JPH02500744A - 新規な薬学的化合物 - Google Patents

新規な薬学的化合物

Info

Publication number
JPH02500744A
JPH02500744A JP63500255A JP50025588A JPH02500744A JP H02500744 A JPH02500744 A JP H02500744A JP 63500255 A JP63500255 A JP 63500255A JP 50025588 A JP50025588 A JP 50025588A JP H02500744 A JPH02500744 A JP H02500744A
Authority
JP
Japan
Prior art keywords
carbon atoms
formula
tables
alkyl
formulas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP63500255A
Other languages
English (en)
Japanese (ja)
Inventor
アルミンゲル，トーマス・ビヨルイエ
ベルイマン，ロルフ・アクセル
ブンガーア，ハンス
リンドベルイ，ペル・レンナート
スンデン，ギユンネル・エリサベート
Original Assignee
アクチエボラゲツト・ヘツスレ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE8604998A external-priority patent/SE8604998D0/xx
Priority claimed from SE8605551A external-priority patent/SE8605551D0/xx
Priority claimed from SE8704049A external-priority patent/SE8704049D0/xx
Application filed by アクチエボラゲツト・ヘツスレ filed Critical アクチエボラゲツト・ヘツスレ
Publication of JPH02500744A publication Critical patent/JPH02500744A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP63500255A 1986-11-21 1987-11-20 新規な薬学的化合物 Pending JPH02500744A (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
SE8604998A SE8604998D0 (sv) 1986-11-21 1986-11-21 Novel pharmacological compounds
SE8604998-8 1986-11-21
SE8605551A SE8605551D0 (sv) 1986-12-23 1986-12-23 Novel pharmacological compounds
SE8605551-4 1986-12-23
SE8704049A SE8704049D0 (sv) 1987-10-16 1987-10-16 Novel pharmacological compounds
SE8704049-9 1987-10-16

Publications (1)

Publication Number Publication Date
JPH02500744A true JPH02500744A (ja) 1990-03-15

Family

ID=27355365

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63500255A Pending JPH02500744A (ja) 1986-11-21 1987-11-20 新規な薬学的化合物

Country Status (24)

Country Link
EP (3) EP0279149B1 (enEXAMPLES)
JP (1) JPH02500744A (enEXAMPLES)
KR (1) KR890700125A (enEXAMPLES)
AT (1) ATE84032T1 (enEXAMPLES)
AU (1) AU612129B2 (enEXAMPLES)
DE (1) DE3783356T2 (enEXAMPLES)
DK (1) DK365488A (enEXAMPLES)
EG (1) EG18379A (enEXAMPLES)
ES (1) ES2052603T3 (enEXAMPLES)
FI (1) FI892454A0 (enEXAMPLES)
GR (1) GR3007385T3 (enEXAMPLES)
HU (1) HU204814B (enEXAMPLES)
IE (2) IE940326L (enEXAMPLES)
IL (1) IL84504A (enEXAMPLES)
IS (1) IS1565B (enEXAMPLES)
LV (1) LV10954B (enEXAMPLES)
MY (1) MY101784A (enEXAMPLES)
NO (1) NO173998C (enEXAMPLES)
NZ (2) NZ222495A (enEXAMPLES)
PL (1) PL157655B1 (enEXAMPLES)
PT (1) PT86186B (enEXAMPLES)
RU (1) RU2062778C1 (enEXAMPLES)
WO (1) WO1988003921A1 (enEXAMPLES)
YU (1) YU47116B (enEXAMPLES)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993023409A1 (en) * 1992-05-21 1993-11-25 Otsuka Pharmaceutical Factory, Inc. Phosphonic diester derivative
JP2009502858A (ja) * 2005-07-28 2009-01-29 インターベツト・インターナシヨナル・ベー・ベー 抗寄生虫活性を有する新規ベンゾイミダゾール（チオ）カルバメートおよびその合成
WO2021033729A1 (ja) * 2019-08-20 2021-02-25 小野薬品工業株式会社 Ｓ１ｐ５受容体作動活性を有する化合物の塩および結晶形

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8801907D0 (sv) * 1988-05-20 1988-05-20 Haessle Ab Novel pharmacological compounds
EP0436025A4 (en) * 1988-09-20 1991-09-11 Hisamitsu Pharmaceutical Co. Inc. Novel dibenz b,e)oxepin derivatives
EG19302A (en) * 1988-12-22 1994-11-30 Haessle Ab Compound with gastric acid inhibitory effect and process for its preparation
SE8804629D0 (sv) * 1988-12-22 1988-12-22 Ab Haessle New therapeutically active compounds
US4965269A (en) * 1989-12-20 1990-10-23 Ab Hassle Therapeutically active chloro substituted benzimidazoles
US5049674A (en) * 1989-12-20 1991-09-17 Aktiebolaget Hassle Therapeutically active fluoro substituted benzimidazoles
US5274099A (en) * 1989-12-20 1993-12-28 Aktiebolaget Hassle Therapeutically active fluoro substituted benzimidazoles
SE9002206D0 (sv) 1990-06-20 1990-06-20 Haessle Ab New compounds
EP0593463B1 (en) * 1990-06-20 1999-09-15 Astra Aktiebolag Dialkoxy-pyridinyl-benzimidazole derivatives, process for their preparation and their pharmaceutical use
EP0481764B1 (en) * 1990-10-17 2000-03-29 Takeda Chemical Industries, Ltd. Pyridine derivatives, their production and use
SE9103776D0 (sv) * 1991-12-19 1991-12-19 Astra Ab New compounds
WO1994026279A1 (en) * 1993-05-18 1994-11-24 The Upjohn Company Bisphosphonate esters for treating gastric disorders
US6875872B1 (en) 1993-05-28 2005-04-05 Astrazeneca Compounds
SE508669C2 (sv) * 1996-04-26 1998-10-26 Astra Ab Nytt förfarande
JP2002510293A (ja) * 1997-05-30 2002-04-02 ドクター・レディーズ・リサーチ・ファウンデーション 抗潰瘍剤として新規なベンゾイミダゾール誘導体、それらの製造方法、及びそれらを含有する薬学的組成物
EP1051181B1 (en) * 1997-12-31 2004-03-17 The University Of Kansas Water soluble prodrugs of tertiary amine containing drugs and methods of making thereof
ZA9810765B (en) * 1998-05-28 1999-08-06 Ranbaxy Lab Ltd Stable oral pharmaceutical composition containing a substituted pyridylsulfinyl benzimidazole.
US20020132819A1 (en) 1999-12-17 2002-09-19 Metcalf Chester A. Novel purinse
CA2425363A1 (en) * 2000-10-12 2003-04-10 Fumihiko Sato Benzimidazole compounds, process for producing the same and use thereof
EP1437352A4 (en) * 2001-09-25 2004-12-08 Takeda Chemical Industries Ltd BENZIMIDAZOLE COMPOUND, METHOD FOR THE PRODUCTION AND USE THEREOF
DK1556371T3 (da) * 2002-07-19 2006-08-21 Winston Pharmaceuticals Llc Benzimidazol-derivater og deres anvendelse som prodrugs for protonpumpe-inhibitorer
GB0400781D0 (en) * 2004-01-14 2004-02-18 Novartis Ag Organic compounds
MX2007002340A (es) * 2004-08-27 2007-10-10 Esteve Labor Dr Inhibidores del receptor sigma.
US10272070B2 (en) 2014-10-14 2019-04-30 The Board of Trustees of the Leland Stanford Junio r University Method for treating neurodegenerative diseases
IL285248B1 (en) 2015-12-15 2025-06-01 Univ Leland Stanford Junior Compound for use as a medicament for preventing and/or treating aging-associated cognitive impairment
IL307972A (en) 2018-08-06 2023-12-01 Univ Leland Stanford Junior 2-arylbenzimidazoles as ppargc1a activators for treating neurodegenerative diseases

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5687818A (en) * 1979-12-19 1981-07-16 Ishikawajima Harima Heavy Ind Co Ltd Reflex type position detector
JPS57137860A (en) * 1981-02-20 1982-08-25 Sumitomo Electric Ind Ltd Optical tachometer
JPS5836312B2 (ja) * 1978-08-21 1983-08-08 日本電信電話株式会社 通信用平衡ケ−ブル線路の障害位置測定方式
JPS5999597A (ja) * 1982-11-30 1984-06-08 株式会社東芝 光学測定装置
JPS6020051U (ja) * 1983-07-19 1985-02-12 三洋電機株式会社 カセツト収納装置

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE418966B (sv) 1974-02-18 1981-07-06 Haessle Ab Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan
SE416649B (sv) 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
IN148930B (enEXAMPLES) 1977-09-19 1981-07-25 Hoffmann La Roche
SE7804231L (sv) 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4359465A (en) * 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
CH644116A5 (de) 1980-08-21 1984-07-13 Hoffmann La Roche Imidazolderivate.
SE8300736D0 (sv) * 1983-02-11 1983-02-11 Haessle Ab Novel pharmacologically active compounds
AU568441B2 (en) * 1984-09-24 1987-12-24 Upjohn Company, The 2-(pyridylalkenesulfinyl) benzimidazole derivatives
IL76839A (en) * 1984-10-31 1988-08-31 Byk Gulden Lomberg Chem Fab Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
SE8505112D0 (sv) * 1985-10-29 1985-10-29 Haessle Ab Novel pharmacological compounds

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5836312B2 (ja) * 1978-08-21 1983-08-08 日本電信電話株式会社 通信用平衡ケ−ブル線路の障害位置測定方式
JPS5687818A (en) * 1979-12-19 1981-07-16 Ishikawajima Harima Heavy Ind Co Ltd Reflex type position detector
JPS57137860A (en) * 1981-02-20 1982-08-25 Sumitomo Electric Ind Ltd Optical tachometer
JPS5999597A (ja) * 1982-11-30 1984-06-08 株式会社東芝 光学測定装置
JPS6020051U (ja) * 1983-07-19 1985-02-12 三洋電機株式会社 カセツト収納装置

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993023409A1 (en) * 1992-05-21 1993-11-25 Otsuka Pharmaceutical Factory, Inc. Phosphonic diester derivative
US5376665A (en) * 1992-05-21 1994-12-27 Otsuka Pharmaceutical Factory, Inc. Phosphonic diester derivatives
JP2009502858A (ja) * 2005-07-28 2009-01-29 インターベツト・インターナシヨナル・ベー・ベー 抗寄生虫活性を有する新規ベンゾイミダゾール（チオ）カルバメートおよびその合成
WO2021033729A1 (ja) * 2019-08-20 2021-02-25 小野薬品工業株式会社 Ｓ１ｐ５受容体作動活性を有する化合物の塩および結晶形
JPWO2021033729A1 (enEXAMPLES) * 2019-08-20 2021-02-25

Also Published As

Publication number Publication date
KR890700125A (ko) 1989-03-02
PT86186B (pt) 1990-08-31
FI892454L (fi) 1989-05-19
NO883229L (no) 1988-09-16
PL268927A1 (en) 1989-01-23
EP0279149A3 (en) 1988-08-31
ES2052603T3 (es) 1994-07-16
LV10954A (lv) 1995-12-20
WO1988003921A1 (en) 1988-06-02
FI892454A7 (fi) 1989-05-19
DK365488D0 (da) 1988-07-01
YU47116B (sh) 1994-12-28
DK365488A (da) 1988-07-01
NZ234564A (en) 1991-04-26
YU211087A (en) 1988-12-31
NO173998B (no) 1993-11-22
DE3783356T2 (de) 1993-04-15
HU204814B (en) 1992-02-28
IS3284A7 (is) 1988-05-22
IE873125L (en) 1988-05-21
PT86186A (en) 1987-12-01
NZ222495A (en) 1991-04-26
ATE84032T1 (de) 1993-01-15
FI892454A0 (fi) 1989-05-19
DE3783356D1 (de) 1993-02-11
AU612129B2 (en) 1991-07-04
LV10954B (en) 1996-08-20
MY101784A (en) 1992-01-17
IL84504A (en) 1994-10-07
IE940326L (en) 1988-05-21
AU8330287A (en) 1988-06-16
EG18379A (en) 1992-11-30
NO883229D0 (no) 1988-07-20
RU2062778C1 (ru) 1996-06-27
NO173998C (no) 1994-03-02
EP0510719A1 (en) 1992-10-28
HUT51269A (en) 1990-04-28
EP0279149A2 (en) 1988-08-24
EP0279149B1 (en) 1992-12-30
IE61178B1 (en) 1994-10-05
GR3007385T3 (enEXAMPLES) 1993-07-30
PL157655B1 (pl) 1992-06-30
EP0332647A1 (en) 1989-09-20
IS1565B (is) 1994-12-13

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