JPH07505865A - ボンベシンのフェニルアラニン類似体類 - Google Patents

ボンベシンのフェニルアラニン類似体類

Info

Publication number
JPH07505865A
JPH07505865A JP5513250A JP51325093A JPH07505865A JP H07505865 A JPH07505865 A JP H07505865A JP 5513250 A JP5513250 A JP 5513250A JP 51325093 A JP51325093 A JP 51325093A JP H07505865 A JPH07505865 A JP H07505865A
Authority
JP
Japan
Prior art keywords
phe
peptide
formula
leu
gly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5513250A
Other languages
English (en)
Japanese (ja)
Inventor
エドワーズ，ジャドソン　ヴィー．
ファンガー，ブラッドフォード　オー．
Original Assignee
メレルダウファーマスーティカルズ　インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by メレルダウファーマスーティカルズ　インコーポレイテッド filed Critical メレルダウファーマスーティカルズ　インコーポレイテッド
Publication of JPH07505865A publication Critical patent/JPH07505865A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57572—Gastrin releasing peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C07K7/086—Bombesin; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nutrition Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP5513250A 1992-02-07 1993-01-07 ボンベシンのフェニルアラニン類似体類 Pending JPH07505865A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83383492A 1992-02-07 1992-02-07
US833,834 1992-02-07
PCT/US1993/000183 WO1993016105A1 (en) 1992-02-07 1993-01-07 Phenylalanine analogs of bombesin

Publications (1)

Publication Number Publication Date
JPH07505865A true JPH07505865A (ja) 1995-06-29

Family

ID=25265391

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5513250A Pending JPH07505865A (ja) 1992-02-07 1993-01-07 ボンベシンのフェニルアラニン類似体類

Country Status (14)

Country Link
US (1) US5428018A (en, 2012)
EP (1) EP0626973A1 (en, 2012)
JP (1) JPH07505865A (en, 2012)
KR (1) KR950700325A (en, 2012)
AU (1) AU668909B2 (en, 2012)
CA (1) CA2129032A1 (en, 2012)
FI (1) FI943638L (en, 2012)
HU (1) HUT71585A (en, 2012)
IL (1) IL104621A0 (en, 2012)
MX (1) MX9300602A (en, 2012)
NO (1) NO942919L (en, 2012)
NZ (1) NZ246815A (en, 2012)
WO (1) WO1993016105A1 (en, 2012)
ZA (1) ZA93716B (en, 2012)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5723578A (en) * 1987-09-24 1998-03-03 The Administrators Of Tulane Educational Fund Peptide analogs of bombesin
US5877277A (en) 1987-09-24 1999-03-02 Biomeasure, Inc. Octapeptide bombesin analogs
US7078413B2 (en) 1996-04-19 2006-07-18 Wisconsin Alumni Research Foundation Compositions and methods of use for a bombesin peptide
UA65549C2 (uk) 1996-11-05 2004-04-15 Елі Ліллі Енд Компані Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція
CA2283854A1 (en) * 1997-04-22 1998-10-29 The Curators Of The University Of Missouri Gastrin receptor-avid peptide conjugates
JP4610345B2 (ja) * 2003-01-13 2011-01-12 ブラッコ・イメージング・ソシエタ・ペル・アチオニ 医薬品化合物のための改善されたリンカー
US8420050B2 (en) * 2003-01-13 2013-04-16 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7922998B2 (en) * 2003-01-13 2011-04-12 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7611692B2 (en) * 2003-01-13 2009-11-03 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7850947B2 (en) 2003-01-13 2010-12-14 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US20060239923A1 (en) * 2003-01-13 2006-10-26 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7226577B2 (en) * 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
AU2013323596C1 (en) 2012-09-25 2020-10-15 Advanced Accelerator Applications International Sa GRPR-antagonists for detection, diagnosis and treatment of GRPR-positive cancer

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1592552A (en) * 1976-12-10 1981-07-08 Inst Nat Sante Rech Med Pseudopeptides used as medicaments
US4631270A (en) * 1978-11-20 1986-12-23 Research Corporation Therapeutically useful pseudopeptides, compositions containing the same and methods of preparation and use
ATE16495T1 (de) * 1981-06-22 1985-11-15 Ici Plc Peptide und pseudopeptide, die zwei substituenten am n-terminus aufweisen.
US4871717A (en) * 1987-01-07 1989-10-03 Administrators Of The Tulane Educational Fund Peptides
JP2795449B2 (ja) * 1987-09-24 1998-09-10 ジ・アドミニストレーターズ・オブ・ザ・ツーレイン・エデュケイショナル・ファンド 治療用ペプチド
EP0313158A3 (en) * 1987-10-23 1990-08-22 Merck & Co. Inc. Gastrin releasing peptide antagonist
US5047502A (en) * 1987-10-23 1991-09-10 Merck And Co., Inc. Gastrin releasing peptide antagonist
AU618029B2 (en) * 1987-11-02 1991-12-12 Imperial Chemical Industries Plc Polypeptide compounds
GB8806644D0 (en) * 1988-03-21 1988-04-20 Imp Cancer Res Tech Neuropeptide antagonists
GB8808768D0 (en) * 1988-04-14 1988-05-18 Erba Carlo Spa Peptide ligands for bombesin receptors
GB8813356D0 (en) * 1988-06-06 1988-07-13 Ici Plc Polypeptide compounds
GR1000608B (el) * 1988-07-21 1992-08-31 Erba Carlo Spa Μεθοδος για την παρασκευη ανταγωνιστων bombesin.
JP2919889B2 (ja) * 1988-10-14 1999-07-19 アドミニストレイターズ オブ ザ テューレイン エデュケイショナル ファンド 治療用ペプチド
US5028692A (en) * 1989-04-25 1991-07-02 Merck & Co., Inc. Gastrin releasing peptide antagonist
JPH04502629A (ja) * 1989-11-06 1992-05-14 フアルミタリア・カルロ・エルバ・エツセ・エルレ・エルレ 還元不可逆性ボンベシンアンタゴニスト
NZ236114A (en) * 1989-11-22 1993-04-28 Merrell Dow Pharma Peptide antagonists of bombesin and of gastrin releasing peptide, and pharmaceutical compositions
HUT62604A (en) * 1990-05-09 1993-05-28 Univ Tulane Process for producing peptides for treating tissue proliferation and pharmaceutical compositions comprising same
ZA915740B (en) * 1990-07-26 1992-05-27 Merrell Dow Pharma Peptides
US5244883A (en) * 1990-11-29 1993-09-14 The Administrators Of The Tulane Educational Fund Nonapeptide bombesin antagonists

Also Published As

Publication number Publication date
ZA93716B (en) 1993-09-01
KR950700325A (ko) 1995-01-16
FI943638A7 (fi) 1994-08-05
WO1993016105A1 (en) 1993-08-19
AU3439993A (en) 1993-09-03
CA2129032A1 (en) 1993-08-19
MX9300602A (es) 1993-08-01
EP0626973A1 (en) 1994-12-07
NO942919D0 (en, 2012) 1994-08-05
FI943638A0 (fi) 1994-08-05
AU668909B2 (en) 1996-05-23
HU9402285D0 (en) 1994-10-28
NZ246815A (en) 1996-02-27
FI943638L (fi) 1994-08-05
HUT71585A (en) 1995-12-28
NO942919L (no) 1994-08-05
IL104621A0 (en) 1993-06-10
US5428018A (en) 1995-06-27

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