JPH0481968B2 - - Google Patents
Info
- Publication number
- JPH0481968B2 JPH0481968B2 JP60034948A JP3494885A JPH0481968B2 JP H0481968 B2 JPH0481968 B2 JP H0481968B2 JP 60034948 A JP60034948 A JP 60034948A JP 3494885 A JP3494885 A JP 3494885A JP H0481968 B2 JPH0481968 B2 JP H0481968B2
- Authority
- JP
- Japan
- Prior art keywords
- test
- tegafur
- dose
- drug
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000284 extract Substances 0.000 claims description 29
- WFWLQNSHRPWKFK-ZCFIWIBFSA-N tegafur Chemical compound O=C1NC(=O)C(F)=CN1[C@@H]1OCCC1 WFWLQNSHRPWKFK-ZCFIWIBFSA-N 0.000 claims description 24
- 229960001674 tegafur Drugs 0.000 claims description 24
- 230000001093 anti-cancer Effects 0.000 claims description 14
- 239000003623 enhancer Substances 0.000 claims description 9
- 239000000843 powder Substances 0.000 description 19
- 206010028980 Neoplasm Diseases 0.000 description 16
- 239000003814 drug Substances 0.000 description 15
- 229940079593 drug Drugs 0.000 description 15
- 241000699670 Mus sp. Species 0.000 description 14
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 13
- 201000011510 cancer Diseases 0.000 description 12
- 239000001768 carboxy methyl cellulose Substances 0.000 description 12
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 12
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 12
- 239000007864 aqueous solution Substances 0.000 description 10
- 230000004083 survival effect Effects 0.000 description 7
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 230000000259 anti-tumor effect Effects 0.000 description 5
- 239000002775 capsule Substances 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- 240000004371 Panax ginseng Species 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 239000008187 granular material Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 238000010998 test method Methods 0.000 description 4
- 241001061264 Astragalus Species 0.000 description 3
- 241000202807 Glycyrrhiza Species 0.000 description 3
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 description 3
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 3
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 235000006484 Paeonia officinalis Nutrition 0.000 description 3
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 3
- 235000003140 Panax quinquefolius Nutrition 0.000 description 3
- 241001080798 Polygala tenuifolia Species 0.000 description 3
- 240000006079 Schisandra chinensis Species 0.000 description 3
- 235000008422 Schisandra chinensis Nutrition 0.000 description 3
- 235000006533 astragalus Nutrition 0.000 description 3
- 239000010227 chenpi Substances 0.000 description 3
- 238000001647 drug administration Methods 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 235000008434 ginseng Nutrition 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 241000411851 herbal medicine Species 0.000 description 3
- 238000011081 inoculation Methods 0.000 description 3
- 229940010454 licorice Drugs 0.000 description 3
- 235000019359 magnesium stearate Nutrition 0.000 description 3
- 239000002075 main ingredient Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 210000004233 talus Anatomy 0.000 description 3
- 231100000419 toxicity Toxicity 0.000 description 3
- 230000001988 toxicity Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 239000010017 yuan zhi Substances 0.000 description 3
- 244000223760 Cinnamomum zeylanicum Species 0.000 description 2
- 229920002261 Corn starch Polymers 0.000 description 2
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 241000736199 Paeonia Species 0.000 description 2
- YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 235000017803 cinnamon Nutrition 0.000 description 2
- 239000008120 corn starch Substances 0.000 description 2
- 229960002949 fluorouracil Drugs 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 239000012046 mixed solvent Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- NHBKXEKEPDILRR-UHFFFAOYSA-N 2,3-bis(butanoylsulfanyl)propyl butanoate Chemical compound CCCC(=O)OCC(SC(=O)CCC)CSC(=O)CCC NHBKXEKEPDILRR-UHFFFAOYSA-N 0.000 description 1
- 244000170916 Paeonia officinalis Species 0.000 description 1
- 235000002789 Panax ginseng Nutrition 0.000 description 1
- 208000006268 Sarcoma 180 Diseases 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229920003123 carboxymethyl cellulose sodium Polymers 0.000 description 1
- 229940063834 carboxymethylcellulose sodium Drugs 0.000 description 1
- 238000000748 compression moulding Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 229910052814 silicon oxide Inorganic materials 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60034948A JPS61194031A (ja) | 1985-02-22 | 1985-02-22 | 制癌作用増強剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60034948A JPS61194031A (ja) | 1985-02-22 | 1985-02-22 | 制癌作用増強剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS61194031A JPS61194031A (ja) | 1986-08-28 |
| JPH0481968B2 true JPH0481968B2 (fr) | 1992-12-25 |
Family
ID=12428387
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP60034948A Granted JPS61194031A (ja) | 1985-02-22 | 1985-02-22 | 制癌作用増強剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS61194031A (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2603256B2 (ja) * | 1987-05-29 | 1997-04-23 | 西吉田酒造株式会社 | 高麗人参エキスを有した添加物の製造方法 |
| JP2818220B2 (ja) * | 1988-11-04 | 1998-10-30 | フロイント産業株式会社 | 食品用の含水有機溶剤抽出物含有組成物および医薬用の含水有機溶剤抽出物含有組成物、並びにそれらの製造方法 |
| JPH05960A (ja) * | 1991-06-19 | 1993-01-08 | Kanebo Ltd | 慢性疲労症候群治療剤 |
| KR100425022B1 (ko) * | 2002-01-05 | 2004-03-27 | 롯데제과주식회사 | 가공인삼 추출물 및 이를 함유하는 약제 조성물 |
| WO2013147125A1 (fr) * | 2012-03-29 | 2013-10-03 | 独立行政法人国立精神・神経医療研究センター | Activateur de prise de médicament |
-
1985
- 1985-02-22 JP JP60034948A patent/JPS61194031A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS61194031A (ja) | 1986-08-28 |
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