KR840005080A - 디노르핀 아미드 동족체의 제조방법 - Google Patents

디노르핀 아미드 동족체의 제조방법 Download PDF

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Publication number
KR840005080A
KR840005080A KR1019830002568A KR830002568A KR840005080A KR 840005080 A KR840005080 A KR 840005080A KR 1019830002568 A KR1019830002568 A KR 1019830002568A KR 830002568 A KR830002568 A KR 830002568A KR 840005080 A KR840005080 A KR 840005080A
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South Korea
Prior art keywords
dinorphine
homologue
amide
tyrosine
preparing
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KR1019830002568A
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English (en)
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엠. 리 낸시 (외 2)
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원본미기재
더 리전츠 오브 더 유니버시티 오브 캘리포니아
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Application filed by 원본미기재, 더 리전츠 오브 더 유니버시티 오브 캘리포니아 filed Critical 원본미기재
Publication of KR840005080A publication Critical patent/KR840005080A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Polyamides (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

내용 없음

Description

디노르핀 아미드 동족체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. Boc―Prc―BHA를 함유하는 수지를 제조하여, Boc―Prc―BHA 수지에 아미노산 AA9AA8AA7AA6AA5AA4AA3AA2및 AA1을 연속하여 커플링시키고, 생성된 수지로부터 다음 일반식(I)의 디노르핀아족체인 동미드 폴리펩타이드를 분리시킴을 특징으로 하여, 다음 일반식(I)의 디노르핀 아미드 동족체를 제조하는 방법.
    상기식에서, R1및 R2는 수소, 알킬, 알릴, 포르밀 또는 아세틸이며 ; R11및 R12는 수소, 알킬 또는 알릴이고; R3내지 R9는 수소 또는 ―(―CH2―)―[여기에서, n은 1 또는 2이다]이며; AA1은 티로신이고; AA2및 AA3는 글리신이며; AA4는 페닐알라닌이고; AA5는 로이신이며; AA6및 AA7은 알기닌이고; AA8은 이소로이신, 티로신 또는 리신이며; AA9는 알기닌 또는 프롤린이고; AA10은 프롤린이다.
  2. 제1항에 있어서, 폴리펩타이드 서열이 TYR―GLY―GLY―PHE-LEU―ARG―AA8―ARC―PRO 이며, 이중 프롤린은 아미드화 되고 AA8은 티로신, 이소로이신 또는 리신인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830002568A 1982-06-10 1983-06-09 디노르핀 아미드 동족체의 제조방법 KR840005080A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US387005 1982-06-10
US06/387,005 US4462941A (en) 1982-06-10 1982-06-10 Dynorphin amide analogs

Publications (1)

Publication Number Publication Date
KR840005080A true KR840005080A (ko) 1984-11-03

Family

ID=23528034

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830002568A KR840005080A (ko) 1982-06-10 1983-06-09 디노르핀 아미드 동족체의 제조방법

Country Status (15)

Country Link
US (1) US4462941A (ko)
EP (1) EP0096592B1 (ko)
JP (1) JPS5925365A (ko)
KR (1) KR840005080A (ko)
AT (1) ATE22449T1 (ko)
AU (1) AU1448983A (ko)
CA (1) CA1241645A (ko)
DE (1) DE3366428D1 (ko)
DK (1) DK262683A (ko)
FI (1) FI832095L (ko)
IL (1) IL68825A0 (ko)
IS (1) IS2812A7 (ko)
NO (1) NO832107L (ko)
PT (1) PT76860B (ko)
ZA (1) ZA834189B (ko)

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Also Published As

Publication number Publication date
JPH0427995B2 (ko) 1992-05-13
EP0096592B1 (en) 1986-09-24
ATE22449T1 (de) 1986-10-15
US4462941A (en) 1984-07-31
PT76860A (en) 1983-07-01
CA1241645A (en) 1988-09-06
PT76860B (en) 1986-01-27
IL68825A0 (en) 1983-09-30
NO832107L (no) 1983-12-12
DK262683A (da) 1983-12-11
DE3366428D1 (en) 1986-10-30
DK262683D0 (da) 1983-06-09
AU1448983A (en) 1983-12-15
FI832095A0 (fi) 1983-06-10
IS2812A7 (is) 1983-10-07
FI832095L (fi) 1983-12-11
EP0096592A1 (en) 1983-12-21
ZA834189B (en) 1984-02-29
JPS5925365A (ja) 1984-02-09

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