JPH0365351B2 - - Google Patents

Info

Publication number
JPH0365351B2
JPH0365351B2 JP58036211A JP3621183A JPH0365351B2 JP H0365351 B2 JPH0365351 B2 JP H0365351B2 JP 58036211 A JP58036211 A JP 58036211A JP 3621183 A JP3621183 A JP 3621183A JP H0365351 B2 JPH0365351 B2 JP H0365351B2
Authority
JP
Japan
Prior art keywords
group
dihydropyridine
dimethyl
carboxylic acid
nitrophenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP58036211A
Other languages
English (en)
Japanese (ja)
Other versions
JPS59161392A (ja
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to JP58036211A priority Critical patent/JPS59161392A/ja
Priority to GB08404386A priority patent/GB2140015B/en
Priority to CA000448718A priority patent/CA1254206A/en
Priority to EP84102249A priority patent/EP0121117B1/en
Priority to ES530248A priority patent/ES8505379A1/es
Priority to DE8484102249T priority patent/DE3479582D1/de
Priority to US06/585,574 priority patent/US4535073A/en
Priority to KR1019840001072A priority patent/KR840007882A/ko
Publication of JPS59161392A publication Critical patent/JPS59161392A/ja
Priority to ES537717A priority patent/ES537717A0/es
Publication of JPH0365351B2 publication Critical patent/JPH0365351B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
JP58036211A 1983-03-04 1983-03-04 ジヒドロピリジン誘導体及びその製法 Granted JPS59161392A (ja)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP58036211A JPS59161392A (ja) 1983-03-04 1983-03-04 ジヒドロピリジン誘導体及びその製法
GB08404386A GB2140015B (en) 1983-03-04 1984-02-20 Derivatives of dihydropyridine and production thereof
DE8484102249T DE3479582D1 (en) 1983-03-04 1984-03-02 Derivatives of dihydropyridine and production thereof
EP84102249A EP0121117B1 (en) 1983-03-04 1984-03-02 Derivatives of dihydropyridine and production thereof
ES530248A ES8505379A1 (es) 1983-03-04 1984-03-02 Un metodo de fabricar 1, 4-dihidropiridina-3-carboxilatos
CA000448718A CA1254206A (en) 1983-03-04 1984-03-02 Derivatives of dihydropyridine and production thereof
US06/585,574 US4535073A (en) 1983-03-04 1984-03-02 Antihypertensive phosphono derivatives of hantzsch dihydropyridines
KR1019840001072A KR840007882A (ko) 1983-03-04 1984-03-03 디히드로피리딘 유도체 및 그 제법
ES537717A ES537717A0 (es) 1983-03-04 1984-11-16 Un metodo de fabricar 1, 4-dihidropiridina-3-carboxilatos

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58036211A JPS59161392A (ja) 1983-03-04 1983-03-04 ジヒドロピリジン誘導体及びその製法

Publications (2)

Publication Number Publication Date
JPS59161392A JPS59161392A (ja) 1984-09-12
JPH0365351B2 true JPH0365351B2 (enExample) 1991-10-11

Family

ID=12463415

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58036211A Granted JPS59161392A (ja) 1983-03-04 1983-03-04 ジヒドロピリジン誘導体及びその製法

Country Status (8)

Country Link
US (1) US4535073A (enExample)
EP (1) EP0121117B1 (enExample)
JP (1) JPS59161392A (enExample)
KR (1) KR840007882A (enExample)
CA (1) CA1254206A (enExample)
DE (1) DE3479582D1 (enExample)
ES (2) ES8505379A1 (enExample)
GB (1) GB2140015B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6069089A (ja) * 1983-09-26 1985-04-19 Nissan Chem Ind Ltd ジヒドロピリジン−５−ホスホネ−ト誘導体およびその製造法
CA1339372C (en) * 1983-09-26 1997-08-26 Nissan Chemical Industries Ltd. Dihydropyridine-5-phosphonic acid cyclic ester
JPS6130591A (ja) * 1984-07-20 1986-02-12 Nissan Chem Ind Ltd ジヒドロピリジン−５−ホスホネ−ト誘導体
EP0141221A1 (en) * 1983-09-26 1985-05-15 Nissan Chemical Industries Ltd. 1,4-Dihydropyridine-5-phosphonic acid ester
JPS60248693A (ja) * 1984-04-19 1985-12-09 Nippon Shinyaku Co Ltd ピリジン誘導体及び製法
JPS6127995A (ja) * 1984-07-18 1986-02-07 Nissan Chem Ind Ltd ジヒドロピリジン−５−ホスホン酸モノエステル誘導体およびその製造法
IT1201444B (it) * 1985-08-01 1989-02-02 Boehringer Biochemia Srl Fosfonopiridine a loro 1,4-diidroderivati
IT1215298B (it) * 1985-08-06 1990-01-31 Boehringer Biochemia Srl 2-(eteroalchil)-1,4-diidropiridine ed un processo per la loro produzione.
US4885284A (en) * 1986-01-22 1989-12-05 Nissan Chemical Industries Ltd. Dihydropyridine-5-phosphonic acid cyclic propylene ester
CN1016063B (zh) 1986-01-22 1992-04-01 日产化学工业株式会社 二氢吡啶-5-膦酸环亚丙基酯的制备
JPH0699458B2 (ja) * 1986-01-23 1994-12-07 日産化学工業株式会社 ジヒドロピリジン−５−ホスホン酸環状エステル類
JPS63115890A (ja) * 1986-10-31 1988-05-20 Nippon Shinyaku Co Ltd ２位置換１，４−ジヒドロピリジン誘導体
US4920225A (en) * 1986-12-22 1990-04-24 Laboratoires Syntex S.A. Resolution of 1,4-dihydropyridine derivatives
JP2850376B2 (ja) * 1988-08-02 1999-01-27 日産化学工業株式会社 抗癌剤薬効増強剤
ATE128623T1 (de) * 1988-08-02 1995-10-15 Nissan Chemical Ind Ltd Mittel zur verbesserung von arzneimitteleffekten für antitumormittel.
RU2326886C2 (ru) 2003-03-28 2008-06-20 Ниссан Кемикал Индастриз, Лтд. Блокатор кальциевых каналов т-типа
JP6017964B2 (ja) 2010-03-01 2016-11-02 ティーエーユー・セラピューティクス・エルエルシー 癌診断および撮像

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670827C3 (de) * 1967-03-20 1974-10-24 Bayer Ag, 5090 Leverkusen 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin

Also Published As

Publication number Publication date
GB2140015A (en) 1984-11-21
ES8603902A1 (es) 1986-01-01
DE3479582D1 (en) 1989-10-05
ES530248A0 (es) 1985-05-16
KR840007882A (ko) 1984-12-11
ES537717A0 (es) 1986-01-01
CA1254206A (en) 1989-05-16
EP0121117A1 (en) 1984-10-10
GB8404386D0 (en) 1984-03-28
US4535073A (en) 1985-08-13
GB2140015B (en) 1987-07-29
JPS59161392A (ja) 1984-09-12
ES8505379A1 (es) 1985-05-16
EP0121117B1 (en) 1989-08-30

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