GB1161586A - 5'-Desoxy-5'-Fluoro-Substituted 2'-Desoxy-Ribonucleosides - Google Patents

5'-Desoxy-5'-Fluoro-Substituted 2'-Desoxy-Ribonucleosides

Info

Publication number
GB1161586A
GB1161586A GB207368A GB207368A GB1161586A GB 1161586 A GB1161586 A GB 1161586A GB 207368 A GB207368 A GB 207368A GB 207368 A GB207368 A GB 207368A GB 1161586 A GB1161586 A GB 1161586A
Authority
GB
United Kingdom
Prior art keywords
substituted
desoxy
fluoro
alkali metal
solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB207368A
Inventor
Peter Langen
Gotthard Kowollik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akademie der Wissenschaften der DDR
Original Assignee
Deutsche Akademie der Wissenschaften zu Berlin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deutsche Akademie der Wissenschaften zu Berlin filed Critical Deutsche Akademie der Wissenschaften zu Berlin
Priority to GB207368A priority Critical patent/GB1161586A/en
Publication of GB1161586A publication Critical patent/GB1161586A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)

Abstract

1,161,586. 5<SP>1</SP> Desoxy 51 - fluoro - substituted desoxyribonucleosides. DEUTSCHE AKADEMIE DER WISSENSCHAFTEN ZU BERLIN. 15 Jan., 1968, No. 2073/68. Heading C2C. Compounds of the formula where R 1 is H or acetyl, and R 2 is a substituted or unsubstituted purine or pyrimidine radical, are made by reacting an optionally acetylated 51-arylsulphonyl or 5<SP>1</SP>-mesyl-substituted 2<SP>1</SP>-desoxyribonucleoside with an alkali metal fluoride for 15 minutes to 5 hours in a solvent at a temperature of 50-160‹ C. After separation of the precipitated alkali metal aryl-sulphonate, the reaction mixture is evaporated in a vacuum and the residue taken up in a solvent mixture then separated into its components by multiple column chromatography.
GB207368A 1968-01-15 1968-01-15 5'-Desoxy-5'-Fluoro-Substituted 2'-Desoxy-Ribonucleosides Expired GB1161586A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB207368A GB1161586A (en) 1968-01-15 1968-01-15 5'-Desoxy-5'-Fluoro-Substituted 2'-Desoxy-Ribonucleosides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB207368A GB1161586A (en) 1968-01-15 1968-01-15 5'-Desoxy-5'-Fluoro-Substituted 2'-Desoxy-Ribonucleosides

Publications (1)

Publication Number Publication Date
GB1161586A true GB1161586A (en) 1969-08-13

Family

ID=9733116

Family Applications (1)

Application Number Title Priority Date Filing Date
GB207368A Expired GB1161586A (en) 1968-01-15 1968-01-15 5'-Desoxy-5'-Fluoro-Substituted 2'-Desoxy-Ribonucleosides

Country Status (1)

Country Link
GB (1) GB1161586A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4879377A (en) * 1983-11-18 1989-11-07 Bristol-Myers Company Nucleoside process
US5157114A (en) * 1988-08-19 1992-10-20 Burroughs Wellcome Co. 2',3'-dideoxy-3'-fluoro-5-ethyngluridine

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4879377A (en) * 1983-11-18 1989-11-07 Bristol-Myers Company Nucleoside process
US5157114A (en) * 1988-08-19 1992-10-20 Burroughs Wellcome Co. 2',3'-dideoxy-3'-fluoro-5-ethyngluridine

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees