JPH0367073B2 - - Google Patents

Info

Publication number
JPH0367073B2
JPH0367073B2 JP58147471A JP14747183A JPH0367073B2 JP H0367073 B2 JPH0367073 B2 JP H0367073B2 JP 58147471 A JP58147471 A JP 58147471A JP 14747183 A JP14747183 A JP 14747183A JP H0367073 B2 JPH0367073 B2 JP H0367073B2
Authority
JP
Japan
Prior art keywords
culture
medium
chloroform
color
growth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP58147471A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6041489A (ja
Inventor
Yuzuru Matsuda
Kazuyuki Iwahashi
Takao Iida
Noriaki Hirayama
Kozo Asano
Katsuichi Shuto
Koji Yamada
Kimikatsu Shirahata
Hiroshi Kase
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP58147471A priority Critical patent/JPS6041489A/ja
Priority to DE8484305465T priority patent/DE3483508D1/de
Priority to EP84305465A priority patent/EP0137632B1/en
Priority to US06/640,159 priority patent/US4555402A/en
Publication of JPS6041489A publication Critical patent/JPS6041489A/ja
Publication of JPH0367073B2 publication Critical patent/JPH0367073B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/04—Actinomyces

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
JP58147471A 1983-08-12 1983-08-12 新規生理活性物質ｋ―２５２ Granted JPS6041489A (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP58147471A JPS6041489A (ja) 1983-08-12 1983-08-12 新規生理活性物質ｋ―２５２
DE8484305465T DE3483508D1 (de) 1983-08-12 1984-08-10 Physiologisch aktive substanz k-252, verfahren zu ihrer herstellung und eine pharmazeutische zusammensetzung die diese enthaelt.
EP84305465A EP0137632B1 (en) 1983-08-12 1984-08-10 Physiologically active substance k-252, process for producing same and a pharmaceutical composition containing same
US06/640,159 US4555402A (en) 1983-08-12 1984-08-10 Physiologically active substance K-252, process for producing same and pharmaceutical composition containing same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58147471A JPS6041489A (ja) 1983-08-12 1983-08-12 新規生理活性物質ｋ―２５２

Publications (2)

Publication Number Publication Date
JPS6041489A JPS6041489A (ja) 1985-03-05
JPH0367073B2 true JPH0367073B2 (forum.php) 1991-10-21

Family

ID=15431133

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58147471A Granted JPS6041489A (ja) 1983-08-12 1983-08-12 新規生理活性物質ｋ―２５２

Country Status (4)

Country Link
US (1) US4555402A (forum.php)
EP (1) EP0137632B1 (forum.php)
JP (1) JPS6041489A (forum.php)
DE (1) DE3483508D1 (forum.php)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62155284A (ja) * 1985-12-27 1987-07-10 Kyowa Hakko Kogyo Co Ltd 生理活性物質ｋ−２５２の誘導体
DE3752123T2 (de) * 1987-03-09 1998-05-14 Kyowa Hakko Kogyo Kk Derivate des physiologisch aktiven mittels k-252
JPH07113027B2 (ja) * 1987-12-24 1995-12-06 協和醗酵工業株式会社 Ｋ−２５２誘導体
US5142096A (en) * 1988-03-31 1992-08-25 Kyowa Hakko Kogyo Co., Ltd. 2,4-dihydroxy-3,5,6-trimethylbenzoic acid compounds
US5223637A (en) * 1988-03-31 1993-06-29 Kyowa Hakko Kogyo Co., Ltd. KS-506 compounds
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
CA2123096A1 (en) 1991-11-08 1993-05-13 Beat J. Knusel Compositions containing k-252 compounds for potentiation of neurotrophin activity
EP0630898B1 (en) * 1992-09-21 2001-11-28 Kyowa Hakko Kogyo Co., Ltd. Thrombocytopenia remedy
US6306421B1 (en) 1992-09-25 2001-10-23 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6663881B2 (en) 1993-01-28 2003-12-16 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US7611533B2 (en) 1995-06-07 2009-11-03 Cook Incorporated Coated implantable medical device
JP3865781B2 (ja) * 1996-04-09 2007-01-10 協和醗酵工業株式会社 Ｋ−２５２ａの精製方法
UA65542C2 (uk) * 1996-06-25 2004-04-15 Сефалон, Інк. Спосіб пригнічення надлишкового продукування фактора некрозу пухлин альфа , спосіб полегшення шкідливих ефектів надлишкового продукування фактора некрозу пухлин альфа та спосіб лікування запального стану або захворювання, пов'язаного з фактором некрозу пухлин.
US6613083B2 (en) 2001-05-02 2003-09-02 Eckhard Alt Stent device and method
US20060014165A1 (en) * 2003-07-14 2006-01-19 Decode Genetics Ehf. Methods of diagnosis and treatment for asthma and other respiratory diseases based on haplotype association
EP1653972A1 (en) * 2003-07-23 2006-05-10 Creabilis Therapeutics s.r.l. Topical use of tyrosine kinase inhibitors of microbial origin to prevent and treat skin disorders characterised by excessive cell proliferation
NZ548857A (en) * 2004-02-27 2010-05-28 Lundbeck & Co As H Crystalline forms of a diazocine pharmaceutical compound for Parkinson's and similar conditions
MX2007001155A (es) * 2004-07-29 2007-08-14 Creabilis Therapeutics Spa Uso de inhibidores de k-252a y de quinasa para la prevencion o el tratamiento de patologias asociadas con hmgb1.
EP1871778A1 (en) * 2005-04-20 2008-01-02 Abbott Laboratories Fermentation broth extraction of k-252a
TWI672141B (zh) 2014-02-20 2019-09-21 美商醫科泰生技 投予ｒｏｓ１突變癌細胞之分子
CN107207471B (zh) 2014-12-02 2020-06-26 伊尼塔公司 用于治疗神经母细胞瘤的组合
EP3389645A4 (en) 2015-12-18 2019-12-18 Ignyta, Inc. COMBINATIONS FOR TREATING CANCER
US10398693B2 (en) 2017-07-19 2019-09-03 Ignyta, Inc. Pharmaceutical compositions and dosage forms
WO2019077506A1 (en) 2017-10-17 2019-04-25 Ignyta, Inc. PHARMACEUTICAL COMPOSITIONS AND SOLID GALENIC FORMS

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5937952B2 (ja) * 1977-09-12 1984-09-12 正 新井 抗生物質サフラマイシンａ，ｂ，ｃ，ｄ，ｅおよびその製造法
JPS5452797A (en) * 1977-10-04 1979-04-25 Meiji Seika Kaisha Ltd Novel antibiotic substance bn-200, and its preparation
US4317812A (en) * 1981-01-15 1982-03-02 Smithkline Corporation Polynitroxin antibiotics produced by Nocardiopsis mutabilis Shearer sp. nov. ATCC 31520

Also Published As

Publication number Publication date
EP0137632A3 (en) 1987-05-20
EP0137632A2 (en) 1985-04-17
DE3483508D1 (de) 1990-12-06
EP0137632B1 (en) 1990-10-31
US4555402A (en) 1985-11-26
JPS6041489A (ja) 1985-03-05

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