FR2142277A5 - Antithrombogenic surfaces - Google Patents

Antithrombogenic surfaces

Info

Publication number
FR2142277A5
FR2142277A5 FR7122360A FR7122360A FR2142277A5 FR 2142277 A5 FR2142277 A5 FR 2142277A5 FR 7122360 A FR7122360 A FR 7122360A FR 7122360 A FR7122360 A FR 7122360A FR 2142277 A5 FR2142277 A5 FR 2142277A5
Authority
FR
France
Prior art keywords
antithrombogenic
partic
indanedione
metallic
vapour
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR7122360A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Electric Co
Original Assignee
General Electric Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Electric Co filed Critical General Electric Co
Priority to FR7122360A priority Critical patent/FR2142277A5/en
Application granted granted Critical
Publication of FR2142277A5 publication Critical patent/FR2142277A5/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0041—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate characterised by the choice of an antithrombatic agent other than heparin

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The surfaces of a variety of metallic and non-metallic substances (partic. marterial used in prosthetic devices and in blood transporting equipment) may be rendered antithrombogenic by the following simple inexpensive treatment: The substance to be coated is placed in a vacuum system with a synthetic organic antithrombogenic cpd. (I). is such that when it is heated and vaporised in vacuo the vapour pressure rises to 10 torr. The vapour is then irradiated with UV light of lambda 1800 - 4000 angstroms, and (I) is surface photopolymerised onto the substrate giving it a good quality, adherent, continuous antithrombogenic coating. (I) is pref. vinyl substd. and may be an anticoagulant drug (partic. bishydroxycoumarin, ethyl biscoumacetate, 3-(alpha-acetonylbenzyl)-4-hydroxycoumarine, 2-phenylindane-1,3-dione, 2- p-(phenylsulphonyl)phenyl -1,3-indanedione , or 2-diphenylacetyl-1,3-indanedione) or a fibrinolytic agent (partic, E-amino-caproic acid, p-aminobenzoic acid, salicylic acid, aspirin, phenylbutazone, urethane, dextran, chlorpeniramine or dipyridamole).
FR7122360A 1971-06-18 1971-06-18 Antithrombogenic surfaces Expired FR2142277A5 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7122360A FR2142277A5 (en) 1971-06-18 1971-06-18 Antithrombogenic surfaces

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7122360A FR2142277A5 (en) 1971-06-18 1971-06-18 Antithrombogenic surfaces

Publications (1)

Publication Number Publication Date
FR2142277A5 true FR2142277A5 (en) 1973-01-26

Family

ID=9078930

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7122360A Expired FR2142277A5 (en) 1971-06-18 1971-06-18 Antithrombogenic surfaces

Country Status (1)

Country Link
FR (1) FR2142277A5 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2410013A1 (en) * 1977-11-23 1979-06-22 Unitika Ltd Polymer articles prodn. with reduced thrombogenic tendency - by treating with soln. of synthetic fibrinolytic cpd.
EP0080908A1 (en) * 1981-12-02 1983-06-08 Becton Dickinson and Company One step anticoagulant coating
EP0136916A2 (en) * 1983-10-03 1985-04-10 Sumitomo Electric Industries Limited Anthithrombic resin composition
EP0149693A1 (en) * 1984-01-20 1985-07-31 Dräger Nederland B.V. Method of forming an antithrombogenic layer on medical devices
EP0568451A1 (en) * 1992-04-28 1993-11-03 Terumo Kabushiki Kaisha Thermoplastic polymer composition and medical devices made of the same
WO1995006487A2 (en) * 1993-08-30 1995-03-09 Med Institute, Inc. Intravascular medical device

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2410013A1 (en) * 1977-11-23 1979-06-22 Unitika Ltd Polymer articles prodn. with reduced thrombogenic tendency - by treating with soln. of synthetic fibrinolytic cpd.
EP0080908A1 (en) * 1981-12-02 1983-06-08 Becton Dickinson and Company One step anticoagulant coating
EP0136916A2 (en) * 1983-10-03 1985-04-10 Sumitomo Electric Industries Limited Anthithrombic resin composition
EP0136916A3 (en) * 1983-10-03 1987-02-04 Sumitomo Electric Industries Limited Anthithrombic resin composition
US4822615A (en) * 1983-10-03 1989-04-18 Sumitomo Electric Industries, Ltd. Antithrombic resin composition
EP0149693A1 (en) * 1984-01-20 1985-07-31 Dräger Nederland B.V. Method of forming an antithrombogenic layer on medical devices
EP0568451A1 (en) * 1992-04-28 1993-11-03 Terumo Kabushiki Kaisha Thermoplastic polymer composition and medical devices made of the same
US5417981A (en) * 1992-04-28 1995-05-23 Terumo Kabushiki Kaisha Thermoplastic polymer composition and medical devices made of the same
WO1995006487A2 (en) * 1993-08-30 1995-03-09 Med Institute, Inc. Intravascular medical device
WO1995006487A3 (en) * 1993-08-30 1995-04-06 Med Inst Inc Intravascular medical device
AU704573B2 (en) * 1993-08-30 1999-04-29 Cook Medical Technologies Llc Intravascular medical device

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Legal Events

Date Code Title Description
ST Notification of lapse