DE602005016659D1 - Wässrige zusammensetzung mit einem thiazol-derivat - Google Patents

Wässrige zusammensetzung mit einem thiazol-derivat

Info

Publication number
DE602005016659D1
DE602005016659D1 DE602005016659T DE602005016659T DE602005016659D1 DE 602005016659 D1 DE602005016659 D1 DE 602005016659D1 DE 602005016659 T DE602005016659 T DE 602005016659T DE 602005016659 T DE602005016659 T DE 602005016659T DE 602005016659 D1 DE602005016659 D1 DE 602005016659D1
Authority
DE
Germany
Prior art keywords
aqueous composition
thiazole derivative
sup
sugar
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005016659T
Other languages
English (en)
Inventor
Ryuji Ueno
Ryu Hirata
Yasuhiro Harada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
R Tech Ueno Ltd
Astellas Pharma Inc
Original Assignee
R Tech Ueno Ltd
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by R Tech Ueno Ltd, Astellas Pharma Inc filed Critical R Tech Ueno Ltd
Publication of DE602005016659D1 publication Critical patent/DE602005016659D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicinal Preparation (AREA)
DE602005016659T 2004-03-18 2005-03-18 Wässrige zusammensetzung mit einem thiazol-derivat Active DE602005016659D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55395604P 2004-03-18 2004-03-18
PCT/JP2005/005607 WO2005089755A1 (en) 2004-03-18 2005-03-18 Aqueous composition comprising thiazole derivative

Publications (1)

Publication Number Publication Date
DE602005016659D1 true DE602005016659D1 (de) 2009-10-29

Family

ID=34961865

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005016659T Active DE602005016659D1 (de) 2004-03-18 2005-03-18 Wässrige zusammensetzung mit einem thiazol-derivat

Country Status (11)

Country Link
US (1) US20070208068A1 (de)
EP (1) EP1737450B1 (de)
JP (2) JP4881159B2 (de)
KR (1) KR101206319B1 (de)
CN (1) CN1933833B (de)
AT (1) ATE442849T1 (de)
CA (1) CA2558135C (de)
DE (1) DE602005016659D1 (de)
ES (1) ES2331890T3 (de)
TW (1) TWI339659B (de)
WO (1) WO2005089755A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040033228A1 (en) 2002-08-16 2004-02-19 Hans-Juergen Krause Formulation of human antibodies for treating TNF-alpha associated disorders
KR20070050932A (ko) * 2004-07-27 2007-05-16 가부시키가이샤 아루떼꾸 우에노 Ｖａｐ―１ 억제 활성을 가지는 티아졸 유도체
TW200835687A (en) * 2006-11-30 2008-09-01 R Tech Ueno Ltd Thiazole derivatives and their use as VAP-1 inhibitor
CN103120690A (zh) * 2007-10-19 2013-05-29 株式会社·R-技术上野 用于治疗白内障的药物组合物
TWI437986B (zh) * 2008-01-31 2014-05-21 R Tech Ueno Ltd 噻唑衍生物及使用該衍生物作為ｖａｐ－１抑制劑之用途
UA112154C2 (uk) 2009-09-08 2016-08-10 Біоті Терапіс Корп. Застосування повністю людського анти-vap-1-антитіла для лікування фіброзних станів
US9079891B2 (en) * 2010-08-27 2015-07-14 Calcimedica, Inc. Compounds that modulate intracellular calcium
US20160113893A1 (en) 2013-06-12 2016-04-28 Proximagen Limited New therapeutic uses of enzyme inhibitors
JP6483148B2 (ja) 2014-03-14 2019-03-13 エアーピオ セラピューティクス インコーポレイテッド ＨＰＴＰ−β阻害剤
WO2015189534A1 (en) 2014-06-12 2015-12-17 Proximagen Limited Vap-1 inhibitors for treating muscular dystrophy
EP3233762A1 (de) * 2014-12-18 2017-10-25 Basaran, Mustafa Organisches und anorganisches düngemittel für bewässerungslandwirtschaft und mit nitrifikationshemmendem mittel und bor
EP3386494A1 (de) 2015-12-07 2018-10-17 Benevolentai Cambridge Limited Vap-1-inhibitoren zur schmerzbehandlung

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0696533B2 (ja) * 1987-01-14 1994-11-30 北陸製薬株式会社 キノロンカルボン酸の水性組成物
CA2125060C (en) * 1993-07-02 1999-03-30 Henry P. Dabrowski Ophthalmic solution for artificial tears
ATE236890T1 (de) * 1996-12-23 2003-04-15 Bristol Myers Squibb Pharma Co Sauerstoff oder schwefel enthaltende 5-gliedrige heteroaromatishe derivative als factor xa hemmer
AR002194A1 (es) * 1997-03-17 1998-01-07 Sanchez Reynaldo Alemany Instrumento computarizado para el analisis del movimiento.
CN1229110C (zh) * 1997-07-29 2005-11-30 阿尔康实验室公司 含半乳甘露聚糖聚合物和硼酸盐的眼用组合物
CA2407587A1 (en) * 2000-04-28 2001-11-08 Sankyo Company, Limited Ppar.gamma. modulators
JP2002179572A (ja) * 2000-10-06 2002-06-26 Nikken Chem Co Ltd アレルギー性眼疾患治療剤
CN100491361C (zh) * 2003-01-27 2009-05-27 安斯泰来制药有限公司 噻唑衍生物及其作为vap-1抑制剂的用途
CA2514573A1 (en) * 2003-01-27 2004-08-12 Astellas Pharma Inc. Thiazole derivatives and their use as vap-1 inhibitors
US20060229346A1 (en) * 2003-03-31 2006-10-12 Sucampo Ag Method for treating vascular hyperpermeable disease

Also Published As

Publication number Publication date
ES2331890T3 (es) 2010-01-19
CN1933833A (zh) 2007-03-21
EP1737450A1 (de) 2007-01-03
EP1737450B1 (de) 2009-09-16
TW200531967A (en) 2005-10-01
ATE442849T1 (de) 2009-10-15
CA2558135C (en) 2012-08-14
JP2012001555A (ja) 2012-01-05
JP4881159B2 (ja) 2012-02-22
KR20060128011A (ko) 2006-12-13
JP2007529413A (ja) 2007-10-25
CA2558135A1 (en) 2005-09-29
US20070208068A1 (en) 2007-09-06
KR101206319B1 (ko) 2012-11-29
TWI339659B (en) 2011-04-01
WO2005089755A1 (en) 2005-09-29
CN1933833B (zh) 2011-09-07

Similar Documents

Publication Publication Date Title
DE602005016659D1 (de) Wässrige zusammensetzung mit einem thiazol-derivat
GB0418900D0 (en) Novel salt forms
MY157871A (en) Mapk/erk kinase inhibitors
RS53638B1 (en) CRYSTAL SOLVATES OF DERIVATIVES (1S) -1,5-ANHYDRO-1-C- (3 - ((PHENYL) METHYL) PHENYL) -D-GLUCITOL WITH ALCOHOLS AS INHIBITORS OF SGLT2 FOR TREATMENT OF DIABETES
MY140841A (en) Indozolone derivatives as 11b-hsd1 inhibitors
WO2008081096A3 (fr) Derives quinolinyliques, leur procede de preparation. les compositions pharmaceutiques qui les contiennent et leur utilisation comme agents hypoglycemiants et hypoli pemiants
RS53503B1 (en) AMORPHIC AND CRYSTAL FORM GENZ 112638 HEMITARTARATE AS A GLYCOSILKERAMIDE SYNTHASIS INHIBITOR
NO20065719L (no) I det vesentlige rene 2-{[2-(2-metylamino-pyrimidin-4-yl)-1H-indol-5-karbonyl]-amlno}-3-(fenylpyridin-2-yl-amino)-propionsyre som en IkB kinaseinhibitor.
WO2008006044A3 (en) Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
WO2009025239A1 (ja) 新規外用剤
DK1753723T3 (da) Substituerede quinolinderivater som mitotiske kinesininhibitorer
WO2004096134A3 (en) Substituted 1,4-diazepines and uses thereof
ECSP099073A (es) Nuevos derivados de piridazina
AR061134A1 (es) Derivados de tioxantina
WO2004020430A3 (fr) Derives de dioxane-2-alkylcarbamates, leur preparation et leur application en therapeutique
MY146042A (en) Water-soluble benzoazepine compound and its pharmaceutical composition
GEP20115166B (en) 2-ARYLINDOLE DERIVATIVES AS mPGES-I INHIBITORS
EA200600878A1 (ru) Производные феноксиуксусных кислот, применимые в качестве двойных агонистов активируемого пероксисомным пролифератором рецептора ( ppar )
CO6331306A2 (es) Derivados de n-heterociclico-imidazo[1,2alfa]piridina-2-carboxamidas su preparacion y su aplicacion en terapeutica
WO2002004598A3 (en) Improvement of cell culture performance by inhibitors of pyruvate dehydrogenase kinase
UY29744A1 (es) Derivados de 5-piridinil-1-azabiciclo(3.2.1) octano, su preparación y su aplicación en terapeutica.
RS54001B1 (en) SUBSTITUTED [(5H-Pyrrolo [2,1-C] [1,4] BENZODIAZEPIN-11-IL-) PIPERAZIN-1-IL] -2,2-DIMETHYLPROPANOIC ACID COMPOUNDS HT 2A
EA201101175A1 (ru) Фармацевтические комбинации 5-фторурацила и производных 1,4-дигидропиридина и их применение для лечения рака
WO2010067010A3 (fr) Derives de morphine-6-glucuronide, leur preparation et leur application en therapeutique
FR2835834B1 (fr) Nouveaux derives de tricyclo-imidazolines, leur procede de preparation et leur utilisation a titre de medicaments

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
R082 Change of representative

Ref document number: 1737450

Country of ref document: EP

Representative=s name: PATENT- UND RECHTSANWAELTE KRAUS & WEISERT, 80539