JPH0323178B2 - - Google Patents
Info
- Publication number
- JPH0323178B2 JPH0323178B2 JP57200249A JP20024982A JPH0323178B2 JP H0323178 B2 JPH0323178 B2 JP H0323178B2 JP 57200249 A JP57200249 A JP 57200249A JP 20024982 A JP20024982 A JP 20024982A JP H0323178 B2 JPH0323178 B2 JP H0323178B2
- Authority
- JP
- Japan
- Prior art keywords
- parts
- water
- range
- coating
- substrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000576 coating method Methods 0.000 claims description 50
- 239000011248 coating agent Substances 0.000 claims description 44
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical class OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 42
- 229960002897 heparin Drugs 0.000 claims description 42
- 229920000669 heparin Polymers 0.000 claims description 42
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 32
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 24
- 239000000758 substrate Substances 0.000 claims description 22
- 239000008367 deionised water Substances 0.000 claims description 10
- 229910021641 deionized water Inorganic materials 0.000 claims description 10
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 8
- 229920001577 copolymer Polymers 0.000 claims description 7
- 230000002209 hydrophobic effect Effects 0.000 claims description 6
- -1 polyethylene Polymers 0.000 claims description 6
- 230000002429 anti-coagulating effect Effects 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 5
- 239000004698 Polyethylene Substances 0.000 claims description 2
- 239000004743 Polypropylene Substances 0.000 claims description 2
- 239000004793 Polystyrene Substances 0.000 claims description 2
- 150000001241 acetals Chemical class 0.000 claims description 2
- 229920000122 acrylonitrile butadiene styrene Polymers 0.000 claims description 2
- 239000011521 glass Substances 0.000 claims description 2
- 229920001778 nylon Polymers 0.000 claims description 2
- 229920000573 polyethylene Polymers 0.000 claims description 2
- 229920001155 polypropylene Polymers 0.000 claims description 2
- 229920002223 polystyrene Polymers 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims 4
- 238000002156 mixing Methods 0.000 claims 2
- 239000004677 Nylon Substances 0.000 claims 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 claims 1
- 229920001296 polysiloxane Polymers 0.000 description 33
- 239000008280 blood Substances 0.000 description 13
- 210000004369 blood Anatomy 0.000 description 13
- 238000000034 method Methods 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 7
- 239000000243 solution Substances 0.000 description 6
- 238000009534 blood test Methods 0.000 description 5
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- 239000003146 anticoagulant agent Substances 0.000 description 2
- 229940127219 anticoagulant drug Drugs 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 description 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- XECAHXYUAAWDEL-UHFFFAOYSA-N acrylonitrile butadiene styrene Chemical compound C=CC=C.C=CC#N.C=CC1=CC=CC=C1 XECAHXYUAAWDEL-UHFFFAOYSA-N 0.000 description 1
- 239000004676 acrylonitrile butadiene styrene Substances 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 239000008135 aqueous vehicle Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 229960003624 creatine Drugs 0.000 description 1
- 239000006046 creatine Substances 0.000 description 1
- 229940109239 creatinine Drugs 0.000 description 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000007567 mass-production technique Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 229920000233 poly(alkylene oxides) Polymers 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C17/00—Surface treatment of glass, not in the form of fibres or filaments, by coating
- C03C17/28—Surface treatment of glass, not in the form of fibres or filaments, by coating with organic material
- C03C17/30—Surface treatment of glass, not in the form of fibres or filaments, by coating with organic material with silicon-containing compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0005—Use of materials characterised by their function or physical properties
- A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0005—Use of materials characterised by their function or physical properties
- A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
- A61L33/0041—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate characterised by the choice of an antithrombatic agent other than heparin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S215/00—Bottles and jars
- Y10S215/03—Medical
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
- Y10S623/92—Method or apparatus for preparing or treating prosthetic
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Materials Engineering (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Surgery (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Geochemistry & Mineralogy (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US326712 | 1981-12-02 | ||
| US06/326,712 US4529614A (en) | 1981-12-02 | 1981-12-02 | One step anticoagulant coating |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5897367A JPS5897367A (ja) | 1983-06-09 |
| JPH0323178B2 true JPH0323178B2 (de) | 1991-03-28 |
Family
ID=23273353
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57200249A Granted JPS5897367A (ja) | 1981-12-02 | 1982-11-15 | 一段式凝固防止コ−テイング |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4529614A (de) |
| EP (1) | EP0080908B1 (de) |
| JP (1) | JPS5897367A (de) |
| AU (1) | AU553928B2 (de) |
| DE (1) | DE3265662D1 (de) |
| NZ (1) | NZ202357A (de) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3523969A1 (de) * | 1985-07-04 | 1987-01-08 | Boehringer Mannheim Gmbh | Gerinnungsneutrale, hydrophile glasfasern |
| US4851337A (en) * | 1986-01-08 | 1989-07-25 | Hygeia Sciences, Inc. | Extraction of test substances |
| US4698207A (en) * | 1986-07-14 | 1987-10-06 | Baxter Travenol Laboratories, Inc. | Integrated membrane oxygenator, heat exchanger and reservoir |
| US4808449A (en) * | 1986-08-25 | 1989-02-28 | Sherwood Medical Company | Method for applying a dried coating of biologicals to the interior of a container |
| US5013717A (en) * | 1988-04-18 | 1991-05-07 | Becton, Dickinson And Company | Blood compatible, lubricious article and composition and method therefor |
| US5061738A (en) * | 1988-04-18 | 1991-10-29 | Becton, Dickinson And Company | Blood compatible, lubricious article and composition and method therefor |
| EP0423369B1 (de) * | 1989-04-25 | 1994-10-19 | Toray Industries, Inc. | Antithrombotisches blutbehandlungssystem |
| AU629412B2 (en) * | 1989-11-30 | 1992-10-01 | Becton Dickinson & Company | Selective fungal medium |
| US5843089A (en) | 1990-12-28 | 1998-12-01 | Boston Scientific Corporation | Stent lining |
| DE69201193T2 (de) * | 1991-05-31 | 1995-09-07 | Baxter Int | Schaumdrückende gerinnungsbeständige beschichtung. |
| JPH06242106A (ja) * | 1993-02-01 | 1994-09-02 | Becton Dickinson & Co | 採血器具 |
| US5464650A (en) * | 1993-04-26 | 1995-11-07 | Medtronic, Inc. | Intravascular stent and method |
| US5824048A (en) * | 1993-04-26 | 1998-10-20 | Medtronic, Inc. | Method for delivering a therapeutic substance to a body lumen |
| US20020055710A1 (en) * | 1998-04-30 | 2002-05-09 | Ronald J. Tuch | Medical device for delivering a therapeutic agent and method of preparation |
| US5593639A (en) * | 1994-05-26 | 1997-01-14 | Japan Synthetic Rubber Co., Ltd. | Blood-sampling vessel |
| EP0698398A1 (de) * | 1994-08-23 | 1996-02-28 | Becton, Dickinson and Company | Blutsammlungsgerät |
| US5624617A (en) * | 1994-12-30 | 1997-04-29 | Medtronic, Inc. | Method of manufacture for catheter lumen lubricity |
| US5820917A (en) * | 1995-06-07 | 1998-10-13 | Medtronic, Inc. | Blood-contacting medical device and method |
| US6238578B1 (en) | 1996-12-09 | 2001-05-29 | Sherwood Services Ag | Method for dispensing separator gel in a blood collection tube |
| WO1997041901A1 (en) * | 1996-05-03 | 1997-11-13 | Uros Corporation | Pentosanpolysulfate coating for medical devices |
| US5906744A (en) * | 1997-04-30 | 1999-05-25 | Becton Dickinson And Company | Tube for preparing a plasma specimen for diagnostic assays and method of making thereof |
| US6224830B1 (en) | 1998-01-30 | 2001-05-01 | The Governors Of The University Of Alberta | Absorbance cell for microfluid devices |
| JP4439114B2 (ja) * | 1998-03-19 | 2010-03-24 | スミスズ メディカル エイエスディー インコーポレイテッド | 抗凝固剤で内側を被覆した針 |
| DE19836559A1 (de) | 1998-08-12 | 2000-03-23 | Antigen Gmbh | Gefäß zur Entnahme von Blut |
| US6248127B1 (en) | 1998-08-21 | 2001-06-19 | Medtronic Ave, Inc. | Thromboresistant coated medical device |
| US6423348B1 (en) | 1998-12-15 | 2002-07-23 | James C. Mickus | Anticoagulant compositions |
| US6730349B2 (en) | 1999-04-19 | 2004-05-04 | Scimed Life Systems, Inc. | Mechanical and acoustical suspension coating of medical implants |
| US6368658B1 (en) * | 1999-04-19 | 2002-04-09 | Scimed Life Systems, Inc. | Coating medical devices using air suspension |
| US6506408B1 (en) * | 2000-07-13 | 2003-01-14 | Scimed Life Systems, Inc. | Implantable or insertable therapeutic agent delivery device |
| US6630460B2 (en) * | 2001-02-09 | 2003-10-07 | Medtronic, Inc. | Heparin compositions and methods of making and using the same |
| GB0117879D0 (en) * | 2001-07-21 | 2001-09-12 | Common Services Agency | Storage of liquid compositions |
| EP1429819B1 (de) * | 2001-09-24 | 2010-11-24 | Boston Scientific Limited | Optimierte dosierung bei paclitaxelhaltigen stents |
| ES2239264T3 (es) * | 2001-11-13 | 2005-09-16 | Becton Dickinson And Company | Proceso de secado por pulverizacion para aplicar anticoagulante sobre un cuerpo de jeringa. |
| US20030165614A1 (en) * | 2002-03-01 | 2003-09-04 | Henrik Hansen | Coating a medical implant using a pan coater |
| AU2003230270A1 (en) * | 2002-05-07 | 2003-11-11 | Becton, Dickinson And Company | Collection assembly |
| US20080075788A1 (en) * | 2006-09-21 | 2008-03-27 | Samuel Lee | Diammonium phosphate and other ammonium salts and their use in preventing clotting |
| GB0701821D0 (en) * | 2007-02-01 | 2007-03-14 | Pentapharm Ag | Diagnostic composition and its use in the determination of coagulation characteristics of a test liquid |
| US11137409B2 (en) | 2014-11-06 | 2021-10-05 | The Regents Of The University Of Colorado, A Body Corporate | Identification of novel disease states using viscoelastic analysis in the presence of a thrombolytic agent |
| US11187710B2 (en) | 2015-06-08 | 2021-11-30 | The Regents Of The University Of Colorado, A Body Corporate | Time independent viscoelastic analysis parameter for prediction of patient outcome |
| US11169142B2 (en) | 2016-05-11 | 2021-11-09 | The Regents Of The University Of Colorado, A Body Corporate | Viscoelastic analysis in patients with disease associated with cardiovascular system |
| RU193728U1 (ru) * | 2019-04-17 | 2019-11-12 | Андрей Александрович Суворов | Двухсекционная пробирка с пленочным покрытием с пробозаборником и крышкой для укупоривания пробирки |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1159659A (en) * | 1966-06-23 | 1969-07-30 | Dow Corning | A Device for Use in Contact with Blood |
| CH496482A (fr) * | 1969-08-07 | 1970-09-30 | Lugon Georges | Procédé pour recouvrir la paroi interne d'un récipient d'une couche de fines particules séparées d'au moins un produit chimique |
| FR2114230A5 (de) * | 1970-11-20 | 1972-06-30 | Silicones Ste Indle | |
| FR2142277A5 (en) * | 1971-06-18 | 1973-01-26 | Gen Electric | Antithrombogenic surfaces |
| JPS5250399A (en) * | 1975-10-21 | 1977-04-22 | Agency Of Ind Science & Technol | Process for preparing anticoagulating organosilicon polymers |
| US4112925A (en) * | 1976-04-22 | 1978-09-12 | Corning Glass Works | Blood sample container having an anticoagulant coating of polyvinyl pyrrolidone and a salt of ethylene diamine tetracetate |
| JPS57103647A (en) * | 1980-12-20 | 1982-06-28 | Yoshiatsu Miura | Antithrombus material |
-
1981
- 1981-12-02 US US06/326,712 patent/US4529614A/en not_active Expired - Lifetime
-
1982
- 1982-10-15 AU AU89405/82A patent/AU553928B2/en not_active Ceased
- 1982-11-01 NZ NZ202357A patent/NZ202357A/en unknown
- 1982-11-15 JP JP57200249A patent/JPS5897367A/ja active Granted
- 1982-12-02 EP EP82306421A patent/EP0080908B1/de not_active Expired
- 1982-12-02 DE DE8282306421T patent/DE3265662D1/de not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5897367A (ja) | 1983-06-09 |
| AU553928B2 (en) | 1986-07-31 |
| EP0080908A1 (de) | 1983-06-08 |
| DE3265662D1 (en) | 1985-09-26 |
| NZ202357A (en) | 1984-12-14 |
| AU8940582A (en) | 1983-06-09 |
| US4529614A (en) | 1985-07-16 |
| EP0080908B1 (de) | 1985-08-21 |
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