|
JPS59141547A
(ja)
*
|
1983-02-01 |
1984-08-14 |
Eisai Co Ltd |
鎮痛作用を有する新規ペプタイドおよび製法
|
|
US4481191A
(en)
*
|
1983-03-30 |
1984-11-06 |
The Regents Of The University Of California |
Method for controlling blood pressure
|
|
US4900811A
(en)
*
|
1983-07-21 |
1990-02-13 |
Scripps Clinic And Research Foundation |
Synthetic polypeptides corresponding to portions of proteinoids translated from brain-specific mRNAs, receptors, methods and diagnostics using the same
|
|
US5242798A
(en)
*
|
1983-07-21 |
1993-09-07 |
Scripps Clinic And Research Foundation |
Synthetic polypeptides corresponding to portions of proteinoids translated from brain-specific mRNAs, receptors, methods and diagnostics using the same
|
|
ATE44751T1
(de)
*
|
1983-12-22 |
1989-08-15 |
Yoshio Hosobuchi |
Zusammensetzungen zum behandeln von ischaemie im gehirn.
|
|
JPH0680079B2
(ja)
*
|
1984-11-09 |
1994-10-12 |
エーザイ株式会社 |
ポリペプチド
|
|
US5017689A
(en)
*
|
1989-07-06 |
1991-05-21 |
Arizona Technology Development Corporation |
Dynorphin analogs specific for kappa opioid receptors
|
|
US5807827A
(en)
*
|
1992-06-12 |
1998-09-15 |
Des-Tyr Dynorphin Partnership |
Des-Tyr dynorphin analogues
|
|
US5817628A
(en)
*
|
1992-12-02 |
1998-10-06 |
The Rockefeller University |
Dynorphin a suppression of natural killer cell activity
|
|
US5482930A
(en)
*
|
1993-06-09 |
1996-01-09 |
The Regents Of The University Of California |
Anti-inflammatory composition and method with des-Tyr dynorphin and analogues
|
|
US6184208B1
(en)
|
1994-06-29 |
2001-02-06 |
Immunotech Developments Inc. |
Peptide, a method for its preparation and a pharmaceutical composition containing the peptide
|
|
WO1996006626A1
(en)
*
|
1994-08-26 |
1996-03-07 |
Lee Nancy M |
Analgesic method with dynorphin analogues truncated at the n-terminus
|
|
US7220737B1
(en)
|
1997-09-04 |
2007-05-22 |
Novoneuron, Inc |
Noribogaine in the treatment of pain and drug addiction
|
|
IL134796A0
(en)
*
|
1997-09-04 |
2001-04-30 |
Novoneuron Inc |
Noribogaine in the treatment of pain and drug addiction
|
|
US6437092B1
(en)
|
1998-11-06 |
2002-08-20 |
Conjuchem, Inc. |
Conjugates of opioids and endogenous carriers
|
|
US6605648B1
(en)
*
|
1999-04-06 |
2003-08-12 |
Phillips Plastics Corporation |
Sinterable structures and method
|
|
US7601691B2
(en)
*
|
1999-05-17 |
2009-10-13 |
Conjuchem Biotechnologies Inc. |
Anti-obesity agents
|
|
SI1180121T1
(en)
*
|
1999-05-17 |
2004-04-30 |
Conjuchem, Inc. |
Long lasting insulinotropic peptides
|
|
EP1598365A1
(en)
|
1999-05-17 |
2005-11-23 |
ConjuChem Inc. |
Protection of endogenous therapeutic peptides
|
|
US20040266673A1
(en)
*
|
2002-07-31 |
2004-12-30 |
Peter Bakis |
Long lasting natriuretic peptide derivatives
|
|
US20090175821A1
(en)
*
|
1999-05-17 |
2009-07-09 |
Bridon Dominique P |
Modified therapeutic peptides with extended half-lives in vivo
|
|
US6849714B1
(en)
|
1999-05-17 |
2005-02-01 |
Conjuchem, Inc. |
Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components
|
|
US6514500B1
(en)
|
1999-10-15 |
2003-02-04 |
Conjuchem, Inc. |
Long lasting synthetic glucagon like peptide {GLP-!}
|
|
US6887470B1
(en)
|
1999-09-10 |
2005-05-03 |
Conjuchem, Inc. |
Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components
|
|
US6706892B1
(en)
*
|
1999-09-07 |
2004-03-16 |
Conjuchem, Inc. |
Pulmonary delivery for bioconjugation
|
|
KR100619612B1
(ko)
*
|
1999-10-04 |
2006-09-01 |
넥타르 테라퓨틱스 에이엘, 코포레이션 |
폴리머 안정화 신경펩타이드
|
|
WO2002062844A2
(en)
*
|
2001-02-02 |
2002-08-15 |
Conjuchem Inc. |
Long lasting growth hormone releasing factor derivatives
|
|
EP1360202B1
(en)
*
|
2001-02-16 |
2008-05-21 |
ConjuChem Biotechnologies Inc. |
Long lasting glucagon-like peptide 2 (glp-2) for the treatment of gastrointestinal diseases and disorders
|
|
US7776314B2
(en)
|
2002-06-17 |
2010-08-17 |
Grunenthal Gmbh |
Abuse-proofed dosage system
|
|
US20070048228A1
(en)
|
2003-08-06 |
2007-03-01 |
Elisabeth Arkenau-Maric |
Abuse-proofed dosage form
|
|
DE102005005446A1
(de)
|
2005-02-04 |
2006-08-10 |
Grünenthal GmbH |
Bruchfeste Darreichungsformen mit retardierter Freisetzung
|
|
US8075872B2
(en)
*
|
2003-08-06 |
2011-12-13 |
Gruenenthal Gmbh |
Abuse-proofed dosage form
|
|
DE10336400A1
(de)
|
2003-08-06 |
2005-03-24 |
Grünenthal GmbH |
Gegen Missbrauch gesicherte Darreichungsform
|
|
DE10361596A1
(de)
|
2003-12-24 |
2005-09-29 |
Grünenthal GmbH |
Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
|
|
DE102004032051A1
(de)
*
|
2004-07-01 |
2006-01-19 |
Grünenthal GmbH |
Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
|
|
PT2100904E
(pt)
*
|
2004-04-23 |
2010-09-24 |
Conjuchem Biotechnologies Inc |
Fase sólida para utilização num método para a purificação de conjugados de albumina
|
|
DE102004032049A1
(de)
|
2004-07-01 |
2006-01-19 |
Grünenthal GmbH |
Gegen Missbrauch gesicherte, orale Darreichungsform
|
|
AU2005286733B2
(en)
*
|
2004-09-23 |
2009-11-05 |
Alexander Michalow |
Methods for regulating neurotransmitter systems by inducing counteradaptations
|
|
US20080045610A1
(en)
*
|
2004-09-23 |
2008-02-21 |
Alexander Michalow |
Methods for regulating neurotransmitter systems by inducing counteradaptations
|
|
DE102005005449A1
(de)
|
2005-02-04 |
2006-08-10 |
Grünenthal GmbH |
Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
|
|
WO2007053946A1
(en)
*
|
2005-11-09 |
2007-05-18 |
Conjuchem Biotechnologies Inc. |
Method of treating diabetes and/or obesity with reduced nausea side effects using an insulinotropic peptide conjugated to albumin
|
|
JP2009520469A
(ja)
*
|
2005-12-22 |
2009-05-28 |
コンジュクヘム ビオテクフノロギエス インコーポレイテッド |
アルブミンと治療薬との前もって形成された抱合体の産生のための方法
|
|
WO2008077194A1
(en)
*
|
2006-12-22 |
2008-07-03 |
Xenome Ltd |
Receptor agonists
|
|
US20090099074A1
(en)
*
|
2007-01-10 |
2009-04-16 |
Conjuchem Biotechnologies Inc. |
Modulating food intake
|
|
DE102007011485A1
(de)
|
2007-03-07 |
2008-09-11 |
Grünenthal GmbH |
Darreichungsform mit erschwertem Missbrauch
|
|
JP2011506442A
(ja)
*
|
2007-12-11 |
2011-03-03 |
コンジュケム バイオテクノロジーズ インコーポレイテッド |
インスリン分泌性ペプチド結合体の製剤
|
|
AU2009207796B2
(en)
|
2008-01-25 |
2014-03-27 |
Grunenthal Gmbh |
Pharmaceutical dosage form
|
|
HRP20161307T1
(hr)
|
2008-05-09 |
2016-12-02 |
Grünenthal GmbH |
Postupak za pripravu praškaste formulacije međuproizvoda i konačni kruti oblik doziranja uz korištenje koraka zgrušavanja raspršivanjem
|
|
CA2765971C
(en)
|
2009-07-22 |
2017-08-22 |
Gruenenthal Gmbh |
Hot-melt extruded controlled release dosage form
|
|
PE20120631A1
(es)
|
2009-07-22 |
2012-06-06 |
Gruenenthal Chemie |
Forma de dosificacion resistente a la manipulacion para opioides sensibles a la oxidacion
|
|
CN102821757B
(zh)
|
2010-02-03 |
2016-01-20 |
格吕伦塔尔有限公司 |
通过挤出机制备粉末状药物组合物
|
|
US8362007B1
(en)
|
2010-05-11 |
2013-01-29 |
Demerx, Inc. |
Substituted noribogaine
|
|
US8765737B1
(en)
|
2010-05-11 |
2014-07-01 |
Demerx, Inc. |
Methods and compositions for preparing and purifying noribogaine
|
|
US9394294B2
(en)
|
2010-05-11 |
2016-07-19 |
Demerx, Inc. |
Methods and compositions for preparing and purifying noribogaine
|
|
US8802832B2
(en)
|
2010-06-22 |
2014-08-12 |
Demerx, Inc. |
Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
|
|
US8637648B1
(en)
|
2010-06-22 |
2014-01-28 |
Demerx, Inc. |
Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
|
|
US9586954B2
(en)
|
2010-06-22 |
2017-03-07 |
Demerx, Inc. |
N-substituted noribogaine prodrugs
|
|
US8741891B1
(en)
|
2010-06-22 |
2014-06-03 |
Demerx, Inc. |
N-substituted noribogaine prodrugs
|
|
US9358237B2
(en)
|
2010-07-23 |
2016-06-07 |
Demerx, Inc. |
Noribogaine compositions
|
|
PL2611426T3
(pl)
|
2010-09-02 |
2014-09-30 |
Gruenenthal Gmbh |
Postać dawkowania zawierająca nieorganiczne sole, odporna na zgniatanie
|
|
AR082862A1
(es)
|
2010-09-02 |
2013-01-16 |
Gruenenthal Gmbh |
Forma de dosificacion resistente a alteracion que comprende un polimero anionico
|
|
EP2481740B1
(en)
|
2011-01-26 |
2015-11-04 |
DemeRx, Inc. |
Methods and compositions for preparing noribogaine from voacangine
|
|
HRP20171458T1
(hr)
|
2011-07-29 |
2017-11-17 |
Grünenthal GmbH |
Tableta otporna na mijenjanje koja pruža neposredno oslobađanje lijeka
|
|
KR20140053159A
(ko)
|
2011-07-29 |
2014-05-07 |
그뤼넨탈 게엠베하 |
즉시 약물 방출을 제공하는 탬퍼-저항성 정제
|
|
US9617274B1
(en)
|
2011-08-26 |
2017-04-11 |
Demerx, Inc. |
Synthetic noribogaine
|
|
EP2788003A4
(en)
|
2011-12-09 |
2015-05-27 |
Demerx Inc |
PHOSPHATESTER OF NORIBOGAIN
|
|
US9150584B2
(en)
|
2012-01-25 |
2015-10-06 |
Demerx, Inc. |
Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them
|
|
WO2013112673A1
(en)
|
2012-01-25 |
2013-08-01 |
Demerx, Inc. |
Synthetic voacangine
|
|
JP6117249B2
(ja)
|
2012-02-28 |
2017-04-19 |
グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング |
薬理学的に活性な化合物および陰イオン性ポリマーを含むタンパーレジスタント剤形
|
|
PT2838512T
(pt)
|
2012-04-18 |
2018-11-09 |
Gruenenthal Gmbh |
Forma farmacêutica resistente à adulteração e resistente à libertação inesperada de alta quantidade (dose-dumping)
|
|
US10064945B2
(en)
|
2012-05-11 |
2018-09-04 |
Gruenenthal Gmbh |
Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
|
|
WO2014098877A1
(en)
|
2012-12-20 |
2014-06-26 |
Demerx, Inc. |
Substituted noribogaine
|
|
US8940728B2
(en)
|
2012-12-20 |
2015-01-27 |
Demerx, Inc. |
Substituted noribogaine
|
|
US9045481B2
(en)
|
2012-12-20 |
2015-06-02 |
Demerx, Inc. |
Substituted noribogaine
|
|
US10428115B2
(en)
|
2013-05-24 |
2019-10-01 |
Arizona Board Of Regents On Behalf Of The University Of Arizona |
Dynorphin A analogs with bradykinin receptors specificity for modulation of neuropathic pain
|
|
US9737490B2
(en)
|
2013-05-29 |
2017-08-22 |
Grünenthal GmbH |
Tamper resistant dosage form with bimodal release profile
|
|
BR112015026549A2
(pt)
|
2013-05-29 |
2017-07-25 |
Gruenenthal Gmbh |
forma de dosagem à prova de violação contendo uma ou mais partículas
|
|
EA032465B1
(ru)
|
2013-07-12 |
2019-05-31 |
Грюненталь Гмбх |
Защищенная от применения не по назначению пероральная фармацевтическая лекарственная форма, содержащая этиленвинилацетатный полимер, и способ ее изготовления
|
|
HK1224189A1
(zh)
|
2013-11-26 |
2017-08-18 |
Grünenthal GmbH |
通过低温研磨制备粉状药物组合物
|
|
EP3142646A1
(en)
|
2014-05-12 |
2017-03-22 |
Grünenthal GmbH |
Tamper resistant immediate release capsule formulation comprising tapentadol
|
|
WO2015181059A1
(en)
|
2014-05-26 |
2015-12-03 |
Grünenthal GmbH |
Multiparticles safeguarded against ethanolic dose-dumping
|
|
WO2015195673A2
(en)
|
2014-06-18 |
2015-12-23 |
Demerx, Inc. |
Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them
|
|
HK1246173A1
(zh)
|
2015-04-24 |
2018-09-07 |
Grünenthal GmbH |
具有立即释放和对溶剂萃取的抗性的抗篡改剂型
|
|
WO2017042325A1
(en)
|
2015-09-10 |
2017-03-16 |
Grünenthal GmbH |
Protecting oral overdose with abuse deterrent immediate release formulations
|