ZA913134B - Pyridazinone derivatives - Google Patents

Pyridazinone derivatives

Info

Publication number
ZA913134B
ZA913134B ZA913134A ZA913134A ZA913134B ZA 913134 B ZA913134 B ZA 913134B ZA 913134 A ZA913134 A ZA 913134A ZA 913134 A ZA913134 A ZA 913134A ZA 913134 B ZA913134 B ZA 913134B
Authority
ZA
South Africa
Prior art keywords
pyridazinone derivatives
salt
vasodilatory
cardiotonic
srs
Prior art date
Application number
ZA913134A
Other languages
English (en)
Inventor
Keizo Tanikawa
Tanikawa Keizo
Akira Saito
Saito Akira
Takashi Matsumoto
Matsumoto Takashi
Ryozo Sakoda
Sakoda Ryozo
Nobutomo Tsuruzoe
Tsuruzoe Nobutomo
Ken-Ichi Shikada
Shikada Ken-Ichi
Original Assignee
Nissan Chemical Ind Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nissan Chemical Ind Ltd filed Critical Nissan Chemical Ind Ltd
Publication of ZA913134B publication Critical patent/ZA913134B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/22—Nitrogen and oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
ZA913134A 1990-04-25 1991-04-25 Pyridazinone derivatives ZA913134B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10991490 1990-04-25

Publications (1)

Publication Number Publication Date
ZA913134B true ZA913134B (en) 1992-04-29

Family

ID=14522343

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA913134A ZA913134B (en) 1990-04-25 1991-04-25 Pyridazinone derivatives

Country Status (17)

Country Link
US (3) US5202323A (OSRAM)
EP (1) EP0482208B1 (OSRAM)
JP (1) JPH07107055B2 (OSRAM)
KR (1) KR970002876B1 (OSRAM)
AT (1) ATE194835T1 (OSRAM)
AU (1) AU634655B2 (OSRAM)
CA (1) CA2053863C (OSRAM)
DE (1) DE69132329T2 (OSRAM)
DK (1) DK0482208T3 (OSRAM)
ES (1) ES2149761T3 (OSRAM)
GR (1) GR3034331T3 (OSRAM)
HU (1) HU208124B (OSRAM)
RU (1) RU2054004C1 (OSRAM)
TW (1) TW204348B (OSRAM)
UA (1) UA27031A1 (OSRAM)
WO (1) WO1991016314A1 (OSRAM)
ZA (1) ZA913134B (OSRAM)

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CA2553915C (en) * 2004-02-09 2010-06-01 Nissan Chemical Industries, Ltd. 3(2h)-pyridazinone compounds as vascular intimal hyperplasia inhibitor
ES2559319T3 (es) 2007-06-04 2016-02-11 Synergy Pharmaceuticals Inc. Agonistas de guanilato cliclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CA2726917C (en) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
EP2374805A4 (en) * 2008-12-25 2012-06-27 Nissan Chemical Ind Ltd PYRIDAZINE-3 (2H) -ONE HYDROCHLORIDE COMPOUND CRYSTALS AND METHOD FOR THE PRODUCTION THEREOF
CN104945420A (zh) 2009-06-29 2015-09-30 因塞特公司 作为pi3k抑制剂的嘧啶酮类
US8680108B2 (en) * 2009-12-18 2014-03-25 Incyte Corporation Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors
US8759359B2 (en) 2009-12-18 2014-06-24 Incyte Corporation Substituted heteroaryl fused derivatives as PI3K inhibitors
JP5699339B2 (ja) 2010-02-12 2015-04-08 日産化学工業株式会社 徐放性製剤
JP5816678B2 (ja) 2010-04-14 2015-11-18 インサイト・コーポレイションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ ＰＩ３Ｋδ阻害剤としての縮合誘導体
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WO2012135009A1 (en) 2011-03-25 2012-10-04 Incyte Corporation Pyrimidine-4,6-diamine derivatives as pi3k inhibitors
ES2873001T3 (es) 2011-09-02 2021-11-03 Incyte Holdings Corp Heterociclaminas como inhibidores de PI3K
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
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EA201592263A1 (ru) 2013-06-05 2016-05-31 Синерджи Фармасьютикалз, Инк. Ультрачистые агонисты гуанилатциклазы c, способ их получения и использования
KR20220147691A (ko) 2013-08-09 2022-11-03 알데릭스, 인코포레이티드 인산염 수송을 억제하기 위한 화합물 및 방법
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WO2015191677A1 (en) 2014-06-11 2015-12-17 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors
JP6816005B2 (ja) 2015-02-27 2021-01-20 インサイト・コーポレイションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ Ｐｉ３ｋ阻害剤の塩及びその調製のためのプロセス
WO2016183060A1 (en) 2015-05-11 2016-11-17 Incyte Corporation Process for the synthesis of a phosphoinositide 3-kinase inhibitor
US9988401B2 (en) 2015-05-11 2018-06-05 Incyte Corporation Crystalline forms of a PI3K inhibitor
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Also Published As

Publication number Publication date
EP0482208A1 (en) 1992-04-29
ES2149761T3 (es) 2000-11-16
HU913497D0 (en) 1992-01-28
DK0482208T3 (da) 2000-09-18
RU2054004C1 (ru) 1996-02-10
HU208124B (en) 1993-08-30
CA2053863A1 (en) 1991-10-26
GR3034331T3 (en) 2000-12-29
DE69132329D1 (de) 2000-08-24
US5202323A (en) 1993-04-13
AU634655B2 (en) 1993-02-25
TW204348B (OSRAM) 1993-04-21
HUT60253A (en) 1992-08-28
DE69132329T2 (de) 2000-11-30
US5318968A (en) 1994-06-07
UA27031A1 (uk) 2000-02-28
CA2053863C (en) 1996-10-29
JPH07107055B1 (OSRAM) 1995-11-15
KR970002876B1 (ko) 1997-03-12
ATE194835T1 (de) 2000-08-15
KR920701169A (ko) 1992-08-11
AU7651191A (en) 1991-11-11
EP0482208B1 (en) 2000-07-19
WO1991016314A1 (en) 1991-10-31
JPH07107055B2 (ja) 1995-11-15
EP0482208A4 (en) 1992-10-07
US5314883A (en) 1994-05-24

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