JPH0450830B2 - - Google Patents
Info
- Publication number
- JPH0450830B2 JPH0450830B2 JP1131693A JP13169389A JPH0450830B2 JP H0450830 B2 JPH0450830 B2 JP H0450830B2 JP 1131693 A JP1131693 A JP 1131693A JP 13169389 A JP13169389 A JP 13169389A JP H0450830 B2 JPH0450830 B2 JP H0450830B2
- Authority
- JP
- Japan
- Prior art keywords
- membrane
- container
- container according
- drying
- freeze
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000012528 membrane Substances 0.000 claims abstract description 34
- 239000000463 material Substances 0.000 claims abstract description 17
- 238000004108 freeze drying Methods 0.000 claims abstract description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- 230000002209 hydrophobic effect Effects 0.000 claims abstract description 4
- 239000000126 substance Substances 0.000 claims description 16
- 239000011148 porous material Substances 0.000 claims description 6
- 239000001913 cellulose Substances 0.000 claims description 4
- 229920002678 cellulose Polymers 0.000 claims description 4
- -1 polytetrafluoroethylene Polymers 0.000 claims description 4
- 239000004743 Polypropylene Substances 0.000 claims description 2
- 229920002301 cellulose acetate Polymers 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 claims description 2
- 229920001155 polypropylene Polymers 0.000 claims description 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 2
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 2
- 239000003708 ampul Substances 0.000 claims 1
- 238000001035 drying Methods 0.000 description 19
- 238000000034 method Methods 0.000 description 12
- 238000012360 testing method Methods 0.000 description 7
- 241000894006 Bacteria Species 0.000 description 4
- 235000015097 nutrients Nutrition 0.000 description 4
- 229920001817 Agar Polymers 0.000 description 3
- 239000008272 agar Substances 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 238000000859 sublimation Methods 0.000 description 3
- 230000008022 sublimation Effects 0.000 description 3
- 238000003466 welding Methods 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 230000036512 infertility Effects 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000008223 sterile water Substances 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229920000544 Gore-Tex Polymers 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- 238000006887 Ullmann reaction Methods 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000006161 blood agar Substances 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000004643 material aging Methods 0.000 description 1
- 238000010297 mechanical methods and process Methods 0.000 description 1
- 229940091925 mediplast Drugs 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B5/00—Drying solid materials or objects by processes not involving the application of heat
- F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
- F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
Landscapes
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Drying Of Solid Materials (AREA)
- Freezing, Cooling And Drying Of Foods (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3817906.7 | 1988-05-26 | ||
DE3817906A DE3817906A1 (de) | 1988-05-26 | 1988-05-26 | Verfahren und behaeltnis zum gefriertrocknen unter sterilen bedingungen |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH0229256A JPH0229256A (ja) | 1990-01-31 |
JPH0450830B2 true JPH0450830B2 (pl) | 1992-08-17 |
Family
ID=6355171
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1131693A Granted JPH0229256A (ja) | 1988-05-26 | 1989-05-26 | 生物学的または薬学的物質を凍結乾燥する容器 |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP0343596B1 (pl) |
JP (1) | JPH0229256A (pl) |
AT (1) | ATE73226T1 (pl) |
CA (1) | CA1337974C (pl) |
DD (1) | DD283864A5 (pl) |
DE (2) | DE3817906A1 (pl) |
DK (1) | DK173643B1 (pl) |
ES (1) | ES2030556T3 (pl) |
FI (1) | FI91442C (pl) |
GR (1) | GR3004584T3 (pl) |
HU (1) | HU204126B (pl) |
IE (1) | IE61012B1 (pl) |
PL (1) | PL159938B1 (pl) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010061876A1 (ja) * | 2008-11-26 | 2010-06-03 | 財団法人化学及血清療法研究所 | 凍結乾燥製剤の包装体の製造方法 |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL90188A0 (en) * | 1988-05-18 | 1989-12-15 | Cryopharm Corp | Process and medium for the lyophilization of erythrocytes |
US5045446A (en) * | 1988-08-26 | 1991-09-03 | Cryopharm Corporation | Lyophilization of cells |
US5257983A (en) * | 1991-04-12 | 1993-11-02 | Cryopharm Corporation | Blood bag for lyophilization |
WO1995027180A1 (en) * | 1994-04-04 | 1995-10-12 | W.L. Gore & Associates, Inc. | Improved method for minimizing contamination of freeze-dried products |
JPH10503993A (ja) * | 1994-08-19 | 1998-04-14 | ダブリュ.エル.ゴア アンド アソシエイツ,インコーポレイティド | 凍結乾燥用のベント式バイアルと凍結乾燥された生産品の汚染を最少限にする方法 |
FR2738057B1 (fr) * | 1995-08-22 | 1997-11-07 | Lab Francais Du Fractionnement | Emballage etanche pour sechage, notamment lyophilisation, et procede de sechage, notamment de lyophilisation, a l'aide d'un tel emballage |
FR2740108B1 (fr) * | 1995-08-22 | 1998-03-27 | Lab Francais Du Fractionnement | Emballage etanche pour sechage, notamment lyophilisation, et procede de sechage, notamment de lyophilisation, a l'aide d'un tel emballage |
CA2232673C (en) | 1995-09-22 | 2008-11-18 | Geoffrey L. Kidd | Container for drying biological samples, method of making such container, and method of using same |
US5596814A (en) * | 1995-11-06 | 1997-01-28 | W. L. Gore & Associates, Inc. | Vented vial stopper for processing freeze-dried products |
AT1399U1 (de) | 1995-11-29 | 1997-04-25 | Immuno Ag | Verfahren und einrichtung zum lyophilisieren |
DE19751031A1 (de) * | 1997-11-19 | 1999-06-24 | Ingo Dipl Ing Heschel | Verfahren zur Herstellung poröser Strukturen |
US6312648B1 (en) | 1998-01-12 | 2001-11-06 | The United States Of America As Represented By The Department Of Health And Human Services | Applicator system |
DE19815993C2 (de) * | 1998-04-09 | 2003-03-06 | Schott Glas | Behälter zur Gefriertrocknung und Aufbewahrung medizinischer Produkte |
EP1958618A1 (de) | 2007-02-15 | 2008-08-20 | Octapharma AG | Verfahren zur Gefriertrocknung mit optimierter Rekonstitution von Biopolymeren |
EP2386399B8 (de) * | 2010-04-23 | 2015-08-05 | MC Beteiligungs-GmbH | Verfahren zum Einbringen von Löchern in eine wasserdichte Beschichtung und Grundkörper mit solcher Beschichtung |
WO2015162273A1 (en) | 2014-04-25 | 2015-10-29 | Merck Sharp & Dohme Bv | A method to dry multiple individual frozen bodies and a system for applying this method |
CN111295094A (zh) | 2017-10-09 | 2020-06-16 | 泰尔茂比司特生物技术有限公司 | 冻干容器及使用冻干容器的方法 |
JP2019090596A (ja) * | 2017-11-10 | 2019-06-13 | エイブル株式会社 | 凍結乾燥生成物の製造方法、及び、凍結乾燥用袋、並びに、凍結乾燥装置 |
CA3130668A1 (en) | 2019-03-14 | 2020-12-03 | Terumo Bct Biotechnologies, Llc | Multi-part lyophilization container and method of use |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60168464A (ja) * | 1983-11-18 | 1985-08-31 | 新技術事業団 | 血液保存方法及びその保存用容器 |
JPS6136942A (ja) * | 1984-07-28 | 1986-02-21 | Sony Corp | 電子部品装置 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE620147A (pl) * | 1961-07-17 | |||
NL283895A (pl) * | 1961-11-28 | |||
GB1154320A (en) * | 1965-09-24 | 1969-06-04 | Unilever Ltd | Freeze Drying |
FR2284842A1 (fr) * | 1974-09-11 | 1976-04-09 | Nestle Sa | Perfectionnement apporte la lyophilisation des produits solides, liquides ou pateux |
-
1988
- 1988-05-26 DE DE3817906A patent/DE3817906A1/de not_active Withdrawn
-
1989
- 1989-05-11 IE IE154189A patent/IE61012B1/en not_active IP Right Cessation
- 1989-05-19 CA CA000600212A patent/CA1337974C/en not_active Expired - Lifetime
- 1989-05-23 AT AT89109246T patent/ATE73226T1/de not_active IP Right Cessation
- 1989-05-23 EP EP89109246A patent/EP0343596B1/de not_active Expired - Lifetime
- 1989-05-23 ES ES198989109246T patent/ES2030556T3/es not_active Expired - Lifetime
- 1989-05-23 DE DE8989109246T patent/DE58900902D1/de not_active Expired - Lifetime
- 1989-05-24 PL PL1989279609A patent/PL159938B1/pl unknown
- 1989-05-24 DD DD89328870A patent/DD283864A5/de not_active IP Right Cessation
- 1989-05-24 DK DK198902525A patent/DK173643B1/da not_active IP Right Cessation
- 1989-05-25 HU HU892683A patent/HU204126B/hu unknown
- 1989-05-25 FI FI892563A patent/FI91442C/fi not_active IP Right Cessation
- 1989-05-26 JP JP1131693A patent/JPH0229256A/ja active Granted
-
1992
- 1992-05-13 GR GR920400224T patent/GR3004584T3/el unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60168464A (ja) * | 1983-11-18 | 1985-08-31 | 新技術事業団 | 血液保存方法及びその保存用容器 |
JPS6136942A (ja) * | 1984-07-28 | 1986-02-21 | Sony Corp | 電子部品装置 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010061876A1 (ja) * | 2008-11-26 | 2010-06-03 | 財団法人化学及血清療法研究所 | 凍結乾燥製剤の包装体の製造方法 |
Also Published As
Publication number | Publication date |
---|---|
DE58900902D1 (de) | 1992-04-09 |
DE3817906A1 (de) | 1989-11-30 |
HU204126B (en) | 1991-11-28 |
ATE73226T1 (de) | 1992-03-15 |
DK252589D0 (da) | 1989-05-24 |
CA1337974C (en) | 1996-01-23 |
DK173643B1 (da) | 2001-05-14 |
FI91442B (fi) | 1994-03-15 |
FI892563A0 (fi) | 1989-05-25 |
ES2030556T3 (es) | 1992-11-01 |
HUT52617A (en) | 1990-07-28 |
JPH0229256A (ja) | 1990-01-31 |
EP0343596B1 (de) | 1992-03-04 |
IE61012B1 (en) | 1994-09-07 |
FI91442C (fi) | 1994-06-27 |
PL279609A1 (en) | 1990-01-22 |
IE891541L (en) | 1989-11-26 |
PL159938B1 (pl) | 1993-01-29 |
EP0343596A2 (de) | 1989-11-29 |
GR3004584T3 (pl) | 1993-04-28 |
DK252589A (da) | 1989-11-27 |
FI892563A (fi) | 1989-11-27 |
DD283864A5 (de) | 1990-10-24 |
EP0343596A3 (en) | 1990-02-28 |
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