US11549878B2 (en) | 2018-08-09 | 2023-01-10 | Albireo Ab | In vitro method for determining the adsorbing capacity of an insoluble adsorbant |
US10722457B2 (en) | 2018-08-09 | 2020-07-28 | Albireo Ab | Oral cholestyramine formulation and use thereof |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63174925A (ja) * | 1987-01-14 | 1988-07-19 | Hisamitsu Pharmaceut Co Inc | マイクロカプセル製剤の製造法 |
JPH01100116A (ja) * | 1987-10-12 | 1989-04-18 | Mitsui Toatsu Chem Inc | 薬物の好ましくない官能的性質を隠蔽した散剤の製造方法 |
JPH01313420A (ja) * | 1988-05-04 | 1989-12-18 | Smith Kline Ltd | 医薬咀しゃく錠組成物 |
JPH02202A (ja) * | 1987-12-21 | 1990-01-05 | Synthelabo Sa | 徐放性医薬製剤 |
JPH0372417A (ja) * | 1989-05-11 | 1991-03-27 | Chugai Pharmaceut Co Ltd | 腸内適所放出経口製剤 |
JPH03204810A (ja) * | 1989-12-28 | 1991-09-06 | Tanabe Seiyaku Co Ltd | 放出制御型製剤およびその製法 |
JPH03258730A (ja) * | 1990-03-07 | 1991-11-19 | Asahi Chem Ind Co Ltd | 顆粒含有錠 |
US5075114A (en) * | 1990-05-23 | 1991-12-24 | Mcneil-Ppc, Inc. | Taste masking and sustained release coatings for pharmaceuticals |
Family Cites Families (6)
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US4800087A (en) * | 1986-11-24 | 1989-01-24 | Mehta Atul M | Taste-masked pharmaceutical compositions |
JPS63188621A (ja) * | 1987-01-30 | 1988-08-04 | Taisho Pharmaceut Co Ltd | 矯味経口製剤 |
KR960011236B1 (ko) * | 1987-05-08 | 1996-08-21 | 스미스 클라인 앤드 프렌취 라보라토리스 리미티드 | 제약학적 조성물 및 고체 제형 |
US4925675A (en) * | 1988-08-19 | 1990-05-15 | Himedics, Inc. | Erythromycin microencapsulated granules |
US5084287A (en) * | 1990-03-15 | 1992-01-28 | Warner-Lambert Company | Pharmaceutically useful micropellets with a drug-coated core and controlled-release polymeric coat |
CA2068402C (en) * | 1991-06-14 | 1998-09-22 | Michael R. Hoy | Taste mask coatings for preparation of chewable pharmaceutical tablets |
-
1993
- 1993-06-04 AT AT93914418T patent/ATE217789T1/de not_active IP Right Cessation
- 1993-06-04 US US08/347,325 patent/US5578316A/en not_active Expired - Lifetime
- 1993-06-04 ES ES93914418T patent/ES2174849T3/es not_active Expired - Lifetime
- 1993-06-04 WO PCT/US1993/005423 patent/WO1993024109A1/en active IP Right Grant
- 1993-06-04 JP JP50088594A patent/JP3839467B2/ja not_active Expired - Fee Related
- 1993-06-04 EP EP93914418A patent/EP0650353B1/en not_active Expired - Lifetime
- 1993-06-04 CA CA002137265A patent/CA2137265C/en not_active Expired - Fee Related
- 1993-06-04 DE DE69331948T patent/DE69331948T2/de not_active Expired - Lifetime
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63174925A (ja) * | 1987-01-14 | 1988-07-19 | Hisamitsu Pharmaceut Co Inc | マイクロカプセル製剤の製造法 |
JPH01100116A (ja) * | 1987-10-12 | 1989-04-18 | Mitsui Toatsu Chem Inc | 薬物の好ましくない官能的性質を隠蔽した散剤の製造方法 |
JPH02202A (ja) * | 1987-12-21 | 1990-01-05 | Synthelabo Sa | 徐放性医薬製剤 |
JPH01313420A (ja) * | 1988-05-04 | 1989-12-18 | Smith Kline Ltd | 医薬咀しゃく錠組成物 |
JPH0372417A (ja) * | 1989-05-11 | 1991-03-27 | Chugai Pharmaceut Co Ltd | 腸内適所放出経口製剤 |
JPH03204810A (ja) * | 1989-12-28 | 1991-09-06 | Tanabe Seiyaku Co Ltd | 放出制御型製剤およびその製法 |
JPH03258730A (ja) * | 1990-03-07 | 1991-11-19 | Asahi Chem Ind Co Ltd | 顆粒含有錠 |
US5075114A (en) * | 1990-05-23 | 1991-12-24 | Mcneil-Ppc, Inc. | Taste masking and sustained release coatings for pharmaceuticals |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000509399A (ja) * | 1996-05-07 | 2000-07-25 | エフ・エイチ・フォールディング・アンド・カンパニー・リミテッド | 味隠蔽された懸濁液 |
JP2001527526A (ja) * | 1996-11-23 | 2001-12-25 | エルティエス ローマン テラピー−ズュステーメ アーゲー | 消化管内での作用物質調整放出用トローチ |
JP2001253826A (ja) * | 2000-03-09 | 2001-09-18 | Maruzen Pharmaceut Co Ltd | 内服用剤 |
JP2005506323A (ja) * | 2001-09-05 | 2005-03-03 | ベクトゥラ・リミテッド | 経口送達用機能性散剤 |
JP2005526756A (ja) * | 2002-03-11 | 2005-09-08 | ノバルティス アクチエンゲゼルシャフト | 味をマスクした獣医用固体組成物 |
JP4663985B2 (ja) * | 2002-03-11 | 2011-04-06 | ノバルティス アーゲー | 味をマスクした獣医用固体組成物 |
JP2013537896A (ja) * | 2010-09-27 | 2013-10-07 | ビーエーエスエフ ソシエタス・ヨーロピア | 酸性有効成分のための保護コーティング |
Also Published As
Publication number | Publication date |
---|---|
CA2137265C (en) | 2003-10-28 |
ATE217789T1 (de) | 2002-06-15 |
EP0650353B1 (en) | 2002-05-22 |
DE69331948D1 (de) | 2002-06-27 |
JP3839467B2 (ja) | 2006-11-01 |
WO1993024109A1 (en) | 1993-12-09 |
DE69331948T2 (de) | 2002-11-28 |
EP0650353A1 (en) | 1995-05-03 |
CA2137265A1 (en) | 1993-12-09 |
ES2174849T3 (es) | 2002-11-16 |
EP0650353A4 (en) | 1996-02-28 |
US5578316A (en) | 1996-11-26 |
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