JPH0569506B2 - - Google Patents
Info
- Publication number
- JPH0569506B2 JPH0569506B2 JP59013397A JP1339784A JPH0569506B2 JP H0569506 B2 JPH0569506 B2 JP H0569506B2 JP 59013397 A JP59013397 A JP 59013397A JP 1339784 A JP1339784 A JP 1339784A JP H0569506 B2 JPH0569506 B2 JP H0569506B2
- Authority
- JP
- Japan
- Prior art keywords
- kym
- cells
- activity
- solution
- culture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- 229960000103 thrombolytic agent Drugs 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 238000007039 two-step reaction Methods 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59013397A JPS60158115A (ja) | 1984-01-30 | 1984-01-30 | プラズミノーゲンアクチベーターの製造法 |
| NL8500132A NL8500132A (nl) | 1984-01-30 | 1985-01-19 | Plasmogeen activeringsmiddel kym. |
| GB08501532A GB2153366B (en) | 1984-01-30 | 1985-01-22 | Plasminogen activator |
| DE19853502760 DE3502760A1 (de) | 1984-01-30 | 1985-01-28 | Plasminogen-aktivator kym |
| CA000472999A CA1275062A (en) | 1984-01-30 | 1985-01-28 | Plasminogen activator kym |
| FR8501183A FR2558848B1 (fr) | 1984-01-30 | 1985-01-29 | Activeur de plasminogene kym, procede de preparation par culture d'un mutant de rhabdomyosarcome humain et composition pharmaceutique le renfermant dotee d'une activite thrombolytique |
| BE0/214409A BE901598A (fr) | 1984-01-30 | 1985-01-29 | Activeur de plasminogene kym. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59013397A JPS60158115A (ja) | 1984-01-30 | 1984-01-30 | プラズミノーゲンアクチベーターの製造法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP60079300A Division JPS611382A (ja) | 1985-04-16 | 1985-04-16 | 変異株ｋｙｍ−ａ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60158115A JPS60158115A (ja) | 1985-08-19 |
| JPH0569506B2 true JPH0569506B2 (pt) | 1993-10-01 |
Family
ID=11831979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59013397A Granted JPS60158115A (ja) | 1984-01-30 | 1984-01-30 | プラズミノーゲンアクチベーターの製造法 |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS60158115A (pt) |
| BE (1) | BE901598A (pt) |
| CA (1) | CA1275062A (pt) |
| DE (1) | DE3502760A1 (pt) |
| FR (1) | FR2558848B1 (pt) |
| GB (1) | GB2153366B (pt) |
| NL (1) | NL8500132A (pt) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6427472A (en) * | 1987-07-21 | 1989-01-30 | Meiji Milk Prod Co Ltd | Production of human tissue plasminogen activator and cell strain using therein |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5728009A (en) * | 1980-06-11 | 1982-02-15 | Leuven Res & Dev Vzw | Novel plasminogen activator and drug having thrombosis dissolving activity |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3015699C2 (de) * | 1979-04-26 | 1982-07-15 | Asahi Kasei Kogyo K.K., Osaka | Herstellung eines Plasminogen-Aktivators |
| AU6642281A (en) * | 1979-11-13 | 1981-06-03 | Husain, S.S. | Isolation of plasminogen activators useful as therapeutic anddiagnostic agents |
| JPS5852634B2 (ja) * | 1980-12-05 | 1983-11-24 | 株式会社林原生物化学研究所 | ウロキナ−ゼの製造法 |
| IL63317A (en) * | 1981-07-15 | 1985-05-31 | Yeda Res & Dev | Production of plasminogen activator |
| ZA831399B (en) * | 1982-03-05 | 1984-02-29 | Health Lab Service Board | New fibrinolytic enzymes and methods for their production and pharmaceutical compositions containing them |
| JPS5913732A (ja) * | 1982-07-16 | 1984-01-24 | Mitsui Toatsu Chem Inc | 血栓溶解剤 |
| JPS5951220A (ja) * | 1982-08-02 | 1984-03-24 | Asahi Chem Ind Co Ltd | 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤 |
-
1984
- 1984-01-30 JP JP59013397A patent/JPS60158115A/ja active Granted
-
1985
- 1985-01-19 NL NL8500132A patent/NL8500132A/nl not_active Application Discontinuation
- 1985-01-22 GB GB08501532A patent/GB2153366B/en not_active Expired
- 1985-01-28 DE DE19853502760 patent/DE3502760A1/de not_active Withdrawn
- 1985-01-28 CA CA000472999A patent/CA1275062A/en not_active Expired - Fee Related
- 1985-01-29 FR FR8501183A patent/FR2558848B1/fr not_active Expired
- 1985-01-29 BE BE0/214409A patent/BE901598A/fr not_active IP Right Cessation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5728009A (en) * | 1980-06-11 | 1982-02-15 | Leuven Res & Dev Vzw | Novel plasminogen activator and drug having thrombosis dissolving activity |
Also Published As
| Publication number | Publication date |
|---|---|
| BE901598A (fr) | 1985-07-29 |
| FR2558848A1 (fr) | 1985-08-02 |
| FR2558848B1 (fr) | 1989-06-09 |
| GB8501532D0 (en) | 1985-02-20 |
| GB2153366A (en) | 1985-08-21 |
| DE3502760A1 (de) | 1985-08-08 |
| JPS60158115A (ja) | 1985-08-19 |
| NL8500132A (nl) | 1985-08-16 |
| CA1275062A (en) | 1990-10-09 |
| GB2153366B (en) | 1988-05-18 |
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