JPH0443261B2 - - Google Patents
Info
- Publication number
- JPH0443261B2 JPH0443261B2 JP21734083A JP21734083A JPH0443261B2 JP H0443261 B2 JPH0443261 B2 JP H0443261B2 JP 21734083 A JP21734083 A JP 21734083A JP 21734083 A JP21734083 A JP 21734083A JP H0443261 B2 JPH0443261 B2 JP H0443261B2
- Authority
- JP
- Japan
- Prior art keywords
- color
- silver halide
- layer
- emulsion
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 silver halide Chemical class 0.000 claims description 133
- 229910052709 silver Inorganic materials 0.000 claims description 111
- 239000004332 silver Substances 0.000 claims description 111
- 239000000463 material Substances 0.000 claims description 51
- 150000001875 compounds Chemical group 0.000 claims description 48
- 239000000470 constituent Substances 0.000 claims description 14
- 125000000217 alkyl group Chemical group 0.000 claims description 8
- 125000003118 aryl group Chemical group 0.000 claims description 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 4
- 239000010410 layer Substances 0.000 description 115
- 239000000839 emulsion Substances 0.000 description 96
- 239000003795 chemical substances by application Substances 0.000 description 68
- 239000000243 solution Substances 0.000 description 45
- 238000011161 development Methods 0.000 description 42
- 238000000034 method Methods 0.000 description 36
- 108010010803 Gelatin Proteins 0.000 description 35
- 229920000159 gelatin Polymers 0.000 description 35
- 239000008273 gelatin Substances 0.000 description 35
- 235000019322 gelatine Nutrition 0.000 description 35
- 235000011852 gelatine desserts Nutrition 0.000 description 35
- 239000000203 mixture Substances 0.000 description 35
- 239000002516 radical scavenger Substances 0.000 description 31
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 22
- 239000000047 product Substances 0.000 description 21
- 239000000084 colloidal system Substances 0.000 description 18
- 238000012545 processing Methods 0.000 description 18
- 239000000975 dye Substances 0.000 description 17
- 239000007788 liquid Substances 0.000 description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 16
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 13
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 12
- 230000000694 effects Effects 0.000 description 12
- 239000007864 aqueous solution Substances 0.000 description 11
- 239000011248 coating agent Substances 0.000 description 11
- 238000000576 coating method Methods 0.000 description 11
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 10
- YSMRWXYRXBRSND-UHFFFAOYSA-N TOTP Chemical compound CC1=CC=CC=C1OP(=O)(OC=1C(=CC=CC=1)C)OC1=CC=CC=C1C YSMRWXYRXBRSND-UHFFFAOYSA-N 0.000 description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- 238000004061 bleaching Methods 0.000 description 9
- 230000035945 sensitivity Effects 0.000 description 9
- 239000000654 additive Substances 0.000 description 7
- 238000006243 chemical reaction Methods 0.000 description 7
- 239000007800 oxidant agent Substances 0.000 description 7
- JHJUUEHSAZXEEO-UHFFFAOYSA-M sodium;4-dodecylbenzenesulfonate Chemical compound [Na+].CCCCCCCCCCCCC1=CC=C(S([O-])(=O)=O)C=C1 JHJUUEHSAZXEEO-UHFFFAOYSA-M 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 238000011282 treatment Methods 0.000 description 7
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 6
- 239000002253 acid Substances 0.000 description 6
- 125000004432 carbon atom Chemical group C* 0.000 description 6
- DOIRQSBPFJWKBE-UHFFFAOYSA-N dibutyl phthalate Chemical compound CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC DOIRQSBPFJWKBE-UHFFFAOYSA-N 0.000 description 6
- 238000009792 diffusion process Methods 0.000 description 6
- 230000001235 sensitizing effect Effects 0.000 description 6
- 239000007787 solid Substances 0.000 description 6
- 125000001424 substituent group Chemical group 0.000 description 6
- 238000005406 washing Methods 0.000 description 6
- 229910021607 Silver chloride Inorganic materials 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- 125000000687 hydroquinonyl group Chemical class C1(O)=C(C=C(O)C=C1)* 0.000 description 5
- 239000004848 polyfunctional curative Substances 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 239000011241 protective layer Substances 0.000 description 5
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 5
- 238000003786 synthesis reaction Methods 0.000 description 5
- 238000012546 transfer Methods 0.000 description 5
- KAMCBFNNGGVPPW-UHFFFAOYSA-N 1-(ethenylsulfonylmethoxymethylsulfonyl)ethene Chemical compound C=CS(=O)(=O)COCS(=O)(=O)C=C KAMCBFNNGGVPPW-UHFFFAOYSA-N 0.000 description 4
- SJOOOZPMQAWAOP-UHFFFAOYSA-N [Ag].BrCl Chemical compound [Ag].BrCl SJOOOZPMQAWAOP-UHFFFAOYSA-N 0.000 description 4
- 229960000583 acetic acid Drugs 0.000 description 4
- 230000002411 adverse Effects 0.000 description 4
- 229940101006 anhydrous sodium sulfite Drugs 0.000 description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
- 238000005859 coupling reaction Methods 0.000 description 4
- 239000003112 inhibitor Substances 0.000 description 4
- 238000002844 melting Methods 0.000 description 4
- 230000008018 melting Effects 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 238000007254 oxidation reaction Methods 0.000 description 4
- 239000001301 oxygen Substances 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 description 4
- 230000002265 prevention Effects 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- ZUNKMNLKJXRCDM-UHFFFAOYSA-N silver bromoiodide Chemical compound [Ag].IBr ZUNKMNLKJXRCDM-UHFFFAOYSA-N 0.000 description 4
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 4
- 230000003595 spectral effect Effects 0.000 description 4
- 230000006641 stabilisation Effects 0.000 description 4
- 238000011105 stabilization Methods 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 3
- 239000007844 bleaching agent Substances 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 125000000623 heterocyclic group Chemical group 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- 230000036961 partial effect Effects 0.000 description 3
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 3
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 3
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N 1,4-Benzenediol Natural products OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 2
- ZRHUHDUEXWHZMA-UHFFFAOYSA-N 1,4-dihydropyrazol-5-one Chemical compound O=C1CC=NN1 ZRHUHDUEXWHZMA-UHFFFAOYSA-N 0.000 description 2
- KJCVRFUGPWSIIH-UHFFFAOYSA-N 1-naphthol Chemical compound C1=CC=C2C(O)=CC=CC2=C1 KJCVRFUGPWSIIH-UHFFFAOYSA-N 0.000 description 2
- XLLIQLLCWZCATF-UHFFFAOYSA-N 2-methoxyethyl acetate Chemical compound COCCOC(C)=O XLLIQLLCWZCATF-UHFFFAOYSA-N 0.000 description 2
- SJSJAWHHGDPBOC-UHFFFAOYSA-N 4,4-dimethyl-1-phenylpyrazolidin-3-one Chemical compound N1C(=O)C(C)(C)CN1C1=CC=CC=C1 SJSJAWHHGDPBOC-UHFFFAOYSA-N 0.000 description 2
- KWOLFJPFCHCOCG-UHFFFAOYSA-N Acetophenone Natural products CC(=O)C1=CC=CC=C1 KWOLFJPFCHCOCG-UHFFFAOYSA-N 0.000 description 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical class [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- XCFIVNQHHFZRNR-UHFFFAOYSA-N [Ag].Cl[IH]Br Chemical compound [Ag].Cl[IH]Br XCFIVNQHHFZRNR-UHFFFAOYSA-N 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 125000003342 alkenyl group Chemical group 0.000 description 2
- 125000003545 alkoxy group Chemical group 0.000 description 2
- 125000005115 alkyl carbamoyl group Chemical group 0.000 description 2
- 125000005153 alkyl sulfamoyl group Chemical group 0.000 description 2
- 235000011114 ammonium hydroxide Nutrition 0.000 description 2
- XYXNTHIYBIDHGM-UHFFFAOYSA-N ammonium thiosulfate Chemical compound [NH4+].[NH4+].[O-]S([O-])(=O)=S XYXNTHIYBIDHGM-UHFFFAOYSA-N 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000002216 antistatic agent Substances 0.000 description 2
- 125000005116 aryl carbamoyl group Chemical group 0.000 description 2
- 125000004104 aryloxy group Chemical group 0.000 description 2
- 239000012298 atmosphere Substances 0.000 description 2
- XNSQZBOCSSMHSZ-UHFFFAOYSA-K azane;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxymethyl)amino]acetate;iron(3+) Chemical compound [NH4+].[Fe+3].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O XNSQZBOCSSMHSZ-UHFFFAOYSA-K 0.000 description 2
- 239000003054 catalyst Substances 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 238000004040 coloring Methods 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 125000004093 cyano group Chemical group *C#N 0.000 description 2
- KYQODXQIAJFKPH-UHFFFAOYSA-N diazanium;2-[2-[bis(carboxymethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [NH4+].[NH4+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O KYQODXQIAJFKPH-UHFFFAOYSA-N 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 238000000921 elemental analysis Methods 0.000 description 2
- FKRCODPIKNYEAC-UHFFFAOYSA-N ethyl propionate Chemical compound CCOC(=O)CC FKRCODPIKNYEAC-UHFFFAOYSA-N 0.000 description 2
- YAGKRVSRTSUGEY-UHFFFAOYSA-N ferricyanide Chemical compound [Fe+3].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] YAGKRVSRTSUGEY-UHFFFAOYSA-N 0.000 description 2
- 239000012362 glacial acetic acid Substances 0.000 description 2
- 125000005843 halogen group Chemical group 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- LOCAIGRSOJUCTB-UHFFFAOYSA-N indazol-3-one Chemical compound C1=CC=C2C(=O)N=NC2=C1 LOCAIGRSOJUCTB-UHFFFAOYSA-N 0.000 description 2
- 239000004816 latex Substances 0.000 description 2
- 229920000126 latex Polymers 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 125000000962 organic group Chemical group 0.000 description 2
- CMCWWLVWPDLCRM-UHFFFAOYSA-N phenidone Chemical compound N1C(=O)CCN1C1=CC=CC=C1 CMCWWLVWPDLCRM-UHFFFAOYSA-N 0.000 description 2
- 150000002989 phenols Chemical class 0.000 description 2
- 239000004014 plasticizer Substances 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 238000006479 redox reaction Methods 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- NDVLTYZPCACLMA-UHFFFAOYSA-N silver oxide Chemical compound [O-2].[Ag+].[Ag+] NDVLTYZPCACLMA-UHFFFAOYSA-N 0.000 description 2
- JHJLBTNAGRQEKS-UHFFFAOYSA-M sodium bromide Chemical compound [Na+].[Br-] JHJLBTNAGRQEKS-UHFFFAOYSA-M 0.000 description 2
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 2
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 2
- 235000019345 sodium thiosulphate Nutrition 0.000 description 2
- GGCZERPQGJTIQP-UHFFFAOYSA-N sodium;9,10-dioxoanthracene-2-sulfonic acid Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)O)=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-N 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 230000000087 stabilizing effect Effects 0.000 description 2
- 238000010186 staining Methods 0.000 description 2
- DHCDFWKWKRSZHF-UHFFFAOYSA-L thiosulfate(2-) Chemical compound [O-]S([S-])(=O)=O DHCDFWKWKRSZHF-UHFFFAOYSA-L 0.000 description 2
- GVEYRUKUJCHJSR-UHFFFAOYSA-N (4-azaniumyl-3-methylphenyl)-ethyl-(2-hydroxyethyl)azanium;sulfate Chemical compound OS(O)(=O)=O.OCCN(CC)C1=CC=C(N)C(C)=C1 GVEYRUKUJCHJSR-UHFFFAOYSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- KPVMVJXYXFUVLR-UHFFFAOYSA-N 12-ethyltetradecan-1-amine Chemical compound CCC(CC)CCCCCCCCCCCN KPVMVJXYXFUVLR-UHFFFAOYSA-N 0.000 description 1
- KQEIJFWAXDQUPR-UHFFFAOYSA-N 2,4-diaminophenol;hydron;dichloride Chemical compound Cl.Cl.NC1=CC=C(O)C(N)=C1 KQEIJFWAXDQUPR-UHFFFAOYSA-N 0.000 description 1
- WEULJWIQMLXOOU-UHFFFAOYSA-N 2-(4-amino-n-ethyl-3-methoxyanilino)ethanol Chemical compound OCCN(CC)C1=CC=C(N)C(OC)=C1 WEULJWIQMLXOOU-UHFFFAOYSA-N 0.000 description 1
- QTLHLXYADXCVCF-UHFFFAOYSA-N 2-(4-amino-n-ethyl-3-methylanilino)ethanol Chemical compound OCCN(CC)C1=CC=C(N)C(C)=C1 QTLHLXYADXCVCF-UHFFFAOYSA-N 0.000 description 1
- WFXLRLQSHRNHCE-UHFFFAOYSA-N 2-(4-amino-n-ethylanilino)ethanol Chemical compound OCCN(CC)C1=CC=C(N)C=C1 WFXLRLQSHRNHCE-UHFFFAOYSA-N 0.000 description 1
- JHKKTXXMAQLGJB-UHFFFAOYSA-N 2-(methylamino)phenol Chemical compound CNC1=CC=CC=C1O JHKKTXXMAQLGJB-UHFFFAOYSA-N 0.000 description 1
- VLZVIIYRNMWPSN-UHFFFAOYSA-N 2-Amino-4-nitrophenol Chemical compound NC1=CC([N+]([O-])=O)=CC=C1O VLZVIIYRNMWPSN-UHFFFAOYSA-N 0.000 description 1
- CDAWCLOXVUBKRW-UHFFFAOYSA-N 2-aminophenol Chemical class NC1=CC=CC=C1O CDAWCLOXVUBKRW-UHFFFAOYSA-N 0.000 description 1
- JKFYKCYQEWQPTM-UHFFFAOYSA-N 2-azaniumyl-2-(4-fluorophenyl)acetate Chemical compound OC(=O)C(N)C1=CC=C(F)C=C1 JKFYKCYQEWQPTM-UHFFFAOYSA-N 0.000 description 1
- JQPKYJBTLNNEON-UHFFFAOYSA-N 2-dodecoxybenzenesulfonyl chloride Chemical compound CCCCCCCCCCCCOC1=CC=CC=C1S(Cl)(=O)=O JQPKYJBTLNNEON-UHFFFAOYSA-N 0.000 description 1
- SVONRAPFKPVNKG-UHFFFAOYSA-N 2-ethoxyethyl acetate Chemical compound CCOCCOC(C)=O SVONRAPFKPVNKG-UHFFFAOYSA-N 0.000 description 1
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 description 1
- OBCSAIDCZQSFQH-UHFFFAOYSA-N 2-methyl-1,4-phenylenediamine Chemical compound CC1=CC(N)=CC=C1N OBCSAIDCZQSFQH-UHFFFAOYSA-N 0.000 description 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
- XRZDIHADHZSFBB-UHFFFAOYSA-N 3-oxo-n,3-diphenylpropanamide Chemical class C=1C=CC=CC=1NC(=O)CC(=O)C1=CC=CC=C1 XRZDIHADHZSFBB-UHFFFAOYSA-N 0.000 description 1
- XBTWVJKPQPQTDW-UHFFFAOYSA-N 4-n,4-n-diethyl-2-methylbenzene-1,4-diamine Chemical compound CCN(CC)C1=CC=C(N)C(C)=C1 XBTWVJKPQPQTDW-UHFFFAOYSA-N 0.000 description 1
- QNGVNLMMEQUVQK-UHFFFAOYSA-N 4-n,4-n-diethylbenzene-1,4-diamine Chemical compound CCN(CC)C1=CC=C(N)C=C1 QNGVNLMMEQUVQK-UHFFFAOYSA-N 0.000 description 1
- GKIFPROMYBQIHS-UHFFFAOYSA-N 4-n-ethyl-2-methoxy-4-n-(2-methoxyethyl)benzene-1,4-diamine Chemical compound COCCN(CC)C1=CC=C(N)C(OC)=C1 GKIFPROMYBQIHS-UHFFFAOYSA-N 0.000 description 1
- ARARZLMQLKXONM-UHFFFAOYSA-N 4-n-ethyl-4-n-[2-[2-(2-methoxyethoxy)ethoxy]ethyl]-2-methylbenzene-1,4-diamine Chemical compound COCCOCCOCCN(CC)C1=CC=C(N)C(C)=C1 ARARZLMQLKXONM-UHFFFAOYSA-N 0.000 description 1
- VWLXPSZDHYNSRA-UHFFFAOYSA-N 5-nitro-2-phenylmethoxyaniline Chemical compound NC1=CC([N+]([O-])=O)=CC=C1OCC1=CC=CC=C1 VWLXPSZDHYNSRA-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- QZCLKYGREBVARF-UHFFFAOYSA-N Acetyl tributyl citrate Chemical compound CCCCOC(=O)CC(C(=O)OCCCC)(OC(C)=O)CC(=O)OCCCC QZCLKYGREBVARF-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
- 241000219198 Brassica Species 0.000 description 1
- 235000003351 Brassica cretica Nutrition 0.000 description 1
- 235000003343 Brassica rupestris Nutrition 0.000 description 1
- DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 229920002284 Cellulose triacetate Polymers 0.000 description 1
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- MQIUGAXCHLFZKX-UHFFFAOYSA-N Di-n-octyl phthalate Natural products CCCCCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCCCCC MQIUGAXCHLFZKX-UHFFFAOYSA-N 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 description 1
- 229910021578 Iron(III) chloride Inorganic materials 0.000 description 1
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 description 1
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- BZORFPDSXLZWJF-UHFFFAOYSA-N N,N-dimethyl-1,4-phenylenediamine Chemical compound CN(C)C1=CC=C(N)C=C1 BZORFPDSXLZWJF-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 229910021612 Silver iodide Inorganic materials 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 235000011941 Tilia x europaea Nutrition 0.000 description 1
- NNLVGZFZQQXQNW-ADJNRHBOSA-N [(2r,3r,4s,5r,6s)-4,5-diacetyloxy-3-[(2s,3r,4s,5r,6r)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6s)-4,5,6-triacetyloxy-2-(acetyloxymethyl)oxan-3-yl]oxyoxan-2-yl]methyl acetate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@H]1[C@@H]([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1)OC(C)=O)COC(=O)C)[C@@H]1[C@@H](COC(C)=O)O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O NNLVGZFZQQXQNW-ADJNRHBOSA-N 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 229940023476 agar Drugs 0.000 description 1
- 235000010419 agar Nutrition 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 description 1
- 125000004422 alkyl sulphonamide group Chemical group 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- SWLVFNYSXGMGBS-UHFFFAOYSA-N ammonium bromide Chemical compound [NH4+].[Br-] SWLVFNYSXGMGBS-UHFFFAOYSA-N 0.000 description 1
- 235000011162 ammonium carbonates Nutrition 0.000 description 1
- 235000019289 ammonium phosphates Nutrition 0.000 description 1
- 150000004982 aromatic amines Chemical class 0.000 description 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 description 1
- 125000004421 aryl sulphonamide group Chemical group 0.000 description 1
- PGVWVVCAXSOASP-UHFFFAOYSA-N azanium;hydroxy-oxido-oxo-sulfanylidene-$l^{6}-sulfane Chemical compound N.OS(O)(=O)=S PGVWVVCAXSOASP-UHFFFAOYSA-N 0.000 description 1
- CJPQIRJHIZUAQP-MRXNPFEDSA-N benalaxyl-M Chemical compound CC=1C=CC=C(C)C=1N([C@H](C)C(=O)OC)C(=O)CC1=CC=CC=C1 CJPQIRJHIZUAQP-MRXNPFEDSA-N 0.000 description 1
- 150000001558 benzoic acid derivatives Chemical class 0.000 description 1
- 235000019445 benzyl alcohol Nutrition 0.000 description 1
- KCXMKQUNVWSEMD-UHFFFAOYSA-N benzyl chloride Chemical compound ClCC1=CC=CC=C1 KCXMKQUNVWSEMD-UHFFFAOYSA-N 0.000 description 1
- 229940073608 benzyl chloride Drugs 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- QKSKPIVNLNLAAV-UHFFFAOYSA-N bis(2-chloroethyl) sulfide Chemical compound ClCCSCCCl QKSKPIVNLNLAAV-UHFFFAOYSA-N 0.000 description 1
- BJQHLKABXJIVAM-UHFFFAOYSA-N bis(2-ethylhexyl) phthalate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)OCC(CC)CCCC BJQHLKABXJIVAM-UHFFFAOYSA-N 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 229910021538 borax Inorganic materials 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 150000001639 boron compounds Chemical class 0.000 description 1
- 125000001246 bromo group Chemical group Br* 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- BTANRVKWQNVYAZ-UHFFFAOYSA-N butan-2-ol Chemical compound CCC(C)O BTANRVKWQNVYAZ-UHFFFAOYSA-N 0.000 description 1
- COPHVUDURPSYBO-UHFFFAOYSA-N butyl dioctyl phosphate Chemical compound CCCCCCCCOP(=O)(OCCCC)OCCCCCCCC COPHVUDURPSYBO-UHFFFAOYSA-N 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- HJMZMZRCABDKKV-UHFFFAOYSA-N carbonocyanidic acid Chemical compound OC(=O)C#N HJMZMZRCABDKKV-UHFFFAOYSA-N 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 229920003090 carboxymethyl hydroxyethyl cellulose Polymers 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- ZUIVNYGZFPOXFW-UHFFFAOYSA-N chembl1717603 Chemical compound N1=C(C)C=C(O)N2N=CN=C21 ZUIVNYGZFPOXFW-UHFFFAOYSA-N 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical class OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- SOCTUWSJJQCPFX-UHFFFAOYSA-N dichromate(2-) Chemical compound [O-][Cr](=O)(=O)O[Cr]([O-])(=O)=O SOCTUWSJJQCPFX-UHFFFAOYSA-N 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- XWVQUJDBOICHGH-UHFFFAOYSA-N dioctyl nonanedioate Chemical compound CCCCCCCCOC(=O)CCCCCCCC(=O)OCCCCCCCC XWVQUJDBOICHGH-UHFFFAOYSA-N 0.000 description 1
- PBULHKIPTBIZHO-UHFFFAOYSA-N dodecane-1-sulfonyl chloride Chemical compound CCCCCCCCCCCCS(Cl)(=O)=O PBULHKIPTBIZHO-UHFFFAOYSA-N 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000010894 electron beam technology Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- PUSKHXMZPOMNTQ-UHFFFAOYSA-N ethyl 2,1,3-benzoselenadiazole-5-carboxylate Chemical compound CCOC(=O)C1=CC=C2N=[Se]=NC2=C1 PUSKHXMZPOMNTQ-UHFFFAOYSA-N 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000006081 fluorescent whitening agent Substances 0.000 description 1
- 125000002541 furyl group Chemical group 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
- 150000003840 hydrochlorides Chemical class 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 125000001165 hydrophobic group Chemical group 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- PTFYQSWHBLOXRZ-UHFFFAOYSA-N imidazo[4,5-e]indazole Chemical compound C1=CC2=NC=NC2=C2C=NN=C21 PTFYQSWHBLOXRZ-UHFFFAOYSA-N 0.000 description 1
- NBZBKCUXIYYUSX-UHFFFAOYSA-N iminodiacetic acid Chemical compound OC(=O)CNCC(O)=O NBZBKCUXIYYUSX-UHFFFAOYSA-N 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000011229 interlayer Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 239000006224 matting agent Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000012046 mixed solvent Substances 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 235000010460 mustard Nutrition 0.000 description 1
- NPKFETRYYSUTEC-UHFFFAOYSA-N n-[2-(4-amino-n-ethyl-3-methylanilino)ethyl]methanesulfonamide Chemical compound CS(=O)(=O)NCCN(CC)C1=CC=C(N)C(C)=C1 NPKFETRYYSUTEC-UHFFFAOYSA-N 0.000 description 1
- CLJDCQWROXMJAZ-UHFFFAOYSA-N n-[2-(4-amino-n-ethyl-3-methylanilino)ethyl]methanesulfonamide;sulfuric acid Chemical compound OS(O)(=O)=O.CS(=O)(=O)NCCN(CC)C1=CC=C(N)C(C)=C1 CLJDCQWROXMJAZ-UHFFFAOYSA-N 0.000 description 1
- YOUKHKXMLCZXRK-UHFFFAOYSA-N n-[2-amino-5-(diethylamino)phenyl]acetamide Chemical compound CCN(CC)C1=CC=C(N)C(NC(C)=O)=C1 YOUKHKXMLCZXRK-UHFFFAOYSA-N 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- MGFYIUFZLHCRTH-UHFFFAOYSA-N nitrilotriacetic acid Chemical compound OC(=O)CN(CC(O)=O)CC(O)=O MGFYIUFZLHCRTH-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-N o-dicarboxybenzene Natural products OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 description 1
- VECVSKFWRQYTAL-UHFFFAOYSA-N octyl benzoate Chemical compound CCCCCCCCOC(=O)C1=CC=CC=C1 VECVSKFWRQYTAL-UHFFFAOYSA-N 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 150000004989 p-phenylenediamines Chemical class 0.000 description 1
- 150000004686 pentahydrates Chemical class 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 150000003014 phosphoric acid esters Chemical class 0.000 description 1
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 235000011181 potassium carbonates Nutrition 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- BHZRJJOHZFYXTO-UHFFFAOYSA-L potassium sulfite Chemical compound [K+].[K+].[O-]S([O-])=O BHZRJJOHZFYXTO-UHFFFAOYSA-L 0.000 description 1
- 235000019252 potassium sulphite Nutrition 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 150000003141 primary amines Chemical group 0.000 description 1
- 150000003142 primary aromatic amines Chemical class 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 125000003373 pyrazinyl group Chemical group 0.000 description 1
- BIJCQARKGMKIJW-UHFFFAOYSA-N pyrazol-3-one;2h-triazole Chemical compound C1=CNN=N1.O=C1C=CN=N1 BIJCQARKGMKIJW-UHFFFAOYSA-N 0.000 description 1
- NDGRWYRVNANFNB-UHFFFAOYSA-N pyrazolidin-3-one Chemical class O=C1CCNN1 NDGRWYRVNANFNB-UHFFFAOYSA-N 0.000 description 1
- MCSKRVKAXABJLX-UHFFFAOYSA-N pyrazolo[3,4-d]triazole Chemical compound N1=NN=C2N=NC=C21 MCSKRVKAXABJLX-UHFFFAOYSA-N 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000003288 salt bathing Methods 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- ADZWSOLPGZMUMY-UHFFFAOYSA-M silver bromide Chemical compound [Ag]Br ADZWSOLPGZMUMY-UHFFFAOYSA-M 0.000 description 1
- 229940045105 silver iodide Drugs 0.000 description 1
- 229910001923 silver oxide Inorganic materials 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 239000012748 slip agent Substances 0.000 description 1
- 239000010802 sludge Substances 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 description 1
- 235000019982 sodium hexametaphosphate Nutrition 0.000 description 1
- 229940001584 sodium metabisulfite Drugs 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- KKCBUQHMOMHUOY-UHFFFAOYSA-N sodium oxide Chemical compound [O-2].[Na+].[Na+] KKCBUQHMOMHUOY-UHFFFAOYSA-N 0.000 description 1
- 229910001948 sodium oxide Inorganic materials 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000004328 sodium tetraborate Substances 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-L sulfite Chemical class [O-]S([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-L 0.000 description 1
- 125000000565 sulfonamide group Chemical group 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- 150000004764 thiosulfuric acid derivatives Chemical class 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical class CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- XZZNDPSIHUTMOC-UHFFFAOYSA-N triphenyl phosphate Chemical compound C=1C=CC=CC=1OP(OC=1C=CC=CC=1)(=O)OC1=CC=CC=C1 XZZNDPSIHUTMOC-UHFFFAOYSA-N 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- QVTVDJWJGGEOGX-UHFFFAOYSA-N urea;cyanide Chemical class N#[C-].NC(N)=O QVTVDJWJGGEOGX-UHFFFAOYSA-N 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03C—PHOTOSENSITIVE MATERIALS FOR PHOTOGRAPHIC PURPOSES; PHOTOGRAPHIC PROCESSES, e.g. CINE, X-RAY, COLOUR, STEREO-PHOTOGRAPHIC PROCESSES; AUXILIARY PROCESSES IN PHOTOGRAPHY
- G03C7/00—Multicolour photographic processes or agents therefor; Regeneration of such processing agents; Photosensitive materials for multicolour processes
- G03C7/30—Colour processes using colour-coupling substances; Materials therefor; Preparing or processing such materials
- G03C7/392—Additives
- G03C7/39208—Organic compounds
- G03C7/39212—Carbocyclic
- G03C7/39216—Carbocyclic with OH groups
Landscapes
- Physics & Mathematics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- General Physics & Mathematics (AREA)
- Silver Salt Photography Or Processing Solution Therefor (AREA)
Description
(a) çºæã®æè¡åé
æ¬çºæã¯ãããã²ã³åéåçæå
ææã«é¢ãã
æŽã«è©³ããã¯è²ã«ããªãæ··è²ã¹ãã€ã³çãé²æ¢ã
ãããšã®ã§ããååç©ãå«æããããã²ã³åéå
çæå ææã«é¢ãããã®ã§ããã (b) å è¡æè¡ãšãã®åé¡ç¹ äžè¬ã«ãããã²ã³åéã«ã©ãŒåçæå ææã¯æ¯
æäœäžã«éè²å ãç·è²å ããã³èµ€è²å ã«æå æ§ã
æããããã«éžæçã«åå å¢æãããïŒçš®ã®ãã
ã²ã³åéåççšä¹³å€å±€ãå¡èšãããŠãããããšã
ã°ãããã²ã³åéã«ã©ãŒåçæå ææã§ã¯ãäžè¬
ã«é²å ãããåŽããéææ§ä¹³å€å±€ãç·ææ§ä¹³å€å±€
ããã³èµ€ææ§ä¹³å€å±€ãé ã«å¡èšãããŠããããã
ãŠãéææ§ä¹³å€å±€ãšç·ææ§ä¹³å€å±€ãšã®éã«ã¯éæ
æ§ä¹³å€å±€ãééããéè²å ãåžåããããã®æŒçœ
å¯èœãªé»è²ãã€ã«ã¿ãŒå±€ãèšããããŠããããã
ã«åä¹³å€å±€ã®éã«ã¯åã ç¹æ®ã®ç®çã§ä»ã®äžéå±€
ãããŸãæå€å±€ãšããŠä¿è·å±€ãããããèšããã
ãŠããããŸããããšãã°ãã«ã©ãŒå°ç»çŽçšæå æ
æã§ã¯ãäžè¬ã«é²å ãããåŽããèµ€ææ§ä¹³å€å±€ã
ç·ææ§ä¹³å€å±€ããã³éææ§ä¹³å€å±€ãé ã«å¡èšãã
ãŠãããã«ã©ãŒãã¬çšæå ææã«ããããšåæ§ã«
åã ç¹æ®ã®ç®çã§çŽ«å€ç·åžåå±€ãã¯ãããšããäž
éå±€ãä¿è·å±€çãããããèšããããŠããããã
ãã®ä¹³å€å±€ã¯ãåèšãšã¯å¥ã®é åã§èšããããšã
ç¥ãããŠãããããã«æå åã®ç°ãªãåä¹³å€å±€ã
äžå±€çšãã代ãã«åã ã®è²å ã«å¯ŸããŠå®è³ªçã«å
ãæå åã«æå æ§ãæããïŒçš®ä»¥äžã®æå æ§ä¹³å€
å±€ãçšããããšãç¥ãããŠããããããã®ããã²
ã³åéã«ã©ãŒåçæå ææã«ãããŠã¯ãçºè²çŸå
äž»è¬ãšããŠäŸãã°è³éŠæ第äžçŽã¢ãã³ç³»ååç©ã
çšããŠé²å ãããããã²ã³åéãçŸåããçæã
ãçºè²çŸåäž»è¬ã®é žåäœãšè²çŽ 圢ææ§ã«ãã©ãŒãš
ã®åå¿ã«ããè²çŽ ç»åã圢æãããããã®æ¹æ³ã«
ãããŠã¯ãéåžžã·ã¢ã³ãããŒã³ã¿ããã³ã€ãšããŒ
ã®åè²çŽ ç»åã圢æããããã«ãããããããšã
ãŒã«ãããã¯ããããŒã«ç³»ã·ã¢ã³ã«ãã©ãŒãïŒâ
ãã©ãŸãã³ããã©ãŸãªããã³ãã€ãããŸãŒã«ãã
ã©ãŸãã³ããªã¢ãŸãŒã«ãã€ã³ããŸãã³ãããã¯ã·
ã¢ãã¢ã»ãã«ç³»ããŒã³ã¿ã«ãã©ãŒããã³ã¢ã·ã«ã¢
ã»ãã¢ãããããã¯ãã³ãŸã€ã«ã¡ã¿ã³ç³»ã€ãšããŒ
ã«ãã©ãŒãçšããããããããã®è²çŽ 圢ææ§ã«ã
ã©ãŒã¯æå æ§ããã²ã³åéä¹³å€å±€äžãããã¯çŸå
液äžã«å«æãããã äžèšã®ããã«ããŠåŸãããããã²ã³åéã«ã©ãŒ
åçæå ææã®è²çŽ ç»åã¯ããã®çºè²çŸåæã«ã
ããŠãé²å ãããããã²ã³åéãä»ããªãã§çºè²
çŸåäž»è¬ã®é žåäœãšã«ãã©ãŒãšã®åå¿ã«ããçºè²
ã«ããªïŒã¹ãã€ã³ïŒãçºçãç»åã®è³ªãäœäžãã
ããããšãããã°ãã°ããã ãã®ãããªçºè²ã«ããªã¯ãïŒã€ã¯ãçºè²çŸåäž»
è¬ãã空æ°äžã®é žçŽ ãŸãã¯æº¶æ¶²äžã«æº¶åããé žçŽ
ã«ããé žåãããçºè²çŸåæã«ããã²ã³åéã«ã©
ãŒåçæå ææã®ããã²ã³åéä¹³å€å±€ã«ãããŠé
åã®åœ¢æãããªãæªé²å éšã§ã«ãã©ãŒãšåå¿ããŠ
è²çŽ ã圢æããå Žåã«çºçãããŸãä»ã®ïŒã€ã¯ã
ã«ã©ãŒæ¡æ£è»¢åçšãã€ã«ã ãŠããããçšããã«ã©
ãŒæ¡æ£è»¢åç»å圢ææ³ã«ãããŠãããã²ã³åéã®
çŸåã«ãããçããçŸåäž»è¬é žåäœãéæ¡æ£æ§è²
çŽ æŸåºæ§ã¬ããã¯ã¹ååç©ïŒDRRååç©ïŒãšã¬
ããã¯ã¹åå¿ããŠæ¡æ£æ§è²çŽ ãæŸåºããå Žåã«ã
çããã æŽã«ãã®ãããªçºè²ã«ããªã¯ãæ··è²ã«ããªãšã
ãŠçŸããããå³ã¡ãéææ§ãç·ææ§ãåã³èµ€ææ§
ä¹³å€å±€ããããããæ¯æäœäžã«å¡åžãããç©å±€æ§
æåã®ããã²ã³åéã«ã©ãŒåçææã«ãããŠã¯ã
ã€ãšããŒãããŒã³ã¿ãã·ã¢ã³ã®åã«ãã©ãŒãçºè²
çŸåéçšã§çããçºè²çŸåäž»è¬é žåäœãšã«ãããª
ã³ã°åå¿ããããããã®å±€ã§ãã€ãšããŒãããŒã³
ã¿ãåã³ã·ã¢ã³è²çŽ ç»åã圢æããããšãããã
é žåãããçºè²çŸåäž»è¬ã¯ããã®ååéãå°ãã
ãããããã«ååšããå±€å åã³é£æ¥ããä»ã®å±€ã«
æ¡æ£ããæè²æ§ãšçºè²æ§ãšã®å¯Ÿå¿é¢ä¿ã«é¢ä¿ãªã
åäžå±€å ã®ä»ã®å Žæåã¯é£æ¥ããä»ã®å±€ã§ããã«
ååšããã«ãã©ãŒãšã«ãããªã³ã°åå¿ããæ··è²ã«
ããªãçããããšãããã ãã®ãããªçºè²ã«ããªãæ··è²ã«ããªãé²æ¢ãã
ç®çã§ãåŸæ¥ããããã²ã³åéåçæå ææäžã«
åçš®ã®çœ®æãã€ããããã³çºè²ã«ããªæå¶æïŒæ±
æé²æ¢æãantistaining agentïŒãæ·»å ãé åã
ãããæ¹æ³ãææ¡ãããŠããã äŸãã°ãã¢ã眮æã¢ã«ãã«ãã€ããããã³ãçš
ããããšã«ã€ããŠã¯ãç±³åœç¹èš±2360290å·ãç±³åœ
ç¹èš±2419613å·ãç±³åœç¹èš±2403721å·ãå3960570
å·çã«ããŸãªã¢ãåå²ã¢ã«ãã«ãã€ããããã³ã
çšããæ¹æ³ã«ã€ããŠã¯ç±³åœç¹èš±3700453å·ã西ç¬
ç¹èš±åºé¡ïŒOLSïŒ2149789å·ãç¹éæ50â156438
å·ãå49â106329å·ã«èšèŒãããŠãããäžæ¹ããž
眮æãã€ããããã³ãçšããäŸã«ã€ããŠã¯ç±³åœç¹
èš±2728659å·ãå2732300å·ãå3243294å·ãè±åœ
ç¹èš±752146å·ããã±ãã«ã«ã»ã¢ãã¹ãã©ã¯ããèª
56å·»6367bçã«ãããã«ãžåå²ã¢ã«ãã«ãã€ãã
ããã³ã«ã€ããŠã¯ãç±³åœç¹èš±3700453å·ãå
2732300å·ãå3243294å·ãåèšãã±ãã«ã«ã»ã¢ã
ã¹ãã©ã¯ããèªãç¹éæ50â156438å·ãç¹éæ53
â9528å·ãç¹éæ54â29637å·ãç¹å ¬æ50â21249
å·çã«èšèŒãããŠããã ãã®ä»ã眮æãã€ããããã³ãçŸåäž»è¬é žåäœ
ã¹ã«ãã³ãžã€ãŒãšããŠçšããããšã«ã€ããŠã¯ç±³åœ
ç¹èš±2701197å·ãç±³åœç¹èš±2710801å·åã³ç±³åœç¹èš±
2704713å·ãç¹éæ55â43521å·ãç¹éæ56â
83742å·ãç¹éæ56â10344å·ãç¹éæ57â22237
å·çã«ããããèšèŒãããŠããããŸãç¹éæ55â
72158å·ã«ã¯ãïŒïŒïŒäœãã¹ã«ãã³ã¢ããåºã§ã
ããã眮æãããããšããŒã«ååç©ã®äŸãé瀺ã
ããŠããã äžè¬ã«ãçºè²ã«ããªæå¶å€ãšããŠçšããããçŸ
åäž»è¬é žåäœã¹ã«ãã³ãžã€ãŒã¯æ¬¡ã®ãããªæ¡ä»¶ã
æºããã®ãæãŸãããšãããŠããã (1) çŸåã®éãããã²ã³åéã®çŸåã§çããçŸå
äž»è¬é žåäœãšåå¿ãåŸãååç©ã§ããããšãäŸ
ãã°ãç°ãªãæè²æ§ã瀺ãå°ãªããšãïŒå±€ã®ã
ãã²ã³åéä¹³å€å±€ã®éã«é èšãããäžéå±€ã«æ·»
å ãããçŸåäž»è¬é žåäœã¹ã«ãã³ãžã€ãŒã¯ãçŸ
ååŠçæã«çããçŸåäž»è¬é žåäœãšåå¿ããã®
çŸåäž»è¬é žåäœãïŒã®æå æ§å±€ããä»ã®æå æ§
å±€ã«æ¡æ£ããã®ãé»æ¢ããããšãå¿ èŠãšãããŠ
ããã (2) çŸåäž»è¬é žåäœã¹ã«ãã³ãžã€ãŒã¯ãããã²ã³
åéåçæå ææã®æ§æå±€ã«æ·»å ãããå Žåã§
ããããã²ã³åéä¹³å€ã®éã®çŸåç¹æ§ã«å®è³ªç
ã«æªåœ±é¿ãåãŒããªãããšã (3) çŸåäž»è¬é žåäœã¹ã«ãã³ãžã€ãŒã¯ãããã²ã³
åéåçæå ææã®åæ§æå±€éã移åããŠåç
çã«å¥œãŸãããªãå¯äœçšãããããªãããã«é
æ¡æ£ã§ããããšããŸããã®ãã®ã¯ããã²ã³åé
åçæå ææã®åŠçåãåŠçäžãåã³åŠçåŸã
éããŠåççã«å¥œãŸãããªãå¯äœçšãå®è³ªçã«
ããããªãããšã (4) ä¹³å€ã®å¡åžäžãããã¯å¡åžåŸã«ä¹³å€å±€å ã§çµ
æ¶ãæåºããŠå¡åžç©ã®è³ªãäœäžãããããå¡åž
æäœäžãåŠçäžã«ãã®ãã®ãé žååå¿ãèµ·ãã
çè²å¯çæç©ãçããªãããšã (5) é·æéã«ããã€ãŠãçŸåäž»è¬é žåäœã®é€å»å¹
çãé«æ°Žæºã«ç¶æããããšãã§ããããšããŸã
é·æéã®ä¿åäžã«ããã®çŸåäž»è¬é žåäœã¹ã«ã
ã³ãžã€ãŒãããã²ã³åéåçæå ææã®æ§æå±€
å ã§é žåããŠçè²ç©è³ªãçæããªãããšã (6) çŸåäž»è¬é žåäœãšåå¿ããéã«çè²çæç©è³ª
ãçæããŠè²ã«ããã®åå ãšãªããªãããšã ããã²ã³åéåçæå ææã®æ§æå±€ã«å«æãã
ããŠçºè²ã«ããªãæ··åã«ããªãé²æ¢ããçŸåäž»è¬
é žåäœã¹ã«ãã³ãžã€ãŒã¯ãçæ³çã«ã¯ãäžèšã®æ¡
件ãå šãŠæºãããŠããããšãå¿ èŠãšãããŠãã
ããäžè¿°ããåçš®ã®çœ®æãã€ããããã³é¡ã¯ãé·
æã«ããã€ãŠã¹ã«ãã³ãžã€ãŒå¹æãé«æ°Žæºã«ç¶æ
ããããšãã§ããªããšããåé¡ããã€ãããŸãã
äžè¿°ãã眮æããšããŒã«é¡ã¯ãé«æž©ãè¿ éã§ã®çŸ
ååŠçéçšäžã«é žåãããŠçè²çæç©ãçãããš
ããæ¬ ç¹ãããããŸãçŸåäž»è¬ã®é žåäœãšåå¿ã
ãŠçè²çæç©ã圢æãããããšããæ¬ ç¹ãæããŠ
ãããããŸã æºè¶³ãã¹ãçŸåäž»è¬é žåäœã¹ã«ãã³
ãžã€ãŒãéçºãããŠããªãã®ãçŸç¶ã§ããã (c) çºæã®ç®ç æ¬çºæã¯äžèšã§è¿°ã¹ãçŸåäž»è¬é žåäœã¹ã«ãã³
ãžã€ãŒãšããŠã®æ¡ä»¶ãè¯ãæºè¶³ããååç©åã³ã
ã®ååç©ã®äœ¿çšæ¹æ³ãèŠãåºããããšã«ããšã¥ã
ãŠããã æ¬çºæã®ç¬¬ïŒã®ç®çã¯ãåçæ§æå±€ã«æ·»å ãã
ãŠãããã²ã³åéã®çŸåç¹æ§ã«æªåœ±é¿ããªããå
çæ§æå±€éã移åããŠåççã«å¥œãŸãããªãå¯äœ
çšããããããšã®ãªãçŸåäž»è¬é žåäœã¹ã«ãã³ãž
ã€ãŒãå«ãããã²ã³åéåçæå ææãæäŸãã
ããšã«ããã æ¬çºæã®ç¬¬ïŒã®ç®çã¯ãä¹³å€ã®å¡åžäžãããã¯
å¡åžåŸã«çµæ¶ãæåºããŠå¡åžç©ã®è³ªãæªããã
ããå¡åžæäœäžãåŠçäžã«é žåããŠçè²çæç©ã
çããªãçŸåäž»è¬é žåäœã¹ã«ãã³ãžã€ãŒãå«æã
ãããã²ã³åéåçæå ææãæäŸããããšã«ã
ãã æ¬çºæã®ç¬¬ïŒã®ç®çã¯ãé·æã«ããã€ãŠçŸåäž»
è¬é žåäœã®é€å»å¹çïŒã¹ã«ãã³ãžã€ãŒå¹çïŒãé«
æ°Žæºã«ç¶æããããšãã§ãããããé·æä¿åäžã«
é žåããŠçè²çæç©ãçæããããšã®ãªãçŸåäž»
è¬é žåäœã¹ã«ãã³ãžã€ãŒãå«æããããã²ã³åé
åçæå ææãæäŸããããšã«ããã æ¬çºæã®ç¬¬ïŒã®ç®çã¯ãçŸåäž»è¬é žåäœãšåå¿
ããŠçºè²ã«ããªãæ··è²ã¹ãã€ã³ã確å®ã«é²æ¢ãã
çŸåäž»è¬é žåäœã¹ã«ãã³ãžã€ãŒãå«æããããã²
ã³åéåçæå ææãæäŸããããšã«ããã æ¬çºæã®ãã®ä»ã®ç®çã¯ã以äžã«èšèŒãã説æ
ããæããã«ãããã (d) çºæã®å ·äœçæ§æ 以äžæ¬çºæã«ã€ããŠæŽã«è©³çŽ°ã«è¿°ã¹ãããæ¬çº
æã®ç¯å²ã¯ããã«ããå¶éããããã®ã§ã¯ãªãã æ¬çºæè ãã¯çš®ã æ€èšãéããçµæãæ¯æäœäž
ã«ãäžèšäžè¬åŒããã§è¡šããããååç©ã®å°ãª
ããšãïŒçš®ãå«æããåçæ§æå±€ãå°ãªããšãïŒ
å±€æããããšãç¹åŸŽãšããããã²ã³åéåçæå
ææãçšããããšã«ããäžèšç®çãéæã§ããã
ãšãèŠåºããæ¬çºæãå®æããã«è³ã€ãã äžè¬åŒãã ïŒãã ããåŒäžãR1ããã³R2ã¯äžäŸ¡ã®ææ©åºã
è¡šãããäºãã«åãã§ãç°ã€ãŠããŠãããããã
ãŠãR1ããã³R2ã®å°ãªããšãïŒã€ã¯ãã¢ã«ãã«
åºãã·ã¯ãã¢ã«ãã«åºãŸãã¯ãããç°åºãè¡šã
ããïŒ äžèšäžè¬åŒããã«ãããŠR1ããã³R2ã§ç€ºã
ããäžäŸ¡ã®ææ©åºãšããŠã¯ã次ã®åºããããã
ãã (1) ã¢ã«ãã«åºã奜ãŸããã¯ççŽ æ°ïŒãã40ã®ã¢
ã«ãã«åºãäŸãã°ãã¡ãã«åºããšãã«åºãïœâ
ãããã«åºãã€ãœãããã«åºãïœâããã«åºã
ïœâããã«åºãïœâãã³ãã«åºãïœâãã·ã«
åºãïœâãã·ã«åºãïœâããã·ã«åºãsecâã
ãã·ã«åºãtertâããã·ã«åºãïœâãããµãã·
ã«åºãsecâãããµãã·ã«åºãtertâãããµã
ã·ã«åºãïœâãªã¯ã¿ãã·ã«åºãsecâãªã¯ã¿ã
ã·ã«åºãtertâãªã¯ã¿ãã·ã«åºçã®çŽéããã
ã¯åå²ã®ã¢ã«ãã«åºã§ããããããã®ã¢ã«ãã«
åºã¯çœ®æåºãæããŠãããã眮æåºãšããŠã¯ã
äŸãã°ãå¡©çŽ ååãããã¯èçŽ ååãªã©ã®ãã
ã²ã³ååãããããã·ã«åºãã¢ã«ã³ãã·åºãã¢
ãªãŒã«ãªãã·åºãã¢ã«ãã«ã¹ã«ãã¢ã¢ã€ã«åºã
ã¢ãªãŒã«ã¹ã«ãã¢ã¢ã€ã«åºãã¢ã«ãã«ã«ã«ãã¢
ã€ã«åºãã¢ãªãŒã«ã«ã«ãã¢ã€ã«åºãã¢ãªãŒã«
åºãã·ã¢ãåºçãæãããããå ·äœäŸãšããŠ
ã¯ãïŒâã¯ããããã«åºãïŒâããããã·ãšã
ã«åºãïŒâã¡ããã·ãããã«åºãïŒâïœâãã
ã«ã¹ã«ãã¢ã¢ã€ã«ãããã«åºããã³ãžã«åºãªã©
ãæããããã (2) ã¢ã«ã±ãã«åºã奜ãŸããã¯ççŽ æ°ïŒãã22ã®
ã¢ã«ã±ãã«åºïŒäŸãã°ã¢ãªã«åºãªã©ïŒïŒ (3) ã·ã¯ãã¢ã«ãã«åºã奜ãŸããã¯ççŽ æ°ïŒãã
12ã®ã·ã¯ãã¢ã«ãã«åºã§ããã奜ãŸããå ·äœäŸ
ãšããŠã¯ãã·ã¯ãããã·ã«åºçããããããã
ã®åºã¯çœ®æåºãæããŠããŠãããã (4) ã¢ãªãŒã«åºã奜ãŸããã¯ççŽ æ°ïŒãã40ã®ã¢
ãªãŒã«åºã§ããããã®ã¢ãªãŒã«åºã¯çœ®æåºãæ
ããŠããŠãããã眮æåºãšããŠã¯ãäŸãã°ãã
ãã²ã³ååãããããã·ã«åºãã¢ã«ãã«åºãã¢
ãªãŒã«åºãã¢ã·ã«åºãã«ã«ããã·ã«åºãã¢ã«ã
ã«ã«ã«ãã¢ã€ã«åºãã¢ãªãŒã«ã«ã«ãã¢ã€ã«åºã
ã¢ã«ã³ãã·åºãã¢ãªãŒã«ãªãã·åºãã¢ã«ãã«ã¹
ã«ããã«åºãã¢ãªãŒã«ã¹ã«ããã«åºãã¢ã«ãã«
ã¹ã«ãã¢ã¢ã€ã«åºãã¢ãªãŒã«ã¹ã«ãã¢ã¢ã€ã«
åºãã¢ã«ãã«ã¹ã«ãã³ã¢ããåºãã¢ãªãŒã«ã¹ã«
ãã³ã¢ããåºãã·ã¢ãåºãªã©ãæãããããå ·
äœäŸãšããŠã¯ãããšãã«åºãïœâããã·ã«ããš
ãã«åºãïŒïŒïŒâãžâtertâã¢ã·ã«ããšãã«
åºãâããã·ã«ãªãã·ããšãã«åºãªã©ãæã
ãããã (5) ççŽ æ°ïŒãã20ã®ãããç°ãäŸãã°ãã©ãã«
åºãããªãžãã«åºããã©ãžãã«åºãããªããžã
ã«åºããããªãã«åºãã€ã³ããã«åºçãæãã
ãããåèšãããç°ã¯çœ®æåºãæããŠããŠãã
ãã æ¬çºæã«ä¿ãååç©ã¯ããã²ã³åéåçæå æ
æã®æå æ§ããã²ã³åéä¹³å€å±€ãããã¯éæå æ§
芪氎æ§ã³ãã€ãå±€ãããªãåçæ§æå±€ã«æ·»å ãã
ãããã®ååç©ã¯ãäžèšåçæ§æå±€ã«ãããŠéæ¡
æ£ã§ããããšã奜ãŸããããã®ãããäžè¬åŒ
ã§è¡šããããR1ããã³R2ã®å šççŽ æ°ã®åã®
å°ãªããšã10ã§ããããšã奜ãŸããããã奜ãŸã
ãã¯12ãã40ã§ããã æ¬çºæã®äžè¬åŒïŒ»ïŒœã§è¡šããããååç©ã§ç¹
ã«å¥œãŸãããã®ã¯ãäžèšäžè¬åŒïŒ»ïŒœäžã®R1ãŸ
ãã¯R2ã眮æåºãæããã¢ãªãŒã«åºã§ãããæ®
ãã®äžæ¹ãã¢ã«ãã«åºã§ãããããªååç©ã§ã
ãã 次ã«æ¬çºæã®äžè¬åŒïŒ»ïŒœã§è¡šããããååç©
ãå ·äœçã«ç€ºããæ¬çºæã®ååç©ã¯ãããã«éå®
ãããªãã 次ã«äžè¬åŒããã§è¡šããããæ¬çºæã®ååç©
ã«ã€ããŠä»£è¡šçãªåæäŸãèšèŒããããæ¬çºæã¯
ããã«éå®ãããªãã åæäŸ ïŒ äŸç€ºååç©(2)ã®åæ ïŒïŒïŒâãžã¢ããããšããŒã«ïŒå¡©é žå¡©(A)40.0ïœ
ãããªãžã³300mlã«æžæ¿ããã溶液ã«ãïœâãã
ã·ã«ã¹ã«ããã«ã¯ãã©ã€ã(B)52.0ïœãããªãžã³
200mlã«æº¶ãããŠæ»Žäžãããåå¿æ¶²ã50âïŒæé
æ¹æããã®ã¡å·åŽãã1Nâå¡©é žã«æ³šããæåºã
ãåºäœãéããã¢ã»ããããªã«ããæçµæ¶ããŠ
çœè²ã®ç²æ«ïŒäŸç€ºååç©(2)ïŒïŒèç¹123ã126âïŒ
73.2ïœãåŸãã å çŽ åæå€C30H56N2O5S2     èšç®å€ 61.19 9.58 4.76 10.89 åæå€ 60.88 9.50 4.86 10.74 åæäŸ ïŒ äŸç€ºååç©(7)ã®åæ ïŒâã¢ããâïŒâãããããšããŒã«(C)30.0ïœãš
å¡©åãã³ãžã«(D)28.0ïœããæ°Žé žåã«ãªãŠã 12.1ïœ
ãå ¥ãããšã¿ããŒã«æº¶æ¶²300mlã«å ããïŒæéå
ç±éæµããããæåºãã液ãéåŸã液ãæžå§
çå»ããŠçŽ2/1ã«æ¿çž®åŸæ°Ž500mlã«æ³šãã ãæåºã
ãåºäœãéããæ°ŽæŽåŸãã¢ã»ããããªã«ããå
çµæ¶ããŠé»è²ã®ç²æ«ïŒâãã³ãžã«ãªãã·âïŒâã
ããã¢ããªã³(E)ïŒèç¹129ã135âïŒ26.1ïœãåŸ
ãã åèšã®çæç©(E)24.4ïœãããªãžã³150mlã«æº¶ã
ãã溶液ã«ããã·ã«ãªãã·ã¹ã«ãã¢ã¢ã€ã«ã¯ãã©
ã€ã(F)30.0ïœãå ãïŒæééæµããããã®åå¿æ¶²
ã2NâHCl氎溶液500mlã«æ³šããæåºããåºäœã
éããæ°Žã§æŽæµããããã®åºäœãã¢ã»ããããª
ã«ããåçµæ¶ããŠãã€è²ã®ç²æ«ãâïŒïŒâãã³
ãžã«ãªãã·âïŒâãããïŒâããšãã«ããã·ã«ã¹
ã«ãã³ã¢ãã(G)ïŒèç¹129ã133âïŒ29.6ïœãåŸ
ãã åèšã®çæç©(G)16.0ïœãTHF60mlã«æº¶ãããŠ
ïŒïŒ PdïŒïŒ£è§ŠåªïŒïœãå ããŠæ°Žæ·»åå¿ã40âã§
ïŒæéè¡ãªã€ããåå¿çµäºåŸãçªçŽ æ°æµäžã§è§Šåª
ãéåŸã液ã2NâHCl氎溶液400mlã«æ³šã
ã ãæåºããåºäœãéããŠïŒâã¢ããâïŒâã
ãã·ã«ã¹ã«ãã³ã¢ããããšããŒã«ã®å¡©é žå¡©(H)12.1
ïœãåŸãã åèšã®çæç©(H)25.0ïœãããªãžã³200mlã«æº¶ã
ãã溶液ã«ããã·ã«ãªãã·ãã³ãŒã³ã¹ã«ããã«ã¯
ãã©ã€ãïŒïŒ14.0ïœã40âã§ïŒæéã«ããã€ãŠ
滎äžãããïŒæéæ¹æåŸåå¿æ¶²ã2NâHCl氎溶
液ã«æ³šããæåºããåºäœãéãããåºäœãã¢ã»
ããããªã«ã«æº¶ãããŠæŽ»æ§çåŠçåŸæçµæ¶ããŠçœ
è²ã®ç²æ«ïŒäŸç€ºååç©(7)ïŒïŒèç¹129ã133âïŒ
25.1ïœãåŸãã å çŽ åæå€ ïŒ£    èšç®å€ 63.49 8.88 4.11 9.42 åæå€ 63.25 8.81 4.30 9.50 æ¬çºæã«ä¿ãååç©ã¯ãããã²ã³åéåçæå
ææã®éæå æ§èŠªæ°Žæ§ã³ãã€ãå±€ã«æ·»å ãããã
ãšã奜ãŸããããã®éæå æ§èŠªæ°Žæ§ã³ãã€ãå±€ã«
ã¯ãäŸãã°äžéå±€ããã€ã«ã¿ãŒå±€ãè¡šé¢ä¿è·å±€ã
æ··è²é²æ¢å±€çãå«ãŸããã æ¬çºæã®å¥œãŸããå®æœæ æ§ã«ãããŠã¯ãæ¬çºæ
ã«ä¿ãååç©ïŒçŸåäž»è¬é žåäœã¹ã«ãã³ãžã€ãŒïŒ
ãåçš®ã®ä¹³å€å±€ã®éã«ããäžéå±€ã«æ·»å ãããã
ãã®å Žåã倫ã æè²æ§ã®ç°ãªãä¹³å€å±€ã®éã«ãã
äžéå±€ã«æ·»å ãããå Žåã奜ãŸããããŸãæè²æ§
ã¯å®è³ªçã«åäžã§ãããæ床ã®ç°ãªãä¹³å€å±€ã®é
ã«ããäžéå±€ã«æ·»å ãããå Žåã奜ãŸããããŸ
ããæ¬çºæã«ä¿ãååç©ã¯ãããã²ã³åéä¹³å€å±€
ã«æ·»å ãããŠããŠããããããã«æ¬çºæã«ä¿ãå
åç©ã¯ãäžé局以å€ã®éæå æ§èŠªæ°Žæ§ã³ãã€ã
å±€ãäŸãã°ããã€ã«ã¿ãŒå±€ãè¡šé¢ä¿è·å±€ã«ãæ·»å
ããããšãã§ããããŸããã®ãããªååç©ã¯ãé
æå æ§èŠªæ°Žæ§ã³ãã€ãå±€ãšæå æ§ããã²ã³åéä¹³
å€å±€ã®åæ¹ã«æ·»å ãããŠããŠãããã ãããã®å±€ã«æ·»å ãããæ¬çºæã«ä¿ãååç©ã®
æ·»å éã¯è©²ååç©ãå®è³ªçã«ç¡è²ã§ãããããã
ãèªèº«ã«ããçè²æ±æçã®æªåœ±é¿ããªãã®ã§ç¹ã«
å¶éãããªãã奜ãŸããå®æœæ æ§ã§ã¯ãæ¬çºæã«
ä¿ãååç©ãäžéå±€ã«æ·»å ããå Žåã«ã¯ãçŽïŒ
mgïŒm2ãã1000mgïŒm2ã®ç¯å²ã§çšããããšãã§ã
ããç¹ã«ãæè²æ§ãç°ãªãä¹³å€å±€ã®éã«ããäžé
å±€ã®ãšãã¯50mgïŒm2ãã500mgïŒm2ã奜ãŸããã
æè²æ§ãå®è³ªçã«åãä¹³å€å±€ã®éã«ããäžéå±€ã®
ãšãã¯ïŒmgïŒm2ãã200mgïŒm2ã®ç¯å²ã奜ãŸããã
ãŸãããã®ååç©ãæå æ§ããã²ã³åéä¹³å€å±€ã«
æ·»å ããå Žåã«ã¯ãããã²ã³åéïŒã¢ã«åœãïŒÃ
10-5ããïŒÃ10-1ã¢ã«ã®ç¯å²ã§çšããã®ã奜ãŸã
ãã ããã«ãæ¬çºæã«ä¿ãååç©ã¯ïŒçš®ä»¥äžäœµçšã
ãŠçšããŠãäœãããã€ãããªãããã®å Žåãæ·»å
éã¯åè¿°ãããšåãéã§ååã§ããã æ¬çºæã®ååç©ïŒçŸåäž»è¬é žåäœã¹ã«ãã³ãžã€
ãŒïŒãããã²ã³åéåçæå ææã®åçæ§æå±€ã«
å°å ¥ããã«ã¯ãå ¬ç¥ã®æ¹æ³ãäŸãã°ãç±³åœç¹èš±ç¬¬
2322027å·ã«èšèŒãããæ¹æ³çãçšãããããäŸ
ãã°ãæ¬çºæã«ä¿ãååç©ãããã¿ã«é žã¢ã«ãã«
ãšã¹ãã«ïŒäŸãã°ããžããã«ãã¿ã¬ãŒãããžãªã¯
ãã«ãã¿ã¬ãŒãçïŒããªã³é žãšã¹ãã«ïŒäŸãã°ã
ããªããšãã«ããªã¹ããšãŒããããªã¯ã¬ãžã«ããª
ã¹ããšãŒãããžãªã¯ãã«ããã«ããªã¹ããšãŒã
çïŒãã¯ãšã³é žãšã¹ãã«ïŒäŸãã°ãã¢ã»ãã«ã¯ãš
ã³é žããªããã«çïŒãå®æ¯éŠé žãšã¹ãã«ïŒäŸãã°ã
å®æ¯éŠé žãªã¯ãã«çïŒãã¢ã«ãã«ã¢ããïŒäŸãã°ã
ãžãšãã«ã©ãŠãªã«ã¢ããïŒãèèªé žãšã¹ãã«ïŒäŸ
ãã°ããžãããã·ãžãšãã«ãµã¯ã·ããŒãããžãªã¯
ãã«ã¢ãŒã¬ãŒãïŒãããã³ïŒãŸãã¯æ²žç¹çŽ30âã
ã150âã®ææ©æº¶åªãäŸãã°é ¢é žãšãã«ãé ¢é žã
ãã«ãããããªã³é žãšãã«ãïŒçŽããã«ã¢ã«ã³ãŒ
ã«ãã¡ãã«ã€ãœããã«ã±ãã³ãβâãšããã·ãšã
ã«ã¢ã»ããŒããã¡ãã«ã»ããœã«ãã¢ã»ããŒãçã®
ïŒçš®é¡ã®æº¶åªãŸãã¯ïŒçš®ä»¥äžã®æ··å溶åªã«æº¶è§£ã
ããã®ã¡ã芪氎æ§ã³ãã€ãã«åæ£ãããã ãŸããç¹å ¬æ51â39853å·ãç¹éæ51â59943å·
ã«èšèŒãããŠããã©ããã¯ã¹ã«ããåæ£æ³ã䜿çš
ããããšãã§ããã æ¬çºæã®ååç©ã¯çš®ã ã®ããã²ã³åéåçæå
ææã«çšããããšãã§ããããã®ãããªããã²ã³
åéåçæå ææäžã«ã¯ãçœé»çšãã«ã©ãŒçšãæ¬
ã«ã©ãŒçšããã²ã³åéåçæå ææãå å«ããã
å ·äœçã«ã¯ãäžè¬çœé»çšãå°å·çšçœé»ãã¬ã€
çšãé»åç·çšãé«è§£åç·çšçœé»çšããã²ã³åéå
çæå ææããäžè¬ã«ã©ãŒçšãã«ã©ãŒïŒžã¬ã€çšã
æ¡æ£è»¢ååã«ã©ãŒçšããã²ã³åéåçæå ææã«
é©çšããããšãã§ããã éæå æ§èŠªæ°Žæ§ã³ãã€ãå±€ã®èŠªæ°Žæ§ã³ãã€ããš
ããŠã¯ãäž»ã«ãŒã©ãã³ãçšããããã æ¬çºæã«çšãããããŒã©ãã³ã¯ãæè¬ã¢ã«ã«ãª
åŠçïŒç³ç°åŠçïŒãŒã©ãã³ãé žåŠçãŒã©ãã³ããŸ
ãã¯ãBull.Soc.Sci.Photo JapanãNo.16ã第30é
ïŒ1966ïŒã«èšèŒãããŠãããããªé µçŽ åŠçãŒã©ã
ã³ã®ãããã§ããããããã«äžéšå æ°Žå解ããäœ
ååéã®ãŒã©ãã³ãçšããããšãåºæ¥ãã ãŸããå¿ èŠã«å¿ããŠã³ãã€ãç¶ã¢ã«ããã³ãã«
ãŒã€ã³ãã«ã«ããã·ã¡ãã«ã»ã«ããŒãºããããã
ã·ãšãã«ã»ã«ããŒãºçã®ã»ã«ããŒãºèªå°äœãå¯
倩ãã¢ã«ã®ã³é žãœãŒãã柱ç²èªå°äœãªã©ã®ç³èªå°
äœãåæ芪氎æ§ã³ãã€ããäŸãã°ããªããã«ã¢ã«
ã³ãŒã«ãããªïŒ®âããã«ãããªãã³ãããªã¢ã¯ãª
ã«é žå ±éåäœãããªã¢ã¯ãªã«ã¢ãããŸãã¯ããã
ã®èªå°äœã»éšåå æ°Žå解ç©çã䜵çšããŠãããã€
ãããªãã æ¬çºæã«æŒãŠéæå æ§èŠªæ°Žæ§ã³ãã€ãå±€ã«ã¯å¿
èŠã«ããããŒã©ãã³ç¡¬èå€ãçé¢æŽ»æ§å€ãããªã
ãŒã©ããã¯ã¹ããããå€ãææã玫å€ç·åžåå€ã
耪è²é²æ¢å€ãå¯å¡å€ãæ»ãå€ã垯é»é²æ¢å€çãå«
æããããããšãåºæ¥ããããããæ·»å å€ã«é¢ã
ãŠã¯ããªãµãŒãã»ãã€ã¹ã¯ããŒãžã€ãŒ
ïŒResearch DisclosureïŒ176å·»ã第22ã28é
ïŒ1978幎12æïŒã®èšèŒãåèã«ããããšãåºæ¥ãã ãŸãæ¬çºæã®ããã²ã³åéä¹³å€å±€ãæ§æããæ
å ä¹³å€ã«çšããããããã²ã³åéãšããŠã¯ãèå
éãå¡©åéãæ²èåéãå¡©èåéãå¡©æ²èåéç
ã®éåžžããã²ã³åéåçä¹³å€ã«äœ¿çšãããä»»æã®
ãã®ãå å«ãããã æ¬çºæã®å€å±€ããã²ã³åéã«ã©ãŒåçæå ææ
ã«çšããããããã²ã³åéä¹³å€ã¯éåžžè¡ãªããã
çš®ã ã®è£œæ³ãããšãã°ç¹å ¬æ46â7772å·å ¬å ±ã«èš
èŒãããŠãããããªæ¹æ³ããããã¯ç±³åœç¹èš±ç¬¬
2592250å·æ现æžã«èšèŒãããŠãããããªæ¹æ³ã
ããªãã¡ãããããã³ã³ããŒãžãšã³ä¹³å€ã®è£œæ³ã
ãããã¯ããããããªãããã³ä¹³å€ã®è£œæ³çã«ã
ã€ãŠäœæããããšãã§ãããã®ããã²ã³åéä¹³å€
ã¯åŸæ¥ç¥ãããŠããååŠå¢æå€ãçšããããšãåº
æ¥ãããŸããã®ä¹³å€ã¯ååŠå¢æ以å€ã«ãéå å€ã§
éå å¢æããããšãã§ãããããŠãŸããã®ä¹³å€
ã¯ã湿最å€ãå¯å¡å€ãèç©æ§æ¹è¯å€çãå«æãã
ããããšãã§ããããã«å¡åžå©å€ãè¢å å¢çœå€ã
垯é»é²æ¢å€çã®çš®ã ã®åççšæ·»å å€ãå«æããã
ãããšãã§ããã æ¬çºæã®ããã²ã³åéåçæå ææã«ã¯ãå ¬ç¥
ã®ïŒåœéã«ãã©ãŒåã³ïŒåœéã«ãã©ãŒãçšããã
ãããããã®ã«ãã©ãŒã®ãã¡ãã€ãšããŒã«ãã©ãŒ
ãšããŠã¯ãäŸãã°ãééã¢ã·ã«ã¢ã»ãã¢ããã«ã
ã©ãŒïŒäŸãã°ããããªã«ã¢ã»ãã¢ããªãé¡ããã³
ãŸã€ã«ã¢ã»ãã¢ããªãé¡ïŒçãæãããããŸãã
ãŒã³ã¿ã«ãã©ãŒãšããŠã¯ïŒâãã©ãŸãã³ã«ãã©
ãŒããã©ãŸããã³ãã€ãããŸãŒã«ã«ãã©ãŒããã©
ãŸãããªã¢ãŸãŒã«ã«ãã©ãŒãã€ã³ããŸãã³ã«ãã©
ãŒçãæããããããŸãã·ã¢ã³ã«ãã©ãŒãšããŠ
ã¯ãããããŒã«ã«ãã©ãŒããã³ããšããŒã«ã«ãã©
ãŒçãæããããããããã®ã«ãã©ãŒã¯ååäžã«
ãã©ã¹ãåºãšåŒã°ããçæ°Žæ§åºãæããéæ¡æ£æ§
ã®ã«ãã©ãŒãæãŸããããŸããè²è£æ£ã®å¹æãã
ã€ã«ã©ãŒãã«ãã©ãŒãããã¯çŸåã®çšåºŠã«äŒŽãªã€
ãŠçŸåæå¶å€ãæŸåºããã«ãã©ãŒïŒããããDIR
ã«ãã©ãŒïŒãããã¯DIRã«ãã©ãŒä»¥å€ã«ããã«ã
ããªã³ã°åå¿ã®çæç©ãç¡è²ã§ãã€ãŠãçŸåæå¶
å€ãæŸåºããç¡åè²DIRã«ãããªã³ã°ååç©ãçš
ããããšãã§ããã ãããã®ã«ãã©ãŒã¯ãäžè¬ã«ä¹³å€å±€äžã®éïŒã¢
ã«ãããïŒÃ10-3ã¢ã«ãªããïŒã¢ã«ã奜ãŸããã¯
ïŒÃ10-2ã¢ã«ãªããïŒÃ10-1ã¢ã«æ·»å ãããã ã«ãã©ãŒãããã²ã³åéä¹³å€å±€ã«å°å ¥ããã«ã¯
å ¬ç¥ã®æ¹æ³ããšãã°ç±³åœç¹èš±ç¬¬2322027å·ã«èšèŒ
ã®æ¹æ³ãªã©ãçšããããã ãŸãç¹å ¬æ51â39853å·ãç¹éæ51â59943å·ã«
èšèŒãããŠããéåç©ã«ããåæ£æ³ã䜿çšããã
ãšãã§ããã ã«ãã©ãŒãã«ã«ãã³é žãã¹ã«ããªã³é žã®ããšã
é žåºãæããå Žåã«ã¯ãã¢ã«ã«ãªæ§æ°Žæº¶æ¶²ãšããŠ
芪氎æ§ã³ãã€ãäžã«å°å ¥ãããã æ¬çºæã®ããã²ã³åéåçæå ææã«çšããã
ãçºè²çŸå液ã®PHã¯ãPHãïŒä»¥äžã奜ãŸããã¯PH
ïŒãã12ã§ããããã®çºè²çŸå液ã«ã¯è³éŠæç°äž
ã«ç¬¬ïŒçŽã¢ãã³åºãæããé²å ãããããã²ã³å
éãçŸåããèœåã®ããè³éŠæ第ïŒçŽã¢ãã³ç³»çº
è²çŸåäž»è¬åã¯ãã®ãããªååç©ã圢æãåŸãå
é§äœã奜ãŸããçšããããã è³éŠæ第ïŒçŽã¢ãã³ç³»çºè²çŸåäž»è¬ãšããŠã¯ã
ïœâããšãã¬ã³ãžã¢ãã³ç³»èªå°äœãå«ãŸããå ·äœ
çã«ã¯ãïŒâã¢ããâïŒïŒ®âãžãšãã«ã¢ããª
ã³ãïŒâã¡ãã«âïŒâã¢ããâïŒïŒ®âãžãšãã«
ã¢ããªã³ãïŒâã¢ããââãšãã«ââβâã
ãããã·ãšãã«ã¢ããªã³ãïŒâã¡ãã«âïŒâã¢ã
ãââãšãã«ââβâããããã·ãšãã«ã¢ã
ãªã³ãïŒâã¡ãã«âïŒâã¢ããââãšãã«â
âβâã¡ã¿ã³ã¹ã«ãã³ã¢ãããšãã«ã¢ããªã³ãïŒ
âã¡ãã«âïŒâã¢ããââãšãã«ââβâã¡
ããã·ãšãã«âïŒâã¢ããâïŒïŒ®âãžãšãã«ã¢
ããªã³ãïŒâã¡ããã·âïŒâã¢ããââãšãã«
ââβâããããã·ãšãã«ã¢ããªã³ãïŒâã¡ã
ãã·âïŒâã¢ããââãšãã«ââβâã¡ãã
ã·ãšãã«ã¢ããªã³ãïŒâã¢ã»ãã¢ããâïŒâã¢ã
ãâïŒïŒ®âãžãšãã«ã¢ããªã³ãïŒâã¢ããâ
ïŒïŒ®âãžã¡ãã«ã¢ããªã³ãâãšãã«ââβ
âãβâïŒÎ²âã¡ããã·ãšããã·ïŒãšããã·ããšã
ã«âïŒâã¡ãã«âïŒâã¢ããã¢ããªã³ãâãšã
ã«ââβâïŒÎ²âã¡ããã·ãšããã·ïŒãšãã«â
ïŒâã¡ãã«âïŒâã¢ããã¢ããªã³ãããããã®å¡©
äŸãã°ç¡«é žå¡©ãå¡©é žå¡©ãäºç¡«é žå¡©ãïœâãã«ãšã³
ã¹ã«ãã³é žå¡©ãªã©ã§ããããŸããããã®çºè²çŸå
液ã«ã¯å¿ èŠã«å¿ããŠçš®ã ã®æ·»å å€ãå ããããšã
ã§ããã æ¬çºæã®ããã²ã³åéåçæå ææã¯åæ§é²å
åŸãçºè²çŸååŠçãããã çºè²çŸååŠçã¯ãéåžžã®çºè²çŸåæ³ã«ãã€ãŠè¡
ãªãããã ããªãã¡ããŸãçºè²çŸåäž»è¬ãå«ãçºè²çŸå液
ã§åŠçããããããã¯ãçºè²çŸåäž»è¬ãŸãã¯ãã®
åé§äœãå«æãããŠããããããããããã¢ã¯ã
ã€ããŒã¿ãŒæ¶²ã§åŠçããã ãã®åŸãéåžžã¯ãåžžæ³ã«åŸããæŒçœå·¥çšãå®ç
å·¥çšãè¡ãªãã ãã®åŠçã¯å®çãšåæã§ããŸãå¥åã§ãããã
ãã®åŠç液ã¯å¿ èŠã«å¿ããŠå®çå€ãå ããããšã«
ããæŒçœå®ç济ãšããããšãã§ãããæŒçœå€ãšã
ãŠã¯çš®ã ã®ååç©ãçšããããæŒçœä¿é²å€ãã¯ã
ããçš®ã ã®æ·»å å€ãå ããããšãã§ããã æ¬çºæã¯çš®ã ã®åœ¢æ ã®ããã²ã³åéã«ã©ãŒåç
æå ææã«ãããŠå®çŸããããäŸãã°ãäžèšãã
ã²ã³åéã«ã©ãŒåçæå ææã¯ãã«ãã©ãŒå«æå
åŒããã²ã³åéã«ã©ãŒåçæå ææããããã¯ã«
ãã©ãŒãçŸå液ã«å«æãããå€åŒããã²ã³åéã«
ã©ãŒåçæå ææã§ããããç¹ã«ã«ãã©ãŒå«æå
åŒããã²ã³åéã«ã©ãŒåçæå ææãæå©ã§ã
ããé²å åŸãçºè²çŸåæ³ã§çºæçŸåãããããã
ã«ã«ãã©ãŒãšçºè²çŸåäž»è¬ãšãæªé²å æã¯æ¥è§Šã
ãªãããä¿è·ããŠåäžå±€ã«ååšãããé²å åŸæ¥è§Š
ãåŸããããªããã²ã³åéã«ã©ãŒåçæå ææã«
ãããããã¯ã«ãã©ãŒãå«æããããã²ã³åéã«
ã©ãŒåçæå ææã«ãããŠã該ã«ãã©ãŒãå«æã
ãªãå±€ã«çºè²çŸåäž»è¬ãå«æããããã¢ã«ã«ãªæ§
åŠç液ã浞éãããæã«è©²çºè²çŸåäž»è¬ã移åã
ãããã«ãã©ãŒãšæ¥è§ŠãåŸããããªããã²ã³åé
ã«ã©ãŒåçæå ææã§ãã€ãŠããããããã«æ¡æ£
転åçšããã²ã³åéã«ã©ãŒåçææã«ãããŠãæ¬
çºæã«ä¿ãäžè¬åŒããã§è¡šããããååç©ã該
æå ææã®åçæ§æå±€äžã«æ·»å ããŠçšããããšã
ã§ããã äžè¬çãªã«ã©ãŒæ¡æ£è»¢åçšçŸåäž»è¬ãšããŠãã
ã€ããããã³é¡ãã¢ããããšããŒã«é¡ïŒäŸãã°ã
âã¡ãã«ã¢ããããšããŒã«ïŒããã©ãŸãªãã³é¡
ãäŸãã°ãããšããã³ïŒïŒâããšãã«âïŒâãã©
ãŸãªãã³ïŒããžã¡ãŸã³ïŒïŒâããšãã«âïŒïŒïŒâ
ãžã¡ãã«âïŒâãã©ãŸãªãã³ïŒãïŒâããšãã«â
ïŒâã¡ãã«âãªãã·ã¡ãã«âïŒâãã©ãŸãªãã³ã
ïŒâïœâããªã«âïŒâã¡ãã«âïŒâãªãã·ã¡ãã«
âïŒâãã©ãŸãªãã³ããªã©ãããã å転æ³ã§ã¯çœé»ãã¬çŸå液ã§çŸåãã次ãã§çœ
è²é²å ãäžãããããããã¯ããŠçŽ ååç©ã®åŠã
ã«ããªå€ãå«æãã济ã§åŠçããããã«çºè²çŸå
äž»è¬ãå«ãã¢ã«ã«ãªçŸå液ã§çºè²çŸåããããã®
æã«ããªå€ãçºè²çŸåäž»è¬ãå«ãã¢ã«ã«ãªçŸå液
ã«å«æãããŠãäœãããã€ãããªããçºè²çŸå
åŸãé žåå€ãšããŠããšãªã·ã¢ãããŸãã¯ã¢ããã
ãªã«ã«ãã³é žã®ç¬¬ïŒéå¡©çãå«æããæŒçœæ¶²ã§æŒ
çœåŠçããããã«ããªãµã«ããšãŒãçã®é塩溶å€
ãå«æããå®ç液ã§å®çåŠçããŠéåãšæ®åãã
ã²ã³åéãé€ãè²çŽ ç»åãæ®ããæŒçœæ¶²ãšå®ç液
ãšãçšãã代ãã«ã¢ããããªã«ã«ãã³é žã®ç¬¬ïŒé
å¡©çã®é žåå€ãšããªãµã«ããšãŒãçã®é塩济å€ãš
ãå«æããäžæµŽæŒçœå®ç液ãçšããŠæŒçœå®çãã
ããšãã§ããããŸãçºè²çŸåãæŒçœãå®çããŸã
ã¯æŒçœå®çã«çµåãããŠå硬èãäžåãæ°ŽæŽãå
æ¢ãå®å®çã®ååŠçãæœãããšãã§ãããç¹ã«å
èšäžè¬åŒããã§è¡šããããæ¬çºæã«ä¿ãååç©
ãå«æããããã²ã³åéã«ã©ãŒåçæå ææãæ
å©ã«çŸååŠçãããåŠçå·¥çšã¯ãããšãã°çºè²çŸ
åãå¿ èŠã«å¿ããŠæ°ŽæŽãæŒçœå®çãæ°ŽæŽãå¿ èŠã«
å¿ããŠå®å®åã也ç¥ã®å·¥çšã§ããããã®åŠçå·¥çš
ã¯ãããšãã°30â以äžã®é«æž©ã§ãããã極ããŠç
æéå ã«è¡ãªãããã çºè²çŸå液ã¯åè¿°ã®åŠãçºè²çŸåäž»è¬ã®ä»ãå¿
èŠã«å¿ããŠãããçš®ã®æ·»å å€ãå ããããã®äž»ãª
äŸãšããŠã¯ãäŸãã°ã¢ã«ã«ãªéå±ãã¢ã³ã¢ããŠã
ã®æ°Žé žåç©ãçé žå¡©ããªã³é žå¡©çã®ã¢ã«ã«ãªå€ã
é ¢é žãç¡Œé žçã®ç·©è¡å€ãPH調ç¯å€ãçŸåä¿é²å€ã
ã«ããªé²æ¢å€ãã¹ãã€ã³ãŸãã¯ã¹ã©ããžé²æ¢å€ã
éå±€å¹æä¿é²å€ãä¿æå€çã§ããã æŒçœåŠçã«çšããããæŒçœå€ãšããŠã¯ãèµ€è¡å¡©
ã®åŠãããšãªã·ã¢ãããéã¯ãã é žå¡©ãéãã³ã¬
ã³é žå¡©ãéé žåæ°ŽçŽ ããµã©ã·ç²ããšãã¬ã³ãžã¢ã
ã³åé ¢é žããããªãããªé ¢é žãã€ãããžé ¢é žçã®
ã¢ããããªã«ã«ãã³é žã®éå±é¯å¡©ãããã³é žãé
ç³é žããªã³ãŽé žçã®ããªã«ã«ãã³é žã®éå±é¯å¡©ã
å¡©å第äºéçãããããããã¯åç¬ã§ããããã¯
å¿ èŠã«å¿ããŠçµåãããŠçšããããããã®æŒçœåŠ
ç液ã¯å¿ èŠã«å¿ããŠæŒçœä¿é²å€çã®çš®ã ã®æ·»å ã
å ããããšãã§ããã å®çåŠçã«çšããããå®çå€ãšããŠã¯ããªç¡«é ž
ãããªãŠã ãããªç¡«é žã¢ã³ã¢ã³çã®ããªç¡«é žå¡©ã
ã·ã¢ã³åç©å°¿çŽ èªå°äœãããããã®å®çåŠçã¯å¿
èŠã«å¿ããŠå®çä¿é²å€çã®çš®ã ã®æ·»å å€ãå ãã
ããšãã§ããã æ¬çºæã®äžè¬åŒããã§ç€ºãããååç©ãå«æ
ããããã²ã³åéåçæå ææã第ïŒè³éŠæã¢ã
ã³ç³»çºè²çŸåäž»è¬ããã³éå±éç»åãã¬ããã¯ã¹
åå¿ã«äŸããé žåå€ã®äž¡æ¹ãå«æããçºè²çŸå液
ãçšããŠåŠçããŠãæå¹ã§ããã ãããã®çºè²çŸå液ãçšããå Žåã«ã¯ãçºè²çŸ
åäž»è¬ã¯é žåå€ã«ããé žåããã次ãã§åççšã«
ã©ãŒã«ãã©ãŒãšã«ãããªã³ã°ããŠè²çŽ ç»åã圢æ
ããããã®ãããªçºè²çŸå液ã¯ãäŸãã°ç¹éæ48
â9729å·å ¬å ±ã«é瀺ãããŠããããã®ç®çã«ãšã€
ãŠå¥œãŸããé žåå€ã¯é äœæ°ïŒãæããã³ãã«ãé¯
å¡©ã§ããããã®ãããªçºè²çŸå液ãå«ãã«ã©ãŒå
çåŠçã¯éåžžã®ããã²ã³åéã«ã©ãŒåçææãã
ééã®å°ãªããããããçéã«ã©ãŒåçææã«å¯Ÿ
ããŠç¹ã«æå¹ã§ããã ãŸããåèšæ¬çºæã«ä¿ãäžè¬åŒããã§ç€ºãã
ãååç©ãå«ãããã²ã³åéã«ã©ãŒåçæå ææ
ã¯ã第ïŒè³éŠæã¢ãã³ç³»çºè²çŸåäž»è¬ãå«æãã
çºè²çŸå液äžã§çŸåãè¡ãªãã次ãã§å¥œãŸããã¯
çºè²çŸåå·¥çšã®éã«æå å±€äžã«åçããããã€è£
å济ïŒamplifying bathïŒäžã«ç§»åãããããã
çºè²çŸåäž»è¬ãååšãããŠãåèšãããããªé žå
å€ãäŸãã°é äœæ°ïŒãæããã³ãã«ãé¯å¡©ãå«æ
ããè£å液ãšæ¥è§Šããããããšãããªãã«ã©ãŒå
çåŠçæ³ãçšããŠãæçšã§ãããããã«ãã®ç®ç
ã«ãšã€ãŠå¥œãŸããä»ã®é žåå€ãšããŠã¯ãéé žåæ°Ž
çŽ æº¶æ¶²ãæçšã§ããã 次ã«æ¬çºæãå åŒã«ã©ãŒãã¬æå ææãšãããš
ãã®åŠçã«çšããããšãã§ããçºè²çŸååŠçå·¥çš
ã®ä»£è¡šçãªå ·äœäŸã瀺ãã ãåŠçå·¥çšã åŠçå·¥çšïŒ33âïŒ åŠçæé çºè²çŸå âŠâŠïŒå15ç§ æŒ çœ âŠâŠïŒå30ç§ æ°Ž æŽ âŠâŠïŒå15ç§ å® ç âŠâŠïŒå30ç§ æ°Ž æŽ âŠâŠïŒå15ç§ å®å®å âŠâŠïŒå30ç§ åèšåŠçå·¥çšã«ãããŠäœ¿çšã§ããååŠç液ã®çµ
æã¯ãäŸãã°äžèšã®åŠãã§ããã ãçºè²çŸå液çµæã ïŒâã¢ããâïŒâã¡ãã«ââãšãã«ââ
ïŒÎ²âããããã·ãšãã«ïŒâã¢ããªã³ç¡«é žå¡©
4.8ïœ ç¡æ°Žäºç¡«é žãããªãŠã 0.14ïœ ããããã·ã¢ãã³ã1/2ç¡«é žå¡© 1.98ïœ ç¡«é ž 0.74mg ç¡æ°Žçé žã«ãªãŠã 28.85ïœ ç¡æ°Žçé žæ°ŽçŽ ã«ãªãŠã 3.46ïœ ç¡æ°Žäºç¡«é žã«ãªãŠã 5.10ïœ èåã«ãªãŠã 1.16ïœ å¡©åãããªãŠã 0.14ïœ ãããªãé ¢é žãïŒãããªãŠã å¡©ïŒïŒæ°Žå¡©ïŒ
1.20ïœ æ°Žé žåã«ãªãŠã 1.48ïœ æ°Žãå ããŠïŒãšããã ãæŒçœæ¶²çµæã ãšãã¬ã³ãžã¢ãã³ããã©é ¢é žéã¢ã³ã¢ããŠã å¡©
100ïœ ãšãã¬ã³ãžã¢ãã³ããã©é ¢é žïŒã¢ã³ã¢ããŠã å¡©
10ïœ èåã¢ã³ã¢ããŠã 150ïœ æ°·é ¢é ž 10ml æ°Žãå ããŠïŒãšããã¢ã³ã¢ãã¢æ°ŽãçšããŠPH
6.0ã«èª¿æŽããã ãå®ç液çµæã ããªç¡«é žã¢ã³ã¢ã㢠175.0ïœ ç¡æ°Žäºç¡«é žãããªãŠã 8.6ïœ ã¡ã¿äºç¡«é žãããªãŠã 2.3ïœ æ°Žãå ããŠïŒãšãé ¢é žãçšããŠPH6.0ã«èª¿æŽã
ãã ãå®å®å液çµæã ãã«ããªã³ïŒ37ïŒ æ°Žæº¶æ¶²ïŒ 1.5ml ã³ãããã¯ã¹ïŒå°è¥¿å åçå·¥æ¥æ ªåŒäŒç€Ÿè£œïŒ
7.5ml æ°Žãå ããŠïŒãšããã 次ã«æ¬çºæãå åŒã«ã©ãŒããžæå ææãšãããš
ãã®åŠçã«çšããããšãã§ããçºè²çŸååŠçå·¥çš
ã®ä»£è¡šçãªå ·äœäŸã瀺ãã ãåŠçå·¥çšã åŠçå·¥çšïŒ30âïŒ åŠçæé çºè²çŸå âŠâŠïŒå30ç§ æŒçœå®ç âŠâŠïŒå30ç§ æ°Ž æŽ âŠâŠïŒå å®å®å âŠâŠïŒå äžèšåŠçå·¥çšã«ãããŠäœ¿çšã§ããååŠç液ã®çµ
æã¯ãäŸãã°äžèšã®åŠãã§ããã ãçºè²çŸå液çµæã ïŒâã¢ããâïŒâã¡ãã«ââãšãã«ââ
ïŒÎ²âã¡ã¿ã³ã¹ã«ãã³ã¢ãããšãã«ïŒâã¢ããªã³
ç¡«é žå¡© 5.0ïœ ãã³ãžã«ã¢ã«ã³ãŒã« 15.0ml ãããµã¡ã¿ãªã³é žãããªãŠã 2.5ïœ ç¡æ°Žäºç¡«é žãããªãŠã 1.85ïœ èåãããªãŠã 1.4ïœ èåã«ãªãŠã 0.5ïœ ããŠç 39.1ïœ æ°Žãå ããŠïŒãšããæ°Žé žåãããªãŠã ãçšã
ãŠPH10.30ã«èª¿æŽããã ãæŒçœå®ç液çµæã ãšãã¬ã³ãžã¢ãã³ããã©é ¢é žéã¢ã³ã¢ããŠã å¡©
61.0ïœ ãšãã¬ã³ãžã¢ãã³ããã©é ¢é žïŒã¢ã³ã¢ããŠã å¡©
5.0ïœ ããªç¡«é žã¢ã³ã¢ããŠã 124.5ïœ ã¡ã¿éäºç¡«çé žãããªãŠã 13.3ïœ ç¡æ°Žäºç¡«é žãããªãŠã 2.7ïœ æ°Žãå ããŠïŒãšããã ãå®å®å液çµæã æ°·é ¢é ž 20ml æ°Žãå ããŠïŒãšããé ¢é žãããªãŠã ãçšããŠPH
3.5ã4.0ã«èª¿æŽããã (e) çºæã®å ·äœçå®æœäŸ 以äžã«æ¬çºæã®å®æœäŸãèšèŒããŠæ¬çºæãæŽã«
詳现ã«èª¬æããããæ¬çºæã¯ãããã®å®æœäŸã«é
å®ããããã®ã§ã¯ãªãã å®æœäŸ ïŒ éåžžã®äžå¡ãå±€ãå¡åžããã»ã«ããŒã¹ããªã¢ã»
ããŒããã€ã«ã äžã«äžèšã«ç€ºãåå±€ãæ¯æäœåŽã
ãé 次å¡èšããŠå¡åžè©ŠæïŒã23ãäœè£œããã å±€âïŒïŒé»è²ã³ãã€ãéããŒã©ãã³äžã«åæ£ãã
ãã¬ãŒã·ãšã³é²æ¢å±€ïŒä¹Ÿç¥èå2.0ÎŒïŒ å±€âïŒïŒãŒã©ãã³äžéå±€ïŒä¹Ÿç¥èå1.0ÎŒïŒ å±€âïŒïŒèµ€ææ§äœæ床乳å€å±€ ïŒã¢ã«ïŒ ã®æ²åéãå«ãæ²èåéä¹³å€ïŒå¹³åç²
åŸ0.3ÎŒãä¹³å€ïŒKgåœãã®ããã²ã³åé100ïœããŒ
ã©ãã³70ïœãå«ãïŒãéåžžã®æ¹æ³ã§èª¿è£œãããã
ã®ä¹³å€ïŒKgã«èµ€ææ§åå å¢æå€ã0.1ïŒ ã¡ã¿ããŒ
ã«æº¶æ¶²210mlã«å ãããããŠå®å®å€ãšããŠïŒâã
ãããã·âïŒâã¡ãã«âïŒïŒïŒïŒ3aïŒïŒâãã
ã©ã¶ã€ã³ãã³ã®ïŒïŒ 氎溶液20mlããã³äžèšåŠæ¹ã«
ããã·ã¢ã³ã«ãã©ãŒä¹³åç©(1)ã400ïœããã³ä¹³å
ç©(2)ã200ïœããããå ããã æŽã«ãŒã©ãã³ç¡¬èå€ãšããŠãã¹ïŒããã«ã¹ã«ã
ãã«ã¡ãã«ïŒãšãŒãã«ã®ïŒïŒ ã¡ã¿ããŒã«æº¶æ¶²30ml
ãå ããŠèµ€ææ§äœæ床ããã²ã³åéä¹³å€æ¶²ãšãã
ãã®æ¶²ã也ç¥èå3.0ÎŒïœã«ãªãããã«å¡åžããã ä¹³åç©(1)ã®çµæïŒ 10ééïŒ ã®ãŒã©ãã³æ°Žæº¶æ¶² 1000ïœ ïŒ°âããã·ã«ãã³ãŒã³ã¹ã«ãã³é žãœãŒãïŒïœ ããªã¯ã¬ãžã«ãã¹ããšãŒã 60ml ã·ã¢ã³ã«ãã©ãŒïŒïŒ£âïŒïŒ 70ïœ é ¢é žãšãã« 100ml ã®æ··åç©ã55âã«ãŠæº¶è§£åŸãäºã55âã«å ç±
ããäžèš10ééïŒ ã®ãŒã©ãã³æ°Žæº¶æ¶²ã«å ããã³ã
ã€ããã«ã«ãŠä¹³åããã âïŒïŒã·ã¢ã³ã«ãã©ãŒïŒ ä¹³åç©(2)ã®çµæïŒ 10ééïŒ ã®ãŒã©ãã³æ°Žæº¶æ¶² 1000ïœ ïŒ°âããã·ã«ãã³ãŒã³ã¹ã«ãã³é žãœãŒãïŒïœ ããªã¯ã¬ãžã«ãã¹ããšãŒã 60ml ã·ã¢ã³ã«ãã©ãŒïŒïŒ£âïŒïŒ 70ïœ ã«ã©ãŒãã·ã¢ã³ã«ãã©ãŒïŒCCâïŒïŒ 20ïœ é ¢é žãšãã« 100ml ã®æ··åç©ã55âã«ãŠæº¶è§£åŸãäºã55âã«å ç±
ããã®ãŒã©ãã³æ°Žæº¶æ¶²ã«å ãã³ãã€ããã«ã«ãŠ
ä¹³åããã CCâïŒïŒã«ã©ãŒãã·ã¢ã³ã«ãã©ãŒïŒ å±€âïŒïŒèµ€ææ§é«æ床乳å€å±€ å±€âïŒã®ããã²ã³åéä¹³å€æ¶²ã«ãããŠæ¬¡ã®å€æŽ
ãè¡ãªã€ãã ä¹³å€ã®å¹³åç²åŸ 1.0ÎŒ èµ€ææ§åå å¢æå€æ·»å é 150ml ä¹³åç©(1) 320ïœ ä¹³åç©(2) 30ïœ ãã®ããã«ããŠã§ããããã²ã³åé溶液ã也ç¥
èå2.4ÎŒã«ãªãæ§ã«å¡åžããã å±€âïŒïŒæ··è²é²æ¢å±€ çŸåäž»è¬é žåäœã¹ã«ãã³ãžã€ãŒãå«æããä¹³å
ç©(3)ã也ç¥èå1.0ÎŒã«ãªãããã«å¡åžããã ä¹³åç©(3)ã®çµæïŒ 10ééïŒ ãŒã©ãã³æ°Žæº¶æ¶² 1000ïœ ããªã¯ã¬ãžã«ãã¹ããšãŒã 120ml çŸåäž»è¬é žåäœã¹ã«ãã³ãžã€ãŒ
ïŒè¡šïŒã«èšèŒïŒ é ¢é žãšãã« 100ml âããã·ã«ãã³ãŒã³ã¹ã«ãã³é žãœãŒãïŒïœ ã®æ··åç©ã55âã«ãŠæº¶è§£åŸãäºã55âã«å ç±
ããã®ãŒã©ãã³æ°Žæº¶æ¶²ã«å ãã³ãã€ããã«ã«ãŠ
ä¹³åããã å±€âïŒïŒç·ææ§äœæ床ããã²ã³åéä¹³å€å±€ å±€âïŒã§çšããæ²èåéä¹³å€ïŒKgã«ç·ææ§åå
å¢æè²çŽ ã®0.1ééïŒ æ°Žæº¶æ¶²220mlãå ããäžèšåŠ
æ¹ã«ããããŒã³ã¿ã«ãã©ãŒä¹³åå€(4)ã320ïœãä¹³
åç©(5)ã50ïœããããå ãããæŽã«ãŒã©ãã³ç¡¬è
å€ãšããŠãã¹ïŒããã«ã¹ã«ããã«ã¡ãã«ïŒãšãŒã
ã«ã®ïŒïŒ ã¡ã¿ããŒã«æº¶æ¶²ïŒmlãå ããŠç·ææ§äœæ
床ããã²ã³åéä¹³å€æ¶²ãšããããã®æ¶²ã也ç¥èå
3.0ÎŒã«ãªãããã«å¡åžããã ä¹³åç©(4)ã®çµæïŒ 10ééïŒ ãŒã©ãã³æ°Žæº¶æ¶² 1000ïœ ïŒ°âããã·ã«ãã³ãŒã³ã¹ã«ãã³é žãœãŒãïŒïœ ããªã¯ã¬ãžã«ãã¹ããšãŒã 80ml ããŒã³ã¿ã«ãã©ãŒïŒïŒâïŒïŒ 50ïœ ã«ã©ãŒãã·ã¢ã³ã«ãã©ãŒïŒCMâïŒïŒ 20ïœ é ¢é žãšãã« 150c.c. ã®æ··åç©ã55âã«ãŠæº¶è§£åŸãäºã55âã«å ç±
ããã®ãŒã©ãã³æ°Žæº¶æ¶²ã«å ããã³ãã€ããã«ã§
ä¹³åããã ïŒâïŒïŒããŒã³ã¿ã«ãã©ãŒïŒ CMâïŒïŒã«ã©ãŒãããŒã³ã¿ã«ãã©ãŒïŒ ä¹³åç©(5)ã®çµæïŒ 10ééïŒ ãŒã©ãã³æ°Žæº¶æ¶² 1000ïœ ïŒ°âããã·ã«ãã³ãŒã³ã¹ã«ãã³é žãœãŒã10ïœ ããªã¯ã¬ãžã«ãã¹ããšãŒã 60ml ããŒã³ã¿ã«ãã©ãŒïŒïŒâïŒïŒ 50ïœ ã«ã©ãŒãããŒã³ã¿ã«ãã©ãŒïŒCMâïŒïŒ ïŒïœ é ¢é žãšãã« 100ml ã®æ··åç©ã55âã«ãŠæº¶è§£åŸãäºã55âã«å ç±
ããã®ãŒã©ãã³æ°Žæº¶æ¶²ã«å ããã³ãã€ããã«ã«
ãŠä¹³åããã å±€âïŒïŒç·ææ§é«æ床ããã²ã³åéä¹³å€å±€ å±€âïŒã®ããã²ã³åéä¹³å€å±€ã«ãããŠæ¬¡ã®å€æŽ
ãè¡ãªã€ãã ä¹³å€ã®å¹³åç²åŸ 1.0ÎŒ ä¹³å€ã®æ²çŽ å«æé 6.5ã¢ã«ïŒ ç·ææ§åå å¢æå€æ·»å é 100ml ä¹³åç©(4) 150ïœ ä¹³åç©(5) 100ïœ ãã®ããã«ããŠã§ããããã²ã³åé溶液ã也ç¥
èå2.5ÎŒã«ãªãããã«å¡åžããã å±€âïŒïŒé»è²ã³ãã€ãéå±€ïŒä¹Ÿç¥èå0.7ÎŒïŒ å±€âïŒïŒéææ§äœæ床ããã²ã³åéä¹³å€å±€ å±€âïŒã§çšãããã®ãšåãæ²èåéä¹³å€ïŒKgã«
éææ§å¢æè²çŽ ã®0.1ééïŒ æ°Žæº¶æ¶²180mlãå ãã
äžèšåŠæ¹ã«ããã€ãšããŒã«ãã©ãŒä¹³åç©(6)ã1400
ïœå ãããæŽã«ãŒã©ãã³ç¡¬èå€ãšããŠããã¹ïŒã
ãã«ã¹ã«ããã«ã¡ãã«ïŒãšãŒãã«ã®ïŒééïŒ æ°Žæº¶
液50mlãå ããŠéææ§äœæ床ããã²ã³åéä¹³å€æ¶²
ãšããããã®æ¶²ã也ç¥èå3.0ÎŒã«ãªãããã«å¡åž
ããã ä¹³åç©(6)ã®çµæïŒ 10ééïŒ ãŒã©ãã³æ°Žæº¶æ¶² 1000ïœ ïŒ°âããã·ã«ãã³ãŒã³ã¹ã«ãã³é žãœãŒãïŒïœ ããªã¯ã¬ãžã«ãã¹ããšãŒã 80ml ã€ãšããŒã«ãã©ãŒïŒïŒ¹âïŒïŒ 80ïœ é ¢é žãšãã« 100ml ã®æ··åç©ã55âã«ãŠæº¶è§£åŸãäºã55âã«å ç±
ããã®ãŒã©ãã³æ°Žæº¶æ¶²ã«å ããã³ãã€ããã«ã«
ãŠä¹³åããã âïŒïŒã€ãšããŒã«ãã©ãŒïŒ å±€â10ïŒéææ§é«æ床ããã²ã³åéä¹³å€å±€ å±€âïŒã®ããã²ã³åéä¹³å€æ¶²ã«æŒããŠæ¬¡ã®å€æŽ
ãè¡ãªã€ãã ä¹³å€ã®å¹³åç²åŸ 1.2ÎŒ éææ§è²å¢æå€æ·»å é 80ml ä¹³åç©(6) 500ïœ ãã®ããã«ããŠã§ããããã²ã³åéä¹³å€æ¶²ã也
ç¥èå2.5ÎŒã«ãªãããã«å¡åžããã å±€â11ïŒãŒã©ãã³ä¿è·å±€ïŒä¹Ÿç¥èå1.0ÎŒïŒ ãã®ããã«ããŠã§ããå¡åžè©Šæã®äžã§å±€âïŒã«
æ·»å ããæ¬çºæã«ä¿ãåã³åŸæ¥ã®çŸåäž»è¬é žåäœ
ã¹ã«ãã³ãžã€ãŒãè¡šâïŒã«ç€ºãæ·»å éã§æ·»å ããŠ
åçš®ã®è©Šæãäœè£œããã äžèšã®ããã«ããŠäœæããè©Šæã«ãé£ç¶ãŠãšã
ãžãéããŠãèµ€è²å ã§1/100ç§ã®é²å ãè¡ãªãã
åèšããå åŒã«ã©ãŒãã¬çšçºè²çŸååŠçå·¥çšã«åŸ
ã€ãŠçºè²çŸåãè¡ãªããèµ€æå±€ããç·æå±€ãžã®æ··
è²ã®çšåºŠãè©äŸ¡ããã ãŸãåè©ŠæïŒãã23ãé žçŽ åå§600mmHgã®é°å²
æ°äžã§æž©åºŠ60âãçžå¯Ÿæ¹¿åºŠ80ïŒ ã®æ¡ä»¶ã§ïŒé±éã
ãã³ïŒé±éä¿åããåŸã®çŸåäž»è¬é žåäœã¹ã«ãã³
ãžã€ãŒã®é€å»å¹çã調ã¹ããïŒãªãåè©Šæãäžèš
枩床åã³çžå¯Ÿæ¹¿åºŠã®æ¡ä»¶äžã§ïŒé±éåã³ïŒé±éä¿
åããããšã¯ã宀枩ã§ã¯çŽïŒå¹Žåã³çŽïŒå¹Žéã®ä¿
åã«çžåœãããã®ã§ãããïŒãããã®çµæãè¡šâ
ïŒã«ç€ºãã å°ã以äžã®å®æœäŸãšãå ±éã«ãçºè²ããç»åã®
æ¿åºŠïŒ€ã¯ãµã¯ã©å é»æ¿åºŠèšPDAâ60ïŒå°è¥¿å åç
å·¥æ¥æ ªåŒäŒç€Ÿè£œïŒã«ãã枬å®ããDaïŒDbã®è¡šç€º
ã¯æå ããä¹³å€å±€ã®çºè²æ¿åºŠïŒDbïŒãšæå ããŠ
ããªãä¹³å€å±€ãçŸåäž»è¬é žåäœã®æ¡æ£ã«ãã€ãŠçº
è²ããæ¿åºŠïŒDaïŒã®å²åãè¡šãããèšå·ïœãïœ
ã¯å€«ã ããïŒæè²æ§ïŒãè¡šããããã®æ°å€
ãå°ããçšãçŸåäž»è¬é žåäœã®é€å»å¹çãè¯ãã
ãšãè¡šããã
æŽã«è©³ããã¯è²ã«ããªãæ··è²ã¹ãã€ã³çãé²æ¢ã
ãããšã®ã§ããååç©ãå«æããããã²ã³åéå
çæå ææã«é¢ãããã®ã§ããã (b) å è¡æè¡ãšãã®åé¡ç¹ äžè¬ã«ãããã²ã³åéã«ã©ãŒåçæå ææã¯æ¯
æäœäžã«éè²å ãç·è²å ããã³èµ€è²å ã«æå æ§ã
æããããã«éžæçã«åå å¢æãããïŒçš®ã®ãã
ã²ã³åéåççšä¹³å€å±€ãå¡èšãããŠãããããšã
ã°ãããã²ã³åéã«ã©ãŒåçæå ææã§ã¯ãäžè¬
ã«é²å ãããåŽããéææ§ä¹³å€å±€ãç·ææ§ä¹³å€å±€
ããã³èµ€ææ§ä¹³å€å±€ãé ã«å¡èšãããŠããããã
ãŠãéææ§ä¹³å€å±€ãšç·ææ§ä¹³å€å±€ãšã®éã«ã¯éæ
æ§ä¹³å€å±€ãééããéè²å ãåžåããããã®æŒçœ
å¯èœãªé»è²ãã€ã«ã¿ãŒå±€ãèšããããŠããããã
ã«åä¹³å€å±€ã®éã«ã¯åã ç¹æ®ã®ç®çã§ä»ã®äžéå±€
ãããŸãæå€å±€ãšããŠä¿è·å±€ãããããèšããã
ãŠããããŸããããšãã°ãã«ã©ãŒå°ç»çŽçšæå æ
æã§ã¯ãäžè¬ã«é²å ãããåŽããèµ€ææ§ä¹³å€å±€ã
ç·ææ§ä¹³å€å±€ããã³éææ§ä¹³å€å±€ãé ã«å¡èšãã
ãŠãããã«ã©ãŒãã¬çšæå ææã«ããããšåæ§ã«
åã ç¹æ®ã®ç®çã§çŽ«å€ç·åžåå±€ãã¯ãããšããäž
éå±€ãä¿è·å±€çãããããèšããããŠããããã
ãã®ä¹³å€å±€ã¯ãåèšãšã¯å¥ã®é åã§èšããããšã
ç¥ãããŠãããããã«æå åã®ç°ãªãåä¹³å€å±€ã
äžå±€çšãã代ãã«åã ã®è²å ã«å¯ŸããŠå®è³ªçã«å
ãæå åã«æå æ§ãæããïŒçš®ä»¥äžã®æå æ§ä¹³å€
å±€ãçšããããšãç¥ãããŠããããããã®ããã²
ã³åéã«ã©ãŒåçæå ææã«ãããŠã¯ãçºè²çŸå
äž»è¬ãšããŠäŸãã°è³éŠæ第äžçŽã¢ãã³ç³»ååç©ã
çšããŠé²å ãããããã²ã³åéãçŸåããçæã
ãçºè²çŸåäž»è¬ã®é žåäœãšè²çŽ 圢ææ§ã«ãã©ãŒãš
ã®åå¿ã«ããè²çŽ ç»åã圢æãããããã®æ¹æ³ã«
ãããŠã¯ãéåžžã·ã¢ã³ãããŒã³ã¿ããã³ã€ãšããŒ
ã®åè²çŽ ç»åã圢æããããã«ãããããããšã
ãŒã«ãããã¯ããããŒã«ç³»ã·ã¢ã³ã«ãã©ãŒãïŒâ
ãã©ãŸãã³ããã©ãŸãªããã³ãã€ãããŸãŒã«ãã
ã©ãŸãã³ããªã¢ãŸãŒã«ãã€ã³ããŸãã³ãããã¯ã·
ã¢ãã¢ã»ãã«ç³»ããŒã³ã¿ã«ãã©ãŒããã³ã¢ã·ã«ã¢
ã»ãã¢ãããããã¯ãã³ãŸã€ã«ã¡ã¿ã³ç³»ã€ãšããŒ
ã«ãã©ãŒãçšããããããããã®è²çŽ 圢ææ§ã«ã
ã©ãŒã¯æå æ§ããã²ã³åéä¹³å€å±€äžãããã¯çŸå
液äžã«å«æãããã äžèšã®ããã«ããŠåŸãããããã²ã³åéã«ã©ãŒ
åçæå ææã®è²çŽ ç»åã¯ããã®çºè²çŸåæã«ã
ããŠãé²å ãããããã²ã³åéãä»ããªãã§çºè²
çŸåäž»è¬ã®é žåäœãšã«ãã©ãŒãšã®åå¿ã«ããçºè²
ã«ããªïŒã¹ãã€ã³ïŒãçºçãç»åã®è³ªãäœäžãã
ããããšãããã°ãã°ããã ãã®ãããªçºè²ã«ããªã¯ãïŒã€ã¯ãçºè²çŸåäž»
è¬ãã空æ°äžã®é žçŽ ãŸãã¯æº¶æ¶²äžã«æº¶åããé žçŽ
ã«ããé žåãããçºè²çŸåæã«ããã²ã³åéã«ã©
ãŒåçæå ææã®ããã²ã³åéä¹³å€å±€ã«ãããŠé
åã®åœ¢æãããªãæªé²å éšã§ã«ãã©ãŒãšåå¿ããŠ
è²çŽ ã圢æããå Žåã«çºçãããŸãä»ã®ïŒã€ã¯ã
ã«ã©ãŒæ¡æ£è»¢åçšãã€ã«ã ãŠããããçšããã«ã©
ãŒæ¡æ£è»¢åç»å圢ææ³ã«ãããŠãããã²ã³åéã®
çŸåã«ãããçããçŸåäž»è¬é žåäœãéæ¡æ£æ§è²
çŽ æŸåºæ§ã¬ããã¯ã¹ååç©ïŒDRRååç©ïŒãšã¬
ããã¯ã¹åå¿ããŠæ¡æ£æ§è²çŽ ãæŸåºããå Žåã«ã
çããã æŽã«ãã®ãããªçºè²ã«ããªã¯ãæ··è²ã«ããªãšã
ãŠçŸããããå³ã¡ãéææ§ãç·ææ§ãåã³èµ€ææ§
ä¹³å€å±€ããããããæ¯æäœäžã«å¡åžãããç©å±€æ§
æåã®ããã²ã³åéã«ã©ãŒåçææã«ãããŠã¯ã
ã€ãšããŒãããŒã³ã¿ãã·ã¢ã³ã®åã«ãã©ãŒãçºè²
çŸåéçšã§çããçºè²çŸåäž»è¬é žåäœãšã«ãããª
ã³ã°åå¿ããããããã®å±€ã§ãã€ãšããŒãããŒã³
ã¿ãåã³ã·ã¢ã³è²çŽ ç»åã圢æããããšãããã
é žåãããçºè²çŸåäž»è¬ã¯ããã®ååéãå°ãã
ãããããã«ååšããå±€å åã³é£æ¥ããä»ã®å±€ã«
æ¡æ£ããæè²æ§ãšçºè²æ§ãšã®å¯Ÿå¿é¢ä¿ã«é¢ä¿ãªã
åäžå±€å ã®ä»ã®å Žæåã¯é£æ¥ããä»ã®å±€ã§ããã«
ååšããã«ãã©ãŒãšã«ãããªã³ã°åå¿ããæ··è²ã«
ããªãçããããšãããã ãã®ãããªçºè²ã«ããªãæ··è²ã«ããªãé²æ¢ãã
ç®çã§ãåŸæ¥ããããã²ã³åéåçæå ææäžã«
åçš®ã®çœ®æãã€ããããã³çºè²ã«ããªæå¶æïŒæ±
æé²æ¢æãantistaining agentïŒãæ·»å ãé åã
ãããæ¹æ³ãææ¡ãããŠããã äŸãã°ãã¢ã眮æã¢ã«ãã«ãã€ããããã³ãçš
ããããšã«ã€ããŠã¯ãç±³åœç¹èš±2360290å·ãç±³åœ
ç¹èš±2419613å·ãç±³åœç¹èš±2403721å·ãå3960570
å·çã«ããŸãªã¢ãåå²ã¢ã«ãã«ãã€ããããã³ã
çšããæ¹æ³ã«ã€ããŠã¯ç±³åœç¹èš±3700453å·ã西ç¬
ç¹èš±åºé¡ïŒOLSïŒ2149789å·ãç¹éæ50â156438
å·ãå49â106329å·ã«èšèŒãããŠãããäžæ¹ããž
眮æãã€ããããã³ãçšããäŸã«ã€ããŠã¯ç±³åœç¹
èš±2728659å·ãå2732300å·ãå3243294å·ãè±åœ
ç¹èš±752146å·ããã±ãã«ã«ã»ã¢ãã¹ãã©ã¯ããèª
56å·»6367bçã«ãããã«ãžåå²ã¢ã«ãã«ãã€ãã
ããã³ã«ã€ããŠã¯ãç±³åœç¹èš±3700453å·ãå
2732300å·ãå3243294å·ãåèšãã±ãã«ã«ã»ã¢ã
ã¹ãã©ã¯ããèªãç¹éæ50â156438å·ãç¹éæ53
â9528å·ãç¹éæ54â29637å·ãç¹å ¬æ50â21249
å·çã«èšèŒãããŠããã ãã®ä»ã眮æãã€ããããã³ãçŸåäž»è¬é žåäœ
ã¹ã«ãã³ãžã€ãŒãšããŠçšããããšã«ã€ããŠã¯ç±³åœ
ç¹èš±2701197å·ãç±³åœç¹èš±2710801å·åã³ç±³åœç¹èš±
2704713å·ãç¹éæ55â43521å·ãç¹éæ56â
83742å·ãç¹éæ56â10344å·ãç¹éæ57â22237
å·çã«ããããèšèŒãããŠããããŸãç¹éæ55â
72158å·ã«ã¯ãïŒïŒïŒäœãã¹ã«ãã³ã¢ããåºã§ã
ããã眮æãããããšããŒã«ååç©ã®äŸãé瀺ã
ããŠããã äžè¬ã«ãçºè²ã«ããªæå¶å€ãšããŠçšããããçŸ
åäž»è¬é žåäœã¹ã«ãã³ãžã€ãŒã¯æ¬¡ã®ãããªæ¡ä»¶ã
æºããã®ãæãŸãããšãããŠããã (1) çŸåã®éãããã²ã³åéã®çŸåã§çããçŸå
äž»è¬é žåäœãšåå¿ãåŸãååç©ã§ããããšãäŸ
ãã°ãç°ãªãæè²æ§ã瀺ãå°ãªããšãïŒå±€ã®ã
ãã²ã³åéä¹³å€å±€ã®éã«é èšãããäžéå±€ã«æ·»
å ãããçŸåäž»è¬é žåäœã¹ã«ãã³ãžã€ãŒã¯ãçŸ
ååŠçæã«çããçŸåäž»è¬é žåäœãšåå¿ããã®
çŸåäž»è¬é žåäœãïŒã®æå æ§å±€ããä»ã®æå æ§
å±€ã«æ¡æ£ããã®ãé»æ¢ããããšãå¿ èŠãšãããŠ
ããã (2) çŸåäž»è¬é žåäœã¹ã«ãã³ãžã€ãŒã¯ãããã²ã³
åéåçæå ææã®æ§æå±€ã«æ·»å ãããå Žåã§
ããããã²ã³åéä¹³å€ã®éã®çŸåç¹æ§ã«å®è³ªç
ã«æªåœ±é¿ãåãŒããªãããšã (3) çŸåäž»è¬é žåäœã¹ã«ãã³ãžã€ãŒã¯ãããã²ã³
åéåçæå ææã®åæ§æå±€éã移åããŠåç
çã«å¥œãŸãããªãå¯äœçšãããããªãããã«é
æ¡æ£ã§ããããšããŸããã®ãã®ã¯ããã²ã³åé
åçæå ææã®åŠçåãåŠçäžãåã³åŠçåŸã
éããŠåççã«å¥œãŸãããªãå¯äœçšãå®è³ªçã«
ããããªãããšã (4) ä¹³å€ã®å¡åžäžãããã¯å¡åžåŸã«ä¹³å€å±€å ã§çµ
æ¶ãæåºããŠå¡åžç©ã®è³ªãäœäžãããããå¡åž
æäœäžãåŠçäžã«ãã®ãã®ãé žååå¿ãèµ·ãã
çè²å¯çæç©ãçããªãããšã (5) é·æéã«ããã€ãŠãçŸåäž»è¬é žåäœã®é€å»å¹
çãé«æ°Žæºã«ç¶æããããšãã§ããããšããŸã
é·æéã®ä¿åäžã«ããã®çŸåäž»è¬é žåäœã¹ã«ã
ã³ãžã€ãŒãããã²ã³åéåçæå ææã®æ§æå±€
å ã§é žåããŠçè²ç©è³ªãçæããªãããšã (6) çŸåäž»è¬é žåäœãšåå¿ããéã«çè²çæç©è³ª
ãçæããŠè²ã«ããã®åå ãšãªããªãããšã ããã²ã³åéåçæå ææã®æ§æå±€ã«å«æãã
ããŠçºè²ã«ããªãæ··åã«ããªãé²æ¢ããçŸåäž»è¬
é žåäœã¹ã«ãã³ãžã€ãŒã¯ãçæ³çã«ã¯ãäžèšã®æ¡
件ãå šãŠæºãããŠããããšãå¿ èŠãšãããŠãã
ããäžè¿°ããåçš®ã®çœ®æãã€ããããã³é¡ã¯ãé·
æã«ããã€ãŠã¹ã«ãã³ãžã€ãŒå¹æãé«æ°Žæºã«ç¶æ
ããããšãã§ããªããšããåé¡ããã€ãããŸãã
äžè¿°ãã眮æããšããŒã«é¡ã¯ãé«æž©ãè¿ éã§ã®çŸ
ååŠçéçšäžã«é žåãããŠçè²çæç©ãçãããš
ããæ¬ ç¹ãããããŸãçŸåäž»è¬ã®é žåäœãšåå¿ã
ãŠçè²çæç©ã圢æãããããšããæ¬ ç¹ãæããŠ
ãããããŸã æºè¶³ãã¹ãçŸåäž»è¬é žåäœã¹ã«ãã³
ãžã€ãŒãéçºãããŠããªãã®ãçŸç¶ã§ããã (c) çºæã®ç®ç æ¬çºæã¯äžèšã§è¿°ã¹ãçŸåäž»è¬é žåäœã¹ã«ãã³
ãžã€ãŒãšããŠã®æ¡ä»¶ãè¯ãæºè¶³ããååç©åã³ã
ã®ååç©ã®äœ¿çšæ¹æ³ãèŠãåºããããšã«ããšã¥ã
ãŠããã æ¬çºæã®ç¬¬ïŒã®ç®çã¯ãåçæ§æå±€ã«æ·»å ãã
ãŠãããã²ã³åéã®çŸåç¹æ§ã«æªåœ±é¿ããªããå
çæ§æå±€éã移åããŠåççã«å¥œãŸãããªãå¯äœ
çšããããããšã®ãªãçŸåäž»è¬é žåäœã¹ã«ãã³ãž
ã€ãŒãå«ãããã²ã³åéåçæå ææãæäŸãã
ããšã«ããã æ¬çºæã®ç¬¬ïŒã®ç®çã¯ãä¹³å€ã®å¡åžäžãããã¯
å¡åžåŸã«çµæ¶ãæåºããŠå¡åžç©ã®è³ªãæªããã
ããå¡åžæäœäžãåŠçäžã«é žåããŠçè²çæç©ã
çããªãçŸåäž»è¬é žåäœã¹ã«ãã³ãžã€ãŒãå«æã
ãããã²ã³åéåçæå ææãæäŸããããšã«ã
ãã æ¬çºæã®ç¬¬ïŒã®ç®çã¯ãé·æã«ããã€ãŠçŸåäž»
è¬é žåäœã®é€å»å¹çïŒã¹ã«ãã³ãžã€ãŒå¹çïŒãé«
æ°Žæºã«ç¶æããããšãã§ãããããé·æä¿åäžã«
é žåããŠçè²çæç©ãçæããããšã®ãªãçŸåäž»
è¬é žåäœã¹ã«ãã³ãžã€ãŒãå«æããããã²ã³åé
åçæå ææãæäŸããããšã«ããã æ¬çºæã®ç¬¬ïŒã®ç®çã¯ãçŸåäž»è¬é žåäœãšåå¿
ããŠçºè²ã«ããªãæ··è²ã¹ãã€ã³ã確å®ã«é²æ¢ãã
çŸåäž»è¬é žåäœã¹ã«ãã³ãžã€ãŒãå«æããããã²
ã³åéåçæå ææãæäŸããããšã«ããã æ¬çºæã®ãã®ä»ã®ç®çã¯ã以äžã«èšèŒãã説æ
ããæããã«ãããã (d) çºæã®å ·äœçæ§æ 以äžæ¬çºæã«ã€ããŠæŽã«è©³çŽ°ã«è¿°ã¹ãããæ¬çº
æã®ç¯å²ã¯ããã«ããå¶éããããã®ã§ã¯ãªãã æ¬çºæè ãã¯çš®ã æ€èšãéããçµæãæ¯æäœäž
ã«ãäžèšäžè¬åŒããã§è¡šããããååç©ã®å°ãª
ããšãïŒçš®ãå«æããåçæ§æå±€ãå°ãªããšãïŒ
å±€æããããšãç¹åŸŽãšããããã²ã³åéåçæå
ææãçšããããšã«ããäžèšç®çãéæã§ããã
ãšãèŠåºããæ¬çºæãå®æããã«è³ã€ãã äžè¬åŒãã ïŒãã ããåŒäžãR1ããã³R2ã¯äžäŸ¡ã®ææ©åºã
è¡šãããäºãã«åãã§ãç°ã€ãŠããŠãããããã
ãŠãR1ããã³R2ã®å°ãªããšãïŒã€ã¯ãã¢ã«ãã«
åºãã·ã¯ãã¢ã«ãã«åºãŸãã¯ãããç°åºãè¡šã
ããïŒ äžèšäžè¬åŒããã«ãããŠR1ããã³R2ã§ç€ºã
ããäžäŸ¡ã®ææ©åºãšããŠã¯ã次ã®åºããããã
ãã (1) ã¢ã«ãã«åºã奜ãŸããã¯ççŽ æ°ïŒãã40ã®ã¢
ã«ãã«åºãäŸãã°ãã¡ãã«åºããšãã«åºãïœâ
ãããã«åºãã€ãœãããã«åºãïœâããã«åºã
ïœâããã«åºãïœâãã³ãã«åºãïœâãã·ã«
åºãïœâãã·ã«åºãïœâããã·ã«åºãsecâã
ãã·ã«åºãtertâããã·ã«åºãïœâãããµãã·
ã«åºãsecâãããµãã·ã«åºãtertâãããµã
ã·ã«åºãïœâãªã¯ã¿ãã·ã«åºãsecâãªã¯ã¿ã
ã·ã«åºãtertâãªã¯ã¿ãã·ã«åºçã®çŽéããã
ã¯åå²ã®ã¢ã«ãã«åºã§ããããããã®ã¢ã«ãã«
åºã¯çœ®æåºãæããŠãããã眮æåºãšããŠã¯ã
äŸãã°ãå¡©çŽ ååãããã¯èçŽ ååãªã©ã®ãã
ã²ã³ååãããããã·ã«åºãã¢ã«ã³ãã·åºãã¢
ãªãŒã«ãªãã·åºãã¢ã«ãã«ã¹ã«ãã¢ã¢ã€ã«åºã
ã¢ãªãŒã«ã¹ã«ãã¢ã¢ã€ã«åºãã¢ã«ãã«ã«ã«ãã¢
ã€ã«åºãã¢ãªãŒã«ã«ã«ãã¢ã€ã«åºãã¢ãªãŒã«
åºãã·ã¢ãåºçãæãããããå ·äœäŸãšããŠ
ã¯ãïŒâã¯ããããã«åºãïŒâããããã·ãšã
ã«åºãïŒâã¡ããã·ãããã«åºãïŒâïœâãã
ã«ã¹ã«ãã¢ã¢ã€ã«ãããã«åºããã³ãžã«åºãªã©
ãæããããã (2) ã¢ã«ã±ãã«åºã奜ãŸããã¯ççŽ æ°ïŒãã22ã®
ã¢ã«ã±ãã«åºïŒäŸãã°ã¢ãªã«åºãªã©ïŒïŒ (3) ã·ã¯ãã¢ã«ãã«åºã奜ãŸããã¯ççŽ æ°ïŒãã
12ã®ã·ã¯ãã¢ã«ãã«åºã§ããã奜ãŸããå ·äœäŸ
ãšããŠã¯ãã·ã¯ãããã·ã«åºçããããããã
ã®åºã¯çœ®æåºãæããŠããŠãããã (4) ã¢ãªãŒã«åºã奜ãŸããã¯ççŽ æ°ïŒãã40ã®ã¢
ãªãŒã«åºã§ããããã®ã¢ãªãŒã«åºã¯çœ®æåºãæ
ããŠããŠãããã眮æåºãšããŠã¯ãäŸãã°ãã
ãã²ã³ååãããããã·ã«åºãã¢ã«ãã«åºãã¢
ãªãŒã«åºãã¢ã·ã«åºãã«ã«ããã·ã«åºãã¢ã«ã
ã«ã«ã«ãã¢ã€ã«åºãã¢ãªãŒã«ã«ã«ãã¢ã€ã«åºã
ã¢ã«ã³ãã·åºãã¢ãªãŒã«ãªãã·åºãã¢ã«ãã«ã¹
ã«ããã«åºãã¢ãªãŒã«ã¹ã«ããã«åºãã¢ã«ãã«
ã¹ã«ãã¢ã¢ã€ã«åºãã¢ãªãŒã«ã¹ã«ãã¢ã¢ã€ã«
åºãã¢ã«ãã«ã¹ã«ãã³ã¢ããåºãã¢ãªãŒã«ã¹ã«
ãã³ã¢ããåºãã·ã¢ãåºãªã©ãæãããããå ·
äœäŸãšããŠã¯ãããšãã«åºãïœâããã·ã«ããš
ãã«åºãïŒïŒïŒâãžâtertâã¢ã·ã«ããšãã«
åºãâããã·ã«ãªãã·ããšãã«åºãªã©ãæã
ãããã (5) ççŽ æ°ïŒãã20ã®ãããç°ãäŸãã°ãã©ãã«
åºãããªãžãã«åºããã©ãžãã«åºãããªããžã
ã«åºããããªãã«åºãã€ã³ããã«åºçãæãã
ãããåèšãããç°ã¯çœ®æåºãæããŠããŠãã
ãã æ¬çºæã«ä¿ãååç©ã¯ããã²ã³åéåçæå æ
æã®æå æ§ããã²ã³åéä¹³å€å±€ãããã¯éæå æ§
芪氎æ§ã³ãã€ãå±€ãããªãåçæ§æå±€ã«æ·»å ãã
ãããã®ååç©ã¯ãäžèšåçæ§æå±€ã«ãããŠéæ¡
æ£ã§ããããšã奜ãŸããããã®ãããäžè¬åŒ
ã§è¡šããããR1ããã³R2ã®å šççŽ æ°ã®åã®
å°ãªããšã10ã§ããããšã奜ãŸããããã奜ãŸã
ãã¯12ãã40ã§ããã æ¬çºæã®äžè¬åŒïŒ»ïŒœã§è¡šããããååç©ã§ç¹
ã«å¥œãŸãããã®ã¯ãäžèšäžè¬åŒïŒ»ïŒœäžã®R1ãŸ
ãã¯R2ã眮æåºãæããã¢ãªãŒã«åºã§ãããæ®
ãã®äžæ¹ãã¢ã«ãã«åºã§ãããããªååç©ã§ã
ãã 次ã«æ¬çºæã®äžè¬åŒïŒ»ïŒœã§è¡šããããååç©
ãå ·äœçã«ç€ºããæ¬çºæã®ååç©ã¯ãããã«éå®
ãããªãã 次ã«äžè¬åŒããã§è¡šããããæ¬çºæã®ååç©
ã«ã€ããŠä»£è¡šçãªåæäŸãèšèŒããããæ¬çºæã¯
ããã«éå®ãããªãã åæäŸ ïŒ äŸç€ºååç©(2)ã®åæ ïŒïŒïŒâãžã¢ããããšããŒã«ïŒå¡©é žå¡©(A)40.0ïœ
ãããªãžã³300mlã«æžæ¿ããã溶液ã«ãïœâãã
ã·ã«ã¹ã«ããã«ã¯ãã©ã€ã(B)52.0ïœãããªãžã³
200mlã«æº¶ãããŠæ»Žäžãããåå¿æ¶²ã50âïŒæé
æ¹æããã®ã¡å·åŽãã1Nâå¡©é žã«æ³šããæåºã
ãåºäœãéããã¢ã»ããããªã«ããæçµæ¶ããŠ
çœè²ã®ç²æ«ïŒäŸç€ºååç©(2)ïŒïŒèç¹123ã126âïŒ
73.2ïœãåŸãã å çŽ åæå€C30H56N2O5S2     èšç®å€ 61.19 9.58 4.76 10.89 åæå€ 60.88 9.50 4.86 10.74 åæäŸ ïŒ äŸç€ºååç©(7)ã®åæ ïŒâã¢ããâïŒâãããããšããŒã«(C)30.0ïœãš
å¡©åãã³ãžã«(D)28.0ïœããæ°Žé žåã«ãªãŠã 12.1ïœ
ãå ¥ãããšã¿ããŒã«æº¶æ¶²300mlã«å ããïŒæéå
ç±éæµããããæåºãã液ãéåŸã液ãæžå§
çå»ããŠçŽ2/1ã«æ¿çž®åŸæ°Ž500mlã«æ³šãã ãæåºã
ãåºäœãéããæ°ŽæŽåŸãã¢ã»ããããªã«ããå
çµæ¶ããŠé»è²ã®ç²æ«ïŒâãã³ãžã«ãªãã·âïŒâã
ããã¢ããªã³(E)ïŒèç¹129ã135âïŒ26.1ïœãåŸ
ãã åèšã®çæç©(E)24.4ïœãããªãžã³150mlã«æº¶ã
ãã溶液ã«ããã·ã«ãªãã·ã¹ã«ãã¢ã¢ã€ã«ã¯ãã©
ã€ã(F)30.0ïœãå ãïŒæééæµããããã®åå¿æ¶²
ã2NâHCl氎溶液500mlã«æ³šããæåºããåºäœã
éããæ°Žã§æŽæµããããã®åºäœãã¢ã»ããããª
ã«ããåçµæ¶ããŠãã€è²ã®ç²æ«ãâïŒïŒâãã³
ãžã«ãªãã·âïŒâãããïŒâããšãã«ããã·ã«ã¹
ã«ãã³ã¢ãã(G)ïŒèç¹129ã133âïŒ29.6ïœãåŸ
ãã åèšã®çæç©(G)16.0ïœãTHF60mlã«æº¶ãããŠ
ïŒïŒ PdïŒïŒ£è§ŠåªïŒïœãå ããŠæ°Žæ·»åå¿ã40âã§
ïŒæéè¡ãªã€ããåå¿çµäºåŸãçªçŽ æ°æµäžã§è§Šåª
ãéåŸã液ã2NâHCl氎溶液400mlã«æ³šã
ã ãæåºããåºäœãéããŠïŒâã¢ããâïŒâã
ãã·ã«ã¹ã«ãã³ã¢ããããšããŒã«ã®å¡©é žå¡©(H)12.1
ïœãåŸãã åèšã®çæç©(H)25.0ïœãããªãžã³200mlã«æº¶ã
ãã溶液ã«ããã·ã«ãªãã·ãã³ãŒã³ã¹ã«ããã«ã¯
ãã©ã€ãïŒïŒ14.0ïœã40âã§ïŒæéã«ããã€ãŠ
滎äžãããïŒæéæ¹æåŸåå¿æ¶²ã2NâHCl氎溶
液ã«æ³šããæåºããåºäœãéãããåºäœãã¢ã»
ããããªã«ã«æº¶ãããŠæŽ»æ§çåŠçåŸæçµæ¶ããŠçœ
è²ã®ç²æ«ïŒäŸç€ºååç©(7)ïŒïŒèç¹129ã133âïŒ
25.1ïœãåŸãã å çŽ åæå€ ïŒ£    èšç®å€ 63.49 8.88 4.11 9.42 åæå€ 63.25 8.81 4.30 9.50 æ¬çºæã«ä¿ãååç©ã¯ãããã²ã³åéåçæå
ææã®éæå æ§èŠªæ°Žæ§ã³ãã€ãå±€ã«æ·»å ãããã
ãšã奜ãŸããããã®éæå æ§èŠªæ°Žæ§ã³ãã€ãå±€ã«
ã¯ãäŸãã°äžéå±€ããã€ã«ã¿ãŒå±€ãè¡šé¢ä¿è·å±€ã
æ··è²é²æ¢å±€çãå«ãŸããã æ¬çºæã®å¥œãŸããå®æœæ æ§ã«ãããŠã¯ãæ¬çºæ
ã«ä¿ãååç©ïŒçŸåäž»è¬é žåäœã¹ã«ãã³ãžã€ãŒïŒ
ãåçš®ã®ä¹³å€å±€ã®éã«ããäžéå±€ã«æ·»å ãããã
ãã®å Žåã倫ã æè²æ§ã®ç°ãªãä¹³å€å±€ã®éã«ãã
äžéå±€ã«æ·»å ãããå Žåã奜ãŸããããŸãæè²æ§
ã¯å®è³ªçã«åäžã§ãããæ床ã®ç°ãªãä¹³å€å±€ã®é
ã«ããäžéå±€ã«æ·»å ãããå Žåã奜ãŸããããŸ
ããæ¬çºæã«ä¿ãååç©ã¯ãããã²ã³åéä¹³å€å±€
ã«æ·»å ãããŠããŠããããããã«æ¬çºæã«ä¿ãå
åç©ã¯ãäžé局以å€ã®éæå æ§èŠªæ°Žæ§ã³ãã€ã
å±€ãäŸãã°ããã€ã«ã¿ãŒå±€ãè¡šé¢ä¿è·å±€ã«ãæ·»å
ããããšãã§ããããŸããã®ãããªååç©ã¯ãé
æå æ§èŠªæ°Žæ§ã³ãã€ãå±€ãšæå æ§ããã²ã³åéä¹³
å€å±€ã®åæ¹ã«æ·»å ãããŠããŠãããã ãããã®å±€ã«æ·»å ãããæ¬çºæã«ä¿ãååç©ã®
æ·»å éã¯è©²ååç©ãå®è³ªçã«ç¡è²ã§ãããããã
ãèªèº«ã«ããçè²æ±æçã®æªåœ±é¿ããªãã®ã§ç¹ã«
å¶éãããªãã奜ãŸããå®æœæ æ§ã§ã¯ãæ¬çºæã«
ä¿ãååç©ãäžéå±€ã«æ·»å ããå Žåã«ã¯ãçŽïŒ
mgïŒm2ãã1000mgïŒm2ã®ç¯å²ã§çšããããšãã§ã
ããç¹ã«ãæè²æ§ãç°ãªãä¹³å€å±€ã®éã«ããäžé
å±€ã®ãšãã¯50mgïŒm2ãã500mgïŒm2ã奜ãŸããã
æè²æ§ãå®è³ªçã«åãä¹³å€å±€ã®éã«ããäžéå±€ã®
ãšãã¯ïŒmgïŒm2ãã200mgïŒm2ã®ç¯å²ã奜ãŸããã
ãŸãããã®ååç©ãæå æ§ããã²ã³åéä¹³å€å±€ã«
æ·»å ããå Žåã«ã¯ãããã²ã³åéïŒã¢ã«åœãïŒÃ
10-5ããïŒÃ10-1ã¢ã«ã®ç¯å²ã§çšããã®ã奜ãŸã
ãã ããã«ãæ¬çºæã«ä¿ãååç©ã¯ïŒçš®ä»¥äžäœµçšã
ãŠçšããŠãäœãããã€ãããªãããã®å Žåãæ·»å
éã¯åè¿°ãããšåãéã§ååã§ããã æ¬çºæã®ååç©ïŒçŸåäž»è¬é žåäœã¹ã«ãã³ãžã€
ãŒïŒãããã²ã³åéåçæå ææã®åçæ§æå±€ã«
å°å ¥ããã«ã¯ãå ¬ç¥ã®æ¹æ³ãäŸãã°ãç±³åœç¹èš±ç¬¬
2322027å·ã«èšèŒãããæ¹æ³çãçšãããããäŸ
ãã°ãæ¬çºæã«ä¿ãååç©ãããã¿ã«é žã¢ã«ãã«
ãšã¹ãã«ïŒäŸãã°ããžããã«ãã¿ã¬ãŒãããžãªã¯
ãã«ãã¿ã¬ãŒãçïŒããªã³é žãšã¹ãã«ïŒäŸãã°ã
ããªããšãã«ããªã¹ããšãŒããããªã¯ã¬ãžã«ããª
ã¹ããšãŒãããžãªã¯ãã«ããã«ããªã¹ããšãŒã
çïŒãã¯ãšã³é žãšã¹ãã«ïŒäŸãã°ãã¢ã»ãã«ã¯ãš
ã³é žããªããã«çïŒãå®æ¯éŠé žãšã¹ãã«ïŒäŸãã°ã
å®æ¯éŠé žãªã¯ãã«çïŒãã¢ã«ãã«ã¢ããïŒäŸãã°ã
ãžãšãã«ã©ãŠãªã«ã¢ããïŒãèèªé žãšã¹ãã«ïŒäŸ
ãã°ããžãããã·ãžãšãã«ãµã¯ã·ããŒãããžãªã¯
ãã«ã¢ãŒã¬ãŒãïŒãããã³ïŒãŸãã¯æ²žç¹çŽ30âã
ã150âã®ææ©æº¶åªãäŸãã°é ¢é žãšãã«ãé ¢é žã
ãã«ãããããªã³é žãšãã«ãïŒçŽããã«ã¢ã«ã³ãŒ
ã«ãã¡ãã«ã€ãœããã«ã±ãã³ãβâãšããã·ãšã
ã«ã¢ã»ããŒããã¡ãã«ã»ããœã«ãã¢ã»ããŒãçã®
ïŒçš®é¡ã®æº¶åªãŸãã¯ïŒçš®ä»¥äžã®æ··å溶åªã«æº¶è§£ã
ããã®ã¡ã芪氎æ§ã³ãã€ãã«åæ£ãããã ãŸããç¹å ¬æ51â39853å·ãç¹éæ51â59943å·
ã«èšèŒãããŠããã©ããã¯ã¹ã«ããåæ£æ³ã䜿çš
ããããšãã§ããã æ¬çºæã®ååç©ã¯çš®ã ã®ããã²ã³åéåçæå
ææã«çšããããšãã§ããããã®ãããªããã²ã³
åéåçæå ææäžã«ã¯ãçœé»çšãã«ã©ãŒçšãæ¬
ã«ã©ãŒçšããã²ã³åéåçæå ææãå å«ããã
å ·äœçã«ã¯ãäžè¬çœé»çšãå°å·çšçœé»ãã¬ã€
çšãé»åç·çšãé«è§£åç·çšçœé»çšããã²ã³åéå
çæå ææããäžè¬ã«ã©ãŒçšãã«ã©ãŒïŒžã¬ã€çšã
æ¡æ£è»¢ååã«ã©ãŒçšããã²ã³åéåçæå ææã«
é©çšããããšãã§ããã éæå æ§èŠªæ°Žæ§ã³ãã€ãå±€ã®èŠªæ°Žæ§ã³ãã€ããš
ããŠã¯ãäž»ã«ãŒã©ãã³ãçšããããã æ¬çºæã«çšãããããŒã©ãã³ã¯ãæè¬ã¢ã«ã«ãª
åŠçïŒç³ç°åŠçïŒãŒã©ãã³ãé žåŠçãŒã©ãã³ããŸ
ãã¯ãBull.Soc.Sci.Photo JapanãNo.16ã第30é
ïŒ1966ïŒã«èšèŒãããŠãããããªé µçŽ åŠçãŒã©ã
ã³ã®ãããã§ããããããã«äžéšå æ°Žå解ããäœ
ååéã®ãŒã©ãã³ãçšããããšãåºæ¥ãã ãŸããå¿ èŠã«å¿ããŠã³ãã€ãç¶ã¢ã«ããã³ãã«
ãŒã€ã³ãã«ã«ããã·ã¡ãã«ã»ã«ããŒãºããããã
ã·ãšãã«ã»ã«ããŒãºçã®ã»ã«ããŒãºèªå°äœãå¯
倩ãã¢ã«ã®ã³é žãœãŒãã柱ç²èªå°äœãªã©ã®ç³èªå°
äœãåæ芪氎æ§ã³ãã€ããäŸãã°ããªããã«ã¢ã«
ã³ãŒã«ãããªïŒ®âããã«ãããªãã³ãããªã¢ã¯ãª
ã«é žå ±éåäœãããªã¢ã¯ãªã«ã¢ãããŸãã¯ããã
ã®èªå°äœã»éšåå æ°Žå解ç©çã䜵çšããŠãããã€
ãããªãã æ¬çºæã«æŒãŠéæå æ§èŠªæ°Žæ§ã³ãã€ãå±€ã«ã¯å¿
èŠã«ããããŒã©ãã³ç¡¬èå€ãçé¢æŽ»æ§å€ãããªã
ãŒã©ããã¯ã¹ããããå€ãææã玫å€ç·åžåå€ã
耪è²é²æ¢å€ãå¯å¡å€ãæ»ãå€ã垯é»é²æ¢å€çãå«
æããããããšãåºæ¥ããããããæ·»å å€ã«é¢ã
ãŠã¯ããªãµãŒãã»ãã€ã¹ã¯ããŒãžã€ãŒ
ïŒResearch DisclosureïŒ176å·»ã第22ã28é
ïŒ1978幎12æïŒã®èšèŒãåèã«ããããšãåºæ¥ãã ãŸãæ¬çºæã®ããã²ã³åéä¹³å€å±€ãæ§æããæ
å ä¹³å€ã«çšããããããã²ã³åéãšããŠã¯ãèå
éãå¡©åéãæ²èåéãå¡©èåéãå¡©æ²èåéç
ã®éåžžããã²ã³åéåçä¹³å€ã«äœ¿çšãããä»»æã®
ãã®ãå å«ãããã æ¬çºæã®å€å±€ããã²ã³åéã«ã©ãŒåçæå ææ
ã«çšããããããã²ã³åéä¹³å€ã¯éåžžè¡ãªããã
çš®ã ã®è£œæ³ãããšãã°ç¹å ¬æ46â7772å·å ¬å ±ã«èš
èŒãããŠãããããªæ¹æ³ããããã¯ç±³åœç¹èš±ç¬¬
2592250å·æ现æžã«èšèŒãããŠãããããªæ¹æ³ã
ããªãã¡ãããããã³ã³ããŒãžãšã³ä¹³å€ã®è£œæ³ã
ãããã¯ããããããªãããã³ä¹³å€ã®è£œæ³çã«ã
ã€ãŠäœæããããšãã§ãããã®ããã²ã³åéä¹³å€
ã¯åŸæ¥ç¥ãããŠããååŠå¢æå€ãçšããããšãåº
æ¥ãããŸããã®ä¹³å€ã¯ååŠå¢æ以å€ã«ãéå å€ã§
éå å¢æããããšãã§ãããããŠãŸããã®ä¹³å€
ã¯ã湿最å€ãå¯å¡å€ãèç©æ§æ¹è¯å€çãå«æãã
ããããšãã§ããããã«å¡åžå©å€ãè¢å å¢çœå€ã
垯é»é²æ¢å€çã®çš®ã ã®åççšæ·»å å€ãå«æããã
ãããšãã§ããã æ¬çºæã®ããã²ã³åéåçæå ææã«ã¯ãå ¬ç¥
ã®ïŒåœéã«ãã©ãŒåã³ïŒåœéã«ãã©ãŒãçšããã
ãããããã®ã«ãã©ãŒã®ãã¡ãã€ãšããŒã«ãã©ãŒ
ãšããŠã¯ãäŸãã°ãééã¢ã·ã«ã¢ã»ãã¢ããã«ã
ã©ãŒïŒäŸãã°ããããªã«ã¢ã»ãã¢ããªãé¡ããã³
ãŸã€ã«ã¢ã»ãã¢ããªãé¡ïŒçãæãããããŸãã
ãŒã³ã¿ã«ãã©ãŒãšããŠã¯ïŒâãã©ãŸãã³ã«ãã©
ãŒããã©ãŸããã³ãã€ãããŸãŒã«ã«ãã©ãŒããã©
ãŸãããªã¢ãŸãŒã«ã«ãã©ãŒãã€ã³ããŸãã³ã«ãã©
ãŒçãæããããããŸãã·ã¢ã³ã«ãã©ãŒãšããŠ
ã¯ãããããŒã«ã«ãã©ãŒããã³ããšããŒã«ã«ãã©
ãŒçãæããããããããã®ã«ãã©ãŒã¯ååäžã«
ãã©ã¹ãåºãšåŒã°ããçæ°Žæ§åºãæããéæ¡æ£æ§
ã®ã«ãã©ãŒãæãŸããããŸããè²è£æ£ã®å¹æãã
ã€ã«ã©ãŒãã«ãã©ãŒãããã¯çŸåã®çšåºŠã«äŒŽãªã€
ãŠçŸåæå¶å€ãæŸåºããã«ãã©ãŒïŒããããDIR
ã«ãã©ãŒïŒãããã¯DIRã«ãã©ãŒä»¥å€ã«ããã«ã
ããªã³ã°åå¿ã®çæç©ãç¡è²ã§ãã€ãŠãçŸåæå¶
å€ãæŸåºããç¡åè²DIRã«ãããªã³ã°ååç©ãçš
ããããšãã§ããã ãããã®ã«ãã©ãŒã¯ãäžè¬ã«ä¹³å€å±€äžã®éïŒã¢
ã«ãããïŒÃ10-3ã¢ã«ãªããïŒã¢ã«ã奜ãŸããã¯
ïŒÃ10-2ã¢ã«ãªããïŒÃ10-1ã¢ã«æ·»å ãããã ã«ãã©ãŒãããã²ã³åéä¹³å€å±€ã«å°å ¥ããã«ã¯
å ¬ç¥ã®æ¹æ³ããšãã°ç±³åœç¹èš±ç¬¬2322027å·ã«èšèŒ
ã®æ¹æ³ãªã©ãçšããããã ãŸãç¹å ¬æ51â39853å·ãç¹éæ51â59943å·ã«
èšèŒãããŠããéåç©ã«ããåæ£æ³ã䜿çšããã
ãšãã§ããã ã«ãã©ãŒãã«ã«ãã³é žãã¹ã«ããªã³é žã®ããšã
é žåºãæããå Žåã«ã¯ãã¢ã«ã«ãªæ§æ°Žæº¶æ¶²ãšããŠ
芪氎æ§ã³ãã€ãäžã«å°å ¥ãããã æ¬çºæã®ããã²ã³åéåçæå ææã«çšããã
ãçºè²çŸå液ã®PHã¯ãPHãïŒä»¥äžã奜ãŸããã¯PH
ïŒãã12ã§ããããã®çºè²çŸå液ã«ã¯è³éŠæç°äž
ã«ç¬¬ïŒçŽã¢ãã³åºãæããé²å ãããããã²ã³å
éãçŸåããèœåã®ããè³éŠæ第ïŒçŽã¢ãã³ç³»çº
è²çŸåäž»è¬åã¯ãã®ãããªååç©ã圢æãåŸãå
é§äœã奜ãŸããçšããããã è³éŠæ第ïŒçŽã¢ãã³ç³»çºè²çŸåäž»è¬ãšããŠã¯ã
ïœâããšãã¬ã³ãžã¢ãã³ç³»èªå°äœãå«ãŸããå ·äœ
çã«ã¯ãïŒâã¢ããâïŒïŒ®âãžãšãã«ã¢ããª
ã³ãïŒâã¡ãã«âïŒâã¢ããâïŒïŒ®âãžãšãã«
ã¢ããªã³ãïŒâã¢ããââãšãã«ââβâã
ãããã·ãšãã«ã¢ããªã³ãïŒâã¡ãã«âïŒâã¢ã
ãââãšãã«ââβâããããã·ãšãã«ã¢ã
ãªã³ãïŒâã¡ãã«âïŒâã¢ããââãšãã«â
âβâã¡ã¿ã³ã¹ã«ãã³ã¢ãããšãã«ã¢ããªã³ãïŒ
âã¡ãã«âïŒâã¢ããââãšãã«ââβâã¡
ããã·ãšãã«âïŒâã¢ããâïŒïŒ®âãžãšãã«ã¢
ããªã³ãïŒâã¡ããã·âïŒâã¢ããââãšãã«
ââβâããããã·ãšãã«ã¢ããªã³ãïŒâã¡ã
ãã·âïŒâã¢ããââãšãã«ââβâã¡ãã
ã·ãšãã«ã¢ããªã³ãïŒâã¢ã»ãã¢ããâïŒâã¢ã
ãâïŒïŒ®âãžãšãã«ã¢ããªã³ãïŒâã¢ããâ
ïŒïŒ®âãžã¡ãã«ã¢ããªã³ãâãšãã«ââβ
âãβâïŒÎ²âã¡ããã·ãšããã·ïŒãšããã·ããšã
ã«âïŒâã¡ãã«âïŒâã¢ããã¢ããªã³ãâãšã
ã«ââβâïŒÎ²âã¡ããã·ãšããã·ïŒãšãã«â
ïŒâã¡ãã«âïŒâã¢ããã¢ããªã³ãããããã®å¡©
äŸãã°ç¡«é žå¡©ãå¡©é žå¡©ãäºç¡«é žå¡©ãïœâãã«ãšã³
ã¹ã«ãã³é žå¡©ãªã©ã§ããããŸããããã®çºè²çŸå
液ã«ã¯å¿ èŠã«å¿ããŠçš®ã ã®æ·»å å€ãå ããããšã
ã§ããã æ¬çºæã®ããã²ã³åéåçæå ææã¯åæ§é²å
åŸãçºè²çŸååŠçãããã çºè²çŸååŠçã¯ãéåžžã®çºè²çŸåæ³ã«ãã€ãŠè¡
ãªãããã ããªãã¡ããŸãçºè²çŸåäž»è¬ãå«ãçºè²çŸå液
ã§åŠçããããããã¯ãçºè²çŸåäž»è¬ãŸãã¯ãã®
åé§äœãå«æãããŠããããããããããã¢ã¯ã
ã€ããŒã¿ãŒæ¶²ã§åŠçããã ãã®åŸãéåžžã¯ãåžžæ³ã«åŸããæŒçœå·¥çšãå®ç
å·¥çšãè¡ãªãã ãã®åŠçã¯å®çãšåæã§ããŸãå¥åã§ãããã
ãã®åŠç液ã¯å¿ èŠã«å¿ããŠå®çå€ãå ããããšã«
ããæŒçœå®ç济ãšããããšãã§ãããæŒçœå€ãšã
ãŠã¯çš®ã ã®ååç©ãçšããããæŒçœä¿é²å€ãã¯ã
ããçš®ã ã®æ·»å å€ãå ããããšãã§ããã æ¬çºæã¯çš®ã ã®åœ¢æ ã®ããã²ã³åéã«ã©ãŒåç
æå ææã«ãããŠå®çŸããããäŸãã°ãäžèšãã
ã²ã³åéã«ã©ãŒåçæå ææã¯ãã«ãã©ãŒå«æå
åŒããã²ã³åéã«ã©ãŒåçæå ææããããã¯ã«
ãã©ãŒãçŸå液ã«å«æãããå€åŒããã²ã³åéã«
ã©ãŒåçæå ææã§ããããç¹ã«ã«ãã©ãŒå«æå
åŒããã²ã³åéã«ã©ãŒåçæå ææãæå©ã§ã
ããé²å åŸãçºè²çŸåæ³ã§çºæçŸåãããããã
ã«ã«ãã©ãŒãšçºè²çŸåäž»è¬ãšãæªé²å æã¯æ¥è§Šã
ãªãããä¿è·ããŠåäžå±€ã«ååšãããé²å åŸæ¥è§Š
ãåŸããããªããã²ã³åéã«ã©ãŒåçæå ææã«
ãããããã¯ã«ãã©ãŒãå«æããããã²ã³åéã«
ã©ãŒåçæå ææã«ãããŠã該ã«ãã©ãŒãå«æã
ãªãå±€ã«çºè²çŸåäž»è¬ãå«æããããã¢ã«ã«ãªæ§
åŠç液ã浞éãããæã«è©²çºè²çŸåäž»è¬ã移åã
ãããã«ãã©ãŒãšæ¥è§ŠãåŸããããªããã²ã³åé
ã«ã©ãŒåçæå ææã§ãã€ãŠããããããã«æ¡æ£
転åçšããã²ã³åéã«ã©ãŒåçææã«ãããŠãæ¬
çºæã«ä¿ãäžè¬åŒããã§è¡šããããååç©ã該
æå ææã®åçæ§æå±€äžã«æ·»å ããŠçšããããšã
ã§ããã äžè¬çãªã«ã©ãŒæ¡æ£è»¢åçšçŸåäž»è¬ãšããŠãã
ã€ããããã³é¡ãã¢ããããšããŒã«é¡ïŒäŸãã°ã
âã¡ãã«ã¢ããããšããŒã«ïŒããã©ãŸãªãã³é¡
ãäŸãã°ãããšããã³ïŒïŒâããšãã«âïŒâãã©
ãŸãªãã³ïŒããžã¡ãŸã³ïŒïŒâããšãã«âïŒïŒïŒâ
ãžã¡ãã«âïŒâãã©ãŸãªãã³ïŒãïŒâããšãã«â
ïŒâã¡ãã«âãªãã·ã¡ãã«âïŒâãã©ãŸãªãã³ã
ïŒâïœâããªã«âïŒâã¡ãã«âïŒâãªãã·ã¡ãã«
âïŒâãã©ãŸãªãã³ããªã©ãããã å転æ³ã§ã¯çœé»ãã¬çŸå液ã§çŸåãã次ãã§çœ
è²é²å ãäžãããããããã¯ããŠçŽ ååç©ã®åŠã
ã«ããªå€ãå«æãã济ã§åŠçããããã«çºè²çŸå
äž»è¬ãå«ãã¢ã«ã«ãªçŸå液ã§çºè²çŸåããããã®
æã«ããªå€ãçºè²çŸåäž»è¬ãå«ãã¢ã«ã«ãªçŸå液
ã«å«æãããŠãäœãããã€ãããªããçºè²çŸå
åŸãé žåå€ãšããŠããšãªã·ã¢ãããŸãã¯ã¢ããã
ãªã«ã«ãã³é žã®ç¬¬ïŒéå¡©çãå«æããæŒçœæ¶²ã§æŒ
çœåŠçããããã«ããªãµã«ããšãŒãçã®é塩溶å€
ãå«æããå®ç液ã§å®çåŠçããŠéåãšæ®åãã
ã²ã³åéãé€ãè²çŽ ç»åãæ®ããæŒçœæ¶²ãšå®ç液
ãšãçšãã代ãã«ã¢ããããªã«ã«ãã³é žã®ç¬¬ïŒé
å¡©çã®é žåå€ãšããªãµã«ããšãŒãçã®é塩济å€ãš
ãå«æããäžæµŽæŒçœå®ç液ãçšããŠæŒçœå®çãã
ããšãã§ããããŸãçºè²çŸåãæŒçœãå®çããŸã
ã¯æŒçœå®çã«çµåãããŠå硬èãäžåãæ°ŽæŽãå
æ¢ãå®å®çã®ååŠçãæœãããšãã§ãããç¹ã«å
èšäžè¬åŒããã§è¡šããããæ¬çºæã«ä¿ãååç©
ãå«æããããã²ã³åéã«ã©ãŒåçæå ææãæ
å©ã«çŸååŠçãããåŠçå·¥çšã¯ãããšãã°çºè²çŸ
åãå¿ èŠã«å¿ããŠæ°ŽæŽãæŒçœå®çãæ°ŽæŽãå¿ èŠã«
å¿ããŠå®å®åã也ç¥ã®å·¥çšã§ããããã®åŠçå·¥çš
ã¯ãããšãã°30â以äžã®é«æž©ã§ãããã極ããŠç
æéå ã«è¡ãªãããã çºè²çŸå液ã¯åè¿°ã®åŠãçºè²çŸåäž»è¬ã®ä»ãå¿
èŠã«å¿ããŠãããçš®ã®æ·»å å€ãå ããããã®äž»ãª
äŸãšããŠã¯ãäŸãã°ã¢ã«ã«ãªéå±ãã¢ã³ã¢ããŠã
ã®æ°Žé žåç©ãçé žå¡©ããªã³é žå¡©çã®ã¢ã«ã«ãªå€ã
é ¢é žãç¡Œé žçã®ç·©è¡å€ãPH調ç¯å€ãçŸåä¿é²å€ã
ã«ããªé²æ¢å€ãã¹ãã€ã³ãŸãã¯ã¹ã©ããžé²æ¢å€ã
éå±€å¹æä¿é²å€ãä¿æå€çã§ããã æŒçœåŠçã«çšããããæŒçœå€ãšããŠã¯ãèµ€è¡å¡©
ã®åŠãããšãªã·ã¢ãããéã¯ãã é žå¡©ãéãã³ã¬
ã³é žå¡©ãéé žåæ°ŽçŽ ããµã©ã·ç²ããšãã¬ã³ãžã¢ã
ã³åé ¢é žããããªãããªé ¢é žãã€ãããžé ¢é žçã®
ã¢ããããªã«ã«ãã³é žã®éå±é¯å¡©ãããã³é žãé
ç³é žããªã³ãŽé žçã®ããªã«ã«ãã³é žã®éå±é¯å¡©ã
å¡©å第äºéçãããããããã¯åç¬ã§ããããã¯
å¿ èŠã«å¿ããŠçµåãããŠçšããããããã®æŒçœåŠ
ç液ã¯å¿ èŠã«å¿ããŠæŒçœä¿é²å€çã®çš®ã ã®æ·»å ã
å ããããšãã§ããã å®çåŠçã«çšããããå®çå€ãšããŠã¯ããªç¡«é ž
ãããªãŠã ãããªç¡«é žã¢ã³ã¢ã³çã®ããªç¡«é žå¡©ã
ã·ã¢ã³åç©å°¿çŽ èªå°äœãããããã®å®çåŠçã¯å¿
èŠã«å¿ããŠå®çä¿é²å€çã®çš®ã ã®æ·»å å€ãå ãã
ããšãã§ããã æ¬çºæã®äžè¬åŒããã§ç€ºãããååç©ãå«æ
ããããã²ã³åéåçæå ææã第ïŒè³éŠæã¢ã
ã³ç³»çºè²çŸåäž»è¬ããã³éå±éç»åãã¬ããã¯ã¹
åå¿ã«äŸããé žåå€ã®äž¡æ¹ãå«æããçºè²çŸå液
ãçšããŠåŠçããŠãæå¹ã§ããã ãããã®çºè²çŸå液ãçšããå Žåã«ã¯ãçºè²çŸ
åäž»è¬ã¯é žåå€ã«ããé žåããã次ãã§åççšã«
ã©ãŒã«ãã©ãŒãšã«ãããªã³ã°ããŠè²çŽ ç»åã圢æ
ããããã®ãããªçºè²çŸå液ã¯ãäŸãã°ç¹éæ48
â9729å·å ¬å ±ã«é瀺ãããŠããããã®ç®çã«ãšã€
ãŠå¥œãŸããé žåå€ã¯é äœæ°ïŒãæããã³ãã«ãé¯
å¡©ã§ããããã®ãããªçºè²çŸå液ãå«ãã«ã©ãŒå
çåŠçã¯éåžžã®ããã²ã³åéã«ã©ãŒåçææãã
ééã®å°ãªããããããçéã«ã©ãŒåçææã«å¯Ÿ
ããŠç¹ã«æå¹ã§ããã ãŸããåèšæ¬çºæã«ä¿ãäžè¬åŒããã§ç€ºãã
ãååç©ãå«ãããã²ã³åéã«ã©ãŒåçæå ææ
ã¯ã第ïŒè³éŠæã¢ãã³ç³»çºè²çŸåäž»è¬ãå«æãã
çºè²çŸå液äžã§çŸåãè¡ãªãã次ãã§å¥œãŸããã¯
çºè²çŸåå·¥çšã®éã«æå å±€äžã«åçããããã€è£
å济ïŒamplifying bathïŒäžã«ç§»åãããããã
çºè²çŸåäž»è¬ãååšãããŠãåèšãããããªé žå
å€ãäŸãã°é äœæ°ïŒãæããã³ãã«ãé¯å¡©ãå«æ
ããè£å液ãšæ¥è§Šããããããšãããªãã«ã©ãŒå
çåŠçæ³ãçšããŠãæçšã§ãããããã«ãã®ç®ç
ã«ãšã€ãŠå¥œãŸããä»ã®é žåå€ãšããŠã¯ãéé žåæ°Ž
çŽ æº¶æ¶²ãæçšã§ããã 次ã«æ¬çºæãå åŒã«ã©ãŒãã¬æå ææãšãããš
ãã®åŠçã«çšããããšãã§ããçºè²çŸååŠçå·¥çš
ã®ä»£è¡šçãªå ·äœäŸã瀺ãã ãåŠçå·¥çšã åŠçå·¥çšïŒ33âïŒ åŠçæé çºè²çŸå âŠâŠïŒå15ç§ æŒ çœ âŠâŠïŒå30ç§ æ°Ž æŽ âŠâŠïŒå15ç§ å® ç âŠâŠïŒå30ç§ æ°Ž æŽ âŠâŠïŒå15ç§ å®å®å âŠâŠïŒå30ç§ åèšåŠçå·¥çšã«ãããŠäœ¿çšã§ããååŠç液ã®çµ
æã¯ãäŸãã°äžèšã®åŠãã§ããã ãçºè²çŸå液çµæã ïŒâã¢ããâïŒâã¡ãã«ââãšãã«ââ
ïŒÎ²âããããã·ãšãã«ïŒâã¢ããªã³ç¡«é žå¡©
4.8ïœ ç¡æ°Žäºç¡«é žãããªãŠã 0.14ïœ ããããã·ã¢ãã³ã1/2ç¡«é žå¡© 1.98ïœ ç¡«é ž 0.74mg ç¡æ°Žçé žã«ãªãŠã 28.85ïœ ç¡æ°Žçé žæ°ŽçŽ ã«ãªãŠã 3.46ïœ ç¡æ°Žäºç¡«é žã«ãªãŠã 5.10ïœ èåã«ãªãŠã 1.16ïœ å¡©åãããªãŠã 0.14ïœ ãããªãé ¢é žãïŒãããªãŠã å¡©ïŒïŒæ°Žå¡©ïŒ
1.20ïœ æ°Žé žåã«ãªãŠã 1.48ïœ æ°Žãå ããŠïŒãšããã ãæŒçœæ¶²çµæã ãšãã¬ã³ãžã¢ãã³ããã©é ¢é žéã¢ã³ã¢ããŠã å¡©
100ïœ ãšãã¬ã³ãžã¢ãã³ããã©é ¢é žïŒã¢ã³ã¢ããŠã å¡©
10ïœ èåã¢ã³ã¢ããŠã 150ïœ æ°·é ¢é ž 10ml æ°Žãå ããŠïŒãšããã¢ã³ã¢ãã¢æ°ŽãçšããŠPH
6.0ã«èª¿æŽããã ãå®ç液çµæã ããªç¡«é žã¢ã³ã¢ã㢠175.0ïœ ç¡æ°Žäºç¡«é žãããªãŠã 8.6ïœ ã¡ã¿äºç¡«é žãããªãŠã 2.3ïœ æ°Žãå ããŠïŒãšãé ¢é žãçšããŠPH6.0ã«èª¿æŽã
ãã ãå®å®å液çµæã ãã«ããªã³ïŒ37ïŒ æ°Žæº¶æ¶²ïŒ 1.5ml ã³ãããã¯ã¹ïŒå°è¥¿å åçå·¥æ¥æ ªåŒäŒç€Ÿè£œïŒ
7.5ml æ°Žãå ããŠïŒãšããã 次ã«æ¬çºæãå åŒã«ã©ãŒããžæå ææãšãããš
ãã®åŠçã«çšããããšãã§ããçºè²çŸååŠçå·¥çš
ã®ä»£è¡šçãªå ·äœäŸã瀺ãã ãåŠçå·¥çšã åŠçå·¥çšïŒ30âïŒ åŠçæé çºè²çŸå âŠâŠïŒå30ç§ æŒçœå®ç âŠâŠïŒå30ç§ æ°Ž æŽ âŠâŠïŒå å®å®å âŠâŠïŒå äžèšåŠçå·¥çšã«ãããŠäœ¿çšã§ããååŠç液ã®çµ
æã¯ãäŸãã°äžèšã®åŠãã§ããã ãçºè²çŸå液çµæã ïŒâã¢ããâïŒâã¡ãã«ââãšãã«ââ
ïŒÎ²âã¡ã¿ã³ã¹ã«ãã³ã¢ãããšãã«ïŒâã¢ããªã³
ç¡«é žå¡© 5.0ïœ ãã³ãžã«ã¢ã«ã³ãŒã« 15.0ml ãããµã¡ã¿ãªã³é žãããªãŠã 2.5ïœ ç¡æ°Žäºç¡«é žãããªãŠã 1.85ïœ èåãããªãŠã 1.4ïœ èåã«ãªãŠã 0.5ïœ ããŠç 39.1ïœ æ°Žãå ããŠïŒãšããæ°Žé žåãããªãŠã ãçšã
ãŠPH10.30ã«èª¿æŽããã ãæŒçœå®ç液çµæã ãšãã¬ã³ãžã¢ãã³ããã©é ¢é žéã¢ã³ã¢ããŠã å¡©
61.0ïœ ãšãã¬ã³ãžã¢ãã³ããã©é ¢é žïŒã¢ã³ã¢ããŠã å¡©
5.0ïœ ããªç¡«é žã¢ã³ã¢ããŠã 124.5ïœ ã¡ã¿éäºç¡«çé žãããªãŠã 13.3ïœ ç¡æ°Žäºç¡«é žãããªãŠã 2.7ïœ æ°Žãå ããŠïŒãšããã ãå®å®å液çµæã æ°·é ¢é ž 20ml æ°Žãå ããŠïŒãšããé ¢é žãããªãŠã ãçšããŠPH
3.5ã4.0ã«èª¿æŽããã (e) çºæã®å ·äœçå®æœäŸ 以äžã«æ¬çºæã®å®æœäŸãèšèŒããŠæ¬çºæãæŽã«
詳现ã«èª¬æããããæ¬çºæã¯ãããã®å®æœäŸã«é
å®ããããã®ã§ã¯ãªãã å®æœäŸ ïŒ éåžžã®äžå¡ãå±€ãå¡åžããã»ã«ããŒã¹ããªã¢ã»
ããŒããã€ã«ã äžã«äžèšã«ç€ºãåå±€ãæ¯æäœåŽã
ãé 次å¡èšããŠå¡åžè©ŠæïŒã23ãäœè£œããã å±€âïŒïŒé»è²ã³ãã€ãéããŒã©ãã³äžã«åæ£ãã
ãã¬ãŒã·ãšã³é²æ¢å±€ïŒä¹Ÿç¥èå2.0ÎŒïŒ å±€âïŒïŒãŒã©ãã³äžéå±€ïŒä¹Ÿç¥èå1.0ÎŒïŒ å±€âïŒïŒèµ€ææ§äœæ床乳å€å±€ ïŒã¢ã«ïŒ ã®æ²åéãå«ãæ²èåéä¹³å€ïŒå¹³åç²
åŸ0.3ÎŒãä¹³å€ïŒKgåœãã®ããã²ã³åé100ïœããŒ
ã©ãã³70ïœãå«ãïŒãéåžžã®æ¹æ³ã§èª¿è£œãããã
ã®ä¹³å€ïŒKgã«èµ€ææ§åå å¢æå€ã0.1ïŒ ã¡ã¿ããŒ
ã«æº¶æ¶²210mlã«å ãããããŠå®å®å€ãšããŠïŒâã
ãããã·âïŒâã¡ãã«âïŒïŒïŒïŒ3aïŒïŒâãã
ã©ã¶ã€ã³ãã³ã®ïŒïŒ 氎溶液20mlããã³äžèšåŠæ¹ã«
ããã·ã¢ã³ã«ãã©ãŒä¹³åç©(1)ã400ïœããã³ä¹³å
ç©(2)ã200ïœããããå ããã æŽã«ãŒã©ãã³ç¡¬èå€ãšããŠãã¹ïŒããã«ã¹ã«ã
ãã«ã¡ãã«ïŒãšãŒãã«ã®ïŒïŒ ã¡ã¿ããŒã«æº¶æ¶²30ml
ãå ããŠèµ€ææ§äœæ床ããã²ã³åéä¹³å€æ¶²ãšãã
ãã®æ¶²ã也ç¥èå3.0ÎŒïœã«ãªãããã«å¡åžããã ä¹³åç©(1)ã®çµæïŒ 10ééïŒ ã®ãŒã©ãã³æ°Žæº¶æ¶² 1000ïœ ïŒ°âããã·ã«ãã³ãŒã³ã¹ã«ãã³é žãœãŒãïŒïœ ããªã¯ã¬ãžã«ãã¹ããšãŒã 60ml ã·ã¢ã³ã«ãã©ãŒïŒïŒ£âïŒïŒ 70ïœ é ¢é žãšãã« 100ml ã®æ··åç©ã55âã«ãŠæº¶è§£åŸãäºã55âã«å ç±
ããäžèš10ééïŒ ã®ãŒã©ãã³æ°Žæº¶æ¶²ã«å ããã³ã
ã€ããã«ã«ãŠä¹³åããã âïŒïŒã·ã¢ã³ã«ãã©ãŒïŒ ä¹³åç©(2)ã®çµæïŒ 10ééïŒ ã®ãŒã©ãã³æ°Žæº¶æ¶² 1000ïœ ïŒ°âããã·ã«ãã³ãŒã³ã¹ã«ãã³é žãœãŒãïŒïœ ããªã¯ã¬ãžã«ãã¹ããšãŒã 60ml ã·ã¢ã³ã«ãã©ãŒïŒïŒ£âïŒïŒ 70ïœ ã«ã©ãŒãã·ã¢ã³ã«ãã©ãŒïŒCCâïŒïŒ 20ïœ é ¢é žãšãã« 100ml ã®æ··åç©ã55âã«ãŠæº¶è§£åŸãäºã55âã«å ç±
ããã®ãŒã©ãã³æ°Žæº¶æ¶²ã«å ãã³ãã€ããã«ã«ãŠ
ä¹³åããã CCâïŒïŒã«ã©ãŒãã·ã¢ã³ã«ãã©ãŒïŒ å±€âïŒïŒèµ€ææ§é«æ床乳å€å±€ å±€âïŒã®ããã²ã³åéä¹³å€æ¶²ã«ãããŠæ¬¡ã®å€æŽ
ãè¡ãªã€ãã ä¹³å€ã®å¹³åç²åŸ 1.0ÎŒ èµ€ææ§åå å¢æå€æ·»å é 150ml ä¹³åç©(1) 320ïœ ä¹³åç©(2) 30ïœ ãã®ããã«ããŠã§ããããã²ã³åé溶液ã也ç¥
èå2.4ÎŒã«ãªãæ§ã«å¡åžããã å±€âïŒïŒæ··è²é²æ¢å±€ çŸåäž»è¬é žåäœã¹ã«ãã³ãžã€ãŒãå«æããä¹³å
ç©(3)ã也ç¥èå1.0ÎŒã«ãªãããã«å¡åžããã ä¹³åç©(3)ã®çµæïŒ 10ééïŒ ãŒã©ãã³æ°Žæº¶æ¶² 1000ïœ ããªã¯ã¬ãžã«ãã¹ããšãŒã 120ml çŸåäž»è¬é žåäœã¹ã«ãã³ãžã€ãŒ
ïŒè¡šïŒã«èšèŒïŒ é ¢é žãšãã« 100ml âããã·ã«ãã³ãŒã³ã¹ã«ãã³é žãœãŒãïŒïœ ã®æ··åç©ã55âã«ãŠæº¶è§£åŸãäºã55âã«å ç±
ããã®ãŒã©ãã³æ°Žæº¶æ¶²ã«å ãã³ãã€ããã«ã«ãŠ
ä¹³åããã å±€âïŒïŒç·ææ§äœæ床ããã²ã³åéä¹³å€å±€ å±€âïŒã§çšããæ²èåéä¹³å€ïŒKgã«ç·ææ§åå
å¢æè²çŽ ã®0.1ééïŒ æ°Žæº¶æ¶²220mlãå ããäžèšåŠ
æ¹ã«ããããŒã³ã¿ã«ãã©ãŒä¹³åå€(4)ã320ïœãä¹³
åç©(5)ã50ïœããããå ãããæŽã«ãŒã©ãã³ç¡¬è
å€ãšããŠãã¹ïŒããã«ã¹ã«ããã«ã¡ãã«ïŒãšãŒã
ã«ã®ïŒïŒ ã¡ã¿ããŒã«æº¶æ¶²ïŒmlãå ããŠç·ææ§äœæ
床ããã²ã³åéä¹³å€æ¶²ãšããããã®æ¶²ã也ç¥èå
3.0ÎŒã«ãªãããã«å¡åžããã ä¹³åç©(4)ã®çµæïŒ 10ééïŒ ãŒã©ãã³æ°Žæº¶æ¶² 1000ïœ ïŒ°âããã·ã«ãã³ãŒã³ã¹ã«ãã³é žãœãŒãïŒïœ ããªã¯ã¬ãžã«ãã¹ããšãŒã 80ml ããŒã³ã¿ã«ãã©ãŒïŒïŒâïŒïŒ 50ïœ ã«ã©ãŒãã·ã¢ã³ã«ãã©ãŒïŒCMâïŒïŒ 20ïœ é ¢é žãšãã« 150c.c. ã®æ··åç©ã55âã«ãŠæº¶è§£åŸãäºã55âã«å ç±
ããã®ãŒã©ãã³æ°Žæº¶æ¶²ã«å ããã³ãã€ããã«ã§
ä¹³åããã ïŒâïŒïŒããŒã³ã¿ã«ãã©ãŒïŒ CMâïŒïŒã«ã©ãŒãããŒã³ã¿ã«ãã©ãŒïŒ ä¹³åç©(5)ã®çµæïŒ 10ééïŒ ãŒã©ãã³æ°Žæº¶æ¶² 1000ïœ ïŒ°âããã·ã«ãã³ãŒã³ã¹ã«ãã³é žãœãŒã10ïœ ããªã¯ã¬ãžã«ãã¹ããšãŒã 60ml ããŒã³ã¿ã«ãã©ãŒïŒïŒâïŒïŒ 50ïœ ã«ã©ãŒãããŒã³ã¿ã«ãã©ãŒïŒCMâïŒïŒ ïŒïœ é ¢é žãšãã« 100ml ã®æ··åç©ã55âã«ãŠæº¶è§£åŸãäºã55âã«å ç±
ããã®ãŒã©ãã³æ°Žæº¶æ¶²ã«å ããã³ãã€ããã«ã«
ãŠä¹³åããã å±€âïŒïŒç·ææ§é«æ床ããã²ã³åéä¹³å€å±€ å±€âïŒã®ããã²ã³åéä¹³å€å±€ã«ãããŠæ¬¡ã®å€æŽ
ãè¡ãªã€ãã ä¹³å€ã®å¹³åç²åŸ 1.0ÎŒ ä¹³å€ã®æ²çŽ å«æé 6.5ã¢ã«ïŒ ç·ææ§åå å¢æå€æ·»å é 100ml ä¹³åç©(4) 150ïœ ä¹³åç©(5) 100ïœ ãã®ããã«ããŠã§ããããã²ã³åé溶液ã也ç¥
èå2.5ÎŒã«ãªãããã«å¡åžããã å±€âïŒïŒé»è²ã³ãã€ãéå±€ïŒä¹Ÿç¥èå0.7ÎŒïŒ å±€âïŒïŒéææ§äœæ床ããã²ã³åéä¹³å€å±€ å±€âïŒã§çšãããã®ãšåãæ²èåéä¹³å€ïŒKgã«
éææ§å¢æè²çŽ ã®0.1ééïŒ æ°Žæº¶æ¶²180mlãå ãã
äžèšåŠæ¹ã«ããã€ãšããŒã«ãã©ãŒä¹³åç©(6)ã1400
ïœå ãããæŽã«ãŒã©ãã³ç¡¬èå€ãšããŠããã¹ïŒã
ãã«ã¹ã«ããã«ã¡ãã«ïŒãšãŒãã«ã®ïŒééïŒ æ°Žæº¶
液50mlãå ããŠéææ§äœæ床ããã²ã³åéä¹³å€æ¶²
ãšããããã®æ¶²ã也ç¥èå3.0ÎŒã«ãªãããã«å¡åž
ããã ä¹³åç©(6)ã®çµæïŒ 10ééïŒ ãŒã©ãã³æ°Žæº¶æ¶² 1000ïœ ïŒ°âããã·ã«ãã³ãŒã³ã¹ã«ãã³é žãœãŒãïŒïœ ããªã¯ã¬ãžã«ãã¹ããšãŒã 80ml ã€ãšããŒã«ãã©ãŒïŒïŒ¹âïŒïŒ 80ïœ é ¢é žãšãã« 100ml ã®æ··åç©ã55âã«ãŠæº¶è§£åŸãäºã55âã«å ç±
ããã®ãŒã©ãã³æ°Žæº¶æ¶²ã«å ããã³ãã€ããã«ã«
ãŠä¹³åããã âïŒïŒã€ãšããŒã«ãã©ãŒïŒ å±€â10ïŒéææ§é«æ床ããã²ã³åéä¹³å€å±€ å±€âïŒã®ããã²ã³åéä¹³å€æ¶²ã«æŒããŠæ¬¡ã®å€æŽ
ãè¡ãªã€ãã ä¹³å€ã®å¹³åç²åŸ 1.2ÎŒ éææ§è²å¢æå€æ·»å é 80ml ä¹³åç©(6) 500ïœ ãã®ããã«ããŠã§ããããã²ã³åéä¹³å€æ¶²ã也
ç¥èå2.5ÎŒã«ãªãããã«å¡åžããã å±€â11ïŒãŒã©ãã³ä¿è·å±€ïŒä¹Ÿç¥èå1.0ÎŒïŒ ãã®ããã«ããŠã§ããå¡åžè©Šæã®äžã§å±€âïŒã«
æ·»å ããæ¬çºæã«ä¿ãåã³åŸæ¥ã®çŸåäž»è¬é žåäœ
ã¹ã«ãã³ãžã€ãŒãè¡šâïŒã«ç€ºãæ·»å éã§æ·»å ããŠ
åçš®ã®è©Šæãäœè£œããã äžèšã®ããã«ããŠäœæããè©Šæã«ãé£ç¶ãŠãšã
ãžãéããŠãèµ€è²å ã§1/100ç§ã®é²å ãè¡ãªãã
åèšããå åŒã«ã©ãŒãã¬çšçºè²çŸååŠçå·¥çšã«åŸ
ã€ãŠçºè²çŸåãè¡ãªããèµ€æå±€ããç·æå±€ãžã®æ··
è²ã®çšåºŠãè©äŸ¡ããã ãŸãåè©ŠæïŒãã23ãé žçŽ åå§600mmHgã®é°å²
æ°äžã§æž©åºŠ60âãçžå¯Ÿæ¹¿åºŠ80ïŒ ã®æ¡ä»¶ã§ïŒé±éã
ãã³ïŒé±éä¿åããåŸã®çŸåäž»è¬é žåäœã¹ã«ãã³
ãžã€ãŒã®é€å»å¹çã調ã¹ããïŒãªãåè©Šæãäžèš
枩床åã³çžå¯Ÿæ¹¿åºŠã®æ¡ä»¶äžã§ïŒé±éåã³ïŒé±éä¿
åããããšã¯ã宀枩ã§ã¯çŽïŒå¹Žåã³çŽïŒå¹Žéã®ä¿
åã«çžåœãããã®ã§ãããïŒãããã®çµæãè¡šâ
ïŒã«ç€ºãã å°ã以äžã®å®æœäŸãšãå ±éã«ãçºè²ããç»åã®
æ¿åºŠïŒ€ã¯ãµã¯ã©å é»æ¿åºŠèšPDAâ60ïŒå°è¥¿å åç
å·¥æ¥æ ªåŒäŒç€Ÿè£œïŒã«ãã枬å®ããDaïŒDbã®è¡šç€º
ã¯æå ããä¹³å€å±€ã®çºè²æ¿åºŠïŒDbïŒãšæå ããŠ
ããªãä¹³å€å±€ãçŸåäž»è¬é žåäœã®æ¡æ£ã«ãã€ãŠçº
è²ããæ¿åºŠïŒDaïŒã®å²åãè¡šãããèšå·ïœãïœ
ã¯å€«ã ããïŒæè²æ§ïŒãè¡šããããã®æ°å€
ãå°ããçšãçŸåäž»è¬é žåäœã®é€å»å¹çãè¯ãã
ãšãè¡šããã
ãè¡šã
å®æœäŸ ïŒ
ããªãšãã¬ã³è¢«èŠçŽãããªãæ¯æäœäžã«äžèšã®
åå±€ãæ¯æäœåŽããé 次å¡èšããè©Šæ24ã37ãäœ
補ããã å±€âïŒïŒéææ§ããã²ã³åéä¹³å€å±€ ïŒã¢ã«ïŒ ã®æ²åéãš19ã¢ã«ïŒ ã®å¡©åéãå«ãå¡©
æ²èåéãããªãããã²ã³åéïŒã¢ã«åœããŒã©ã
ã³400ïœãå«ã¿ãéææ§å¢æè²çŽ 2.5Ã10-1ã¢ã«ïŒ
ããã²ã³åéïŒã¢ã«ã§å¢æããããžããã«ãã¿ã¬
ãŒãã«æº¶è§£ããŠåæ£ããããã€ãšããŒã«ãã©ãŒ
ïŒïŒ¹âïŒïŒãããã²ã³åéïŒã¢ã«åœãïŒÃ10-1ã¢
ã«å«æããããã²ã³åéä¹³å€æ¶²ããå¡åžééã
400mgïŒm2ã«ãªãããã«å¡åžããïŒä¹Ÿç¥èå
2.0ÎŒïŒã å±€âïŒïŒæ··è²é²æ¢å±€ 10ééïŒ ãŒã©ãã³æ°Žæº¶æ¶²500ïœã«çŸåäž»è¬é žå
äœã¹ã«ãã³ãžã€ãŒã®ä¹³åç©(7)ã500ïœå ãã也ç¥
èåã0.8ÎŒã«ãªãããã«å¡åžããã ä¹³åç©(7)ã®çµæïŒ 10ééïŒ ãŒã©ãã³æ°Žæº¶æ¶² 1000ïœ ïŒ°âããã·ã«ãã³ãŒã³ã¹ã«ãã³é žãœãŒã12ïœ ããªã¯ã¬ãžã«ãã¹ããšãŒã 100ml çŸåäž»è¬é žåäœã¹ã«ãã³ãžã€ãŒ
ïŒè¡šâïŒã«èšèŒïŒ é ¢é žãšãã« 70ml ã®æ··åç©ã55âã«ãŠæº¶è§£åŸãäºã55âã«å ç±
ããã®ãŒã©ãã³æ°Žæº¶æ¶²ã«å ãã³ãã€ããã«ã§ä¹³
åããã å±€âïŒïŒç·ææ§ããã²ã³åéä¹³å€å±€ 20ã¢ã«ïŒ ã®å¡©åéãå«ãå¡©èåéã§ããã²ã³å
éïŒã¢ã«åœããŒã©ãã³500ïœãå«ã¿ãããã²ã³å
éïŒã¢ã«åœãç·ææ§å¢æè²çŽ 2.5Ã10-4ã¢ã«ãçš
ããŠå¢æãããããªã¯ã¬ãžã«ãã¹ããšãŒãã«æº¶è§£
ããŠåæ£ããããããŒã³ã¿ã«ãã©ãŒïŒïŒâïŒïŒ
ãšãïŒïŒïŒâãžãªã¯ãã«ãªãã·âïŒïŒïŒâãžâ
tertâã¢ãããã³ãŒã³ããããã²ã³åéïŒã¢ã«åœ
ããããããïŒÃ10-1ã¢ã«ããã³1.2Ã10-1ã¢ã«
å«æããããã²ã³åéä¹³å€æ¶²ããå¡åžééã500
mgïŒm2ã«ãªãããã«å¡åžããïŒä¹Ÿç¥èå2.2ÎŒïŒã å±€âïŒïŒæ··è²é²æ¢å±€ å±€âïŒã«åãã å±€âïŒïŒèµ€ææ§ããã²ã³åéä¹³å€å±€ 20ã¢ã«ïŒ ã®å¡©åéãå«ãå¡©èåéä¹³å€ã§ããã²
ã³åéïŒã¢ã«åœããŒã©ãã³500ïœãå«ã¿ãããã²
ã³åéïŒã¢ã«åœãèµ€ææ§å¢æè²çŽ 2.5Ã10-1ã¢ã«
ãçšããŠå¢æãããããªã¯ã¬ãžã«ãã¹ããšãŒãã«
溶解ããŠåæ£ããããã·ã¢ã³ã«ãã©ãŒïŒïŒ£âïŒïŒ
ãããã²ã³åéåœããïŒÃ10-1ã¢ã«å«æãããã
ã²ã³åéä¹³å€æ¶²ãå¡åžéé500mgïŒm2ã«ãªããã
ã«å¡åžããïŒä¹Ÿç¥èå2.3ÎŒïŒã å±€âïŒïŒä¿è·å±€âŠãŒã©ãã³å±€ ãã®å Žåãå±€ïŒãå±€ïŒããã³å±€ïŒã«çšããåã
ãã²ã³åéä¹³å€ã¯ç¹å ¬æ46â7772å·å ¬å ±ã«èšèŒã
ããŠããæ¹æ³ã§äœããããããããªç¡«é žãããªãŠ
ã ã»ïŒæ°Žåç©ãçšããŠååŠå¢æããå®å®å€ãšããŠ
ã®ïŒâããããã·âïŒâã¡ãã«âïŒïŒïŒïŒ3aïŒ
ïŒâããã©ã¶ã€ã³ãã³ã»ãããªãŠã å¡©ã硬èå€ãš
ããŠã®ãã¹ïŒããã«ã¹ã«ããã«ã¡ãã«ïŒãšãŒãã«
ããã³å¡åžå©å€ãšããŠã®ãµããã³ãå«æããã
ãã âïŒïŒã€ãšããŒã«ãã©ãŒïŒ ïŒâïŒïŒããŒã³ã¿ã«ãã©ãŒïŒ âïŒïŒã·ã¢ã³ã«ãã©ãŒïŒ ãã®ããã«ããŠã€ãã€ãè©Šæ24ãã37ã«ã¯è¡šâ
ïŒã«ç€ºããããªçŸåäž»è¬é žåäœã¹ã«ãã³ãžã€ãŒã
æ·»å ãããŠããããããã®è©Šæã¯ãé žçŽ åå§600
mmHgã®é°å²æ°äžã§æž©åºŠ60âãçžå¯Ÿæ¹¿åºŠ80ïŒ ã®æ¡
件ã§ïŒé±éä¿åããïŒããã¯å®€æž©ã§çŽïŒå¹Žéä¿å
ãããšåãã§ãããïŒã äžèšã®ããã«ããŠäœæããè©Šæã«é£ç¶ãŠãšããž
ãéããŠç·è²å ã®é²å ãè¡ãªããåèšããå åŒã«
ã©ãŒããžçšçºè²çŸååŠçå·¥çšã«åŸã€ãŠçºè²çŸåã
è¡ãªãç·ææ§å±€ããéææ§å±€ããã³èµ€ææ§å±€ãžã®
æ··è²ã®çšåºŠãè©äŸ¡ããã
åå±€ãæ¯æäœåŽããé 次å¡èšããè©Šæ24ã37ãäœ
補ããã å±€âïŒïŒéææ§ããã²ã³åéä¹³å€å±€ ïŒã¢ã«ïŒ ã®æ²åéãš19ã¢ã«ïŒ ã®å¡©åéãå«ãå¡©
æ²èåéãããªãããã²ã³åéïŒã¢ã«åœããŒã©ã
ã³400ïœãå«ã¿ãéææ§å¢æè²çŽ 2.5Ã10-1ã¢ã«ïŒ
ããã²ã³åéïŒã¢ã«ã§å¢æããããžããã«ãã¿ã¬
ãŒãã«æº¶è§£ããŠåæ£ããããã€ãšããŒã«ãã©ãŒ
ïŒïŒ¹âïŒïŒãããã²ã³åéïŒã¢ã«åœãïŒÃ10-1ã¢
ã«å«æããããã²ã³åéä¹³å€æ¶²ããå¡åžééã
400mgïŒm2ã«ãªãããã«å¡åžããïŒä¹Ÿç¥èå
2.0ÎŒïŒã å±€âïŒïŒæ··è²é²æ¢å±€ 10ééïŒ ãŒã©ãã³æ°Žæº¶æ¶²500ïœã«çŸåäž»è¬é žå
äœã¹ã«ãã³ãžã€ãŒã®ä¹³åç©(7)ã500ïœå ãã也ç¥
èåã0.8ÎŒã«ãªãããã«å¡åžããã ä¹³åç©(7)ã®çµæïŒ 10ééïŒ ãŒã©ãã³æ°Žæº¶æ¶² 1000ïœ ïŒ°âããã·ã«ãã³ãŒã³ã¹ã«ãã³é žãœãŒã12ïœ ããªã¯ã¬ãžã«ãã¹ããšãŒã 100ml çŸåäž»è¬é žåäœã¹ã«ãã³ãžã€ãŒ
ïŒè¡šâïŒã«èšèŒïŒ é ¢é žãšãã« 70ml ã®æ··åç©ã55âã«ãŠæº¶è§£åŸãäºã55âã«å ç±
ããã®ãŒã©ãã³æ°Žæº¶æ¶²ã«å ãã³ãã€ããã«ã§ä¹³
åããã å±€âïŒïŒç·ææ§ããã²ã³åéä¹³å€å±€ 20ã¢ã«ïŒ ã®å¡©åéãå«ãå¡©èåéã§ããã²ã³å
éïŒã¢ã«åœããŒã©ãã³500ïœãå«ã¿ãããã²ã³å
éïŒã¢ã«åœãç·ææ§å¢æè²çŽ 2.5Ã10-4ã¢ã«ãçš
ããŠå¢æãããããªã¯ã¬ãžã«ãã¹ããšãŒãã«æº¶è§£
ããŠåæ£ããããããŒã³ã¿ã«ãã©ãŒïŒïŒâïŒïŒ
ãšãïŒïŒïŒâãžãªã¯ãã«ãªãã·âïŒïŒïŒâãžâ
tertâã¢ãããã³ãŒã³ããããã²ã³åéïŒã¢ã«åœ
ããããããïŒÃ10-1ã¢ã«ããã³1.2Ã10-1ã¢ã«
å«æããããã²ã³åéä¹³å€æ¶²ããå¡åžééã500
mgïŒm2ã«ãªãããã«å¡åžããïŒä¹Ÿç¥èå2.2ÎŒïŒã å±€âïŒïŒæ··è²é²æ¢å±€ å±€âïŒã«åãã å±€âïŒïŒèµ€ææ§ããã²ã³åéä¹³å€å±€ 20ã¢ã«ïŒ ã®å¡©åéãå«ãå¡©èåéä¹³å€ã§ããã²
ã³åéïŒã¢ã«åœããŒã©ãã³500ïœãå«ã¿ãããã²
ã³åéïŒã¢ã«åœãèµ€ææ§å¢æè²çŽ 2.5Ã10-1ã¢ã«
ãçšããŠå¢æãããããªã¯ã¬ãžã«ãã¹ããšãŒãã«
溶解ããŠåæ£ããããã·ã¢ã³ã«ãã©ãŒïŒïŒ£âïŒïŒ
ãããã²ã³åéåœããïŒÃ10-1ã¢ã«å«æãããã
ã²ã³åéä¹³å€æ¶²ãå¡åžéé500mgïŒm2ã«ãªããã
ã«å¡åžããïŒä¹Ÿç¥èå2.3ÎŒïŒã å±€âïŒïŒä¿è·å±€âŠãŒã©ãã³å±€ ãã®å Žåãå±€ïŒãå±€ïŒããã³å±€ïŒã«çšããåã
ãã²ã³åéä¹³å€ã¯ç¹å ¬æ46â7772å·å ¬å ±ã«èšèŒã
ããŠããæ¹æ³ã§äœããããããããªç¡«é žãããªãŠ
ã ã»ïŒæ°Žåç©ãçšããŠååŠå¢æããå®å®å€ãšããŠ
ã®ïŒâããããã·âïŒâã¡ãã«âïŒïŒïŒïŒ3aïŒ
ïŒâããã©ã¶ã€ã³ãã³ã»ãããªãŠã å¡©ã硬èå€ãš
ããŠã®ãã¹ïŒããã«ã¹ã«ããã«ã¡ãã«ïŒãšãŒãã«
ããã³å¡åžå©å€ãšããŠã®ãµããã³ãå«æããã
ãã âïŒïŒã€ãšããŒã«ãã©ãŒïŒ ïŒâïŒïŒããŒã³ã¿ã«ãã©ãŒïŒ âïŒïŒã·ã¢ã³ã«ãã©ãŒïŒ ãã®ããã«ããŠã€ãã€ãè©Šæ24ãã37ã«ã¯è¡šâ
ïŒã«ç€ºããããªçŸåäž»è¬é žåäœã¹ã«ãã³ãžã€ãŒã
æ·»å ãããŠããããããã®è©Šæã¯ãé žçŽ åå§600
mmHgã®é°å²æ°äžã§æž©åºŠ60âãçžå¯Ÿæ¹¿åºŠ80ïŒ ã®æ¡
件ã§ïŒé±éä¿åããïŒããã¯å®€æž©ã§çŽïŒå¹Žéä¿å
ãããšåãã§ãããïŒã äžèšã®ããã«ããŠäœæããè©Šæã«é£ç¶ãŠãšããž
ãéããŠç·è²å ã®é²å ãè¡ãªããåèšããå åŒã«
ã©ãŒããžçšçºè²çŸååŠçå·¥çšã«åŸã€ãŠçºè²çŸåã
è¡ãªãç·ææ§å±€ããéææ§å±€ããã³èµ€ææ§å±€ãžã®
æ··è²ã®çšåºŠãè©äŸ¡ããã
ãè¡šã
è¡šâïŒããã³è¡šâïŒããæãããªããã«ïŒçš®é¡
以äžã®ããã²ã³åéä¹³å€å±€ã®éã®å±€ã«æ¬çºæã«ä¿
ãååç©ïŒçŸåäž»è¬é žåäœã¹ã«ãã³ãžã€ãŒïŒãå«
ãŸãªãè©Šæã§ã¯é žåãããçŸåäž»è¬ãéçŸåãã
ãªãã€ãä¹³å€å±€ãžæ¡æ£ãããã®å±€äžã«å«æãããŠ
ããã«ãã©ãŒãšåå¿ããŠè²çŽ ãçæãããæ¬çºæ
ã«ä¿ãååç©ãçšãããšãåå±€ã®æ··è²ã®å²åãè
ããæžå°ããããŸãå¡åžçŽåŸã®è©Šæããã³é·æä¿
åããè©Šæãšãæ¯èŒååç©ã«æ¯ã¹ãé žåãããçŸ
åäž»è¬ãé€å»ããå¹æãããããŠé«ãããšãæã
ãã§ããã å®æœäŸ ïŒ ããªãšãã¬ã³è¢«èŠçŽãããªãæ¯æäœäžã«ã20ã¢
ã«ïŒ ã®å¡©åéãå«ãå¡©èåéã§ããã²ã³åéïŒã¢
ã«åœãããŒã©ãã³400ïœãå«ã¿ãããã²ã³åéïŒ
ã¢ã«åœããéææ§å¢æè²çŽ 2.5Ã10-1ã¢ã«ãçšã
ãŠå¢æããããžããã«ãã¿ã¬ãŒãã«æº¶è§£ããŠåæ£
ããããæ¬çºæã®ååç©ïŒçŸåäž»è¬é žåäœã¹ã«ã
ã³ãžã€ãŒïŒãããã²ã³åéïŒã¢ã«åœãïŒÃ10-1ã¢
ã«å«æããããã²ã³åéä¹³å€æ¶²ãå¡åžéé400
mgïŒm2ã«ãªãããã«å¡åžããè©Šæ38ã46ãäœæã
ããäžèšã®ããã«äœæããè©Šæ38ã46ã«é£ç¶ãŠãš
ããžãéããŠçœè²å ã®é²å ãè¡ãªããåèšããå
åŒã«ã©ãŒããžçšçºè²çŸååŠçã«åŸã€ãŠçºè²çŸå(A)
ãšããŠåèšã®å åŒã«ã©ãŒããžçšçºè²çŸååŠçå·¥çš
ãçšãããŸãçºè²çŸå(B)ãšããŠè©²åŠçå·¥çšã®çºè²
çŸååŠçã36âãïŒåã«å€æŽããŠè¡ãªãçŸåäž»è¬
é žåäœã¹ã«ãã³ãžã€ãŒã«ããè²ã«ããã«ã€ããŠè©
䟡ããã
以äžã®ããã²ã³åéä¹³å€å±€ã®éã®å±€ã«æ¬çºæã«ä¿
ãååç©ïŒçŸåäž»è¬é žåäœã¹ã«ãã³ãžã€ãŒïŒãå«
ãŸãªãè©Šæã§ã¯é žåãããçŸåäž»è¬ãéçŸåãã
ãªãã€ãä¹³å€å±€ãžæ¡æ£ãããã®å±€äžã«å«æãããŠ
ããã«ãã©ãŒãšåå¿ããŠè²çŽ ãçæãããæ¬çºæ
ã«ä¿ãååç©ãçšãããšãåå±€ã®æ··è²ã®å²åãè
ããæžå°ããããŸãå¡åžçŽåŸã®è©Šæããã³é·æä¿
åããè©Šæãšãæ¯èŒååç©ã«æ¯ã¹ãé žåãããçŸ
åäž»è¬ãé€å»ããå¹æãããããŠé«ãããšãæã
ãã§ããã å®æœäŸ ïŒ ããªãšãã¬ã³è¢«èŠçŽãããªãæ¯æäœäžã«ã20ã¢
ã«ïŒ ã®å¡©åéãå«ãå¡©èåéã§ããã²ã³åéïŒã¢
ã«åœãããŒã©ãã³400ïœãå«ã¿ãããã²ã³åéïŒ
ã¢ã«åœããéææ§å¢æè²çŽ 2.5Ã10-1ã¢ã«ãçšã
ãŠå¢æããããžããã«ãã¿ã¬ãŒãã«æº¶è§£ããŠåæ£
ããããæ¬çºæã®ååç©ïŒçŸåäž»è¬é žåäœã¹ã«ã
ã³ãžã€ãŒïŒãããã²ã³åéïŒã¢ã«åœãïŒÃ10-1ã¢
ã«å«æããããã²ã³åéä¹³å€æ¶²ãå¡åžéé400
mgïŒm2ã«ãªãããã«å¡åžããè©Šæ38ã46ãäœæã
ããäžèšã®ããã«äœæããè©Šæ38ã46ã«é£ç¶ãŠãš
ããžãéããŠçœè²å ã®é²å ãè¡ãªããåèšããå
åŒã«ã©ãŒããžçšçºè²çŸååŠçã«åŸã€ãŠçºè²çŸå(A)
ãšããŠåèšã®å åŒã«ã©ãŒããžçšçºè²çŸååŠçå·¥çš
ãçšãããŸãçºè²çŸå(B)ãšããŠè©²åŠçå·¥çšã®çºè²
çŸååŠçã36âãïŒåã«å€æŽããŠè¡ãªãçŸåäž»è¬
é žåäœã¹ã«ãã³ãžã€ãŒã«ããè²ã«ããã«ã€ããŠè©
䟡ããã
ãè¡šã
è¡šâïŒã«ç€ºãããã«ãæ¬çºæã®ååç©ã¯çŸååŠ
çã«ãã€ãŠã¹ãã€ã³ãçºçããªãããšãã«ãçŸå
åŠç枩床ãäžããŠè¿ éãªåŠçãè¡ãªã€ãŠãã¹ãã€
ã³ãçºçããªãããšãæããã«ãªãã (f) çºæã®å ·äœçå¹æ æ¬çºæã«ä¿ãååç©ãããã²ã³åéåçæå æ
æã®åçæ§æå±€ã«å«æããããšãåŸæ¥ã®çœ®æãã€
ããããã³ã«æ¯ã¹ãŠãåªããã¹ã«ãã³ãžã€ãŒå¹æ
ãçºæ®ãããå³ã¡ãæ¬çºæã«ä¿ãååç©ã¯ãåç
æ§æå±€å ã§çŸåäž»è¬é žåäœã®ã¹ã«ãã³ãžã€ãŒãšã
ãŠäœçšããçŸåäž»è¬é žåäœã®ã¹ã«ãã³ãžã€ãŒå¹ç
ããããäžã€é·æã«ããã€ãŠåèšã¹ã«ãã³ãžã€ãŒ
å¹æãæç¶ããããšãã§ãããããããã²ã³åé
ã®çŸåã«æªåœ±é¿ãå®è³ªçã«äžããããšããªãããŸ
ãæ¬çºæã«ä¿ãååç©ã¯ãããèªäœãé žåãã
ãŠãçè²çæç©ãçæããããšããªãããŸãçŸå
äž»è¬ã®é žåäœãšã«ãããªã³ã°åå¿ããŠçè²çæç©
ãçæããããšããªããå®è³ªçç¡è²ã®ååç©ã§ã
ããããçºè²ã«ããªãçããããšããªãçããã
ãŠåªããç¹æ§ãæããŠããã
çã«ãã€ãŠã¹ãã€ã³ãçºçããªãããšãã«ãçŸå
åŠç枩床ãäžããŠè¿ éãªåŠçãè¡ãªã€ãŠãã¹ãã€
ã³ãçºçããªãããšãæããã«ãªãã (f) çºæã®å ·äœçå¹æ æ¬çºæã«ä¿ãååç©ãããã²ã³åéåçæå æ
æã®åçæ§æå±€ã«å«æããããšãåŸæ¥ã®çœ®æãã€
ããããã³ã«æ¯ã¹ãŠãåªããã¹ã«ãã³ãžã€ãŒå¹æ
ãçºæ®ãããå³ã¡ãæ¬çºæã«ä¿ãååç©ã¯ãåç
æ§æå±€å ã§çŸåäž»è¬é žåäœã®ã¹ã«ãã³ãžã€ãŒãšã
ãŠäœçšããçŸåäž»è¬é žåäœã®ã¹ã«ãã³ãžã€ãŒå¹ç
ããããäžã€é·æã«ããã€ãŠåèšã¹ã«ãã³ãžã€ãŒ
å¹æãæç¶ããããšãã§ãããããããã²ã³åé
ã®çŸåã«æªåœ±é¿ãå®è³ªçã«äžããããšããªãããŸ
ãæ¬çºæã«ä¿ãååç©ã¯ãããèªäœãé žåãã
ãŠãçè²çæç©ãçæããããšããªãããŸãçŸå
äž»è¬ã®é žåäœãšã«ãããªã³ã°åå¿ããŠçè²çæç©
ãçæããããšããªããå®è³ªçç¡è²ã®ååç©ã§ã
ããããçºè²ã«ããªãçããããšããªãçããã
ãŠåªããç¹æ§ãæããŠããã
Claims (1)
- ãç¹èš±è«æ±ã®ç¯å²ã ïŒ æ¯æäœäžã«ãäžèšäžè¬åŒïŒ»ïŒœã§è¡šãããã
ååç©ã®å°ãªããšãïŒçš®ãå«æããåçæ§æå±€ã
å°ãªããšãïŒå±€æããããšãç¹åŸŽãšããããã²ã³
åéåçæå ææã äžè¬åŒïŒ»ïŒœ ïŒãã ããåŒäžR1ããã³R2ã®äžæ¹ã¯ã¢ãªãŒã«åº
ã§ãããä»æ¹ãã¢ã«ãã«åºãŸãã¯ã·ã¯ãã¢ã«ãã«
åºãè¡šãããïŒ
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21734083A JPS60108843A (ja) | 1983-11-18 | 1983-11-18 | ããã²ã³åéåçæå ææ |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21734083A JPS60108843A (ja) | 1983-11-18 | 1983-11-18 | ããã²ã³åéåçæå ææ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60108843A JPS60108843A (ja) | 1985-06-14 |
| JPH0443261B2 true JPH0443261B2 (ja) | 1992-07-16 |
Family
ID=16702638
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP21734083A Granted JPS60108843A (ja) | 1983-11-18 | 1983-11-18 | ããã²ã³åéåçæå ææ |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS60108843A (ja) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6239851A (ja) * | 1985-08-15 | 1987-02-20 | Konishiroku Photo Ind Co Ltd | ããã²ã³åéã«ã©âåçæå ææ |
| JPS6249349A (ja) * | 1985-08-23 | 1987-03-04 | Konishiroku Photo Ind Co Ltd | ããã²ã³åéã«ã©âåçæå ææ |
-
1983
- 1983-11-18 JP JP21734083A patent/JPS60108843A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS60108843A (ja) | 1985-06-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPH0480375B2 (ja) | ||
| JPS6248820B2 (ja) | ||
| JPH0327103B2 (ja) | ||
| JPH0335653B2 (ja) | ||
| US4203768A (en) | Silver halide color photographic material and method for formation of color photographic images | |
| JPS5814668B2 (ja) | ã·ã€ã·ã³ãšãŠã²ã³ãŸãŠã€ã¯ | |
| JPS6113748B2 (ja) | ||
| JPH0454939B2 (ja) | ||
| US4254213A (en) | Process for forming black dye images | |
| JPH0443261B2 (ja) | ||
| JPH0510662B2 (ja) | ||
| JPS6361649B2 (ja) | ||
| JPH04261530A (ja) | ããã²ã³åéã«ã©ãŒåçæå ææ | |
| JPS60172041A (ja) | ããã²ã³åéåçæå ææ | |
| JPS60118836A (ja) | ããã²ã³åéåçæå ææ | |
| JPS60118835A (ja) | ããã²ã³åéåçæå ææ | |
| JPS59220733A (ja) | ããã²ã³åéåçæå ææ | |
| JPH0685073B2 (ja) | ããã²ã³åéåçæå ææã®åŠçæ¹æ³ | |
| JPH05249603A (ja) | éé žåç©å«æåŠç液ã§äœ¿çšããããã®ãããã¯ãããåççã«æçšãªååç©é¡ãå«ãã§ãªãåçèŠçŽ | |
| JPS5847702B2 (ja) | ã«ã©âã·ã€ã·ã³ã«ã³ã³ãŠã¶ã€ãªãšãŠ | |
| JPS6113582B2 (ja) | ||
| JPS6156502B2 (ja) | ||
| JPH0468615B2 (ja) | ||
| JPH04177248A (ja) | ããã²ã³åéåçæå ææ | |
| JPS6349216B2 (ja) |