JPH0586391B2 - - Google Patents

Info

Publication number
JPH0586391B2
JPH0586391B2 JP84243142A JP24314284A JPH0586391B2 JP H0586391 B2 JPH0586391 B2 JP H0586391B2 JP 84243142 A JP84243142 A JP 84243142A JP 24314284 A JP24314284 A JP 24314284A JP H0586391 B2 JPH0586391 B2 JP H0586391B2
Authority
JP
Japan
Prior art keywords
carbon atoms
alkyl
formula
imidazo
quinoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP84243142A
Other languages
English (en)
Japanese (ja)
Other versions
JPS60123488A (ja
Inventor
Efu Gaasutaa Jon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Riker Laboratories Inc
Original Assignee
Riker Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riker Laboratories Inc filed Critical Riker Laboratories Inc
Publication of JPS60123488A publication Critical patent/JPS60123488A/ja
Publication of JPH0586391B2 publication Critical patent/JPH0586391B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Physical Water Treatments (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Alarm Systems (AREA)
  • Quinoline Compounds (AREA)
  • Luminescent Compositions (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Lubricants (AREA)
JP59243142A 1983-11-18 1984-11-17 １ｈ‐イミダゾ〔４，５‐ｃ〕キノリン類および１ｈ‐イミダゾ〔４，５‐ｃ〕キノリン‐４‐アミン類 Granted JPS60123488A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US55315783A 1983-11-18 1983-11-18
US55315883A 1983-11-18 1983-11-18
US553158 1983-11-18
US553157 1983-11-18

Publications (2)

Publication Number Publication Date
JPS60123488A JPS60123488A (ja) 1985-07-02
JPH0586391B2 true JPH0586391B2 (forum.php) 1993-12-10

Family

ID=27070262

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59243142A Granted JPS60123488A (ja) 1983-11-18 1984-11-17 １ｈ‐イミダゾ〔４，５‐ｃ〕キノリン類および１ｈ‐イミダゾ〔４，５‐ｃ〕キノリン‐４‐アミン類

Country Status (15)

Country Link
EP (2) EP0310950B1 (forum.php)
JP (1) JPS60123488A (forum.php)
KR (1) KR900005657B1 (forum.php)
AT (2) ATE84525T1 (forum.php)
AU (2) AU581190B2 (forum.php)
CA (1) CA1271477A (forum.php)
DE (3) DE19975027I2 (forum.php)
DK (6) DK164280C (forum.php)
ES (1) ES537677A0 (forum.php)
IE (1) IE57874B1 (forum.php)
IL (2) IL84537A (forum.php)
NL (2) NL980043I1 (forum.php)
NO (7) NO163819C (forum.php)
NZ (1) NZ210228A (forum.php)
PH (1) PH22338A (forum.php)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1306260C (en) 1985-10-18 1992-08-11 Shionogi & Co., Ltd. Condensed imidazopyridine derivatives
US4942168A (en) * 1987-07-13 1990-07-17 Hoechst-Roussel Pharmaceuticals Inc. Hydroxyquinoline amines, and method of enhancing memory in mammals
CA1335996C (en) * 1988-02-16 1995-06-20 Susumu Takada 2-substituted carbonylimidazo¬4,5-c|quinolines
EP0361489A3 (en) * 1988-09-30 1991-06-12 Chugai Seiyaku Kabushiki Kaisha Novel 3,4-diaminoquinoline and pyridine compounds
EP0385630B1 (en) * 1989-02-27 1996-11-27 Riker Laboratories, Inc. 1H-imidazo(4,5-c)Quinolin-4-amines as antivirals
US4994468A (en) * 1989-03-07 1991-02-19 Kyowa Hakko Kogyo Co., Ltd. Imidazoquinolone derivatives
US4929624A (en) * 1989-03-23 1990-05-29 Minnesota Mining And Manufacturing Company Olefinic 1H-imidazo(4,5-c)quinolin-4-amines
JP2988692B2 (ja) * 1989-07-18 1999-12-13 協和醗酵工業株式会社 イミダゾキノロン誘導体
US4988815A (en) * 1989-10-26 1991-01-29 Riker Laboratories, Inc. 3-Amino or 3-nitro quinoline compounds which are intermediates in preparing 1H-imidazo[4,5-c]quinolines
FR2654021B1 (fr) * 1989-11-07 1992-02-28 Simond Jacques Procede de vitrification de cendres volantes et dispositif pour sa mise en óoeuvre.
GB8928281D0 (en) * 1989-12-14 1990-02-21 Smith Kline French Lab Compounds
DE69122427T2 (de) * 1990-06-01 1997-03-06 Kyowa Hakko Kogyo Kk Imidazonaphthyridinderivate
SG70625A1 (en) * 1991-03-01 2000-02-22 Minnesota Mining & Mfg 1-Substituted 2-substituted 1H-imidazo(4, 5-c) quinolin-4-amines
US5266575A (en) * 1991-11-06 1993-11-30 Minnesota Mining And Manufacturing Company 2-ethyl 1H-imidazo[4,5-ciquinolin-4-amines
IL105325A (en) * 1992-04-16 1996-11-14 Minnesota Mining & Mfg Immunogen/vaccine adjuvant composition
US5395937A (en) * 1993-01-29 1995-03-07 Minnesota Mining And Manufacturing Company Process for preparing quinoline amines
US5693811A (en) * 1996-06-21 1997-12-02 Minnesota Mining And Manufacturing Company Process for preparing tetrahdroimidazoquinolinamines
US6069149A (en) * 1997-01-09 2000-05-30 Terumo Kabushiki Kaisha Amide derivatives and intermediates for the synthesis thereof
JPH10298181A (ja) * 1997-04-25 1998-11-10 Sumitomo Pharmaceut Co Ltd タイプ２ヘルパーｔ細胞選択的免疫応答抑制剤
JP2000119271A (ja) * 1998-08-12 2000-04-25 Hokuriku Seiyaku Co Ltd １ｈ―イミダゾピリジン誘導体
UA75622C2 (en) * 2000-12-08 2006-05-15 3M Innovative Properties Co Aryl ether substituted imidazoquinolines, pharmaceutical composition based thereon
US7253199B2 (en) * 2001-10-23 2007-08-07 Applied Research Systems Ars Holding N.V. Azole derivatives and pharmaceutical compositions containing them
GB0211649D0 (en) * 2002-05-21 2002-07-03 Novartis Ag Organic compounds
DK1543002T3 (da) 2002-07-23 2006-12-27 Teva Gyogyszergyar Zartkoeruee Fremstilling af 1H-imidazo (4,5-c) quinolin-4-aminer via 1H-imidazo (4,5-c) quinolin-4-phtalimid mellemprodukter
PL374866A1 (en) 2002-07-26 2005-11-14 Teva Gyogyszergyar Zartköruen Muködo Reszvenytarsasag Preparation of 1h-imidazo [4,5-c] quinolin-4-amines via novel 1h-imidazo [4,5-c] quinolin-4-cyano and 1h-imidazo [4,5-c] quinolin-4-carboxamide intermediates
AU2004266641A1 (en) 2003-08-12 2005-03-03 3M Innovative Properties Company Oxime substituted imidazo-containing compounds
ES2406730T3 (es) * 2003-08-27 2013-06-07 3M Innovative Properties Company Imidazoquinolinas sustituidas con ariloxi y arilalquilenoxi
WO2005023190A2 (en) 2003-09-05 2005-03-17 3M Innovative Properties Company Treatment for cd5+ b cell lymphoma
CA2536530A1 (en) 2003-10-01 2005-04-14 Taro Pharmaceuticals U.S.A., Inc. Method of preparing 4-amino-1h-imidazo(4,5-c)quinolines and acid addition salts thereof
US7544697B2 (en) 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
SG149828A1 (en) * 2003-10-03 2009-02-27 3M Innovative Properties Co Alkoxy substituted imidazoquinolines
ITMI20032121A1 (it) * 2003-11-04 2005-05-05 Dinamite Dipharma Spa In Forma Abbr Eviata Dipharm Procedimento per la preparazione di imiquimod e suoi intermedi
CA2545774A1 (en) 2003-11-14 2005-06-02 3M Innovative Properties Company Oxime substituted imidazo ring compounds
JP2007511535A (ja) 2003-11-14 2007-05-10 スリーエム イノベイティブ プロパティズ カンパニー ヒドロキシルアミン置換イミダゾ環化合物
KR101130928B1 (ko) 2003-11-25 2012-04-12 쓰리엠 이노베이티브 프로퍼티즈 컴파니 치환된 이미다조 고리 시스템 및 방법
JP2007517035A (ja) 2003-12-29 2007-06-28 スリーエム イノベイティブ プロパティズ カンパニー アリールアルケニルおよびアリールアルキニル置換されたイミダゾキノリン
CA2551399A1 (en) 2003-12-30 2005-07-21 3M Innovative Properties Company Imidazoquinolinyl, imidazopyridinyl, and imidazonaphthyridinyl sulfonamides
TW200612932A (en) 2004-03-24 2006-05-01 3M Innovative Properties Co Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
US8017779B2 (en) 2004-06-15 2011-09-13 3M Innovative Properties Company Nitrogen containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
US8026366B2 (en) 2004-06-18 2011-09-27 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
US7897609B2 (en) 2004-06-18 2011-03-01 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
US7915281B2 (en) 2004-06-18 2011-03-29 3M Innovative Properties Company Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and method
WO2006074003A2 (en) 2004-12-30 2006-07-13 3M Innovative Properties Company CHIRAL FUSED [1,2]IMIDAZO[4,5-c] RING COMPOUNDS
CA2594674C (en) 2004-12-30 2016-05-17 3M Innovative Properties Company Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds
JP2008530022A (ja) 2005-02-04 2008-08-07 コーリー ファーマシューティカル グループ，インコーポレイテッド 免疫反応調節物質を含む水性ゲル処方物
US7968563B2 (en) 2005-02-11 2011-06-28 3M Innovative Properties Company Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods
JP2008538550A (ja) 2005-04-01 2008-10-30 コーリー ファーマシューティカル グループ，インコーポレイテッド ウイルス感染および腫瘍性疾患を処置するためのサイトカイン生合成の調節因子としての１−置換ピラゾロ（３，４−ｃ）環状化合物
US7943610B2 (en) 2005-04-01 2011-05-17 3M Innovative Properties Company Pyrazolopyridine-1,4-diamines and analogs thereof
JP2009504803A (ja) 2005-08-22 2009-02-05 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Ｔｌｒアゴニスト
US8846697B2 (en) 2006-05-31 2014-09-30 The Regents Of The University Of California Purine analogs
WO2008008432A2 (en) 2006-07-12 2008-01-17 Coley Pharmaceutical Group, Inc. Substituted chiral fused( 1,2) imidazo (4,5-c) ring compounds and methods
JP5425642B2 (ja) 2007-02-07 2014-02-26 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 合成ｔｌｒアゴニストの結合体およびそのための使用
EP2009002A1 (en) * 2007-06-21 2008-12-31 Institut National De La Sante Et De La Recherche Medicale (Inserm) New process for the manufacture of 1H-imidazo [4,5-c]-quinoline ring systems
WO2010088924A1 (en) 2009-02-06 2010-08-12 Telormedix Sa Pharmaceutical compositions comprising imidazoquinolin(amines) and derivatives thereof suitable for local administration
KR20110117705A (ko) 2009-02-11 2011-10-27 더 리전트 오브 더 유니버시티 오브 캘리포니아 톨-유사 수용체 조정제 및 질병의 치료
EP2606047B1 (en) 2010-08-17 2017-01-25 3M Innovative Properties Company Lipidated immune response modifier compound compositions, formulations, and methods
US8728486B2 (en) 2011-05-18 2014-05-20 University Of Kansas Toll-like receptor-7 and -8 modulatory 1H imidazoquinoline derived compounds
IN2014KN00948A (forum.php) 2011-10-04 2015-08-21 Janus Biotherapeutics Inc
DK2950649T3 (da) 2013-02-01 2020-05-04 Wellstat Therapeutics Corp Aminforbindelser med antiinflammations-, antisvampe-, antiparasit- og anticanceraktivitet
MX2015012790A (es) 2013-03-15 2016-02-03 Syngenta Participations Ag Derivados de imidazopiridina activos como microbiocidas.
ES2538880B1 (es) * 2013-12-24 2016-09-08 Laboratorios Viñas S.A. Un procedimiento para obtener 4-amino-1-isobutil-1H-imidazo[4,5-c]quinoleína
EP3092254A4 (en) 2014-01-10 2017-09-20 Birdie Biopharmaceuticals Inc. Compounds and compositions for treating her2 positive tumors
EP3166976B1 (en) 2014-07-09 2022-02-23 Birdie Biopharmaceuticals Inc. Anti-pd-l1 combinations for treating tumors
WO2017046675A1 (en) * 2015-09-14 2017-03-23 Pfizer Inc. Novel imidazo [4,5-c] quinoline and imidazo [4,5-c][1,5] naphthyridine derivatives as lrrk2 inhibitors
CN115252792A (zh) 2016-01-07 2022-11-01 博笛生物科技有限公司 用于治疗肿瘤的抗-egfr组合
CN106943596A (zh) 2016-01-07 2017-07-14 博笛生物科技（北京）有限公司 用于治疗肿瘤的抗-cd20组合
WO2017184735A1 (en) * 2016-04-19 2017-10-26 Ifm Therapeutics, Inc Nlrp3 modulators
CN109071535B (zh) 2016-04-19 2021-10-08 先天肿瘤免疫公司 Nlrp3调节剂
US11697851B2 (en) 2016-05-24 2023-07-11 The Regents Of The University Of California Early ovarian cancer detection diagnostic test based on mRNA isoforms
TWI674261B (zh) 2017-02-17 2019-10-11 美商英能腫瘤免疫股份有限公司 Nlrp3 調節劑
CN118515666A (zh) 2017-04-27 2024-08-20 博笛生物科技有限公司 2-氨基-喹啉衍生物
US11517567B2 (en) 2017-06-23 2022-12-06 Birdie Biopharmaceuticals, Inc. Pharmaceutical compositions
FR3113287B1 (fr) 2020-08-07 2023-06-23 Phv Pharma Procédé industriel de synthèse de l’imiquimod à partir de la quinolèine-2,4-diol applicable à son utilisation pharmaceutique
AU2021396262A1 (en) * 2020-12-09 2023-07-27 Pharma Cinq, Llc Imidazoquinoline compound having anti-inflammatory, antifungal, antiparasitic, and anticancer activity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3700674A (en) * 1969-04-30 1972-10-24 American Cyanamid Co 4-alkylamino-3-nitroquinolines
RO86850B (ro) * 1982-05-03 1985-05-31 Eli Lilly And Company Procedeu pentru prepararea unor 2-fenilimidazo [4,5 c] piridine

Also Published As

Publication number Publication date
NO890826L (no) 1985-05-20
EP0145340A3 (en) 1986-06-11
IE57874B1 (en) 1993-05-05
NO165145C (no) 1991-01-02
JPS60123488A (ja) 1985-07-02
ATE84525T1 (de) 1993-01-15
NZ210228A (en) 1989-01-27
NL980043I1 (nl) 1999-02-01
AU2991189A (en) 1989-06-15
DE19975027I2 (de) 2000-09-21
PH22338A (en) 1988-08-12
NO163819B (no) 1990-04-17
DK164455B (da) 1992-06-29
DK164451C (da) 1992-11-09
IL84537A (en) 1990-12-23
NL980041I2 (nl) 1999-07-01
NO890823D0 (no) 1989-02-27
DK164452B (da) 1992-06-29
CA1271477A (en) 1990-07-10
AU3540284A (en) 1985-05-23
NO890822L (no) 1985-05-20
NO165147C (no) 1991-01-02
DK136091A (da) 1991-07-16
NO165146C (no) 1991-01-02
DE3486043T2 (de) 1993-06-03
NO890825L (no) 1985-05-20
DK135991D0 (da) 1991-07-16
DK542684A (da) 1985-05-19
DK136091D0 (da) 1991-07-16
DK135891D0 (da) 1991-07-16
NO890824L (no) 1985-05-20
NO890822D0 (no) 1989-02-27
DK542684D0 (da) 1984-11-15
DE3486043D1 (de) 1993-02-25
DK164455C (da) 1992-11-16
NO165147B (no) 1990-09-24
DK136191D0 (da) 1991-07-16
DK164451B (da) 1992-06-29
DK135991A (da) 1991-07-16
NO168705C (no) 1992-03-25
NO844565L (no) 1985-05-20
DK164280C (da) 1992-11-30
EP0145340B1 (en) 1990-01-24
NO165146B (no) 1990-09-24
KR850003890A (ko) 1985-06-29
DE3481124D1 (de) 1990-03-01
NL980041I1 (nl) 1999-02-01
DK165921C (da) 1993-06-28
EP0145340A2 (en) 1985-06-19
NO163819C (no) 1990-08-01
EP0310950B1 (en) 1993-01-13
ATE49763T1 (de) 1990-02-15
NO1999015I1 (no) 1999-07-08
DK169179B1 (da) 1994-09-05
AU581190B2 (en) 1989-02-16
DK135791D0 (da) 1991-07-16
NO169437C (no) 1992-06-24
NO890825D0 (no) 1989-02-27
EP0310950A1 (en) 1989-04-12
DK136191A (da) 1991-07-16
NO168705B (no) 1991-12-16
NO165145B (no) 1990-09-24
NO169437B (no) 1992-03-16
NO890823L (no) 1985-05-20
ES8603477A1 (es) 1985-12-16
DK135791A (da) 1991-07-16
KR900005657B1 (ko) 1990-08-03
IE842952L (en) 1985-05-18
DK165921B (da) 1993-02-08
NO890824D0 (no) 1989-02-27
AU611997B2 (en) 1991-06-27
IL84537A0 (en) 1988-04-29
DK135891A (da) 1991-07-16
NO890826D0 (no) 1989-02-27
DK164280B (da) 1992-06-01
DK164452C (da) 1992-11-09
ES537677A0 (es) 1985-12-16

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