JPH05501062A - Ｈｉｖ―１のウイルス性コンプレックス抗原に結合する組換え蛋白質 - Google Patents
Ｈｉｖ―１のウイルス性コンプレックス抗原に結合する組換え蛋白質Info
- Publication number
- JPH05501062A JPH05501062A JP50946491A JP50946491A JPH05501062A JP H05501062 A JPH05501062 A JP H05501062A JP 50946491 A JP50946491 A JP 50946491A JP 50946491 A JP50946491 A JP 50946491A JP H05501062 A JPH05501062 A JP H05501062A
- Authority
- JP
- Japan
- Prior art keywords
- protein
- sc3d6
- chain
- antibody
- recombinant protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- YPZRWBKMTBYPTK-BJDJZHNGSA-N glutathione disulfide Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@H](C(=O)NCC(O)=O)CSSC[C@@H](C(=O)NCC(O)=O)NC(=O)CC[C@H](N)C(O)=O YPZRWBKMTBYPTK-BJDJZHNGSA-N 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 108010089804 glycyl-threonine Proteins 0.000 description 1
- 108010037850 glycylvaline Proteins 0.000 description 1
- 229960000789 guanidine hydrochloride Drugs 0.000 description 1
- PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 210000004754 hybrid cell Anatomy 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 238000004191 hydrophobic interaction chromatography Methods 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 150000002605 large molecules Chemical class 0.000 description 1
- 108010073472 leucyl-prolyl-proline Proteins 0.000 description 1
- 230000002934 lysing effect Effects 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- YFDLHELOZYVNJE-UHFFFAOYSA-L mercury diiodide Chemical compound I[Hg]I YFDLHELOZYVNJE-UHFFFAOYSA-L 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000010369 molecular cloning Methods 0.000 description 1
- 210000000066 myeloid cell Anatomy 0.000 description 1
- 229960004927 neomycin Drugs 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229920002113 octoxynol Polymers 0.000 description 1
- 239000002751 oligonucleotide probe Substances 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- YPZRWBKMTBYPTK-UHFFFAOYSA-N oxidized gamma-L-glutamyl-L-cysteinylglycine Natural products OC(=O)C(N)CCC(=O)NC(C(=O)NCC(O)=O)CSSCC(C(=O)NCC(O)=O)NC(=O)CCC(N)C(O)=O YPZRWBKMTBYPTK-UHFFFAOYSA-N 0.000 description 1
- 229940055729 papain Drugs 0.000 description 1
- 235000019834 papain Nutrition 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- -1 peptidoglycans Proteins 0.000 description 1
- 102000013415 peroxidase activity proteins Human genes 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229950004354 phosphorylcholine Drugs 0.000 description 1
- 239000013600 plasmid vector Substances 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 108010031719 prolyl-serine Proteins 0.000 description 1
- 235000019419 proteases Nutrition 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000004366 reverse phase liquid chromatography Methods 0.000 description 1
- 238000004007 reversed phase HPLC Methods 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 108010026333 seryl-proline Proteins 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000000547 structure data Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
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- 108010080629 tryptophan-leucine Proteins 0.000 description 1
- 238000005199 ultracentrifugation Methods 0.000 description 1
- 108010052774 valyl-lysyl-glycyl-phenylalanyl-tyrosine Proteins 0.000 description 1
- 108010073969 valyllysine Proteins 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1036—Retroviridae, e.g. leukemia viruses
- C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
- C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/22—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a Strep-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT1178/90 | 1990-05-29 | ||
| AT117890A AT396939B (de) | 1990-05-29 | 1990-05-29 | Komplexes virales antigen von hiv-1 bindendes rekombinantes protein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH05501062A true JPH05501062A (ja) | 1993-03-04 |
Family
ID=3508299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50946491A Pending JPH05501062A (ja) | 1990-05-29 | 1991-05-28 | Ｈｉｖ―１のウイルス性コンプレックス抗原に結合する組換え蛋白質 |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0484500A1 (ar) |
| JP (1) | JPH05501062A (ar) |
| AT (1) | AT396939B (ar) |
| CA (1) | CA2064710A1 (ar) |
| SK (1) | SK160391A3 (ar) |
| WO (1) | WO1991018983A1 (ar) |
| YU (1) | YU114691A (ar) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994026895A1 (en) * | 1993-05-10 | 1994-11-24 | Japan Tobacco Inc. | Human immunoglobulin vh gene and dna fragment containing the same |
| US6096878A (en) * | 1993-05-10 | 2000-08-01 | Japan Tobacco Inc. | Human immunoglobulin VH gene segments and DNA fragments containing the same |
| US6936705B1 (en) | 1993-05-10 | 2005-08-30 | Japan Tobacco Inc. | Human immunoglobulin VH gene segments and DNA fragments containing the same |
| JP2008542278A (ja) * | 2005-05-27 | 2008-11-27 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | Ｔｗｅａｋ結合抗体 |
| US8440189B2 (en) | 1999-01-15 | 2013-05-14 | Biogen Idec Ma Inc. | Antagonists of TWEAK and of TWEAK receptor and their use to treat immunological disorders |
| US9011859B2 (en) | 2002-04-09 | 2015-04-21 | Biogen Idec Ma Inc. | Methods for treating TWEAK-related conditions |
| US9730947B2 (en) | 2005-06-13 | 2017-08-15 | Biogen Ma Inc. | Method of treating lupus nephritis |
| US9775899B2 (en) | 2005-02-17 | 2017-10-03 | Biogen Ma Inc. | Treating neurological disorders |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0591548A4 (en) * | 1992-03-30 | 1999-04-28 | Suntory Ltd | Anti-hbs antibody gene and expression plasmid thereof |
| EP1265918A1 (en) * | 2000-03-15 | 2002-12-18 | Incyte Genomics, Inc. | Human immune response proteins |
| JP5339901B2 (ja) | 2005-05-10 | 2013-11-13 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 炎症傷害の処置および評価 |
| JP2010528583A (ja) * | 2007-06-11 | 2010-08-26 | エーシー イミューン ソシエテ アノニム | アミロイドβに対するヒト化抗体 |
| US8048420B2 (en) | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
| US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
| CA2701793C (en) | 2007-10-05 | 2017-04-25 | Genentech, Inc. | Use of anti-amyloid beta antibody in ocular diseases |
| SG190572A1 (en) | 2008-04-29 | 2013-06-28 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| WO2009149185A2 (en) | 2008-06-03 | 2009-12-10 | Abbott Laboratories | Dual variable domain immunoglobulins and uses thereof |
| CA2772628A1 (en) | 2009-09-01 | 2011-03-10 | Abbott Laboratories | Dual variable domain immunoglobulins and uses thereof |
| PE20121531A1 (es) | 2009-10-15 | 2012-12-22 | Abbott Lab | Inmunoglobulinas con dominio variable dual |
| UY32979A (es) | 2009-10-28 | 2011-02-28 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| WO2012016173A2 (en) | 2010-07-30 | 2012-02-02 | Ac Immune S.A. | Safe and functional humanized antibodies |
| US8735546B2 (en) | 2010-08-03 | 2014-05-27 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
| EP2608803A4 (en) | 2010-08-26 | 2014-01-15 | Abbvie Inc | IMMUNOGLOBULINS WITH TWO VARIABLE DOMAINS AND USES THEREOF |
| JP2015508994A (ja) | 2011-12-30 | 2015-03-26 | アッヴィ・インコーポレイテッド | Ｉｌ−１３および／またはｉｌ−１７に対する二重可変ドメイン免疫グロブリン |
| AU2013337775B2 (en) | 2012-11-01 | 2017-03-30 | Abbvie Inc. | Anti-VEGF/DLL4 dual variable domain immunoglobulins and uses thereof |
| JP2016522793A (ja) | 2013-03-15 | 2016-08-04 | アッヴィ・インコーポレイテッド | ＩＬ−１βおよび／またはＩＬ−１７に対して指向された二重特異的結合タンパク質 |
| WO2016094881A2 (en) | 2014-12-11 | 2016-06-16 | Abbvie Inc. | Lrp-8 binding proteins |
| TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗ｖｅｇｆ、ｐｄｇｆ及／或其受體之結合蛋白 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4851341A (en) * | 1986-12-19 | 1989-07-25 | Immunex Corporation | Immunoaffinity purification system |
| PT88641B (pt) * | 1987-10-02 | 1993-04-30 | Genentech Inc | Metodo para a preparacao de uma variante de adesao |
| EP0312164A1 (en) * | 1987-10-16 | 1989-04-19 | Merck & Co. Inc. | Purification of recombinant epstein-barr virus antigens from vero cells, yeast cells or L cells |
| WO1989004370A1 (en) * | 1987-11-13 | 1989-05-18 | Cl-Pharma Aktiengesellschaft | Human monoclonal anti-hiv-i-antibodies |
-
1990
- 1990-05-29 AT AT117890A patent/AT396939B/de not_active IP Right Cessation
-
1991
- 1991-05-28 JP JP50946491A patent/JPH05501062A/ja active Pending
- 1991-05-28 YU YU114691A patent/YU114691A/sh unknown
- 1991-05-28 CA CA 2064710 patent/CA2064710A1/en not_active Abandoned
- 1991-05-28 WO PCT/AT1991/000067 patent/WO1991018983A1/de not_active Application Discontinuation
- 1991-05-28 EP EP19910910271 patent/EP0484500A1/de not_active Withdrawn
- 1991-05-29 SK SK160391A patent/SK160391A3/sk unknown
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994026895A1 (en) * | 1993-05-10 | 1994-11-24 | Japan Tobacco Inc. | Human immunoglobulin vh gene and dna fragment containing the same |
| US6096878A (en) * | 1993-05-10 | 2000-08-01 | Japan Tobacco Inc. | Human immunoglobulin VH gene segments and DNA fragments containing the same |
| US6936705B1 (en) | 1993-05-10 | 2005-08-30 | Japan Tobacco Inc. | Human immunoglobulin VH gene segments and DNA fragments containing the same |
| US8440189B2 (en) | 1999-01-15 | 2013-05-14 | Biogen Idec Ma Inc. | Antagonists of TWEAK and of TWEAK receptor and their use to treat immunological disorders |
| US9011859B2 (en) | 2002-04-09 | 2015-04-21 | Biogen Idec Ma Inc. | Methods for treating TWEAK-related conditions |
| US9775899B2 (en) | 2005-02-17 | 2017-10-03 | Biogen Ma Inc. | Treating neurological disorders |
| JP2008542278A (ja) * | 2005-05-27 | 2008-11-27 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | Ｔｗｅａｋ結合抗体 |
| JP2017025105A (ja) * | 2005-05-27 | 2017-02-02 | バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． | Ｔｗｅａｋ結合抗体 |
| US9730947B2 (en) | 2005-06-13 | 2017-08-15 | Biogen Ma Inc. | Method of treating lupus nephritis |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0484500A1 (de) | 1992-05-13 |
| ATA117890A (de) | 1993-05-15 |
| AT396939B (de) | 1993-12-27 |
| SK160391A3 (en) | 1995-07-11 |
| YU114691A (sh) | 1994-06-10 |
| CA2064710A1 (en) | 1991-11-30 |
| WO1991018983A1 (de) | 1991-12-12 |
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