ES2174849T3 - Composiciones farmaceuticas con sabor agradable. - Google Patents

Composiciones farmaceuticas con sabor agradable.

Info

Publication number
ES2174849T3
ES2174849T3 ES93914418T ES93914418T ES2174849T3 ES 2174849 T3 ES2174849 T3 ES 2174849T3 ES 93914418 T ES93914418 T ES 93914418T ES 93914418 T ES93914418 T ES 93914418T ES 2174849 T3 ES2174849 T3 ES 2174849T3
Authority
ES
Spain
Prior art keywords
pct
drug
sec
date
coated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93914418T
Other languages
English (en)
Inventor
Sanjay Bhardwaj
Marshall Hayward
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Application granted granted Critical
Publication of ES2174849T3 publication Critical patent/ES2174849T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

UNA COMPOSICION GRANULAR FARMACEUTICA Y METODO PARA ENMASCARAR EL SABOR AMARGO, MEDICAMENTOS DE SABOR DESAGRADABLE QUE COMPRENDE UN NUCLEO DEL MEDICAMENTO Y COMO AGENTE ENMASCARADOR DEL SABOR COPOLIMEROS DE ESTER METACRILATO. EL METODO COMPRENDE EL RECUBRIMIENTO DEL NUCLEO DEL MEDICAMENTO CON CAPAS SEPARADAS DE DISPERSIONES ACUOSAS DE LOS COPOLIMEROS. ADICIONALMENTE LA COMPOSICION DEL RECUBRIMIENTO PUEDE CONTENER PLASTIFICANTES Y EXCIPIENTES CONVENCIONALES. LOS GRANULOS DE LA PRESENTE INVENCION PUEDEN SER USADOS EN LA PREPARACION DE TABLETAS MASTICABLES QUE TIENEN BUEN SABOR Y BIODISPONIBILIDAD. SON COPOLIMEROS PREFERIBLES EL POLI(ETILACRILATO, EL METILMETACRILATO) EN LOS CUALES HAN SIDO INTRODUCIDOS GRUPOS AMONIO CUATERNARIOS PARA MODIFICAR LA PERMEABILIDAD DEL ESTER. EL SISTEMA DE RECUBRIMIENTO DE ESTA INVENCION LIBERA EL MEDICAMENTO POR DIFUSION Y ES INFLUENCIADO POR LA SOLUBILIDAD DEL MEDICAMENTO Y POR EL PH MEDIO.
ES93914418T 1992-06-04 1993-06-04 Composiciones farmaceuticas con sabor agradable. Expired - Lifetime ES2174849T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US89328892A 1992-06-04 1992-06-04

Publications (1)

Publication Number Publication Date
ES2174849T3 true ES2174849T3 (es) 2002-11-16

Family

ID=25401342

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93914418T Expired - Lifetime ES2174849T3 (es) 1992-06-04 1993-06-04 Composiciones farmaceuticas con sabor agradable.

Country Status (8)

Country Link
US (1) US5578316A (es)
EP (1) EP0650353B1 (es)
JP (1) JP3839467B2 (es)
AT (1) ATE217789T1 (es)
CA (1) CA2137265C (es)
DE (1) DE69331948T2 (es)
ES (1) ES2174849T3 (es)
WO (1) WO1993024109A1 (es)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5837277A (en) * 1992-06-04 1998-11-17 Smithkline Beecham Corporation Palatable pharmaceutical compositions
AU1655595A (en) * 1994-04-29 1995-11-09 Mcneil-Ppc, Inc. Solid pharmaceutical dosage form containing flavored film coating
US5853756A (en) * 1995-01-11 1998-12-29 J. B. Chemicals & Pharmaceuticals Limited Controlled release formulations of Ranitidine
AUPN969796A0 (en) * 1996-05-07 1996-05-30 F.H. Faulding & Co. Limited Taste masked liquid suspensions
FR2752732B1 (fr) * 1996-08-28 1998-11-20 Pf Medicament Forme galenique a liberation prolongee de milnacipran
AU722289B2 (en) * 1996-10-01 2000-07-27 Aptalis Pharmatech, Inc. Taste-masked microcapsule compositions and methods of manufacture
DE19648576C2 (de) * 1996-11-23 1999-08-12 Lohmann Therapie Syst Lts Lutschtablette zur modifizierten Freisetzung von Wirkstoffen im Gastrointestinaltrakt
UA65607C2 (uk) 1998-03-04 2004-04-15 Орто-Макнейл Фармацевтикал, Інк. Фармацевтична композиція (варіанти) та спосіб її приготування
US8231899B2 (en) * 1998-09-10 2012-07-31 Nycomed Danmark Aps Quick release pharmaceutical compositions of drug substances
WO2000016742A1 (en) * 1998-09-24 2000-03-30 The Procter & Gamble Company Chewable compositions containing dextromethorphan
US6270807B1 (en) 1999-03-02 2001-08-07 L. Perrigo Company Taste-masked pharmaceutical composition
IN191482B (es) * 1999-03-19 2003-12-06 Ranbaxy Lab Ltd
WO2001035930A1 (en) * 1999-11-16 2001-05-25 Ranbaxy Laboratories Limited Taste masked oral compositions
EP1313486A1 (en) * 2000-02-29 2003-05-28 Teva Pharmaceutical Industries Ltd. Processes for preparing clarithromycin and clarithromycin intermediate, essentially oxime-free clarithromycin, and pharmaceutical composition comprising the same
JP2001253826A (ja) * 2000-03-09 2001-09-18 Maruzen Pharmaceut Co Ltd 内服用剤
ES2220789T3 (es) * 2000-10-30 2004-12-16 Lupin Limited Composicion de cefuroxima axetilo de liberacion lenta que se desintegra rapidamente.
CA2403831C (en) * 2001-02-27 2009-11-24 Evonik Operations Gmbh Coating and binding agent for pharmaceutical formulations having improved storage stability
US7914811B2 (en) * 2001-06-29 2011-03-29 Mcneil-Ppc, Inc. Brittle-coating, soft core dosage form
JP2005506323A (ja) * 2001-09-05 2005-03-03 ベクトゥラ・リミテッド 経口送達用機能性散剤
US7838026B2 (en) 2001-09-28 2010-11-23 Mcneil-Ppc, Inc. Burst-release polymer composition and dosage forms comprising the same
US7122143B2 (en) 2001-09-28 2006-10-17 Mcneil-Ppc, Inc. Methods for manufacturing dosage forms
US6723348B2 (en) * 2001-11-16 2004-04-20 Ethypharm Orodispersible tablets containing fexofenadine
CO5400144A1 (es) 2002-03-11 2004-05-31 Novartis Ag Compuestos organicos
US20030220351A1 (en) * 2002-05-24 2003-11-27 Gilbert Gonzales Enteric coated caffeine tablet
US7632521B2 (en) * 2003-07-15 2009-12-15 Eurand, Inc. Controlled release potassium chloride tablets
WO2005020961A1 (en) * 2003-08-28 2005-03-10 Sandoz Ag Pharmaceutical composition comprising anticonvulsant with taste mask coating
US20050181050A1 (en) * 2004-01-28 2005-08-18 Collegium Pharmaceutical, Inc. Dosage forms using drug-loaded ion exchange resins
US8609198B2 (en) * 2004-07-21 2013-12-17 Hewlett-Packard Development Company, L.P. Pharmaceutical dose form with a patterned coating and method of making the same
EP1846040A2 (en) * 2005-01-28 2007-10-24 Collegium Pharmaceutical, Inc. Non-ionic non-aqueous vehicles for topical and oral administration of carrier-complexed active agents
US20070292510A1 (en) * 2006-06-19 2007-12-20 Hugh Huang Enteric coated particles containing an active ingredient
EP2548928A4 (en) * 2010-03-15 2013-09-18 Taisho Pharmaceutical Co Ltd PIGMENT COMPOSITION
US9795576B2 (en) 2010-09-27 2017-10-24 Basf Se Protective coatings for acidic active ingredients
WO2012041788A1 (de) * 2010-09-27 2012-04-05 Basf Se Protektive überzüge für saure wirkstoffe
PL3400944T3 (pl) 2010-11-04 2020-11-16 Albireo Ab Inhibitory ibat w leczeniu chorób wątroby
ES2728850T3 (es) * 2012-05-02 2019-10-29 Capsugel Belgium Nv Dispersiones acuosas de acetato acetato succinato de hidroxipropilmetilcelulosa (HPMCAS)
EP3065720A1 (en) 2013-11-04 2016-09-14 Capsugel Belgium NV Methods and systems for improved bioavailability of active pharmaceutical ingredients including esomeprazole
WO2015130760A1 (en) 2014-02-25 2015-09-03 Orbis Biosciences, Inc. Taste masking drug formulations
KR102560954B1 (ko) 2014-06-25 2023-07-31 이에이 파마 가부시키가이샤 고형 제제 및 그의 착색 방지 또는 착색 감소 방법
US10441605B2 (en) 2016-02-09 2019-10-15 Albireo Ab Oral cholestyramine formulation and use thereof
US10441604B2 (en) 2016-02-09 2019-10-15 Albireo Ab Cholestyramine pellets and methods for preparation thereof
US10786529B2 (en) * 2016-02-09 2020-09-29 Albireo Ab Oral cholestyramine formulation and use thereof
CN111032019B (zh) 2017-08-09 2022-07-05 阿尔比里奥公司 考来烯胺颗粒、口服考来烯胺制剂及其用途
US10793534B2 (en) 2018-06-05 2020-10-06 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
EP3810084A1 (en) 2018-06-20 2021-04-28 Albireo AB Pharmaceutical formulation of odevixibat
US11007142B2 (en) 2018-08-09 2021-05-18 Albireo Ab Oral cholestyramine formulation and use thereof
US10722457B2 (en) 2018-08-09 2020-07-28 Albireo Ab Oral cholestyramine formulation and use thereof
US11549878B2 (en) 2018-08-09 2023-01-10 Albireo Ab In vitro method for determining the adsorbing capacity of an insoluble adsorbant

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4800087A (en) * 1986-11-24 1989-01-24 Mehta Atul M Taste-masked pharmaceutical compositions
JPS63188621A (ja) * 1987-01-30 1988-08-04 Taisho Pharmaceut Co Ltd 矯味経口製剤
JPH07551B2 (ja) * 1987-01-14 1995-01-11 久光製薬株式会社 マイクロカプセル製剤の製造法
KR960011236B1 (ko) * 1987-05-08 1996-08-21 스미스 클라인 앤드 프렌취 라보라토리스 리미티드 제약학적 조성물 및 고체 제형
JPH0774151B2 (ja) * 1987-10-12 1995-08-09 三井東圧化学株式会社 薬物の好ましくない官能的性質を隠蔽した散剤の製造方法
FR2624732B1 (fr) * 1987-12-21 1991-02-15 Synthelabo Formulation pharmaceutique a liberation prolongee
DE68903605T2 (de) * 1988-05-04 1993-04-01 Smith Kline French Lab Kautablette.
US4925675A (en) * 1988-08-19 1990-05-15 Himedics, Inc. Erythromycin microencapsulated granules
DE69011618T2 (de) * 1989-05-11 1994-12-15 Chugai Pharmaceutical Co Ltd Mundzubereitung zur verabreichung an bestimmter stelle des darmes.
JPH0674206B2 (ja) * 1989-12-28 1994-09-21 田辺製薬株式会社 放出制御型製剤およびその製法
JP2856485B2 (ja) * 1990-03-07 1999-02-10 旭化成工業株式会社 顆粒含有錠
US5084287A (en) * 1990-03-15 1992-01-28 Warner-Lambert Company Pharmaceutically useful micropellets with a drug-coated core and controlled-release polymeric coat
US5075114A (en) * 1990-05-23 1991-12-24 Mcneil-Ppc, Inc. Taste masking and sustained release coatings for pharmaceuticals
CA2068402C (en) * 1991-06-14 1998-09-22 Michael R. Hoy Taste mask coatings for preparation of chewable pharmaceutical tablets

Also Published As

Publication number Publication date
US5578316A (en) 1996-11-26
EP0650353A4 (en) 1996-02-28
WO1993024109A1 (en) 1993-12-09
EP0650353A1 (en) 1995-05-03
JP3839467B2 (ja) 2006-11-01
ATE217789T1 (de) 2002-06-15
DE69331948T2 (de) 2002-11-28
DE69331948D1 (de) 2002-06-27
CA2137265C (en) 2003-10-28
JPH07507549A (ja) 1995-08-24
EP0650353B1 (en) 2002-05-22
CA2137265A1 (en) 1993-12-09

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