NL7507554A - Allopurinol prodn in high yield - by reacting ethoxymethylenecyanoethyl acetate with hydrazine then with formamide - Google Patents

Allopurinol prodn in high yield - by reacting ethoxymethylenecyanoethyl acetate with hydrazine then with formamide

Info

Publication number
NL7507554A
NL7507554A NL7507554A NL7507554A NL7507554A NL 7507554 A NL7507554 A NL 7507554A NL 7507554 A NL7507554 A NL 7507554A NL 7507554 A NL7507554 A NL 7507554A NL 7507554 A NL7507554 A NL 7507554A
Authority
NL
Netherlands
Prior art keywords
acetate
ethoxymethylenecyanoethyl
formamide
hydrazine
reacting
Prior art date
Application number
NL7507554A
Other languages
Dutch (nl)
Original Assignee
Gea As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gea As filed Critical Gea As
Publication of NL7507554A publication Critical patent/NL7507554A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

4-Hydroxypyrazole 3,4-d pyrimidine (allopyrinol) (I) is prepd. by reacting ethoxymethylenecyanoethyl acetate (II) with hydrazine at is not >20 degrees C. to give hydrazinomethylenecyanoethyl acetate (III) which is isolated and reacted with formamide. The process gives a pure prod. in high yield, as (III) does not dissolve in organic solvents and is easily isolated.
NL7507554A 1974-07-15 1975-06-25 Allopurinol prodn in high yield - by reacting ethoxymethylenecyanoethyl acetate with hydrazine then with formamide NL7507554A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK378674A DK133432B (en) 1974-07-15 1974-07-15 Process for the preparation of allopurinol.

Publications (1)

Publication Number Publication Date
NL7507554A true NL7507554A (en) 1976-01-19

Family

ID=8126758

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7507554A NL7507554A (en) 1974-07-15 1975-06-25 Allopurinol prodn in high yield - by reacting ethoxymethylenecyanoethyl acetate with hydrazine then with formamide

Country Status (3)

Country Link
JP (1) JPS518290A (en)
DK (1) DK133432B (en)
NL (1) NL7507554A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102643279A (en) * 2012-02-09 2012-08-22 临海市恒源化工有限公司 Synthesis method of allopurinol

Also Published As

Publication number Publication date
JPS518290A (en) 1976-01-23
DK133432C (en) 1976-10-11
DK378674A (en) 1976-01-16
DK133432B (en) 1976-05-17

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Legal Events

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