JPH0243734B2 - - Google Patents
Info
- Publication number
- JPH0243734B2 JPH0243734B2 JP56029439A JP2943981A JPH0243734B2 JP H0243734 B2 JPH0243734 B2 JP H0243734B2 JP 56029439 A JP56029439 A JP 56029439A JP 2943981 A JP2943981 A JP 2943981A JP H0243734 B2 JPH0243734 B2 JP H0243734B2
- Authority
- JP
- Japan
- Prior art keywords
- reaction
- aminoalkylthiols
- hydrolysis
- acid
- mercaptothiazolines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002253 acid Substances 0.000 claims description 16
- WGJCBBASTRWVJL-UHFFFAOYSA-N 1,3-thiazolidine-2-thione Chemical class SC1=NCCS1 WGJCBBASTRWVJL-UHFFFAOYSA-N 0.000 claims description 15
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 238000006243 chemical reaction Methods 0.000 description 48
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 32
- 238000006460 hydrolysis reaction Methods 0.000 description 22
- 230000007062 hydrolysis Effects 0.000 description 21
- 238000001953 recrystallisation Methods 0.000 description 11
- 238000000034 method Methods 0.000 description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- 239000000543 intermediate Substances 0.000 description 8
- 239000013078 crystal Substances 0.000 description 7
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 4
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 4
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 4
- 230000003301 hydrolyzing effect Effects 0.000 description 4
- 239000003960 organic solvent Substances 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 230000035484 reaction time Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- BGPJLYIFDLICMR-UHFFFAOYSA-N 1,4,2,3-dioxadithiolan-5-one Chemical compound O=C1OSSO1 BGPJLYIFDLICMR-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 3
- 239000012141 concentrate Substances 0.000 description 3
- 235000008504 concentrate Nutrition 0.000 description 3
- 239000012043 crude product Substances 0.000 description 3
- -1 etc. Substances 0.000 description 3
- 229910000039 hydrogen halide Inorganic materials 0.000 description 3
- 239000012433 hydrogen halide Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 2
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 229910052740 iodine Inorganic materials 0.000 description 2
- 239000011630 iodine Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 150000001356 alkyl thiols Chemical class 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 238000005660 chlorination reaction Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- UFULAYFCSOUIOV-UHFFFAOYSA-N cysteamine Chemical compound NCCS UFULAYFCSOUIOV-UHFFFAOYSA-N 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 229940071870 hydroiodic acid Drugs 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000009790 rate-determining step (RDS) Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56029439A JPS57144253A (en) | 1981-03-03 | 1981-03-03 | Preparation of crude aminoalkylthiol |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56029439A JPS57144253A (en) | 1981-03-03 | 1981-03-03 | Preparation of crude aminoalkylthiol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57144253A JPS57144253A (en) | 1982-09-06 |
| JPH0243734B2 true JPH0243734B2 (ru) | 1990-10-01 |
Family
ID=12276159
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56029439A Granted JPS57144253A (en) | 1981-03-03 | 1981-03-03 | Preparation of crude aminoalkylthiol |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57144253A (ru) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0625035U (ja) * | 1991-04-10 | 1994-04-05 | 株式会社本田ロック | 車両用ドアミラーの取付構造 |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5256362A (en) * | 1989-07-14 | 1993-10-26 | Nippon Shokubai Co., Ltd. | Method for production of granular cysteamine hydrochloride |
| CN109503441B (zh) * | 2017-09-15 | 2021-04-06 | 阜新达得利化工股份有限公司 | 高含量半胱胺盐酸盐的制备方法 |
-
1981
- 1981-03-03 JP JP56029439A patent/JPS57144253A/ja active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0625035U (ja) * | 1991-04-10 | 1994-04-05 | 株式会社本田ロック | 車両用ドアミラーの取付構造 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS57144253A (en) | 1982-09-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA1156257A (en) | Process for the preparation of an alkyl 2-chloropropionate | |
| JPH0243734B2 (ru) | ||
| US10053420B2 (en) | Processes for the preparation of compounds, such as 3-arylbutanals, useful in the synthesis of medetomidine | |
| JPH0217544B2 (ru) | ||
| US8569544B2 (en) | Process for preparation of benzphetamine and its pharmaceutically acceptable salts | |
| KR101557702B1 (ko) | 미티글리니드 칼슘 이수화물의 제조방법 | |
| US6087499A (en) | Process for producing 5-perfluoroalkyluracil derivatives | |
| JP3907787B2 (ja) | 安息香酸誘導体の製造方法 | |
| JPS63425B2 (ru) | ||
| JP2657642B2 (ja) | クロロアルキルアミン塩酸塩類の製造方法 | |
| JP2657641B2 (ja) | クロロアルキルアミン塩酸塩類の製造方法 | |
| JPH01275590A (ja) | アルキルジハロゲノホスファンの製造法 | |
| JP3257779B2 (ja) | タートラニル酸類の製造法 | |
| JPS61178947A (ja) | アリ−ルアルキルケトンの製造方法 | |
| JPS6325577B2 (ru) | ||
| JPS58105959A (ja) | アミノアルキルチオ−ル類の製造法 | |
| JPH1121281A (ja) | ２，４−オキサゾリジンジオンの製造方法 | |
| JPH01146849A (ja) | フエニルアラニン−ｎ−プロピルエステル−塩酸塩の製法 | |
| JPH0751539B2 (ja) | ２，６‐ジハロアニリン誘導体の製造方法 | |
| JP2000212136A (ja) | １，３―ビス（アミノフェノキシベンゼン）の再結晶法 | |
| JPH0710856B2 (ja) | チアゾリジン−２−オン誘導体の製造方法 | |
| HU203516B (en) | Process for producing 1-naphtyl-acetic acid | |
| JPH0791246B2 (ja) | ジメチルホルムアミドの精製法 | |
| JPS60190756A (ja) | １，７−ジ（４−ヒドロキシフエニルチオ）−３，５−ジオキサヘプタンの製造方法 | |
| JPH04253955A (ja) | メルカプトアミン類の製造法 |