JPH02138A - Ｌ‐ドーパ誘導体 - Google Patents

Ｌ‐ドーパ誘導体

Info

Publication number
JPH02138A
JPH02138A JP63227086A JP22708688A JPH02138A JP H02138 A JPH02138 A JP H02138A JP 63227086 A JP63227086 A JP 63227086A JP 22708688 A JP22708688 A JP 22708688A JP H02138 A JPH02138 A JP H02138A
Authority
JP
Japan
Prior art keywords
group
dopa
formula
optionally substituted
acid addition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP63227086A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0541626B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html
Inventor
Yoshimi Tsuchiya
義己 土谷
Masahiro Hayashi
正弘 林
Hiroshi Takehana
竹花　博
Akihiro Hisaka
樋坂　章博
Yoshio Sawazaki
沢崎　芳男
Masaki Ihara
伊原　正樹
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD KK
Original Assignee
Banyu Phamaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Phamaceutical Co Ltd filed Critical Banyu Phamaceutical Co Ltd
Priority to JP63227086A priority Critical patent/JPH02138A/ja
Publication of JPH02138A publication Critical patent/JPH02138A/ja
Publication of JPH0541626B2 publication Critical patent/JPH0541626B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP63227086A 1987-09-18 1988-09-10 Ｌ‐ドーパ誘導体 Granted JPH02138A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP63227086A JPH02138A (ja) 1987-09-18 1988-09-10 Ｌ‐ドーパ誘導体

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP23429987 1987-09-18
JP62-234299 1987-09-18
JP3126088 1988-02-13
JP63-31260 1988-02-13
JP63227086A JPH02138A (ja) 1987-09-18 1988-09-10 Ｌ‐ドーパ誘導体

Publications (2)

Publication Number Publication Date
JPH02138A true JPH02138A (ja) 1990-01-05
JPH0541626B2 JPH0541626B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-06-24

Family

ID=26369718

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63227086A Granted JPH02138A (ja) 1987-09-18 1988-09-10 Ｌ‐ドーパ誘導体

Country Status (12)

Country Link
US (1) US4966915A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0309827B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPH02138A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR890005031A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (1) CN1032785A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE71083T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU2234088A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1316180C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3867403D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK517588A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL87765A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT88526B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005526728A (ja) * 2002-02-15 2005-09-08 ダーファーマ，インコーポレイテッド ドーパミンｄ１受容体アゴニストのモノエステルプロドラッグおよび非対称置換ジエステルプロドラッグ

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004052841A1 (en) * 2002-12-06 2004-06-24 Xenoport, Inc. Carbidopa prodrugs and uses thereof
US6970629B2 (en) 2002-12-19 2005-11-29 Corning Cable Systems Llc Optical tube assembly having a dry insert and methods of making the same
US7471862B2 (en) 2002-12-19 2008-12-30 Corning Cable Systems, Llc Dry fiber optic cables and assemblies
US20090190890A1 (en) 2002-12-19 2009-07-30 Freeland Riley S Fiber optic cable having a dry insert and methods of making the same
IL154318A (en) 2003-02-06 2010-05-31 Sarah Herzog Memorial Hospital Pharmaceutical compositions for the treatment of movement disorders
KR101287297B1 (ko) 2004-06-04 2013-07-23 제노포트 인코포레이티드 레보도파 프로드러그, 및 그의 조성물 및 용도
US7323585B2 (en) * 2004-06-04 2008-01-29 Xenoport, Inc. Levodopa prodrugs, and compositions and uses thereof
AU2006322051B2 (en) * 2005-12-05 2011-09-29 Xenoport, Inc. Levodopa prodrug mesylate, compositions thereof, and uses thereof
CA2673336A1 (en) 2006-12-21 2008-06-26 Xenoport, Inc. Levodopa dimethyl-substituted diester prodrugs, compositions, and methods of use
US7829592B2 (en) 2006-12-21 2010-11-09 Xenoport, Inc. Catechol protected levodopa diester prodrugs, compositions, and methods of use
US8399513B2 (en) 2008-10-20 2013-03-19 Xenoport, Inc. Levodopa prodrug mesylate hydrate
CN102186804A (zh) 2008-10-20 2011-09-14 克塞诺波特公司 合成左旋多巴酯前药的方法
KR101025612B1 (ko) * 2008-11-10 2011-03-30 한국해양연구원 신규 화합물인 Ｒａｍａｌｉｎ 및 그 용도
JP2013520521A (ja) 2009-11-09 2013-06-06 ゼノポート，インコーポレーテッド レボドパプロドラッグの医薬組成物及び経口剤形並びに使用方法
ES2614179T3 (es) 2010-03-04 2017-05-30 Orion Corporation Uso de levodopa, carbidopa y entacapona para el tratamiento de la enfermedad de Parkinson
CN103694127B (zh) * 2013-12-30 2015-04-01 上海交通大学 链霉菌属菌种所产的化合物及该化合物的制备方法和应用
SG11201703170RA (en) 2014-10-21 2017-05-30 Abbvie Inc Carbidopa and l-dopa prodrugs and their use to treat parkinson's disease
KR20180004756A (ko) 2015-05-06 2018-01-12 신애질 코포레이션 약물 입자를 함유하는 제약 현탁액, 그의 투여를 위한 장치, 및 그의 사용 방법
WO2019097120A1 (en) 2017-11-16 2019-05-23 Orion Corporation New use and pharmaceutical dosage forms
BR112021009353A2 (pt) 2018-11-15 2021-11-23 Abbvie Inc Formulações farmacêuticas para administração subcutânea
US20220213128A1 (en) * 2021-01-03 2022-07-07 RockGen Therapeutics LLC L-Dopa Enhanced with a Neuroprotective Agent as a Therapy for Parkinson's Disease
US20240415800A1 (en) * 2021-10-11 2024-12-19 The Johns Hopkins University Dopa and caffeic acid analogs as novel gcpii inhibitors
WO2025075499A1 (en) 2023-10-02 2025-04-10 Universiteit Van Amsterdam Reducing dopamine feed-back inhibition in dopaminergic cells by tadalafil.

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2868818A (en) * 1953-12-15 1959-01-13 Merck & Co Inc Alpha methyl phenylalanines
GB1378419A (en) * 1971-12-28 1974-12-27 Lannacher Heilmittel Phenylalanine derivatives
US3939253A (en) * 1973-11-02 1976-02-17 Interx Research Corporation Novel, transient pro-drug forms of l-dopa useful in the treatment of parkinson's disease

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US393923A (en) * 1888-12-04 Samuel preston
US3725470A (en) * 1969-05-14 1973-04-03 Hoffmann La Roche Amino acid derivatives
CH562199A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1970-10-30 1975-05-30 Hoffmann La Roche
US3983138A (en) * 1973-09-25 1976-09-28 Merck & Co., Inc. Amino acid esters
US3891696A (en) * 1973-11-02 1975-06-24 Interx Research Corp Novel, transient pro-drug forms of l-dopa
US4401676A (en) * 1977-06-01 1983-08-30 Merck & Co., Inc. Novel α-amino acids
US4311706A (en) * 1980-01-22 1982-01-19 Interx Research Corporation Novel dopa/dopamine prodrugs

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2868818A (en) * 1953-12-15 1959-01-13 Merck & Co Inc Alpha methyl phenylalanines
GB1378419A (en) * 1971-12-28 1974-12-27 Lannacher Heilmittel Phenylalanine derivatives
US3939253A (en) * 1973-11-02 1976-02-17 Interx Research Corporation Novel, transient pro-drug forms of l-dopa useful in the treatment of parkinson's disease

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005526728A (ja) * 2002-02-15 2005-09-08 ダーファーマ，インコーポレイテッド ドーパミンｄ１受容体アゴニストのモノエステルプロドラッグおよび非対称置換ジエステルプロドラッグ

Also Published As

Publication number Publication date
JPH0541626B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-06-24
IL87765A0 (en) 1989-02-28
EP0309827A1 (en) 1989-04-05
DK517588A (da) 1989-03-19
CA1316180C (en) 1993-04-13
DE3867403D1 (de) 1992-02-13
DK517588D0 (da) 1988-09-16
EP0309827B1 (en) 1992-01-02
PT88526A (pt) 1988-10-01
KR890005031A (ko) 1989-05-11
US4966915A (en) 1990-10-30
ATE71083T1 (de) 1992-01-15
AU2234088A (en) 1989-03-23
PT88526B (pt) 1992-11-30
CN1032785A (zh) 1989-05-10

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