JPH07107055B2 - ピリダジノン誘導体 - Google Patents

ピリダジノン誘導体

Info

Publication number
JPH07107055B2
JPH07107055B2 JP3-507543A JP50754391A JPH07107055B2 JP H07107055 B2 JPH07107055 B2 JP H07107055B2 JP 50754391 A JP50754391 A JP 50754391A JP H07107055 B2 JPH07107055 B2 JP H07107055B2
Authority
JP
Japan
Prior art keywords
carbon atoms
group
alkyl group
linear
branched alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP3-507543A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO1991016314A1 (ja
JPH07107055B1 (OSRAM
Inventor
啓造 谷川
晃 斉藤
貴志 松本
良三 迫田
暢智 水流添
謙一 鹿田
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nissan Chemical Corp
Original Assignee
Nissan Chemical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nissan Chemical Corp filed Critical Nissan Chemical Corp
Priority to JP3-507543A priority Critical patent/JPH07107055B2/ja
Publication of JPWO1991016314A1 publication Critical patent/JPWO1991016314A1/ja
Publication of JPH07107055B1 publication Critical patent/JPH07107055B1/ja
Publication of JPH07107055B2 publication Critical patent/JPH07107055B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/22—Nitrogen and oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP3-507543A 1990-04-25 1991-04-19 ピリダジノン誘導体 Expired - Lifetime JPH07107055B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3-507543A JPH07107055B2 (ja) 1990-04-25 1991-04-19 ピリダジノン誘導体

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP10991490 1990-04-25
JP2-109914 1990-04-25
JP3-507543A JPH07107055B2 (ja) 1990-04-25 1991-04-19 ピリダジノン誘導体

Publications (3)

Publication Number Publication Date
JPWO1991016314A1 JPWO1991016314A1 (ja) 1992-05-07
JPH07107055B1 JPH07107055B1 (OSRAM) 1995-11-15
JPH07107055B2 true JPH07107055B2 (ja) 1995-11-15

Family

ID=14522343

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3-507543A Expired - Lifetime JPH07107055B2 (ja) 1990-04-25 1991-04-19 ピリダジノン誘導体

Country Status (17)

Country Link
US (3) US5202323A (OSRAM)
EP (1) EP0482208B1 (OSRAM)
JP (1) JPH07107055B2 (OSRAM)
KR (1) KR970002876B1 (OSRAM)
AT (1) ATE194835T1 (OSRAM)
AU (1) AU634655B2 (OSRAM)
CA (1) CA2053863C (OSRAM)
DE (1) DE69132329T2 (OSRAM)
DK (1) DK0482208T3 (OSRAM)
ES (1) ES2149761T3 (OSRAM)
GR (1) GR3034331T3 (OSRAM)
HU (1) HU208124B (OSRAM)
RU (1) RU2054004C1 (OSRAM)
TW (1) TW204348B (OSRAM)
UA (1) UA27031A1 (OSRAM)
WO (1) WO1991016314A1 (OSRAM)
ZA (1) ZA913134B (OSRAM)

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US5403590A (en) * 1992-12-21 1995-04-04 New England Deaconess Hospital Corporation Method of pulsatile drug infusion
JP3080131B2 (ja) 1993-06-29 2000-08-21 日産化学工業株式会社 ピリダジノン誘導体
IL110040A (en) * 1993-06-29 2000-07-16 Nissan Chemical Ind Ltd Pyridazinone derivatives their preparation and pharmaceutical compositions comprising them
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NZ270130A (en) * 1993-12-16 1995-12-21 Nihon Nohyaku Co Ltd Pyridazinone derivatives, preparation and pharmaceutical compositions thereof
WO1995019969A1 (en) * 1994-01-25 1995-07-27 Nissan Chemical Industries, Ltd. Pyridazinone derivative
IL112695A (en) * 1994-02-22 1999-04-11 Green Cross Corp Pharmaceutical compositions containing pyridazinone derivatives
GB9514160D0 (en) * 1994-07-25 1995-09-13 Zeneca Ltd Aromatic compounds
US5670504A (en) * 1995-02-23 1997-09-23 Merck & Co. Inc. 2,6-diaryl pyridazinones with immunosuppressant activity
TW434240B (en) 1995-06-20 2001-05-16 Zeneca Ltd Aromatic compounds, preparation thereof and pharmaceutical composition comprising same
WO1997049704A1 (en) 1996-06-27 1997-12-31 Janssen Pharmaceutica N.V. N-[4-(heteroarylmethyl)phenyl]-heteroarylamines
TW482675B (en) * 1997-01-31 2002-04-11 Green Cross Corp Compositions for oral administration containing pyridazinone compounds technical field of the invention
CA2301852C (en) 1997-08-28 2007-07-10 Yoshitomi Pharmaceutical Industries Ltd. Angiogenesis promoters and angiogenesis potentiators
RU2211217C2 (ru) * 1998-06-05 2003-08-27 Эгиш Дьёдьсердьяр Рт. Способ получения 5-хлор-4-аминозамещенного производного 3(2н)-пиридазинона
AU5445699A (en) * 1998-09-01 2000-03-21 Nissan Chemical Industries Ltd. Remedies for spinal canal stenosis
IL143530A0 (en) * 1998-12-07 2002-04-21 Nissan Chemical Ind Ltd Pyridazinone derivatives
DE20009841U1 (de) * 2000-05-31 2001-10-25 Phyt-Immun GmbH, 66424 Homburg Nasensalbe auf Basis von Vaselin
CA2439593C (en) * 2001-04-05 2010-02-09 Torrent Pharmaceuticals Ltd. Heterocyclic compounds for aging-related and diabetic vascular complications
US7399864B2 (en) * 2001-05-02 2008-07-15 Otsuka Pharmaceutical Co., Ltd. Process for producing carbostyril derivatives
US20050101631A1 (en) * 2002-08-01 2005-05-12 Otsuka Pharmaceuticals Company Process for producing carbostyril derivatives
EP1389467B1 (en) 2001-05-23 2013-07-03 Mitsubishi Tanabe Pharma Corporation Therapeutic composition for the regenerative treatment of cartilage diseases
JP4510384B2 (ja) 2001-05-23 2010-07-21 田辺三菱製薬株式会社 骨折治癒促進用組成物
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
ATE380027T1 (de) * 2003-09-09 2007-12-15 Fumapharm Ag Verwendung von fumarsäure-derivaten zur behandlung von herzinsuffizienz und asthma
EP1698339A4 (en) * 2003-12-26 2009-06-17 Nissan Chemical Ind Ltd INHIBITOR OF NEUTROPHILY
CA2553915C (en) * 2004-02-09 2010-06-01 Nissan Chemical Industries, Ltd. 3(2h)-pyridazinone compounds as vascular intimal hyperplasia inhibitor
ES2559319T3 (es) 2007-06-04 2016-02-11 Synergy Pharmaceuticals Inc. Agonistas de guanilato cliclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CA2726917C (en) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
EP2374805A4 (en) * 2008-12-25 2012-06-27 Nissan Chemical Ind Ltd PYRIDAZINE-3 (2H) -ONE HYDROCHLORIDE COMPOUND CRYSTALS AND METHOD FOR THE PRODUCTION THEREOF
CN104945420A (zh) 2009-06-29 2015-09-30 因塞特公司 作为pi3k抑制剂的嘧啶酮类
US8680108B2 (en) * 2009-12-18 2014-03-25 Incyte Corporation Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors
US8759359B2 (en) 2009-12-18 2014-06-24 Incyte Corporation Substituted heteroaryl fused derivatives as PI3K inhibitors
JP5699339B2 (ja) 2010-02-12 2015-04-08 日産化学工業株式会社 徐放性製剤
JP5816678B2 (ja) 2010-04-14 2015-11-18 インサイト・コーポレイションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ ＰＩ３Ｋδ阻害剤としての縮合誘導体
US9062055B2 (en) 2010-06-21 2015-06-23 Incyte Corporation Fused pyrrole derivatives as PI3K inhibitors
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CA2822070C (en) 2010-12-20 2019-09-17 Incyte Corporation N-(1-(substituted-phenyl)ethyl)-9h-purin-6-amines as pi3k inhibitors
EP2681236B1 (en) 2011-03-01 2018-01-03 Synergy Pharmaceuticals Inc. Process of preparing guanylate cyclase c agonists
US9108984B2 (en) 2011-03-14 2015-08-18 Incyte Corporation Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors
WO2012135009A1 (en) 2011-03-25 2012-10-04 Incyte Corporation Pyrimidine-4,6-diamine derivatives as pi3k inhibitors
ES2873001T3 (es) 2011-09-02 2021-11-03 Incyte Holdings Corp Heterociclaminas como inhibidores de PI3K
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
CA2902348C (en) 2013-02-25 2021-11-30 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
EP2968439A2 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
CA2905438A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
EA201592263A1 (ru) 2013-06-05 2016-05-31 Синерджи Фармасьютикалз, Инк. Ультрачистые агонисты гуанилатциклазы c, способ их получения и использования
KR20220147691A (ko) 2013-08-09 2022-11-03 알데릭스, 인코포레이티드 인산염 수송을 억제하기 위한 화합물 및 방법
MX370085B (es) 2013-09-12 2019-11-29 Janssen Biopharma Inc Compuestos de piridazinona y usos de los mismos.
WO2015191677A1 (en) 2014-06-11 2015-12-17 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors
JP6816005B2 (ja) 2015-02-27 2021-01-20 インサイト・コーポレイションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ Ｐｉ３ｋ阻害剤の塩及びその調製のためのプロセス
WO2016183060A1 (en) 2015-05-11 2016-11-17 Incyte Corporation Process for the synthesis of a phosphoinositide 3-kinase inhibitor
US9988401B2 (en) 2015-05-11 2018-06-05 Incyte Corporation Crystalline forms of a PI3K inhibitor
CN107793362B (zh) * 2016-08-30 2022-04-22 江苏恩华药业股份有限公司 一种苯基哒嗪酮类衍生物的合成及其应用
MA52761A (fr) 2018-06-01 2021-04-14 Incyte Corp Schéma posologique destiné au traitement de troubles liés à la pi3k
EP3972599B1 (en) 2019-05-21 2025-10-22 Ardelyx, Inc. Combination for lowering serum phosphate in a patient

Family Cites Families (8)

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Publication number Priority date Publication date Assignee Title
DE2534893A1 (de) * 1975-08-05 1977-02-17 Bayer Ag (thiono)(thiol)pyridazinonalkanphosphonsaeureester, verfahren zu ihrer herstellung sowie ihre verwendung als insektizide und akarizide
EP0186817B1 (en) * 1984-12-10 1989-08-02 Nissan Chemical Industries Ltd. 3(2h)pyridazinone, process for its preparation and anti-allergic agent containing it
PT83530B (pt) * 1985-10-17 1989-05-31 Smith Kline French Lab Processo de preparacao de derivados da piridona, em especial derivados fenilicos
US4978665A (en) * 1987-01-20 1990-12-18 Nissan Chemical Industries Ltd. 3(2H)pyridazinone, and antagonistic agent against SRS-A containing it
JP2550631B2 (ja) * 1987-01-20 1996-11-06 日産化学工業株式会社 ピリダジノン誘導体
IE62890B1 (en) * 1988-12-06 1995-03-08 Hafslund Nycomed Pharma New piperazinylalkyl-3(2h)-pyridazinones process for the preparation thereof and the use thereof as agents lowering blood pressure
JPH02256668A (ja) * 1988-12-20 1990-10-17 Nissan Chem Ind Ltd ピリダジノン誘導体
DK0482208T3 (da) * 1990-04-25 2000-09-18 Nissan Chemical Ind Ltd Pyridazinonderivat

Also Published As

Publication number Publication date
EP0482208A1 (en) 1992-04-29
ES2149761T3 (es) 2000-11-16
HU913497D0 (en) 1992-01-28
ZA913134B (en) 1992-04-29
DK0482208T3 (da) 2000-09-18
RU2054004C1 (ru) 1996-02-10
HU208124B (en) 1993-08-30
CA2053863A1 (en) 1991-10-26
GR3034331T3 (en) 2000-12-29
DE69132329D1 (de) 2000-08-24
US5202323A (en) 1993-04-13
AU634655B2 (en) 1993-02-25
TW204348B (OSRAM) 1993-04-21
HUT60253A (en) 1992-08-28
DE69132329T2 (de) 2000-11-30
US5318968A (en) 1994-06-07
UA27031A1 (uk) 2000-02-28
CA2053863C (en) 1996-10-29
JPH07107055B1 (OSRAM) 1995-11-15
KR970002876B1 (ko) 1997-03-12
ATE194835T1 (de) 2000-08-15
KR920701169A (ko) 1992-08-11
AU7651191A (en) 1991-11-11
EP0482208B1 (en) 2000-07-19
WO1991016314A1 (en) 1991-10-31
EP0482208A4 (en) 1992-10-07
US5314883A (en) 1994-05-24

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