JPH02108695A - 治療用ヌクレオシド - Google Patents
治療用ヌクレオシドInfo
- Publication number
- JPH02108695A JPH02108695A JP1212848A JP21284889A JPH02108695A JP H02108695 A JPH02108695 A JP H02108695A JP 1212848 A JP1212848 A JP 1212848A JP 21284889 A JP21284889 A JP 21284889A JP H02108695 A JPH02108695 A JP H02108695A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- group
- pharmaceutically acceptable
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB888819732A GB8819732D0 (en) | 1988-08-19 | 1988-08-19 | Therapeutic nucleosides |
| GB8819732.2 | 1988-08-19 | ||
| GB8901294.2 | 1989-01-20 | ||
| GB898901294A GB8901294D0 (en) | 1989-01-20 | 1989-01-20 | Therapeutic nucleosides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH02108695A true JPH02108695A (ja) | 1990-04-20 |
Family
ID=26294302
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1212848A Pending JPH02108695A (ja) | 1988-08-19 | 1989-08-18 | 治療用ヌクレオシド |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5157114A (es) |
| EP (1) | EP0356166B1 (es) |
| JP (1) | JPH02108695A (es) |
| KR (1) | KR900011468A (es) |
| AU (1) | AU617210B2 (es) |
| CA (1) | CA1336430C (es) |
| DE (1) | DE68914750T2 (es) |
| DK (1) | DK406689A (es) |
| ES (1) | ES2052922T3 (es) |
| FI (1) | FI893897A (es) |
| HU (1) | HU204841B (es) |
| IE (1) | IE892654L (es) |
| IL (1) | IL91356A0 (es) |
| MX (1) | MX9203420A (es) |
| MY (1) | MY105855A (es) |
| NZ (1) | NZ230356A (es) |
| PH (1) | PH26733A (es) |
| PT (1) | PT91489B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5215970A (en) * | 1987-04-16 | 1993-06-01 | Medivir Ab | Nucleosides and nucleotide analogues, pharmaceutical composition and processes for the preparation of the compounds |
| US5506215A (en) * | 1987-11-03 | 1996-04-09 | Medivir Ab | 1-(3'-fluoro-2',3'-dideoxy-β-D-ribofuranosyl)-5-substituted pyrimidine nucleosides |
| GB9012899D0 (en) * | 1990-06-09 | 1990-08-01 | Wellcome Found | Anti-hbv pyrimidine nucleoside |
| GB9014618D0 (en) * | 1990-06-30 | 1990-08-22 | Wellcome Found | Process for the preparation of pyrimidine nucleosides |
| GB9020930D0 (en) * | 1990-09-26 | 1990-11-07 | Wellcome Found | Pharmaceutical combinations |
| GB9309787D0 (en) * | 1993-05-12 | 1993-06-23 | Rhone Poulenc Chemicals | Purification of fluoronucleosides |
| ATE169027T1 (de) * | 1993-05-12 | 1998-08-15 | Rhodia Limited | Herstellung von fluoro-nukleosiden und dafür geeignete zwischenprodukte |
| GB9309795D0 (en) * | 1993-05-12 | 1993-06-23 | Rhone Poulenc Chemicals | Preparation of flouro-compounds |
| US6620977B1 (en) * | 1998-01-30 | 2003-09-16 | Daiso Co., Ltd. | Process for producing butanetriol derivative |
| AU2005311730B2 (en) | 2004-12-03 | 2011-11-17 | Adherex Technologies, Inc. | Methods for administering DPD inhibitors in combination with 5-FU and 5-FU prodrugs |
| EP2488182B1 (en) | 2009-10-14 | 2017-07-19 | Elion Oncology LLC | Treating neurotoxicity associated with combinations of 5-FU or its prodrugs and DPD inhibitors |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6212793A (ja) * | 1985-07-10 | 1987-01-21 | ザ ウエルカム フアウンデ−シヨン リミテツド | 抗ウイルス化合物 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1161586A (en) * | 1968-01-15 | 1969-08-13 | Deptsche Akademie Der Wissensc | 5'-Desoxy-5'-Fluoro-Substituted 2'-Desoxy-Ribonucleosides |
| US3562250A (en) * | 1968-07-30 | 1971-02-09 | Akad Wissenschaften Ddr | 2',5'-dideoxy-5'-fluoro nucleosides and process for preparing same |
| US3775397A (en) * | 1969-11-12 | 1973-11-27 | Akad Wissenschaften Ddr | Novel cytostatic 2',3'-dideoxy-3'-fluoropyrimidine-nucleosides |
| US3928319A (en) * | 1971-06-16 | 1975-12-23 | Syntex Inc | 4 -Fluoro nucleosides, novel intermediates and methods of preparing same |
| US4526988A (en) * | 1983-03-10 | 1985-07-02 | Eli Lilly And Company | Difluoro antivirals and intermediate therefor |
| US4666892A (en) * | 1984-03-06 | 1987-05-19 | Sloan-Kettering Memorial Cancer Center | Method and composition for hepatitis treatment with pyrimidine nucleoside compounds |
| SE8602981D0 (sv) * | 1986-07-04 | 1986-07-04 | Astra Laekemedel Ab | Novel medicinal use |
| DD279407A1 (de) * | 1986-07-24 | 1990-06-06 | Akad Wissenschaften Ddr | Verfahren zur herstellung eines mittels gegen aids |
| GB8629892D0 (en) * | 1986-12-15 | 1987-01-28 | Wellcome Found | Antiviral compounds |
| EP0286825A3 (en) * | 1987-03-18 | 1989-04-12 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Use of 3'-fluro-3' deoxythymidine for the manufacture of a medicament for the treatment of virus infections |
| SE8701605D0 (sv) * | 1987-04-16 | 1987-04-16 | Astra Ab | Novel medicinal compounds |
| JPS6422894A (en) * | 1987-07-17 | 1989-01-25 | Asahi Glass Co Ltd | Nulceosides |
| JPS6426593A (en) * | 1987-07-21 | 1989-01-27 | Asahi Glass Co Ltd | Nucleoside derivative |
| JPS6429393A (en) * | 1987-07-24 | 1989-01-31 | Asahi Glass Co Ltd | Nucleoside analog |
| GB8719877D0 (en) * | 1987-08-22 | 1987-09-30 | Wellcome Found | Antiviral compounds |
| SE8704298D0 (sv) * | 1987-11-03 | 1987-11-03 | Astra Ab | Compounds for use in therapy |
| GB8726136D0 (en) * | 1987-11-07 | 1987-12-09 | Wellcome Found | Therapeutic nucleosides |
| EP0316592A3 (en) * | 1987-11-13 | 1990-09-19 | Stichting REGA V.Z.W. | 3'-fluoro-2',3'-dideoxyuridine, and its therapeutic application |
-
1989
- 1989-08-17 US US07/394,987 patent/US5157114A/en not_active Expired - Fee Related
- 1989-08-18 AU AU40061/89A patent/AU617210B2/en not_active Ceased
- 1989-08-18 CA CA000608761A patent/CA1336430C/en not_active Expired - Fee Related
- 1989-08-18 DE DE68914750T patent/DE68914750T2/de not_active Expired - Fee Related
- 1989-08-18 IE IE892654A patent/IE892654L/xx unknown
- 1989-08-18 KR KR1019890011849A patent/KR900011468A/ko not_active Application Discontinuation
- 1989-08-18 FI FI893897A patent/FI893897A/fi not_active Application Discontinuation
- 1989-08-18 JP JP1212848A patent/JPH02108695A/ja active Pending
- 1989-08-18 PT PT91489A patent/PT91489B/pt not_active IP Right Cessation
- 1989-08-18 ES ES89308400T patent/ES2052922T3/es not_active Expired - Lifetime
- 1989-08-18 MY MYPI89001126A patent/MY105855A/en unknown
- 1989-08-18 IL IL91356A patent/IL91356A0/xx unknown
- 1989-08-18 DK DK406689A patent/DK406689A/da not_active Application Discontinuation
- 1989-08-18 NZ NZ230356A patent/NZ230356A/xx unknown
- 1989-08-18 EP EP89308400A patent/EP0356166B1/en not_active Expired - Lifetime
- 1989-08-18 HU HU894245A patent/HU204841B/hu not_active IP Right Cessation
- 1989-08-18 PH PH39112A patent/PH26733A/en unknown
-
1992
- 1992-06-25 MX MX9203420A patent/MX9203420A/es unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6212793A (ja) * | 1985-07-10 | 1987-01-21 | ザ ウエルカム フアウンデ−シヨン リミテツド | 抗ウイルス化合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| IE892654L (en) | 1990-02-19 |
| DE68914750T2 (de) | 1994-10-20 |
| PT91489B (pt) | 1995-05-04 |
| NZ230356A (en) | 1991-09-25 |
| MX9203420A (es) | 1992-07-01 |
| PH26733A (en) | 1992-09-28 |
| FI893897A (fi) | 1990-02-20 |
| EP0356166B1 (en) | 1994-04-20 |
| DK406689D0 (da) | 1989-08-18 |
| HUT51285A (en) | 1990-04-28 |
| EP0356166A2 (en) | 1990-02-28 |
| DK406689A (da) | 1990-02-20 |
| MY105855A (en) | 1995-02-28 |
| US5157114A (en) | 1992-10-20 |
| PT91489A (pt) | 1990-03-08 |
| IL91356A0 (en) | 1990-03-19 |
| EP0356166A3 (en) | 1990-09-12 |
| KR900011468A (ko) | 1990-08-01 |
| AU4006189A (en) | 1990-02-22 |
| AU617210B2 (en) | 1991-11-21 |
| FI893897A0 (fi) | 1989-08-18 |
| HU204841B (en) | 1992-02-28 |
| ES2052922T3 (es) | 1994-07-16 |
| DE68914750D1 (de) | 1994-05-26 |
| CA1336430C (en) | 1995-07-25 |
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