JPH0339508B2 - - Google Patents

Info

Publication number
JPH0339508B2
JPH0339508B2 JP59163772A JP16377284A JPH0339508B2 JP H0339508 B2 JPH0339508 B2 JP H0339508B2 JP 59163772 A JP59163772 A JP 59163772A JP 16377284 A JP16377284 A JP 16377284A JP H0339508 B2 JPH0339508 B2 JP H0339508B2
Authority
JP
Japan
Prior art keywords
group
lower alkyl
alkyl group
hydrogen
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP59163772A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6143190A (ja
Inventor
Noriaki Kihara
Tatsukazu Ishida
Shigeru Isayama
Takeshi Ishitoku
Hiroaki Tan
Katsuya Takahashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Petrochemical Industries Ltd
Original Assignee
Mitsui Petrochemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Petrochemical Industries Ltd filed Critical Mitsui Petrochemical Industries Ltd
Priority to JP59163772A priority Critical patent/JPS6143190A/ja
Priority to PCT/JP1985/000441 priority patent/WO1986001207A1/ja
Publication of JPS6143190A publication Critical patent/JPS6143190A/ja
Publication of JPH0339508B2 publication Critical patent/JPH0339508B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
JP59163772A 1984-08-06 1984-08-06 ピリドピリミジン誘導体およびその製法 Granted JPS6143190A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP59163772A JPS6143190A (ja) 1984-08-06 1984-08-06 ピリドピリミジン誘導体およびその製法
PCT/JP1985/000441 WO1986001207A1 (fr) 1984-08-06 1985-08-06 Derives de pyridopyrimidine et leur procede de preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59163772A JPS6143190A (ja) 1984-08-06 1984-08-06 ピリドピリミジン誘導体およびその製法

Publications (2)

Publication Number Publication Date
JPS6143190A JPS6143190A (ja) 1986-03-01
JPH0339508B2 true JPH0339508B2 (esLanguage) 1991-06-14

Family

ID=15780422

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59163772A Granted JPS6143190A (ja) 1984-08-06 1984-08-06 ピリドピリミジン誘導体およびその製法

Country Status (2)

Country Link
JP (1) JPS6143190A (esLanguage)
WO (1) WO1986001207A1 (esLanguage)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102399225B (zh) * 2011-11-28 2014-09-24 江西师范大学 一类具有除草活性的含氟取代嘧啶并[4,5-d]嘧啶及制备
CN102491977B (zh) * 2011-11-28 2014-06-11 江西师范大学 一类具有除草活性的多取代嘧啶并[5,4-e]-1,2,4-三唑并[1,5-c]嘧啶及制备
US9227978B2 (en) 2013-03-15 2016-01-05 Araxes Pharma Llc Covalent inhibitors of Kras G12C
TWI659021B (zh) 2013-10-10 2019-05-11 亞瑞克西斯製藥公司 Ｋｒａｓ ｇ１２ｃ之抑制劑
JO3556B1 (ar) 2014-09-18 2020-07-05 Araxes Pharma Llc علاجات مدمجة لمعالجة السرطان
EA201792214A1 (ru) 2015-04-10 2018-01-31 Араксис Фарма Ллк Соединения замещенного хиназолина
CA2982360A1 (en) 2015-04-15 2016-10-20 Liansheng Li Fused-tricyclic inhibitors of kras and methods of use thereof
US10144724B2 (en) 2015-07-22 2018-12-04 Araxes Pharma Llc Substituted quinazoline compounds and methods of use thereof
EP3356354A1 (en) 2015-09-28 2018-08-08 Araxes Pharma LLC Inhibitors of kras g12c mutant proteins
EP3356351A1 (en) 2015-09-28 2018-08-08 Araxes Pharma LLC Inhibitors of kras g12c mutant proteins
US10875842B2 (en) 2015-09-28 2020-12-29 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
WO2017058728A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
EP3356359B1 (en) 2015-09-28 2021-10-20 Araxes Pharma LLC Inhibitors of kras g12c mutant proteins
US10975071B2 (en) 2015-09-28 2021-04-13 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
US10689356B2 (en) 2015-09-28 2020-06-23 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
KR20180081596A (ko) 2015-11-16 2018-07-16 아락세스 파마 엘엘씨 치환된 헤테로사이클릭 그룹을 포함하는 2-치환된 퀴나졸린 화합물 및 이의 사용 방법
US10646488B2 (en) 2016-07-13 2020-05-12 Araxes Pharma Llc Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof
CN110036010A (zh) 2016-09-29 2019-07-19 亚瑞克西斯制药公司 Kras g12c突变蛋白的抑制剂
WO2018068017A1 (en) 2016-10-07 2018-04-12 Araxes Pharma Llc Heterocyclic compounds as inhibitors of ras and methods of use thereof
CN110382483A (zh) * 2017-01-26 2019-10-25 亚瑞克西斯制药公司 稠合的n-杂环化合物及其使用方法
WO2018140514A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc 1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer
US11358959B2 (en) 2017-01-26 2022-06-14 Araxes Pharma Llc Benzothiophene and benzothiazole compounds and methods of use thereof
JP7327802B2 (ja) * 2017-01-26 2023-08-16 アラクセス ファーマ エルエルシー 縮合ヘテロ－ヘテロ二環式化合物およびその使用方法
EP3573971A1 (en) 2017-01-26 2019-12-04 Araxes Pharma LLC 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer
US11274093B2 (en) 2017-01-26 2022-03-15 Araxes Pharma Llc Fused bicyclic benzoheteroaromatic compounds and methods of use thereof
AU2018271990A1 (en) 2017-05-25 2019-12-12 Araxes Pharma Llc Covalent inhibitors of KRAS
EP3630747A1 (en) 2017-05-25 2020-04-08 Araxes Pharma LLC Quinazoline derivatives as modulators of mutant kras, hras or nras
WO2018218071A1 (en) 2017-05-25 2018-11-29 Araxes Pharma Llc Compounds and methods of use thereof for treatment of cancer
CA3107168A1 (en) 2018-08-01 2020-02-06 Araxes Pharma Llc Heterocyclic spiro compounds and methods of use thereof for the treatment of cancer

Also Published As

Publication number Publication date
JPS6143190A (ja) 1986-03-01
WO1986001207A1 (fr) 1986-02-27

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