JPH0696533B2 - キノロンカルボン酸の水性組成物 - Google Patents
キノロンカルボン酸の水性組成物Info
- Publication number
- JPH0696533B2 JPH0696533B2 JP62006727A JP672787A JPH0696533B2 JP H0696533 B2 JPH0696533 B2 JP H0696533B2 JP 62006727 A JP62006727 A JP 62006727A JP 672787 A JP672787 A JP 672787A JP H0696533 B2 JPH0696533 B2 JP H0696533B2
- Authority
- JP
- Japan
- Prior art keywords
- compound
- aqueous composition
- present
- isotonic
- aqueous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title claims description 21
- XOQQVKDBGLYPGH-UHFFFAOYSA-N 2-oxo-1h-quinoline-3-carboxylic acid Chemical group C1=CC=C2NC(=O)C(C(=O)O)=CC2=C1 XOQQVKDBGLYPGH-UHFFFAOYSA-N 0.000 title claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 28
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 27
- 235000011187 glycerol Nutrition 0.000 claims description 13
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 8
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 239000003889 eye drop Substances 0.000 description 5
- 229940012356 eye drops Drugs 0.000 description 4
- 239000007951 isotonicity adjuster Substances 0.000 description 4
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 3
- 229960000686 benzalkonium chloride Drugs 0.000 description 3
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000003221 ear drop Substances 0.000 description 3
- 229940047652 ear drops Drugs 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000001103 potassium chloride Substances 0.000 description 3
- 235000011164 potassium chloride Nutrition 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000012266 salt solution Substances 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- WADQOGCINABPRT-UHFFFAOYSA-N 3-chloro-2-methylphenol Chemical compound CC1=C(O)C=CC=C1Cl WADQOGCINABPRT-UHFFFAOYSA-N 0.000 description 1
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 239000008351 acetate buffer Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 229960004926 chlorobutanol Drugs 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000001727 glucose Nutrition 0.000 description 1
- 150000003840 hydrochlorides Chemical class 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000007923 nasal drop Substances 0.000 description 1
- 229940100662 nasal drops Drugs 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- -1 polypropylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 229940037001 sodium edetate Drugs 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 239000012929 tonicity agent Substances 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62006727A JPH0696533B2 (ja) | 1987-01-14 | 1987-01-14 | キノロンカルボン酸の水性組成物 |
| SE8701961A SE503256C2 (sv) | 1987-01-14 | 1987-05-13 | Stabil isoton vattenlösning innehållande en kinolonkarboxylsyra |
| GB8711275A GB2199745B (en) | 1987-01-14 | 1987-05-13 | Isotonic aqueous solution containing a quinolone carboxylic acid |
| DE19873715918 DE3715918A1 (de) | 1987-01-14 | 1987-05-13 | Eine chinoloncarbonsaeure enthaltende waessrige loesung |
| CH1953/87A CH676549A5 (en, 2012) | 1987-01-14 | 1987-05-19 | |
| FR878707078A FR2609394B1 (fr) | 1987-01-14 | 1987-05-20 | Solution aqueuse contenant un acide quinolone carboxylique |
| US07/052,576 US4780465A (en) | 1987-01-14 | 1987-05-20 | Aqueous solution containing a quinolone carboxylic acid |
| IT20727/87A IT1205113B (it) | 1987-01-14 | 1987-05-29 | Soluzione acquosa contenente un acido chinolon-carbossilico |
| CA000539567A CA1284109C (en) | 1987-01-14 | 1987-06-12 | Aqueous solution containing a quinolone carboxylic acid |
| ES8702231A ES2007377A6 (es) | 1987-01-14 | 1987-07-29 | Un procedimiento para la preparacion de una composicion farmaceutica |
| PT85808A PT85808B (pt) | 1987-01-14 | 1987-09-28 | Processo de preparacao de uma solucao aquosa contendo uma quinolona do acido carboxilico |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62006727A JPH0696533B2 (ja) | 1987-01-14 | 1987-01-14 | キノロンカルボン酸の水性組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS63174930A JPS63174930A (ja) | 1988-07-19 |
| JPH0696533B2 true JPH0696533B2 (ja) | 1994-11-30 |
Family
ID=11646274
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62006727A Expired - Lifetime JPH0696533B2 (ja) | 1987-01-14 | 1987-01-14 | キノロンカルボン酸の水性組成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4780465A (en, 2012) |
| JP (1) | JPH0696533B2 (en, 2012) |
| CA (1) | CA1284109C (en, 2012) |
| CH (1) | CH676549A5 (en, 2012) |
| DE (1) | DE3715918A1 (en, 2012) |
| ES (1) | ES2007377A6 (en, 2012) |
| FR (1) | FR2609394B1 (en, 2012) |
| GB (1) | GB2199745B (en, 2012) |
| IT (1) | IT1205113B (en, 2012) |
| PT (1) | PT85808B (en, 2012) |
| SE (1) | SE503256C2 (en, 2012) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2549285B2 (ja) * | 1987-02-02 | 1996-10-30 | 第一製薬株式会社 | 鼻用噴霧剤 |
| US5290774A (en) * | 1989-08-03 | 1994-03-01 | Eisai Co., Ltd. | Photostabilizing method for ophthalmic solutions and the resulting ophthalmic solutions therefrom |
| EP0436726B1 (en) * | 1989-08-03 | 1993-10-20 | Eisai Co., Ltd. | Method of photostabilizing eyewash |
| FR2679773A1 (fr) * | 1991-07-30 | 1993-02-05 | Merck Sharp & Dohme | Preparation ophtalmique contenant un agent osmotique acceptable antimicrobien. |
| US5505953A (en) | 1992-05-06 | 1996-04-09 | Alcon Laboratories, Inc. | Use of borate-polyol complexes in ophthalmic compositions |
| NZ504017A (en) * | 1998-08-21 | 2001-09-28 | Senju Pharma Co | Preparation of gatifloxacin and disodium edetate |
| KR100473963B1 (ko) * | 1998-12-14 | 2005-08-02 | 씨제이 주식회사 | 퀴놀론계항균화합물의주사또는주입용수용액제제 |
| EP1283031B1 (en) * | 2001-09-28 | 2008-01-02 | Shiseido Co., Ltd. | Skin treatment composition comprising a polyoxyethylene polyoxyalkylene dialkyl substituted ether |
| DE602005016659D1 (de) * | 2004-03-18 | 2009-10-29 | R Tech Ueno Ltd | Wässrige zusammensetzung mit einem thiazol-derivat |
| ITTO20050533A1 (it) * | 2005-07-29 | 2007-01-30 | Euro Pharma S R L | Soluzioni otologiche a base di estratti di lapacho |
| CA2666058A1 (en) | 2006-10-12 | 2008-04-17 | Kyorin-Pharmaceutical Co., Ltd. | Aqueous liquid preparation comprising gatifloxacin |
| TW200900066A (en) * | 2007-03-22 | 2009-01-01 | Daiichi Sankyo Co Ltd | Quinolone medical composition containing alcohols |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4017622A (en) * | 1972-12-18 | 1977-04-12 | Dainippon Pharmaceutical Co., Ltd. | Piperazine derivatives |
| CA1175836A (en) * | 1977-09-20 | 1984-10-09 | Marcel Pesson | Production of 1,4-dihydroquinoline-3-carboxylic acid derivatives |
| DE3333719A1 (de) * | 1983-09-17 | 1985-04-04 | Bayer Ag | Loesungen milchsaurer salze von piperazinylchinolon- und piperazinyl-azachinoloncarbonsaeuren |
| AU553415B2 (en) * | 1983-09-19 | 1986-07-17 | Abbott Japan Co., Ltd. | 6-fluoro-1-4-dihydro-4-oxo-7-substituted piperazinyl- quinoline-3-carboxylic acids |
| US4551456A (en) * | 1983-11-14 | 1985-11-05 | Merck & Co., Inc. | Ophthalmic use of norfloxacin and related antibiotics |
| IT1196051B (it) * | 1984-03-16 | 1988-11-10 | Schiena Ricerche | Composti ad attivita' antibatterica |
| JPS60246313A (ja) * | 1984-05-22 | 1985-12-06 | Yamanouchi Pharmaceut Co Ltd | 塩酸ニカルジピンの注射剤およびその製法 |
| JPS61180771A (ja) * | 1985-01-05 | 1986-08-13 | バイエル・アクチエンゲゼルシヤフト | 安定な抗バクテリア剤水溶液 |
| DE3517709A1 (de) * | 1985-01-05 | 1986-07-10 | Bayer Ag | Basische zubereitungen von chinoloncarbonsaeuren |
| HUT40429A (en) * | 1985-04-29 | 1986-12-28 | Chinoin Gyogyszer Es Vegyeszet | Process for production of salts of derivatives of kynolin carbonic acid |
-
1987
- 1987-01-14 JP JP62006727A patent/JPH0696533B2/ja not_active Expired - Lifetime
- 1987-05-13 GB GB8711275A patent/GB2199745B/en not_active Expired - Lifetime
- 1987-05-13 SE SE8701961A patent/SE503256C2/sv not_active IP Right Cessation
- 1987-05-13 DE DE19873715918 patent/DE3715918A1/de active Granted
- 1987-05-19 CH CH1953/87A patent/CH676549A5/de not_active IP Right Cessation
- 1987-05-20 FR FR878707078A patent/FR2609394B1/fr not_active Expired - Lifetime
- 1987-05-20 US US07/052,576 patent/US4780465A/en not_active Expired - Lifetime
- 1987-05-29 IT IT20727/87A patent/IT1205113B/it active
- 1987-06-12 CA CA000539567A patent/CA1284109C/en not_active Expired - Lifetime
- 1987-07-29 ES ES8702231A patent/ES2007377A6/es not_active Expired
- 1987-09-28 PT PT85808A patent/PT85808B/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SE8701961D0 (sv) | 1987-05-13 |
| JPS63174930A (ja) | 1988-07-19 |
| FR2609394B1 (fr) | 1991-06-21 |
| US4780465A (en) | 1988-10-25 |
| PT85808A (en) | 1987-10-01 |
| IT8720727A0 (it) | 1987-05-29 |
| CH676549A5 (en, 2012) | 1991-02-15 |
| ES2007377A6 (es) | 1989-06-16 |
| DE3715918C2 (en, 2012) | 1992-04-02 |
| GB8711275D0 (en) | 1987-06-17 |
| FR2609394A1 (fr) | 1988-07-15 |
| DE3715918A1 (de) | 1988-07-28 |
| SE503256C2 (sv) | 1996-04-29 |
| PT85808B (pt) | 1990-11-20 |
| GB2199745B (en) | 1990-09-26 |
| GB2199745A (en) | 1988-07-20 |
| IT1205113B (it) | 1989-03-15 |
| SE8701961L (sv) | 1988-07-15 |
| CA1284109C (en) | 1991-05-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6483299B2 (ja) | ジクアホソル含有点眼液 | |
| US4728509A (en) | Aqueous liquid preparation | |
| EP1225898B1 (en) | Pharmaceutical compositions containing a fluoroquinolone antibiotic drug and xanthan gum | |
| JPH07116029B2 (ja) | トラニラスト水溶液製剤 | |
| JPH0696533B2 (ja) | キノロンカルボン酸の水性組成物 | |
| BR112013016008B1 (pt) | Solução oftálmica compreendendo diquafosol, método para a produção da mesma, e método para a inibição da formação de precipitado insolúvel | |
| KR101130252B1 (ko) | 아지스로마이신 함유 수성 의약 조성물 및 그 조제 방법 | |
| EP0233615B1 (en) | Aqueous preparation and method of preparation thereof | |
| PL170357B1 (en) | Method of obtaining a soluble parafloxine salt | |
| JPH0892102A (ja) | ビスホスホン酸又はその誘導体を含有する注射液とその安定化方法、及び注射液アンプル | |
| JP2004238346A (ja) | トラニラストの安定な水溶液製剤 | |
| HUP0302256A2 (hu) | Csökkentett savtartalmú és tároláskor stabil ciprofloxacin infúzió és eljárás az előállítására | |
| JPS61180771A (ja) | 安定な抗バクテリア剤水溶液 | |
| JPH03206040A (ja) | 注射用溶液及びその調製方法 | |
| HU195513B (en) | Process for producing stable solutions of alkaloides with bis-indole skeleton | |
| JPH0366617A (ja) | 静脈内投与用フエニトインナトリウム製剤 | |
| JP4512700B2 (ja) | アシクロビル含有水溶液製剤 | |
| EP0640074B1 (en) | Salts of a quinolone-carboxylic acid | |
| JPS5989616A (ja) | 点眼液 | |
| JP2002037746A (ja) | キノロンカルボン酸系抗菌剤を含有する液剤 | |
| CA1142093A (en) | Antiglaucomatous ophthalmic solution | |
| KR20210101193A (ko) | 이부프로펜 및 아르기닌을 함유하는 안정성이 개선된 주사용 제제 | |
| JP2003146881A (ja) | 抗アレルギー眼科用剤 | |
| JPH05262644A (ja) | アミノ酸含有輸液の安定化方法 | |
| JPH04305525A (ja) | オキサトミド点眼剤 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| EXPY | Cancellation because of completion of term |